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The map label for this gene is pepP [H]

Identifier: 158337258

GI number: 158337258

Start: 4171237

End: 4172628

Strand: Direct

Name: pepP [H]

Synonym: AM1_4135

Alternate gene names: 158337258

Gene position: 4171237-4172628 (Clockwise)

Preceding gene: 158337257

Following gene: 158337259

Centisome position: 64.14

GC content: 55.17

Gene sequence:

>1392_bases
GTGTTAACCCCCACGGATCAATCCTGTTTACACCAACGAAGACACCAGCTAGGACAGCAGTTTGAGGGCCAAGCACTGCT
CTGGTCTGGCGTTGCCCCTTCCCGAAACTTTGCTGCCAATCAGTTTCCCTTTCGTGCCAGCAGTCATTTTTTGTACTTGG
CTGGATTGCCCCTACAAAATGCGGTGATTGGCCTAGAGGCGGGTCAGCTGACCTTATTTTGGGATGAGCCCCACCCCGAC
ACCGCCCTATGGCATGGTCCGAGTTTAAGTCGAGCCGAAATCGCGGATCAGATCGGGGCTGAGACTCACTTACCTCTCTC
TGCGGTCTCCAGCTGGGCAAGCCATGCAGCCACCTTGCCTGTCCCCTCATCAGCGACCCATCAACAGCAAATCGAGTGGC
TAGGACGCCCTGTTCCGCCGATTCAAGGGAGTCAGGATCAGGAGAGCAACCGAGATCATCATCTAGCGAATGCCCTCATT
CAATTGCGGCTACAGCAGGATGAGTTTGCTCTGGCTCAGCTACGGCAGGCGGCCGAAATTACGGTGGCAGCTCATTTGCG
TGGGATGAGGTCAACCCTTAATCACACCTCTGAAGCAGCGATTCGAGCCGAAATTGAATCCGTGATGATGGCCCACCAAT
GCCCGACGGCCTATGCCAGCATTGTCACAGTTCACGGCGAAGTCCTTCATAACGATGCTTATCCCCATGCCTTGGCACCG
GGCGATTTGCTGTTAGTGGATGCTGGGGCAGAAACGCCCTTGGGCTGGGCTGCCGATGTCACTCGAACATGGCCAGTATC
AGGACAATTCTCGGCCACCCAGCGCGATCTGTATGACCTGGTCCTGGCGGCTCATGATGCTTGTATTGCCGCCATCCAAC
CGGGGGTAGAATTTCGCGATCTGCATCTGTTGGCGGCTCAGACCATTGCCTCGGGTCTGGTCGATATCGGTATTCTCAAG
GGCCAGCCGGAAGCCCTGGTAGAACGAGATGCCCATGCGCTGTTTTTCCCCCATGGGATTGGTCACCTACTAGGGTTGGA
TGTGCACGACATGGAAGATTTAGGAGACTTGGCAGGTTATGCACCGGGGAGACAGAGATGCGATCGCAGGGGGTTACGCT
ATCTACGTTTAGATCGGCCCTTGCGCCCCCAGATGCTGGTTACCATTGAACCCGGCTTTTACCAAATTCCCGCCCTGCTC
CAGAACCCTGACCTCCGCCAGCAGTATGGAGATTGTGTCAATTGGGATCGACTGGCTCAATTTGAAGATGTCCGAGGGAT
TCGCATTGAAGACGATGTTTTGGTAACACCAGAGGGATGCCAGGTCTTAACGTCCGCTTTACCCACCCAAGCCCCTGAAG
TGGAAGCCTATGTACAAGGCTCAACGGCTTAA

Upstream 100 bases:

>100_bases
AGACGATTAAATGGTTAGTTGGCGCTTTGATTGCGGGGCTGTCTTTTCTTTATATTGGCAATACGGCTCGTAAATTTCCC
AATGTGAGAACGAGGTAAGG

Downstream 100 bases:

>100_bases
TCCATAAGACTTTACCCGCACTTCCTTCACTGTCGGATGAGTGGTTCTCGTAGAAAGCAGTTCTAAACATTCCGACTTCC
TGGTACTTTGAGAAGAAGGC

Product: xaa-pro dipeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLTPTDQSCLHQRRHQLGQQFEGQALLWSGVAPSRNFAANQFPFRASSHFLYLAGLPLQNAVIGLEAGQLTLFWDEPHPD
TALWHGPSLSRAEIADQIGAETHLPLSAVSSWASHAATLPVPSSATHQQQIEWLGRPVPPIQGSQDQESNRDHHLANALI
QLRLQQDEFALAQLRQAAEITVAAHLRGMRSTLNHTSEAAIRAEIESVMMAHQCPTAYASIVTVHGEVLHNDAYPHALAP
GDLLLVDAGAETPLGWAADVTRTWPVSGQFSATQRDLYDLVLAAHDACIAAIQPGVEFRDLHLLAAQTIASGLVDIGILK
GQPEALVERDAHALFFPHGIGHLLGLDVHDMEDLGDLAGYAPGRQRCDRRGLRYLRLDRPLRPQMLVTIEPGFYQIPALL
QNPDLRQQYGDCVNWDRLAQFEDVRGIRIEDDVLVTPEGCQVLTSALPTQAPEVEAYVQGSTA

Sequences:

>Translated_463_residues
MLTPTDQSCLHQRRHQLGQQFEGQALLWSGVAPSRNFAANQFPFRASSHFLYLAGLPLQNAVIGLEAGQLTLFWDEPHPD
TALWHGPSLSRAEIADQIGAETHLPLSAVSSWASHAATLPVPSSATHQQQIEWLGRPVPPIQGSQDQESNRDHHLANALI
QLRLQQDEFALAQLRQAAEITVAAHLRGMRSTLNHTSEAAIRAEIESVMMAHQCPTAYASIVTVHGEVLHNDAYPHALAP
GDLLLVDAGAETPLGWAADVTRTWPVSGQFSATQRDLYDLVLAAHDACIAAIQPGVEFRDLHLLAAQTIASGLVDIGILK
GQPEALVERDAHALFFPHGIGHLLGLDVHDMEDLGDLAGYAPGRQRCDRRGLRYLRLDRPLRPQMLVTIEPGFYQIPALL
QNPDLRQQYGDCVNWDRLAQFEDVRGIRIEDDVLVTPEGCQVLTSALPTQAPEVEAYVQGSTA
>Mature_463_residues
MLTPTDQSCLHQRRHQLGQQFEGQALLWSGVAPSRNFAANQFPFRASSHFLYLAGLPLQNAVIGLEAGQLTLFWDEPHPD
TALWHGPSLSRAEIADQIGAETHLPLSAVSSWASHAATLPVPSSATHQQQIEWLGRPVPPIQGSQDQESNRDHHLANALI
QLRLQQDEFALAQLRQAAEITVAAHLRGMRSTLNHTSEAAIRAEIESVMMAHQCPTAYASIVTVHGEVLHNDAYPHALAP
GDLLLVDAGAETPLGWAADVTRTWPVSGQFSATQRDLYDLVLAAHDACIAAIQPGVEFRDLHLLAAQTIASGLVDIGILK
GQPEALVERDAHALFFPHGIGHLLGLDVHDMEDLGDLAGYAPGRQRCDRRGLRYLRLDRPLRPQMLVTIEPGFYQIPALL
QNPDLRQQYGDCVNWDRLAQFEDVRGIRIEDDVLVTPEGCQVLTSALPTQAPEVEAYVQGSTA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=444, Percent_Identity=30.4054054054054, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI260593665, Length=318, Percent_Identity=34.9056603773585, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI260593663, Length=273, Percent_Identity=36.996336996337, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI11559925, Length=475, Percent_Identity=25.6842105263158, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1789275, Length=474, Percent_Identity=28.2700421940928, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1790282, Length=297, Percent_Identity=34.3434343434343, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1788728, Length=268, Percent_Identity=28.3582089552239, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508215, Length=478, Percent_Identity=28.6610878661088, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71989583, Length=236, Percent_Identity=28.8135593220339, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321118, Length=424, Percent_Identity=27.5943396226415, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320922, Length=221, Percent_Identity=31.2217194570136, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21357079, Length=438, Percent_Identity=29.4520547945205, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19920384, Length=467, Percent_Identity=27.4089935760171, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50712; Mature: 50712

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTPTDQSCLHQRRHQLGQQFEGQALLWSGVAPSRNFAANQFPFRASSHFLYLAGLPLQN
CCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCHHH
AVIGLEAGQLTLFWDEPHPDTALWHGPSLSRAEIADQIGAETHLPLSAVSSWASHAATLP
EEEEEECCEEEEEECCCCCCCEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCEECC
VPSSATHQQQIEWLGRPVPPIQGSQDQESNRDHHLANALIQLRLQQDEFALAQLRQAAEI
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TVAAHLRGMRSTLNHTSEAAIRAEIESVMMAHQCPTAYASIVTVHGEVLHNDAYPHALAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEHHHHCCCCCCCCCCC
GDLLLVDAGAETPLGWAADVTRTWPVSGQFSATQRDLYDLVLAAHDACIAAIQPGVEFRD
CCEEEEECCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LHLLAAQTIASGLVDIGILKGQPEALVERDAHALFFPHGIGHLLGLDVHDMEDLGDLAGY
HHHHHHHHHHHHHHHEEEECCCCHHHHHCCCCEEECCCCHHHHHCCCCCCHHHHHHHHCC
APGRQRCDRRGLRYLRLDRPLRPQMLVTIEPGFYQIPALLQNPDLRQQYGDCVNWDRLAQ
CCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCEECCHHHCCCCHHHHHCCCCCHHHHHH
FEDVRGIRIEDDVLVTPEGCQVLTSALPTQAPEVEAYVQGSTA
HHHCCCEEECCCEEECCCHHHHHHHHCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MLTPTDQSCLHQRRHQLGQQFEGQALLWSGVAPSRNFAANQFPFRASSHFLYLAGLPLQN
CCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCHHH
AVIGLEAGQLTLFWDEPHPDTALWHGPSLSRAEIADQIGAETHLPLSAVSSWASHAATLP
EEEEEECCEEEEEECCCCCCCEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCEECC
VPSSATHQQQIEWLGRPVPPIQGSQDQESNRDHHLANALIQLRLQQDEFALAQLRQAAEI
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TVAAHLRGMRSTLNHTSEAAIRAEIESVMMAHQCPTAYASIVTVHGEVLHNDAYPHALAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEHHHHCCCCCCCCCCC
GDLLLVDAGAETPLGWAADVTRTWPVSGQFSATQRDLYDLVLAAHDACIAAIQPGVEFRD
CCEEEEECCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LHLLAAQTIASGLVDIGILKGQPEALVERDAHALFFPHGIGHLLGLDVHDMEDLGDLAGY
HHHHHHHHHHHHHHHEEEECCCCHHHHHCCCCEEECCCCHHHHHCCCCCCHHHHHHHHCC
APGRQRCDRRGLRYLRLDRPLRPQMLVTIEPGFYQIPALLQNPDLRQQYGDCVNWDRLAQ
CCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCEECCHHHCCCCHHHHHCCCCCHHHHHH
FEDVRGIRIEDDVLVTPEGCQVLTSALPTQAPEVEAYVQGSTA
HHHCCCEEECCCEEECCCHHHHHHHHCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]