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The map label for this gene is argH

Identifier: 158337534

GI number: 158337534

Start: 4440463

End: 4441893

Strand: Reverse

Name: argH

Synonym: AM1_4415

Alternate gene names: 158337534

Gene position: 4441893-4440463 (Counterclockwise)

Preceding gene: 158337535

Following gene: 158337532

Centisome position: 68.3

GC content: 47.31

Gene sequence:

>1431_bases
TTGACATCTTCTCCCGTACCTCCTACAAACAGCTCTGACTCTTCTGACTCCAAAGTTTGGAGTCAAAGATTTGAATCTGC
CTTAAATCCTGTGATTGCTGCTTTTAATGCCAGCATTCATTTCGACATCGCCTTGATTGAATATGATCTAACGGGTTCAC
AAGCTCATGTGCAGATGTTGGCCCACAGTGGCATTATTTCTCAAGCAGAAGCCGATGCCATTGATCAAGGGCTAGAGGCC
ATTCGGCAAGAATATCGCCAAGGTCAATTTCAGCCTGGCATTGAAGCGGAAGACATCCATTTTGCCGTCGAAAACCGCTT
AATTGAACTGATCGGCGACACAGGCAAAAAACTGCATACGGGGCGTTCGCGGAATGACCAAGTAGGTACCGATCTTCGTC
TCTATCTACATGATCAAATTCTGCAAGTTCAAACACTGATTCGGAACTGGCAACAAGCACTCGTCATCTTAGCCAGCGAT
CATGTACAGACACTTATTCCTGGATATACCCATTTACAGCGGGCTCAGCCGATCAGCTTAGCCCATCACCTGTTGGCCTA
CTTTGAAATGGCTGAACGAGACTGGCAGCGTCTGAGGGAAATTGATCGGCGCGTCAATGTTTCTCCTCTAGGTTTAGGAG
CCTTAGCCGGAACGCCTTTCCCTATCGACCGCCAATACACCGCCGACAAGCTAGGGTTTGCCGATCTGTATCGCAATAGT
TTGGATGGCGTCAGCGATCGCGATTTTGCGATTGAGTTTCTCTGTGCAGCCAGTCTAATCATGGTGCATCTCAGCCGCTT
TTCAGAAGAAGTCATCCTTTGGGCCTCGGAAGAGTTTGGATTCATCAAACTGAAGGATAGCTGTGCGACAGGCTCCAGCA
TCATGCCCCAAAAGAAAAATCCTGATGTTCCCGAATTGGTACGGGGCAAATCAGGGCGGGTTTTTGGGCATTTGCAAAGC
TTACTGGTTGTAATGAAAGGGTTGCCCTTAGCCTATAACAAGGATCTACAAGAAGATAAAGAAGCCATTTTTGATGGTGT
GACAACGATTAAGGCTTGTTTAGAGGCCATGACTATTTTGGTGGCAGAGGGCTTAGAATTCCAAACCCCACGTCTTGAAT
CTGCAGTGGGCGAAGATTTTTCCAATGCCACGGATGTCGCAGACTATTTATCCAAGCAAGGAGTGCCCTTTCGGGAAGCC
TACAATATCGTTGGTGCTGTGGTGAAAACATGTCTCTCCCAAAACAAGCTACTCAAAGACTTAACGCTAGAGGAATGGCA
GCAGTTTCATCCCCAGTTCGCTGACGATATCTATTCAGCCATTTCACCCCGACAAGTCGTTGCCGTCCGCAATAGCTTTG
GTGGAACAGGATTCACTCAAGTGCAAAACGCACTAGAACAGGCCAAAACTCTTCTATCACAATCAAAGTAG

Upstream 100 bases:

>100_bases
GGTATGGGCCCTGATCATCGGTTTTATTGTTGGCTATGTGTTCCGCAGCATTACATCCTATTAGCAGCGACTGAATCTCT
ATTATTTCGGACCTGATATA

Downstream 100 bases:

>100_bases
GCCCTTATCACAGGGCAAAATTGAGTAGCAGCGTTCAAAGCTCTCTCTTTAGCGCACATCAAAAGGGGTAGACCCTTTCC
AAGGAATGCGCTTAACCGCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTSSPVPPTNSSDSSDSKVWSQRFESALNPVIAAFNASIHFDIALIEYDLTGSQAHVQMLAHSGIISQAEADAIDQGLEA
IRQEYRQGQFQPGIEAEDIHFAVENRLIELIGDTGKKLHTGRSRNDQVGTDLRLYLHDQILQVQTLIRNWQQALVILASD
HVQTLIPGYTHLQRAQPISLAHHLLAYFEMAERDWQRLREIDRRVNVSPLGLGALAGTPFPIDRQYTADKLGFADLYRNS
LDGVSDRDFAIEFLCAASLIMVHLSRFSEEVILWASEEFGFIKLKDSCATGSSIMPQKKNPDVPELVRGKSGRVFGHLQS
LLVVMKGLPLAYNKDLQEDKEAIFDGVTTIKACLEAMTILVAEGLEFQTPRLESAVGEDFSNATDVADYLSKQGVPFREA
YNIVGAVVKTCLSQNKLLKDLTLEEWQQFHPQFADDIYSAISPRQVVAVRNSFGGTGFTQVQNALEQAKTLLSQSK

Sequences:

>Translated_476_residues
MTSSPVPPTNSSDSSDSKVWSQRFESALNPVIAAFNASIHFDIALIEYDLTGSQAHVQMLAHSGIISQAEADAIDQGLEA
IRQEYRQGQFQPGIEAEDIHFAVENRLIELIGDTGKKLHTGRSRNDQVGTDLRLYLHDQILQVQTLIRNWQQALVILASD
HVQTLIPGYTHLQRAQPISLAHHLLAYFEMAERDWQRLREIDRRVNVSPLGLGALAGTPFPIDRQYTADKLGFADLYRNS
LDGVSDRDFAIEFLCAASLIMVHLSRFSEEVILWASEEFGFIKLKDSCATGSSIMPQKKNPDVPELVRGKSGRVFGHLQS
LLVVMKGLPLAYNKDLQEDKEAIFDGVTTIKACLEAMTILVAEGLEFQTPRLESAVGEDFSNATDVADYLSKQGVPFREA
YNIVGAVVKTCLSQNKLLKDLTLEEWQQFHPQFADDIYSAISPRQVVAVRNSFGGTGFTQVQNALEQAKTLLSQSK
>Mature_475_residues
TSSPVPPTNSSDSSDSKVWSQRFESALNPVIAAFNASIHFDIALIEYDLTGSQAHVQMLAHSGIISQAEADAIDQGLEAI
RQEYRQGQFQPGIEAEDIHFAVENRLIELIGDTGKKLHTGRSRNDQVGTDLRLYLHDQILQVQTLIRNWQQALVILASDH
VQTLIPGYTHLQRAQPISLAHHLLAYFEMAERDWQRLREIDRRVNVSPLGLGALAGTPFPIDRQYTADKLGFADLYRNSL
DGVSDRDFAIEFLCAASLIMVHLSRFSEEVILWASEEFGFIKLKDSCATGSSIMPQKKNPDVPELVRGKSGRVFGHLQSL
LVVMKGLPLAYNKDLQEDKEAIFDGVTTIKACLEAMTILVAEGLEFQTPRLESAVGEDFSNATDVADYLSKQGVPFREAY
NIVGAVVKTCLSQNKLLKDLTLEEWQQFHPQFADDIYSAISPRQVVAVRNSFGGTGFTQVQNALEQAKTLLSQSK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=459, Percent_Identity=43.5729847494553, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI68303542, Length=459, Percent_Identity=43.5729847494553, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI68303549, Length=459, Percent_Identity=41.1764705882353, Blast_Score=345, Evalue=7e-95,
Organism=Homo sapiens, GI68303547, Length=459, Percent_Identity=40.958605664488, Blast_Score=343, Evalue=3e-94,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=46.9298245614035, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321806, Length=462, Percent_Identity=43.0735930735931, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=39.1592920353982, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=39.1592920353982, Blast_Score=330, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_ACAM1 (B0CEZ5)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001518709.1
- ProteinModelPortal:   B0CEZ5
- SMR:   B0CEZ5
- GeneID:   5683217
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_4415
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   AMAR329726:AM1_4415-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52918; Mature: 52786

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSPVPPTNSSDSSDSKVWSQRFESALNPVIAAFNASIHFDIALIEYDLTGSQAHVQML
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHH
AHSGIISQAEADAIDQGLEAIRQEYRQGQFQPGIEAEDIHFAVENRLIELIGDTGKKLHT
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCC
GRSRNDQVGTDLRLYLHDQILQVQTLIRNWQQALVILASDHVQTLIPGYTHLQRAQPISL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHCCHHHH
AHHLLAYFEMAERDWQRLREIDRRVNVSPLGLGALAGTPFPIDRQYTADKLGFADLYRNS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCHHHCCHHHHHHHH
LDGVSDRDFAIEFLCAASLIMVHLSRFSEEVILWASEEFGFIKLKDSCATGSSIMPQKKN
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCC
PDVPELVRGKSGRVFGHLQSLLVVMKGLPLAYNKDLQEDKEAIFDGVTTIKACLEAMTIL
CCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VAEGLEFQTPRLESAVGEDFSNATDVADYLSKQGVPFREAYNIVGAVVKTCLSQNKLLKD
HHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LTLEEWQQFHPQFADDIYSAISPRQVVAVRNSFGGTGFTQVQNALEQAKTLLSQSK
CCHHHHHHHCCHHHHHHHHHCCCHHEEEEHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSSPVPPTNSSDSSDSKVWSQRFESALNPVIAAFNASIHFDIALIEYDLTGSQAHVQML
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHH
AHSGIISQAEADAIDQGLEAIRQEYRQGQFQPGIEAEDIHFAVENRLIELIGDTGKKLHT
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCC
GRSRNDQVGTDLRLYLHDQILQVQTLIRNWQQALVILASDHVQTLIPGYTHLQRAQPISL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHCCHHHH
AHHLLAYFEMAERDWQRLREIDRRVNVSPLGLGALAGTPFPIDRQYTADKLGFADLYRNS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCHHHCCHHHHHHHH
LDGVSDRDFAIEFLCAASLIMVHLSRFSEEVILWASEEFGFIKLKDSCATGSSIMPQKKN
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCC
PDVPELVRGKSGRVFGHLQSLLVVMKGLPLAYNKDLQEDKEAIFDGVTTIKACLEAMTIL
CCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VAEGLEFQTPRLESAVGEDFSNATDVADYLSKQGVPFREAYNIVGAVVKTCLSQNKLLKD
HHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LTLEEWQQFHPQFADDIYSAISPRQVVAVRNSFGGTGFTQVQNALEQAKTLLSQSK
CCHHHHHHHCCHHHHHHHHHCCCHHEEEEHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA