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The map label for this gene is pdxH

Identifier: 158337713

GI number: 158337713

Start: 4630964

End: 4631623

Strand: Direct

Name: pdxH

Synonym: AM1_4597

Alternate gene names: 158337713

Gene position: 4630964-4631623 (Clockwise)

Preceding gene: 158337708

Following gene: 158337714

Centisome position: 71.2

GC content: 49.24

Gene sequence:

>660_bases
ATGTCTTTAATCGATCCAACACAAACCTCCATTTCAGATCTGCGCCGTGATTATCGACAGCAGGCCCTTTTAGAAACAGA
GGTCAATGCCAATCCCATCCTTCAATTTCAGTCTTGGTTTGAGCAAGCGGTCCAAGCAGAATTACCCGAACCAAATGCCA
TGACCTTAGCGACTGTCTCTGCAGACAGTCAGCCCTCTGCCCGCATGGTGTTATTGAAAGGGTTCGATCAGCAGGGATTC
ATTTTTTATACCAATTATCTCAGTCGAAAAGGGCAAGATTTAGCCCAAAGACCTTGGGCTGCCTTAGTATTTTGGTGGGC
AGAATTGGAACGTCAGGTCCGAATTGAAGGGAAAGTGGTGAAGGTCAGTGACTCAGAAACGAAGGCCTATTTTGAGAGTC
GGCCTCGGGGCAGTCAACTTGGGGCATGGGCATCAGACCAAAGCCAAGTGATTGGTGATCGCGATATTCTAGACCAGCGC
CTGCAAGCACTGGAACAAAAATATCAGAATCAACCGATTCCCCGGCCTCCCCATTGGGGGGGCTATCGGGTCACCCCTCA
TCTGATCGAATTTTGGCAAGGGCGTACTAGCCGTCTCCATGACCGTCTCTGTTATCGATATTCGGATCAGGAGTGGATCC
TTGAGCGATTATCTCCCTAA

Upstream 100 bases:

>100_bases
GTTCGATAATTGAAGAGCGCTTGCCCATCAGCGGTCAACCCAGCCCATCCAGGTTTAGTTATACCTAAGAAATTATGAGT
ATTCGAGTAAGCAAGCCCTG

Downstream 100 bases:

>100_bases
AGTTGAATAGCCTATGACACTCATCCAAGTTTGGGGATGCTTACTCATTTTCGTTCTATGTCCCTTATTGGGGGGCATAC
CGGCATCAGAATGGTTGATT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSLIDPTQTSISDLRRDYRQQALLETEVNANPILQFQSWFEQAVQAELPEPNAMTLATVSADSQPSARMVLLKGFDQQGF
IFYTNYLSRKGQDLAQRPWAALVFWWAELERQVRIEGKVVKVSDSETKAYFESRPRGSQLGAWASDQSQVIGDRDILDQR
LQALEQKYQNQPIPRPPHWGGYRVTPHLIEFWQGRTSRLHDRLCYRYSDQEWILERLSP

Sequences:

>Translated_219_residues
MSLIDPTQTSISDLRRDYRQQALLETEVNANPILQFQSWFEQAVQAELPEPNAMTLATVSADSQPSARMVLLKGFDQQGF
IFYTNYLSRKGQDLAQRPWAALVFWWAELERQVRIEGKVVKVSDSETKAYFESRPRGSQLGAWASDQSQVIGDRDILDQR
LQALEQKYQNQPIPRPPHWGGYRVTPHLIEFWQGRTSRLHDRLCYRYSDQEWILERLSP
>Mature_218_residues
SLIDPTQTSISDLRRDYRQQALLETEVNANPILQFQSWFEQAVQAELPEPNAMTLATVSADSQPSARMVLLKGFDQQGFI
FYTNYLSRKGQDLAQRPWAALVFWWAELERQVRIEGKVVKVSDSETKAYFESRPRGSQLGAWASDQSQVIGDRDILDQRL
QALEQKYQNQPIPRPPHWGGYRVTPHLIEFWQGRTSRLHDRLCYRYSDQEWILERLSP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=228, Percent_Identity=46.4912280701754, Blast_Score=214, Evalue=4e-56,
Organism=Escherichia coli, GI1787926, Length=209, Percent_Identity=44.9760765550239, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17553712, Length=204, Percent_Identity=44.6078431372549, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319509, Length=210, Percent_Identity=42.8571428571429, Blast_Score=164, Evalue=7e-42,
Organism=Drosophila melanogaster, GI45551845, Length=232, Percent_Identity=42.6724137931034, Blast_Score=173, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24644901, Length=232, Percent_Identity=42.6724137931034, Blast_Score=173, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24644903, Length=176, Percent_Identity=32.9545454545455, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_ACAM1 (B0C079)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001518889.1
- ProteinModelPortal:   B0C079
- SMR:   B0C079
- GeneID:   5683399
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_4597
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   CLSK2475862
- BioCyc:   AMAR329726:AM1_4597-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25529; Mature: 25398

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 68-68 BINDING 71-71 BINDING 73-73 BINDING 90-90 BINDING 130-130 BINDING 134-134 BINDING 138-138

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIDPTQTSISDLRRDYRQQALLETEVNANPILQFQSWFEQAVQAELPEPNAMTLATVS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
ADSQPSARMVLLKGFDQQGFIFYTNYLSRKGQDLAQRPWAALVFWWAELERQVRIEGKVV
CCCCCCCEEEEEECCCCCCEEEEEHHHHHCCCHHHHCCHHHHHHHHHHHHHHEEECCEEE
KVSDSETKAYFESRPRGSQLGAWASDQSQVIGDRDILDQRLQALEQKYQNQPIPRPPHWG
EECCCHHHHHHHCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GYRVTPHLIEFWQGRTSRLHDRLCYRYSDQEWILERLSP
CCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
SLIDPTQTSISDLRRDYRQQALLETEVNANPILQFQSWFEQAVQAELPEPNAMTLATVS
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
ADSQPSARMVLLKGFDQQGFIFYTNYLSRKGQDLAQRPWAALVFWWAELERQVRIEGKVV
CCCCCCCEEEEEECCCCCCEEEEEHHHHHCCCHHHHCCHHHHHHHHHHHHHHEEECCEEE
KVSDSETKAYFESRPRGSQLGAWASDQSQVIGDRDILDQRLQALEQKYQNQPIPRPPHWG
EECCCHHHHHHHCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GYRVTPHLIEFWQGRTSRLHDRLCYRYSDQEWILERLSP
CCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA