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The map label for this gene is adk [H]

Identifier: 158337829

GI number: 158337829

Start: 4739260

End: 4739820

Strand: Direct

Name: adk [H]

Synonym: AM1_4715

Alternate gene names: 158337829

Gene position: 4739260-4739820 (Clockwise)

Preceding gene: 158337828

Following gene: 158337830

Centisome position: 72.87

GC content: 49.73

Gene sequence:

>561_bases
GTGGCACGTTTAATTCTGTTTGGGCCACCTGGGGCAGGCAAAGGTACGCAAGCCGTTACCCTCGCAGCAGACTTTAGTAT
TCCTCATATTTCGACGGGAGATTTATTCCGAGCAGCTATTTCGGGTAAAACTCCTCTAGGATTGAAAGTTCAATCCTACT
TGGATCAAGGGCAATTGGTCCCGGATCAAGTGGTGATTGATATGGTCCAAGAGCGATTGGCCCAGTCGGATACTGCTGGT
GGATGGTTATTGGATGGATTTCCCCGGACTATTCCTCAAGCCCAAACGTTGGACAAGCTTCTACAGGAGATGAACCAAAG
TTGCGATCGCGTCATCAATCTCCAGGTCCCTGAACAGACTTTGGTCACCCGGATGCTAAGCCGAGGACGGAAGGATGATA
CGGAAGCCGTTATCCAAGATCGTCTCCAGGTCTACCATACAGAGACTGCAACCATCTTAGATTTCTATCGTGAACGCAAC
TGCTTAGCGGATATCGATGGCGATACGACAGTGGAAGCCGTGACCGAACGCATCAAAGCGGCTTTGGCAGATCTCACATA
A

Upstream 100 bases:

>100_bases
CAACATCACTTCTGATTTTGGTGGGTGTTGCGATTGATACGGCTAAGCAAATTCAGACCTATGTGATTTCCCAACGGTAT
GAAGGGATGGTGAAACAGTA

Downstream 100 bases:

>100_bases
TTCTTTATACTCTCTGTGTAGAAGCTGGATAACCTATCATTCGGTAAATCGGTTCAAACTCATCCCTAGGAGGATCAACT
TTTTGGCTAAGCAAGATGCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MARLILFGPPGAGKGTQAVTLAADFSIPHISTGDLFRAAISGKTPLGLKVQSYLDQGQLVPDQVVIDMVQERLAQSDTAG
GWLLDGFPRTIPQAQTLDKLLQEMNQSCDRVINLQVPEQTLVTRMLSRGRKDDTEAVIQDRLQVYHTETATILDFYRERN
CLADIDGDTTVEAVTERIKAALADLT

Sequences:

>Translated_186_residues
MARLILFGPPGAGKGTQAVTLAADFSIPHISTGDLFRAAISGKTPLGLKVQSYLDQGQLVPDQVVIDMVQERLAQSDTAG
GWLLDGFPRTIPQAQTLDKLLQEMNQSCDRVINLQVPEQTLVTRMLSRGRKDDTEAVIQDRLQVYHTETATILDFYRERN
CLADIDGDTTVEAVTERIKAALADLT
>Mature_185_residues
ARLILFGPPGAGKGTQAVTLAADFSIPHISTGDLFRAAISGKTPLGLKVQSYLDQGQLVPDQVVIDMVQERLAQSDTAGG
WLLDGFPRTIPQAQTLDKLLQEMNQSCDRVINLQVPEQTLVTRMLSRGRKDDTEAVIQDRLQVYHTETATILDFYRERNC
LADIDGDTTVEAVTERIKAALADLT

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=34.8837209302326, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=34.8837209302326, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI4502011, Length=180, Percent_Identity=30, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI19923437, Length=201, Percent_Identity=30.8457711442786, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28144899, Length=177, Percent_Identity=28.8135593220339, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI28144897, Length=177, Percent_Identity=28.8135593220339, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI7706497, Length=191, Percent_Identity=28.7958115183246, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=32.2834645669291, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1786680, Length=208, Percent_Identity=36.5384615384615, Blast_Score=131, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=34.0540540540541, Blast_Score=119, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=29.7674418604651, Blast_Score=119, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17533833, Length=174, Percent_Identity=27.0114942528736, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17537943, Length=213, Percent_Identity=27.6995305164319, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147457, Length=184, Percent_Identity=25, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=196, Percent_Identity=35.7142857142857, Blast_Score=135, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=30.8080808080808, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322828, Length=189, Percent_Identity=27.5132275132275, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI22026816, Length=215, Percent_Identity=33.0232558139535, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17737899, Length=201, Percent_Identity=28.8557213930348, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24645822, Length=201, Percent_Identity=28.8557213930348, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17647141, Length=180, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24663208, Length=180, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221459597, Length=179, Percent_Identity=29.0502793296089, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356893, Length=179, Percent_Identity=29.0502793296089, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20411; Mature: 20279

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLILFGPPGAGKGTQAVTLAADFSIPHISTGDLFRAAISGKTPLGLKVQSYLDQGQLV
CCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCC
PDQVVIDMVQERLAQSDTAGGWLLDGFPRTIPQAQTLDKLLQEMNQSCDRVINLQVPEQT
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHH
LVTRMLSRGRKDDTEAVIQDRLQVYHTETATILDFYRERNCLADIDGDTTVEAVTERIKA
HHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
ALADLT
HHHCCC
>Mature Secondary Structure 
ARLILFGPPGAGKGTQAVTLAADFSIPHISTGDLFRAAISGKTPLGLKVQSYLDQGQLV
CEEEEECCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCC
PDQVVIDMVQERLAQSDTAGGWLLDGFPRTIPQAQTLDKLLQEMNQSCDRVINLQVPEQT
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHH
LVTRMLSRGRKDDTEAVIQDRLQVYHTETATILDFYRERNCLADIDGDTTVEAVTERIKA
HHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
ALADLT
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA