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The map label for this gene is iscS [H]

Identifier: 158337883

GI number: 158337883

Start: 4810964

End: 4812121

Strand: Direct

Name: iscS [H]

Synonym: AM1_4769

Alternate gene names: 158337883

Gene position: 4810964-4812121 (Clockwise)

Preceding gene: 158337882

Following gene: 158337887

Centisome position: 73.97

GC content: 50.69

Gene sequence:

>1158_bases
ATGCAAATCTACTTAGATTACAGTGCAACCACTCCTTGTCACCCAGACGTGATTATCGCCATGGGTAAAGTTTGGACAGA
ACAATGGGGCAATCCGTCTAGTTTGCATGAGTGGGGACAACGGTCTGCCACCGTTTTAGAGCAGGCACGCATGCAGATTG
CAGACTTGATTCATGCTCCCGCTGAGTCGATTATTTTTACGTCGGGTGGGACTGAAGCCAATAACTTAGCGTTAATGGGG
ATTGCTCGAACCTTTACCCAACCCCAGCATTTAATCATCTCTAGTATTGAGCACTCTGCGATTACTGAACCAGCTCGCCT
GTTAGAGCAACAGGGATGGCAAGTCACTCGTTTGCCCGTAGATTCCCAAGGTCATATCTCACCAGATGCTCTGAATGACT
CAATTCAAAACAACACTGTTTTAGTCTCAGTGATTTATGGTCAGAGCGAGATTGGTACTCTACAATCGATCCACACTTTA
GGGCAAATCGCGCGCGATCGAGGCGTGCTCTTTCATTCCGATGCGGTGCAGGTAGCGGGTCGTCTCCCCATTGATGTGCA
AACCTTGCCCGTGGATTTACTCTCCCTCTCTAGCCATAAACTCTATGGTCCCCAAGGAGCAGGCGCTTTATATGTGCGTC
CTGGGACTCACCTGATTCCCCTATTGGCAGGGGGCGGACAGGAACAAGGTATGCGTTCAGGGACACCCGCTGTACCCATT
ATTGCTGGGTTTGGTTTGGCGGCTGAGATGGCGGCGGAAGAGATGGAGGCAGAGGGGGTGCGACTGATGCAGCTGCGCGA
TCGCATGTTTGCTCAACTCAGCCACTCTCCCTACCTACTGCCAACGGGAGATCTGAGCCAGCGATTACCCCATCACGTCA
GCTTTTGCCTCCCTCCTACCACGGAGATAACAGGTAAGACCTTAGTCCGACAGATGAATTTGGCAGGCATTGCCATTAGT
GCCGGGTCGGCGTGCCATAGCGGTAAGCTATCCCCCAGCCCTATTTTGAAAGCCATGGGATACTCAGATCAACAAGCGTT
ATCCGGTATTCGCTTGACCCTAGGTAAGCAAACAACTCTCGAAGATATCGATTGGACCATTACAGCCTTAAATCAACTAT
TGCATCGACTAATGCCTCAATCGGCGGCAATTGTCTAA

Upstream 100 bases:

>100_bases
TTCGGGTGACTATACCTTGCCTGCAGAATCCCGCTAGACTGTGAAGCAGACCTTCCCATGATCTAGAGGTAGTACAGTTG
CCTGTCAAACGAACATCCCC

Downstream 100 bases:

>100_bases
ACCCCGTCGGATCTTAAGGCGATACGCTCACAGGCCGTTCGGACTGCATTAACTGCATGGCATTGAGTTGAGCATGGGCT
AAGAATCCTAAACTGACCAT

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MQIYLDYSATTPCHPDVIIAMGKVWTEQWGNPSSLHEWGQRSATVLEQARMQIADLIHAPAESIIFTSGGTEANNLALMG
IARTFTQPQHLIISSIEHSAITEPARLLEQQGWQVTRLPVDSQGHISPDALNDSIQNNTVLVSVIYGQSEIGTLQSIHTL
GQIARDRGVLFHSDAVQVAGRLPIDVQTLPVDLLSLSSHKLYGPQGAGALYVRPGTHLIPLLAGGGQEQGMRSGTPAVPI
IAGFGLAAEMAAEEMEAEGVRLMQLRDRMFAQLSHSPYLLPTGDLSQRLPHHVSFCLPPTTEITGKTLVRQMNLAGIAIS
AGSACHSGKLSPSPILKAMGYSDQQALSGIRLTLGKQTTLEDIDWTITALNQLLHRLMPQSAAIV

Sequences:

>Translated_385_residues
MQIYLDYSATTPCHPDVIIAMGKVWTEQWGNPSSLHEWGQRSATVLEQARMQIADLIHAPAESIIFTSGGTEANNLALMG
IARTFTQPQHLIISSIEHSAITEPARLLEQQGWQVTRLPVDSQGHISPDALNDSIQNNTVLVSVIYGQSEIGTLQSIHTL
GQIARDRGVLFHSDAVQVAGRLPIDVQTLPVDLLSLSSHKLYGPQGAGALYVRPGTHLIPLLAGGGQEQGMRSGTPAVPI
IAGFGLAAEMAAEEMEAEGVRLMQLRDRMFAQLSHSPYLLPTGDLSQRLPHHVSFCLPPTTEITGKTLVRQMNLAGIAIS
AGSACHSGKLSPSPILKAMGYSDQQALSGIRLTLGKQTTLEDIDWTITALNQLLHRLMPQSAAIV
>Mature_385_residues
MQIYLDYSATTPCHPDVIIAMGKVWTEQWGNPSSLHEWGQRSATVLEQARMQIADLIHAPAESIIFTSGGTEANNLALMG
IARTFTQPQHLIISSIEHSAITEPARLLEQQGWQVTRLPVDSQGHISPDALNDSIQNNTVLVSVIYGQSEIGTLQSIHTL
GQIARDRGVLFHSDAVQVAGRLPIDVQTLPVDLLSLSSHKLYGPQGAGALYVRPGTHLIPLLAGGGQEQGMRSGTPAVPI
IAGFGLAAEMAAEEMEAEGVRLMQLRDRMFAQLSHSPYLLPTGDLSQRLPHHVSFCLPPTTEITGKTLVRQMNLAGIAIS
AGSACHSGKLSPSPILKAMGYSDQQALSGIRLTLGKQTTLEDIDWTITALNQLLHRLMPQSAAIV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=384, Percent_Identity=40.8854166666667, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI156713448, Length=419, Percent_Identity=34.3675417661098, Blast_Score=212, Evalue=4e-55,
Organism=Escherichia coli, GI48994898, Length=383, Percent_Identity=42.2976501305483, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1789175, Length=397, Percent_Identity=26.448362720403, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787970, Length=401, Percent_Identity=24.9376558603491, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25143064, Length=381, Percent_Identity=40.9448818897638, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17533177, Length=334, Percent_Identity=33.2335329341317, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6319831, Length=386, Percent_Identity=41.7098445595855, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI20129463, Length=384, Percent_Identity=39.5833333333333, Blast_Score=283, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41464; Mature: 41464

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIYLDYSATTPCHPDVIIAMGKVWTEQWGNPSSLHEWGQRSATVLEQARMQIADLIHAP
CEEEEEECCCCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AESIIFTSGGTEANNLALMGIARTFTQPQHLIISSIEHSAITEPARLLEQQGWQVTRLPV
CCCEEEECCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECC
DSQGHISPDALNDSIQNNTVLVSVIYGQSEIGTLQSIHTLGQIARDRGVLFHSDAVQVAG
CCCCCCCHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCHHHHCC
RLPIDVQTLPVDLLSLSSHKLYGPQGAGALYVRPGTHLIPLLAGGGQEQGMRSGTPAVPI
CCCEEEEECCHHHHHCCCCCEECCCCCCEEEECCCCCEEEEEECCCHHCCCCCCCCCCHH
IAGFGLAAEMAAEEMEAEGVRLMQLRDRMFAQLSHSPYLLPTGDLSQRLPHHVSFCLPPT
HCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCEEEECCCC
TEITGKTLVRQMNLAGIAISAGSACHSGKLSPSPILKAMGYSDQQALSGIRLTLGKQTTL
CCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHCCCCHHHHHCCEEEEECCCCCH
EDIDWTITALNQLLHRLMPQSAAIV
HHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQIYLDYSATTPCHPDVIIAMGKVWTEQWGNPSSLHEWGQRSATVLEQARMQIADLIHAP
CEEEEEECCCCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AESIIFTSGGTEANNLALMGIARTFTQPQHLIISSIEHSAITEPARLLEQQGWQVTRLPV
CCCEEEECCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECC
DSQGHISPDALNDSIQNNTVLVSVIYGQSEIGTLQSIHTLGQIARDRGVLFHSDAVQVAG
CCCCCCCHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCHHHHCC
RLPIDVQTLPVDLLSLSSHKLYGPQGAGALYVRPGTHLIPLLAGGGQEQGMRSGTPAVPI
CCCEEEEECCHHHHHCCCCCEECCCCCCEEEECCCCCEEEEEECCCHHCCCCCCCCCCHH
IAGFGLAAEMAAEEMEAEGVRLMQLRDRMFAQLSHSPYLLPTGDLSQRLPHHVSFCLPPT
HCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCEEEECCCC
TEITGKTLVRQMNLAGIAISAGSACHSGKLSPSPILKAMGYSDQQALSGIRLTLGKQTTL
CCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHCCCCHHHHHCCEEEEECCCCCH
EDIDWTITALNQLLHRLMPQSAAIV
HHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA