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The map label for this gene is ilvA [H]

Identifier: 158337581

GI number: 158337581

Start: 4489803

End: 4491317

Strand: Reverse

Name: ilvA [H]

Synonym: AM1_4462

Alternate gene names: 158337581

Gene position: 4491317-4489803 (Counterclockwise)

Preceding gene: 158337582

Following gene: 158337580

Centisome position: 69.06

GC content: 52.61

Gene sequence:

>1515_bases
GTGAGTCATCCAGATTACCTTGAACGCATCCTGACAGCACGGGTCTATGATGTGGCACAGGAAAGTCCACTGGAATTGGC
CCCCCGTCTATCCGACCGTTTGCACAATCGTATTCTCCTCAAGCGAGAAGATATGCAGTCAGTGTTTTCCTTTAAGTTGC
GGGGTGCTTATAACAAGATGGCTCAGCTGCCCCCGGATCAACTGCATCAAGGGGTGATTGCGGCTTCTGCAGGCAACCAT
GCCCAGGGCGTCGCTTTAGGGGCTCGCCAATTGGGCACAACGGCGTTGATTGTGATGCCCGTGACCACGCCCAAAGTCAA
AGTTGATGCCGTCAAAGCCCGAGGAGGCCAGGTGGTCCTTTTCGGAGATACCTATGACGACGCCTATGCCCATGCCCGGC
AGCTCTCAACAGAAAAAGGGCTGACGTTTATCCATCCCTTTGATGACCCGGATGTAATTGCAGGCCAAGGCACCATTGGC
ATGGAGATTTTGCGCCAATATCAAAAGCCGATTCATGCCATTTTTATTGCCATTGGAGGGGGTGGCTTAATTTCTGGGAT
TGGGGCCTATATCAAGCGATTGCGTCCCGATATTCGGATTATTGGGGTCGAACCCGTAGATGCGGCAGCCATGCATCAGT
CCTTGCAGGTGGGCAAGCGGGTGCGGCTCTCCCATGTTGGGCTATTTGCCGATGGGGTGGCGGTCCGAGAAGTGGGCGAA
GAGACATTTCGCCTCTGCCAGAAATATGTCGATGAAATCGTCCTCGTGAATACGGACGATACCTGCGCGGCCATTAAAGA
TGTCTTTGAAGATACCCGTTCTATTCTGGAGCCAGCGGGGGCTCTGGCAGTGGCGGGCGCCAAAGCCTATATTGAGCGGG
AGCAACTCCAGGACCAAACCCTAGTTGCCTTAGCCTGCGGTGCCAATATGAATTTTGATCGGCTTCGCTTTGTCGCTGAA
CGGGCTGAGTTAGGAGAACGACGAGAAGCGATCTTTGCCGTTACCATCCCTGAGGAGCGCGGAAGCTTTCGTAAGTTTTG
CGCCTGTCTCGGCAACCATAATTTGACGGAGTTCAATTATCGGATTGCCGATCGTCAGGAAGCCCATATTTTTGTCGGTG
TACAAATTCAAAACCGGGCCGATGCGGCCCACATTGCCCAAGCCTTGGAAGAACAAGGGTTTAAAACCTTGGACCTCACG
GATGACGAATTAGCGAAGCTGCACCTGCGACATATGGTGGGGGGCCGATCGCCCATGGCTGGCAATGAATTACTTTACCG
ATTCGAGTTTCCGGAACGGCCAGGTGCCCTAACGAAGTTTTTAGGCTGTATGAGTCCCGATTGGAATATCAGCTTATTTC
ACTACCGAAATAATGGCGCGGATTATGGGCGTATCGTCGTCGGAACCCAGGTCCCTCCTGACGAAATGAATGAATGGCAA
TCCTTCTTGGATACCCTGGGCTATCCCTATTCTGACGAAAGTCAAAACCCTGCCTACCAGCTCTTTCTGGGATAA

Upstream 100 bases:

>100_bases
CTAACCTAATACTTGTTATCACCTCGACCATAGGACTCGTATTTCGGTTGTAAGAAAGCGTACAGTAGAGTTAATCTTTC
GCTTTTAGATCGGTAGCCCC

Downstream 100 bases:

>100_bases
ATTATGATTACGGGTTTTCTGGTGCTGCTTCTCTATGAGCTATTAGGAGAAGTATTGGTGCTGCTGCTGAATTTACCAAC
GCCAGGGCCGGTCGTAGGCA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSHPDYLERILTARVYDVAQESPLELAPRLSDRLHNRILLKREDMQSVFSFKLRGAYNKMAQLPPDQLHQGVIAASAGNH
AQGVALGARQLGTTALIVMPVTTPKVKVDAVKARGGQVVLFGDTYDDAYAHARQLSTEKGLTFIHPFDDPDVIAGQGTIG
MEILRQYQKPIHAIFIAIGGGGLISGIGAYIKRLRPDIRIIGVEPVDAAAMHQSLQVGKRVRLSHVGLFADGVAVREVGE
ETFRLCQKYVDEIVLVNTDDTCAAIKDVFEDTRSILEPAGALAVAGAKAYIEREQLQDQTLVALACGANMNFDRLRFVAE
RAELGERREAIFAVTIPEERGSFRKFCACLGNHNLTEFNYRIADRQEAHIFVGVQIQNRADAAHIAQALEEQGFKTLDLT
DDELAKLHLRHMVGGRSPMAGNELLYRFEFPERPGALTKFLGCMSPDWNISLFHYRNNGADYGRIVVGTQVPPDEMNEWQ
SFLDTLGYPYSDESQNPAYQLFLG

Sequences:

>Translated_504_residues
MSHPDYLERILTARVYDVAQESPLELAPRLSDRLHNRILLKREDMQSVFSFKLRGAYNKMAQLPPDQLHQGVIAASAGNH
AQGVALGARQLGTTALIVMPVTTPKVKVDAVKARGGQVVLFGDTYDDAYAHARQLSTEKGLTFIHPFDDPDVIAGQGTIG
MEILRQYQKPIHAIFIAIGGGGLISGIGAYIKRLRPDIRIIGVEPVDAAAMHQSLQVGKRVRLSHVGLFADGVAVREVGE
ETFRLCQKYVDEIVLVNTDDTCAAIKDVFEDTRSILEPAGALAVAGAKAYIEREQLQDQTLVALACGANMNFDRLRFVAE
RAELGERREAIFAVTIPEERGSFRKFCACLGNHNLTEFNYRIADRQEAHIFVGVQIQNRADAAHIAQALEEQGFKTLDLT
DDELAKLHLRHMVGGRSPMAGNELLYRFEFPERPGALTKFLGCMSPDWNISLFHYRNNGADYGRIVVGTQVPPDEMNEWQ
SFLDTLGYPYSDESQNPAYQLFLG
>Mature_503_residues
SHPDYLERILTARVYDVAQESPLELAPRLSDRLHNRILLKREDMQSVFSFKLRGAYNKMAQLPPDQLHQGVIAASAGNHA
QGVALGARQLGTTALIVMPVTTPKVKVDAVKARGGQVVLFGDTYDDAYAHARQLSTEKGLTFIHPFDDPDVIAGQGTIGM
EILRQYQKPIHAIFIAIGGGGLISGIGAYIKRLRPDIRIIGVEPVDAAAMHQSLQVGKRVRLSHVGLFADGVAVREVGEE
TFRLCQKYVDEIVLVNTDDTCAAIKDVFEDTRSILEPAGALAVAGAKAYIEREQLQDQTLVALACGANMNFDRLRFVAER
AELGERREAIFAVTIPEERGSFRKFCACLGNHNLTEFNYRIADRQEAHIFVGVQIQNRADAAHIAQALEEQGFKTLDLTD
DELAKLHLRHMVGGRSPMAGNELLYRFEFPERPGALTKFLGCMSPDWNISLFHYRNNGADYGRIVVGTQVPPDEMNEWQS
FLDTLGYPYSDESQNPAYQLFLG

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:
GO:0003824: Threonine dehydratase
GO:0004794: Threonine dehydratase
GO:0006520: Threonine dehydratase
GO:0008152: Threonine dehydratase
GO:0009097: Threonine dehydratase
GO:0030170: Threonine dehydratase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=272, Percent_Identity=32.7205882352941, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI33469958, Length=320, Percent_Identity=28.75, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI19923959, Length=317, Percent_Identity=26.813880126183, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1790207, Length=500, Percent_Identity=51.8, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1789505, Length=305, Percent_Identity=37.3770491803279, Blast_Score=168, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI71991565, Length=335, Percent_Identity=29.5522388059701, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17537387, Length=322, Percent_Identity=32.6086956521739, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17508781, Length=281, Percent_Identity=29.1814946619217, Blast_Score=125, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=515, Percent_Identity=52.621359223301, Blast_Score=508, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6322631, Length=301, Percent_Identity=34.8837209302326, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=300, Percent_Identity=25.6666666666667, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322024, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355833, Length=320, Percent_Identity=31.25, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=29.7619047619048, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55878; Mature: 55747

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPDYLERILTARVYDVAQESPLELAPRLSDRLHNRILLKREDMQSVFSFKLRGAYNKM
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHH
AQLPPDQLHQGVIAASAGNHAQGVALGARQLGTTALIVMPVTTPKVKVDAVKARGGQVVL
HCCCHHHHHCCEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCEEEE
FGDTYDDAYAHARQLSTEKGLTFIHPFDDPDVIAGQGTIGMEILRQYQKPIHAIFIAIGG
EECCCCHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCHHHHHHHHHHCCEEEEEEEECC
GGLISGIGAYIKRLRPDIRIIGVEPVDAAAMHQSLQVGKRVRLSHVGLFADGVAVREVGE
CHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHH
ETFRLCQKYVDEIVLVNTDDTCAAIKDVFEDTRSILEPAGALAVAGAKAYIEREQLQDQT
HHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCE
LVALACGANMNFDRLRFVAERAELGERREAIFAVTIPEERGSFRKFCACLGNHNLTEFNY
EEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECHHCCHHHHHHHHHCCCCCEEEEE
RIADRQEAHIFVGVQIQNRADAAHIAQALEEQGFKTLDLTDDELAKLHLRHMVGGRSPMA
EECCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCCCCC
GNELLYRFEFPERPGALTKFLGCMSPDWNISLFHYRNNGADYGRIVVGTQVPPDEMNEWQ
CCCEEEEEECCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCHHHHHHHH
SFLDTLGYPYSDESQNPAYQLFLG
HHHHHHCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SHPDYLERILTARVYDVAQESPLELAPRLSDRLHNRILLKREDMQSVFSFKLRGAYNKM
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHH
AQLPPDQLHQGVIAASAGNHAQGVALGARQLGTTALIVMPVTTPKVKVDAVKARGGQVVL
HCCCHHHHHCCEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCEEEE
FGDTYDDAYAHARQLSTEKGLTFIHPFDDPDVIAGQGTIGMEILRQYQKPIHAIFIAIGG
EECCCCHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCHHHHHHHHHHCCEEEEEEEECC
GGLISGIGAYIKRLRPDIRIIGVEPVDAAAMHQSLQVGKRVRLSHVGLFADGVAVREVGE
CHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHH
ETFRLCQKYVDEIVLVNTDDTCAAIKDVFEDTRSILEPAGALAVAGAKAYIEREQLQDQT
HHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCE
LVALACGANMNFDRLRFVAERAELGERREAIFAVTIPEERGSFRKFCACLGNHNLTEFNY
EEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECHHCCHHHHHHHHHCCCCCEEEEE
RIADRQEAHIFVGVQIQNRADAAHIAQALEEQGFKTLDLTDDELAKLHLRHMVGGRSPMA
EECCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCCCCC
GNELLYRFEFPERPGALTKFLGCMSPDWNISLFHYRNNGADYGRIVVGTQVPPDEMNEWQ
CCCEEEEEECCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCHHHHHHHH
SFLDTLGYPYSDESQNPAYQLFLG
HHHHHHCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA