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The map label for this gene is yuxL [H]

Identifier: 158337426

GI number: 158337426

Start: 4324512

End: 4326539

Strand: Direct

Name: yuxL [H]

Synonym: AM1_4305

Alternate gene names: 158337426

Gene position: 4324512-4326539 (Clockwise)

Preceding gene: 158337424

Following gene: 158337427

Centisome position: 66.49

GC content: 54.24

Gene sequence:

>2028_bases
ATGCAACCCTTACCGCGCACCGTTAGCCTAATGTTTATGGCTAGCTTGATGGGGCTGACCCCCATCTCTGCCAGCCTCGC
AGCGGAAAGCCCCAGCCCTCAAACCAGCCTGCCCCCACTGATCGACCGCGAGCTGTTTTTCTCCGATCCAGAGATTTCCG
GTGCCCAACTGTCCCCGGATGGTCAATTTCTGGCCTTCCAAAAACCTCTAAAGGGGGTGATTAATGTCTGGGTTAAAGGC
ATTAATGAACCGATGTCCGCTGCTCGTCCCGTCACGGCCGACGCTACAAGCCCGATTATGATCTATTTCTGGAGTGCGGA
CGGTCGCTATATTCTCTACGGTCAGGATAAAGGGGGCAATGAAAATTTCCGGCTCTATGCCGTTGACCCCAAAACCGTCG
GTGGCCAGACTCAAGCTCGTGACCTTACCCCGTTTGAAGGGATAACAGCTCAGGTCTATGCCGTGCCGAAACGGACCCCC
AATGAAGTGATTATTGGCCTCAATGACCGTAATCCACAGGTCCATGATGTCTATCGTCTCAATCTCACCACGGGAGAGCG
GACCCTCCTGATCCAAAACGATCAGAATATTGCGGGCTGGGTCACGGACTTAGATGGAACAGTTCGCCTGGCGGCCCGCC
AAACCCTTGAGAAAGGCAATGAACTGCTCAAGGTTGAAAACGGCAAGCTCACCCCCCTGTATTCCTGCAAGGTTGAGGAG
ACCTGTGCCCCGATTCGCTTTCACCCAGACGGTCAGCGGGTTTATCTGCGCACCAACCGAGACGTGAATTTTACCCGGCT
GGAACTGCTCAATGTGGACACTCAGCAGAGCCAACCCGTTGAATCCGATCCTGAAAATCAGGTGGACTTTGGAGGTGCAT
TATTTTCCCAGGCCACGGATGAATTGGTTGCCACCTATTACGTGGGCGATCGCCGTCGCGTCTATCCCAAAACCGATCAG
CTCACTGCGGATTTGAAGTTTTTGCGCCAGCAGCTTCCTAAGCTGGAGCTGTCCATTGGGTCGGTCACTCGGGATGATCG
ATTGGCATTGATTAATGCCCAAAGTGATGTAAATCCTGGAGCCACCTACCTATTTGATCGCCAGGCTCAAACTCTGAAAA
AGCTCTATGATGTGCGCCCAGAGCTACCCAGTCAACACTTGGCCCCTCGCCAACCGATTCGCTACCGAGGTCGCGATGGC
CAAGAAATTCCAGCCTATCTGACCTTACCCAAAGGCGTTGAGCCCAAGAATCTCCCAGTGATTGTGTTTCCCCACGGTGG
CCCTTGGGCGCGGGATTACTGGGGCTATGACGGTGCCGCCCAGTTCTTGGCCAATCGAGGCTATGCCATTTTGCAGCCCA
ACTTTCGCGGGTCGACGGGCTATGGAAAGGCGTTTCTCAATGCGGGAAATGAGCAATGGGGAACCGGCATTATGCAGCAT
GATGTGACGGATGGCGTCCAGTATCTCATTGACCAGGGTATTGCGGATCCTAAGCGGGTCGGCATTACCGGGATTTCCTA
TGGTGGCTATGCGACCTTGGCTGGGTTGGCCTTTACTCCTGAACTGTATGCAGCGGGGGCTTCGGTGGTGGGTCCCTCCA
ATATTATGACCCTGCTCAATTCTATTCCCCCCTACTGGGTACCGATGAAATCCATGTTTGCCCTCCGGGTCGGCGACCCA
AAGGATCCAGCCGATCAGGACCGTTTGAAAGCTCAGTCGCCGCTATTCTCGGCCCAGAATATTCAAGCGCCGTTGCTGGT
GATTCAAGGTGCCAATGACCCTCGGGTGAAACAGGCCGAGTCAGATCAGATCGTAGCGGCCTTAAGAGACCTCGGTCGCC
CCGTGGACTATCTGATTGCCCCAGATGAAGGTCATGGCTTTCGGAAAGAGATCAATCTGTTAACCATGACTGCCTCTCTG
GAACGCTTTTTTGCCCAGCATCTCGGCGGCCGCTATCAAAAGGAGTTGTCCCCTGAGCTGCAAACCAACATTGAAGCTCT
GACGGTGGATATCAAGACGGTGCAGTAG

Upstream 100 bases:

>100_bases
CTGTCCTTGAATATCTATCGCATCCGTATTGGAGCGTGCGATCGCAACCCATAGACCACATTCAATCAGATCCGAACTAA
CCTATTGTGGAGTACACCCT

Downstream 100 bases:

>100_bases
GAGCCATCCATATTAGGGGTGAGACCGATTCAGTGTATTGCCCCGCAGTTTTTTGAATGTAGGTTATGGAGAAGATGGTT
AACCACGCTGATAAAAAGTT

Product: dipeptidyl aminopeptidase family protein

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MQPLPRTVSLMFMASLMGLTPISASLAAESPSPQTSLPPLIDRELFFSDPEISGAQLSPDGQFLAFQKPLKGVINVWVKG
INEPMSAARPVTADATSPIMIYFWSADGRYILYGQDKGGNENFRLYAVDPKTVGGQTQARDLTPFEGITAQVYAVPKRTP
NEVIIGLNDRNPQVHDVYRLNLTTGERTLLIQNDQNIAGWVTDLDGTVRLAARQTLEKGNELLKVENGKLTPLYSCKVEE
TCAPIRFHPDGQRVYLRTNRDVNFTRLELLNVDTQQSQPVESDPENQVDFGGALFSQATDELVATYYVGDRRRVYPKTDQ
LTADLKFLRQQLPKLELSIGSVTRDDRLALINAQSDVNPGATYLFDRQAQTLKKLYDVRPELPSQHLAPRQPIRYRGRDG
QEIPAYLTLPKGVEPKNLPVIVFPHGGPWARDYWGYDGAAQFLANRGYAILQPNFRGSTGYGKAFLNAGNEQWGTGIMQH
DVTDGVQYLIDQGIADPKRVGITGISYGGYATLAGLAFTPELYAAGASVVGPSNIMTLLNSIPPYWVPMKSMFALRVGDP
KDPADQDRLKAQSPLFSAQNIQAPLLVIQGANDPRVKQAESDQIVAALRDLGRPVDYLIAPDEGHGFRKEINLLTMTASL
ERFFAQHLGGRYQKELSPELQTNIEALTVDIKTVQ

Sequences:

>Translated_675_residues
MQPLPRTVSLMFMASLMGLTPISASLAAESPSPQTSLPPLIDRELFFSDPEISGAQLSPDGQFLAFQKPLKGVINVWVKG
INEPMSAARPVTADATSPIMIYFWSADGRYILYGQDKGGNENFRLYAVDPKTVGGQTQARDLTPFEGITAQVYAVPKRTP
NEVIIGLNDRNPQVHDVYRLNLTTGERTLLIQNDQNIAGWVTDLDGTVRLAARQTLEKGNELLKVENGKLTPLYSCKVEE
TCAPIRFHPDGQRVYLRTNRDVNFTRLELLNVDTQQSQPVESDPENQVDFGGALFSQATDELVATYYVGDRRRVYPKTDQ
LTADLKFLRQQLPKLELSIGSVTRDDRLALINAQSDVNPGATYLFDRQAQTLKKLYDVRPELPSQHLAPRQPIRYRGRDG
QEIPAYLTLPKGVEPKNLPVIVFPHGGPWARDYWGYDGAAQFLANRGYAILQPNFRGSTGYGKAFLNAGNEQWGTGIMQH
DVTDGVQYLIDQGIADPKRVGITGISYGGYATLAGLAFTPELYAAGASVVGPSNIMTLLNSIPPYWVPMKSMFALRVGDP
KDPADQDRLKAQSPLFSAQNIQAPLLVIQGANDPRVKQAESDQIVAALRDLGRPVDYLIAPDEGHGFRKEINLLTMTASL
ERFFAQHLGGRYQKELSPELQTNIEALTVDIKTVQ
>Mature_675_residues
MQPLPRTVSLMFMASLMGLTPISASLAAESPSPQTSLPPLIDRELFFSDPEISGAQLSPDGQFLAFQKPLKGVINVWVKG
INEPMSAARPVTADATSPIMIYFWSADGRYILYGQDKGGNENFRLYAVDPKTVGGQTQARDLTPFEGITAQVYAVPKRTP
NEVIIGLNDRNPQVHDVYRLNLTTGERTLLIQNDQNIAGWVTDLDGTVRLAARQTLEKGNELLKVENGKLTPLYSCKVEE
TCAPIRFHPDGQRVYLRTNRDVNFTRLELLNVDTQQSQPVESDPENQVDFGGALFSQATDELVATYYVGDRRRVYPKTDQ
LTADLKFLRQQLPKLELSIGSVTRDDRLALINAQSDVNPGATYLFDRQAQTLKKLYDVRPELPSQHLAPRQPIRYRGRDG
QEIPAYLTLPKGVEPKNLPVIVFPHGGPWARDYWGYDGAAQFLANRGYAILQPNFRGSTGYGKAFLNAGNEQWGTGIMQH
DVTDGVQYLIDQGIADPKRVGITGISYGGYATLAGLAFTPELYAAGASVVGPSNIMTLLNSIPPYWVPMKSMFALRVGDP
KDPADQDRLKAQSPLFSAQNIQAPLLVIQGANDPRVKQAESDQIVAALRDLGRPVDYLIAPDEGHGFRKEINLLTMTASL
ERFFAQHLGGRYQKELSPELQTNIEALTVDIKTVQ

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=249, Percent_Identity=26.9076305220884, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25144537, Length=653, Percent_Identity=33.843797856049, Blast_Score=340, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI25144540, Length=403, Percent_Identity=38.7096774193548, Blast_Score=268, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI25144543, Length=557, Percent_Identity=30.8797127468582, Blast_Score=251, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17552908, Length=249, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25149159, Length=274, Percent_Identity=28.4671532846715, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 74659; Mature: 74659

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLPRTVSLMFMASLMGLTPISASLAAESPSPQTSLPPLIDRELFFSDPEISGAQLSPD
CCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEECCC
GQFLAFQKPLKGVINVWVKGINEPMSAARPVTADATSPIMIYFWSADGRYILYGQDKGGN
CCEEEEHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCC
ENFRLYAVDPKTVGGQTQARDLTPFEGITAQVYAVPKRTPNEVIIGLNDRNPQVHDVYRL
CCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCEEEEEEE
NLTTGERTLLIQNDQNIAGWVTDLDGTVRLAARQTLEKGNELLKVENGKLTPLYSCKVEE
EEECCCEEEEEECCCCCEEEEECCCCEEEHHHHHHHHCCCCEEEECCCCCCEEEECCCCC
TCAPIRFHPDGQRVYLRTNRDVNFTRLELLNVDTQQSQPVESDPENQVDFGGALFSQATD
CCCCEEECCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ELVATYYVGDRRRVYPKTDQLTADLKFLRQQLPKLELSIGSVTRDDRLALINAQSDVNPG
HEEEEEEECCCEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCC
ATYLFDRQAQTLKKLYDVRPELPSQHLAPRQPIRYRGRDGQEIPAYLTLPKGVEPKNLPV
EEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCEEEECCCCCCCCCCEE
IVFPHGGPWARDYWGYDGAAQFLANRGYAILQPNFRGSTGYGKAFLNAGNEQWGTGIMQH
EEEECCCCCCHHCCCCCHHHHHHHCCCEEEECCCCCCCCCCCHHEECCCCCCCCCCCHHH
DVTDGVQYLIDQGIADPKRVGITGISYGGYATLAGLAFTPELYAAGASVVGPSNIMTLLN
HHHHHHHHHHHCCCCCCHHCCEEEECCCCHHHHHHHEECCHHHHCCCCCCCHHHHHHHHH
SIPPYWVPMKSMFALRVGDPKDPADQDRLKAQSPLFSAQNIQAPLLVIQGANDPRVKQAE
CCCCCEECCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCC
SDQIVAALRDLGRPVDYLIAPDEGHGFRKEINLLTMTASLERFFAQHLGGRYQKELSPEL
CHHHHHHHHHHCCCEEEEEECCCCCCCHHEEEEEEEHHHHHHHHHHHHCCHHHHHCCCHH
QTNIEALTVDIKTVQ
HCCEEEEEEEEEECC
>Mature Secondary Structure
MQPLPRTVSLMFMASLMGLTPISASLAAESPSPQTSLPPLIDRELFFSDPEISGAQLSPD
CCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEECCC
GQFLAFQKPLKGVINVWVKGINEPMSAARPVTADATSPIMIYFWSADGRYILYGQDKGGN
CCEEEEHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCC
ENFRLYAVDPKTVGGQTQARDLTPFEGITAQVYAVPKRTPNEVIIGLNDRNPQVHDVYRL
CCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCEEEEEEE
NLTTGERTLLIQNDQNIAGWVTDLDGTVRLAARQTLEKGNELLKVENGKLTPLYSCKVEE
EEECCCEEEEEECCCCCEEEEECCCCEEEHHHHHHHHCCCCEEEECCCCCCEEEECCCCC
TCAPIRFHPDGQRVYLRTNRDVNFTRLELLNVDTQQSQPVESDPENQVDFGGALFSQATD
CCCCEEECCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ELVATYYVGDRRRVYPKTDQLTADLKFLRQQLPKLELSIGSVTRDDRLALINAQSDVNPG
HEEEEEEECCCEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCC
ATYLFDRQAQTLKKLYDVRPELPSQHLAPRQPIRYRGRDGQEIPAYLTLPKGVEPKNLPV
EEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCEEEECCCCCCCCCCEE
IVFPHGGPWARDYWGYDGAAQFLANRGYAILQPNFRGSTGYGKAFLNAGNEQWGTGIMQH
EEEECCCCCCHHCCCCCHHHHHHHCCCEEEECCCCCCCCCCCHHEECCCCCCCCCCCHHH
DVTDGVQYLIDQGIADPKRVGITGISYGGYATLAGLAFTPELYAAGASVVGPSNIMTLLN
HHHHHHHHHHHCCCCCCHHCCEEEECCCCHHHHHHHEECCHHHHCCCCCCCHHHHHHHHH
SIPPYWVPMKSMFALRVGDPKDPADQDRLKAQSPLFSAQNIQAPLLVIQGANDPRVKQAE
CCCCCEECCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCC
SDQIVAALRDLGRPVDYLIAPDEGHGFRKEINLLTMTASLERFFAQHLGGRYQKELSPEL
CHHHHHHHHHHCCCEEEEEECCCCCCCHHEEEEEEEHHHHHHHHHHHHCCHHHHHCCCHH
QTNIEALTVDIKTVQ
HCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]