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The map label for this gene is pkn1 [H]

Identifier: 158337622

GI number: 158337622

Start: 4529793

End: 4531442

Strand: Reverse

Name: pkn1 [H]

Synonym: AM1_4503

Alternate gene names: 158337622

Gene position: 4531442-4529793 (Counterclockwise)

Preceding gene: 158337624

Following gene: 158337621

Centisome position: 69.67

GC content: 46.85

Gene sequence:

>1650_bases
ATGCCCAATTCCTGCTTAGACCAGGCACTTAAGCCGGTTAAAGTGATGATCTCGAATGCTGATCAGCACCTTGAGTTATG
CCAGTCACTGGAACTGCATCTGAGGGATTTGCAGCAGAAAGGGTTAATTGAATTGGGGTGCGATCGCAGGTCTGATACAG
GAGTCCCTATAAAACACCCCAGTGATAGTCTCCTTCACCAGGCTGATGTGATTTTGTTCTTAACAGCCACACCAACCCTC
TCCATCTTTATCCGCTCCAGCTACTTCGAGCAGACTTCATTACCCAAGCTCCAAGATGTGGCTCAAGATCAAGAACTTGA
AACGGCTCAACCCCAGTTTGCCCATATGACTCAAGGCCCCTCTTGGACACCCGTTGTCCAAGAGGTGAGTCGAATCGCCC
AAGATATTCAAGCACAGATTCTGGCAGCACAACAAGCCCAGAGAAGGCAGACAGGCATTACGGAGTATAAGCAGCTAGCA
GAGAAGTTTTTCCAAGATGGTGATATCTCTCCGGCTGAGCGAAAAATGTTAGCTCGGTTGGCTGAACAATATCAACTGTC
TGATAGGGATATCGATCAGATCAGGATTGAGCTGAAGGCCGCCTATGACACTGAAAAGTCTAATCGTCAGGAATTTAGAA
ACGCAGTGCAGCTTGAACTCCAACATCGGCAAGGAAAGTTGGAAAAAGCTCAAGAAGTTCTAAATGACCTGCGTCTGGCA
TTAGGAATTTCGGAGGACGTCGCTGGCCAAATTCAGCAGGAAATACTGAAAGAGTGGCCCCCCTCAGAGCCAGATACACA
TACACCATTCGATGTGGTGTTGATAAACCAGGAAGGAAAAGAAAAACAGCGCACAACACATCAAATTCAATATTATGTCG
AGACATTGGTGTCTGACGTGGACCTAGAGCTCGCCGAAATTCCTGGGGGGAAATTTCATATGGGATCCACAGATGATGAC
AAATATCATGATAAAAATGAAAAGCCACAGCATGTTGTAGAACTTCCGCCGTTCTACATGAGTAAGTATCCCATCACTCA
AGAACAGTGGCGTGCTGTTGCCCAGCTAGAGAAAATTTCTATTGAATTAAAGGCTGACCCATCCCACTTTAAGGGAAGTC
AACTGCCCGTTGAGAGTGTTTCTTGGTATGAGGCCGTCGAGTTTTGTGATCGTCTCTCTCGACTAACGGGAATGGCTTAC
CGCTTGCCGAGCGAAGCGGAGTGGGAATACGCCTGTCGGGCCAAAACCGAAACTATCTTTCACTTTGGCAATACAATCAG
CCCTGAATTTGCTAACTATGATTCCACAATCCTCATGACCTTTGTCAATATATTCCGGGAAGAAGCAGGTAAGGTAGGCC
GAGAGACAACGCCTGTAGGCCACTTTAAGGTCGCCAATGCTTTTGGCCTCTATGATATGCATGGCAATGTTTCTGAATGG
TGTCTTGATACGTATCAAACAACCTATGACTTAGCACCGGCAGATGGTTCAGCTTGGATTGATATGCATAATGGCCGCTC
TCAATGTGTCAAAAGAGGGGGGGATTGGTTCTCATCTTCCATGAACTGTTATTCTGCATCACGCGATTCTAATGCCCCGG
ATGAGAGCAGCAGCCAGCTTGGGTTTCGTGTAGTTCGTACCTCTATATGA

Upstream 100 bases:

>100_bases
GTCAGATTGGTGATCTGTCTCAAAATAGGTGTTTAGTCTGCAGGGTTGATCACGAGACATAAAGGCCGGGGAACATTAAC
GAGAAATGGTGAAACGTCCC

Downstream 100 bases:

>100_bases
GGTAAATACCTTAAACATTTGGAGTGTGATGGAAGGTGGGGAATGAAACCTTAATGATACAAACATGAGCGGTATTCTGA
GCATGAGCACTTTTTAGCAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MPNSCLDQALKPVKVMISNADQHLELCQSLELHLRDLQQKGLIELGCDRRSDTGVPIKHPSDSLLHQADVILFLTATPTL
SIFIRSSYFEQTSLPKLQDVAQDQELETAQPQFAHMTQGPSWTPVVQEVSRIAQDIQAQILAAQQAQRRQTGITEYKQLA
EKFFQDGDISPAERKMLARLAEQYQLSDRDIDQIRIELKAAYDTEKSNRQEFRNAVQLELQHRQGKLEKAQEVLNDLRLA
LGISEDVAGQIQQEILKEWPPSEPDTHTPFDVVLINQEGKEKQRTTHQIQYYVETLVSDVDLELAEIPGGKFHMGSTDDD
KYHDKNEKPQHVVELPPFYMSKYPITQEQWRAVAQLEKISIELKADPSHFKGSQLPVESVSWYEAVEFCDRLSRLTGMAY
RLPSEAEWEYACRAKTETIFHFGNTISPEFANYDSTILMTFVNIFREEAGKVGRETTPVGHFKVANAFGLYDMHGNVSEW
CLDTYQTTYDLAPADGSAWIDMHNGRSQCVKRGGDWFSSSMNCYSASRDSNAPDESSSQLGFRVVRTSI

Sequences:

>Translated_549_residues
MPNSCLDQALKPVKVMISNADQHLELCQSLELHLRDLQQKGLIELGCDRRSDTGVPIKHPSDSLLHQADVILFLTATPTL
SIFIRSSYFEQTSLPKLQDVAQDQELETAQPQFAHMTQGPSWTPVVQEVSRIAQDIQAQILAAQQAQRRQTGITEYKQLA
EKFFQDGDISPAERKMLARLAEQYQLSDRDIDQIRIELKAAYDTEKSNRQEFRNAVQLELQHRQGKLEKAQEVLNDLRLA
LGISEDVAGQIQQEILKEWPPSEPDTHTPFDVVLINQEGKEKQRTTHQIQYYVETLVSDVDLELAEIPGGKFHMGSTDDD
KYHDKNEKPQHVVELPPFYMSKYPITQEQWRAVAQLEKISIELKADPSHFKGSQLPVESVSWYEAVEFCDRLSRLTGMAY
RLPSEAEWEYACRAKTETIFHFGNTISPEFANYDSTILMTFVNIFREEAGKVGRETTPVGHFKVANAFGLYDMHGNVSEW
CLDTYQTTYDLAPADGSAWIDMHNGRSQCVKRGGDWFSSSMNCYSASRDSNAPDESSSQLGFRVVRTSI
>Mature_548_residues
PNSCLDQALKPVKVMISNADQHLELCQSLELHLRDLQQKGLIELGCDRRSDTGVPIKHPSDSLLHQADVILFLTATPTLS
IFIRSSYFEQTSLPKLQDVAQDQELETAQPQFAHMTQGPSWTPVVQEVSRIAQDIQAQILAAQQAQRRQTGITEYKQLAE
KFFQDGDISPAERKMLARLAEQYQLSDRDIDQIRIELKAAYDTEKSNRQEFRNAVQLELQHRQGKLEKAQEVLNDLRLAL
GISEDVAGQIQQEILKEWPPSEPDTHTPFDVVLINQEGKEKQRTTHQIQYYVETLVSDVDLELAEIPGGKFHMGSTDDDK
YHDKNEKPQHVVELPPFYMSKYPITQEQWRAVAQLEKISIELKADPSHFKGSQLPVESVSWYEAVEFCDRLSRLTGMAYR
LPSEAEWEYACRAKTETIFHFGNTISPEFANYDSTILMTFVNIFREEAGKVGRETTPVGHFKVANAFGLYDMHGNVSEWC
LDTYQTTYDLAPADGSAWIDMHNGRSQCVKRGGDWFSSSMNCYSASRDSNAPDESSSQLGFRVVRTSI

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI257470975, Length=269, Percent_Identity=30.8550185873606, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI38202250, Length=294, Percent_Identity=28.9115646258503, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI194248087, Length=272, Percent_Identity=27.5735294117647, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI194248088, Length=282, Percent_Identity=25.886524822695, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI257470977, Length=290, Percent_Identity=27.5862068965517, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI226437577, Length=172, Percent_Identity=31.9767441860465, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20130397, Length=313, Percent_Identity=27.1565495207668, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 62444; Mature: 62312

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNSCLDQALKPVKVMISNADQHLELCQSLELHLRDLQQKGLIELGCDRRSDTGVPIKHP
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCC
SDSLLHQADVILFLTATPTLSIFIRSSYFEQTSLPKLQDVAQDQELETAQPQFAHMTQGP
CHHHHHHCCEEEEEECCCCEEEEEEHHHHHHCCCCHHHHHHCCCHHHHCCCHHHHHCCCC
SWTPVVQEVSRIAQDIQAQILAAQQAQRRQTGITEYKQLAEKFFQDGDISPAERKMLARL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AEQYQLSDRDIDQIRIELKAAYDTEKSNRQEFRNAVQLELQHRQGKLEKAQEVLNDLRLA
HHHHCCCCCCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LGISEDVAGQIQQEILKEWPPSEPDTHTPFDVVLINQEGKEKQRTTHQIQYYVETLVSDV
HCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
DLELAEIPGGKFHMGSTDDDKYHDKNEKPQHVVELPPFYMSKYPITQEQWRAVAQLEKIS
CCCHHHCCCCEEECCCCCCCCCCCCCCCCCCEEECCCHHHCCCCCCHHHHHHHHHHHHHE
IELKADPSHFKGSQLPVESVSWYEAVEFCDRLSRLTGMAYRLPSEAEWEYACRAKTETIF
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHE
HFGNTISPEFANYDSTILMTFVNIFREEAGKVGRETTPVGHFKVANAFGLYDMHGNVSEW
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEECCCCHHHH
CLDTYQTTYDLAPADGSAWIDMHNGRSQCVKRGGDWFSSSMNCYSASRDSNAPDESSSQL
HHHHHHHHEECCCCCCCEEEEECCCHHHHHHCCCHHHHCCCCHHCCCCCCCCCCCCCHHH
GFRVVRTSI
HHEEHEECC
>Mature Secondary Structure 
PNSCLDQALKPVKVMISNADQHLELCQSLELHLRDLQQKGLIELGCDRRSDTGVPIKHP
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCC
SDSLLHQADVILFLTATPTLSIFIRSSYFEQTSLPKLQDVAQDQELETAQPQFAHMTQGP
CHHHHHHCCEEEEEECCCCEEEEEEHHHHHHCCCCHHHHHHCCCHHHHCCCHHHHHCCCC
SWTPVVQEVSRIAQDIQAQILAAQQAQRRQTGITEYKQLAEKFFQDGDISPAERKMLARL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AEQYQLSDRDIDQIRIELKAAYDTEKSNRQEFRNAVQLELQHRQGKLEKAQEVLNDLRLA
HHHHCCCCCCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LGISEDVAGQIQQEILKEWPPSEPDTHTPFDVVLINQEGKEKQRTTHQIQYYVETLVSDV
HCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
DLELAEIPGGKFHMGSTDDDKYHDKNEKPQHVVELPPFYMSKYPITQEQWRAVAQLEKIS
CCCHHHCCCCEEECCCCCCCCCCCCCCCCCCEEECCCHHHCCCCCCHHHHHHHHHHHHHE
IELKADPSHFKGSQLPVESVSWYEAVEFCDRLSRLTGMAYRLPSEAEWEYACRAKTETIF
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHE
HFGNTISPEFANYDSTILMTFVNIFREEAGKVGRETTPVGHFKVANAFGLYDMHGNVSEW
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEECCCCHHHH
CLDTYQTTYDLAPADGSAWIDMHNGRSQCVKRGGDWFSSSMNCYSASRDSNAPDESSSQL
HHHHHHHHEECCCCCCCEEEEECCCHHHHHHCCCHHHHCCCCHHCCCCCCCCCCCCCHHH
GFRVVRTSI
HHEEHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]