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The map label for this gene is cyoE

Identifier: 158337739

GI number: 158337739

Start: 4656991

End: 4657965

Strand: Direct

Name: cyoE

Synonym: AM1_4623

Alternate gene names: 158337739

Gene position: 4656991-4657965 (Clockwise)

Preceding gene: 158337738

Following gene: 158337740

Centisome position: 71.6

GC content: 50.56

Gene sequence:

>975_bases
ATGCAAAAAACCATATGGGCTGAGGTTCCTTGGCTTCATCCTGGTTTTGCTCAGACCTGCATCGATTTCTATCAACTGAC
TAAACCCCGGCTGATTCTGTTGTTTTTGATTACAACGGCGGCTGCCATGTGGGTTGCTTCCTCTGGACAAGTCGGCCCGC
GATTATTTCTAACGACTTTACTCGCAGGCGCTTGTGCTGCGGGGTCGGCCAATACCATCAACTGTATTTACGATCGCGAC
ATCGACTACATCATGGAGCGAACCCGGCATCGTCCTCTCCCCTCTGGGCGAATCCAAGTCTGGCAGGCTAGTGTTTTTGC
TGCATCATTAGCCCTCACCGCCTTTTTCCTGTTGGCCTTTGGGGCCAATCTTTTGAGTGCCTGTCTAGCGATGGCGGGTA
TAGCTGTTTATATTGGTGTCTATACTTACTGGCTGAAGCGCTCATCCACCCAAAATATCGTAATTGGTGGTGCTGCAGGG
GCTATTCCCCCCCTAGTGGGTTGGGCTGCGGTCACTGGAGAATTGAGCTGGGCCGCTTGGGTACTGTTTGCCATCATCTT
CATCTGGACGCCACCCCATTTTTGGCCCCTCGCCATGATGATTGAAGAAGATTATTCCAAAGTCGGCGTTCCCATGATGC
CTGTGGTGAATGGTATGGCCACCACTGCCAATCAGACCTTTATCTACACGCTCCTGTTGTTACCCGTCACCCTGTTATTG
GTTTATCCCTTAAAAGTGTCTGGTGCGTTATATGCGTCGATAGCCATTGTGCTCTGGGTGCAGTTTATTCACAAAGCCTG
GCAACTGACTCAAACCCCAGATGATAAGCAGATGGCCCGGTCCGTCTTTAAGTTCTCGATTCTGTATATGATGCTGCTCT
GTGCAGGGATGGGAGTCGATAGTCTTCCCTGGACTCAACAGATATGGCACCACTCCACTCATATCCTTCAAGCTTGGATA
CCCAGCATTGGTTGA

Upstream 100 bases:

>100_bases
TCCCCTCGCAATGACAGGCTCTTTAGAACCGTCTTAAGTCTTCCCCTCGCTACGTTTTCATCGTCTTGCCCCATCTTGGA
ATTTATTCAGAGGCTTAAAT

Downstream 100 bases:

>100_bases
AGTCATCAACTTCACCTTGAAGCTACCCCATCTGGAATTTTTTTATCCAGATTGATAGGTACCTCTGTTTTTATTGAAAC
TATGGCAATATTCGGCGGAT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQKTIWAEVPWLHPGFAQTCIDFYQLTKPRLILLFLITTAAAMWVASSGQVGPRLFLTTLLAGACAAGSANTINCIYDRD
IDYIMERTRHRPLPSGRIQVWQASVFAASLALTAFFLLAFGANLLSACLAMAGIAVYIGVYTYWLKRSSTQNIVIGGAAG
AIPPLVGWAAVTGELSWAAWVLFAIIFIWTPPHFWPLAMMIEEDYSKVGVPMMPVVNGMATTANQTFIYTLLLLPVTLLL
VYPLKVSGALYASIAIVLWVQFIHKAWQLTQTPDDKQMARSVFKFSILYMMLLCAGMGVDSLPWTQQIWHHSTHILQAWI
PSIG

Sequences:

>Translated_324_residues
MQKTIWAEVPWLHPGFAQTCIDFYQLTKPRLILLFLITTAAAMWVASSGQVGPRLFLTTLLAGACAAGSANTINCIYDRD
IDYIMERTRHRPLPSGRIQVWQASVFAASLALTAFFLLAFGANLLSACLAMAGIAVYIGVYTYWLKRSSTQNIVIGGAAG
AIPPLVGWAAVTGELSWAAWVLFAIIFIWTPPHFWPLAMMIEEDYSKVGVPMMPVVNGMATTANQTFIYTLLLLPVTLLL
VYPLKVSGALYASIAIVLWVQFIHKAWQLTQTPDDKQMARSVFKFSILYMMLLCAGMGVDSLPWTQQIWHHSTHILQAWI
PSIG
>Mature_324_residues
MQKTIWAEVPWLHPGFAQTCIDFYQLTKPRLILLFLITTAAAMWVASSGQVGPRLFLTTLLAGACAAGSANTINCIYDRD
IDYIMERTRHRPLPSGRIQVWQASVFAASLALTAFFLLAFGANLLSACLAMAGIAVYIGVYTYWLKRSSTQNIVIGGAAG
AIPPLVGWAAVTGELSWAAWVLFAIIFIWTPPHFWPLAMMIEEDYSKVGVPMMPVVNGMATTANQTFIYTLLLLPVTLLL
VYPLKVSGALYASIAIVLWVQFIHKAWQLTQTPDDKQMARSVFKFSILYMMLLCAGMGVDSLPWTQQIWHHSTHILQAWI
PSIG

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=193, Percent_Identity=37.8238341968912, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=35.4838709677419, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71998235, Length=290, Percent_Identity=30, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325085, Length=220, Percent_Identity=32.2727272727273, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19921064, Length=287, Percent_Identity=31.0104529616725, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_ACAM1 (B0C0A5)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001518915.1
- GeneID:   5683425
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_4623
- HOGENOM:   HBG656003
- OMA:   ANTINCI
- ProtClustDB:   CLSK2475865
- BioCyc:   AMAR329726:AM1_4623-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 35874; Mature: 35874

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12f687c8)-; HASH(0x12e08fa0)-; HASH(0x13c5bf14)-; HASH(0x136b9aec)-; HASH(0x136b9ec4)-; HASH(0x136b9bf4)-; HASH(0x135c8810)-; HASH(0x136b9e34)-; HASH(0x13e71658)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTIWAEVPWLHPGFAQTCIDFYQLTKPRLILLFLITTAAAMWVASSGQVGPRLFLTTL
CCCCEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAGACAAGSANTINCIYDRDIDYIMERTRHRPLPSGRIQVWQASVFAASLALTAFFLLAF
HHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GANLLSACLAMAGIAVYIGVYTYWLKRSSTQNIVIGGAAGAIPPLVGWAAVTGELSWAAW
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHH
VLFAIIFIWTPPHFWPLAMMIEEDYSKVGVPMMPVVNGMATTANQTFIYTLLLLPVTLLL
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCHHHHHHHHHHHHHHHH
VYPLKVSGALYASIAIVLWVQFIHKAWQLTQTPDDKQMARSVFKFSILYMMLLCAGMGVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
SLPWTQQIWHHSTHILQAWIPSIG
CCCHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MQKTIWAEVPWLHPGFAQTCIDFYQLTKPRLILLFLITTAAAMWVASSGQVGPRLFLTTL
CCCCEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAGACAAGSANTINCIYDRDIDYIMERTRHRPLPSGRIQVWQASVFAASLALTAFFLLAF
HHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GANLLSACLAMAGIAVYIGVYTYWLKRSSTQNIVIGGAAGAIPPLVGWAAVTGELSWAAW
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHH
VLFAIIFIWTPPHFWPLAMMIEEDYSKVGVPMMPVVNGMATTANQTFIYTLLLLPVTLLL
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCHHHHHHHHHHHHHHHH
VYPLKVSGALYASIAIVLWVQFIHKAWQLTQTPDDKQMARSVFKFSILYMMLLCAGMGVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
SLPWTQQIWHHSTHILQAWIPSIG
CCCHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA