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The map label for this gene is lexA [H]

Identifier: 158337075

GI number: 158337075

Start: 3998568

End: 3999188

Strand: Direct

Name: lexA [H]

Synonym: AM1_3948

Alternate gene names: 158337075

Gene position: 3998568-3999188 (Clockwise)

Preceding gene: 158337073

Following gene: 158337077

Centisome position: 61.48

GC content: 44.77

Gene sequence:

>621_bases
GTGGAACCTTTATCAAAAGCTCAACAAGAATTATTTGATTGGTTGGTTCAATTCATTGAACAACATCAACATGCGCCTTC
TATTCGGCAGATGATGCAGGCCATGAAACTCAAATCTCCTGCCCCGGTTCAGAGTCGTTTGGATCATTTGCGCAAGAAAG
GCTATGTCGATTGGGAAATTGGCCAAGCCCGGACGTTGCGGATTGTGCACCCAGAGCACTTACAGTCGGACATGGATCAG
ATTCCGATCTTAGGTGCGATCGCAGCAGGGGGATTAATTGAGCCCTTTGTTGAAGTAGTGGATTCTTTAGAATTCAGCCC
TAAACAATTGCCCCCTAAATCCTATGCCCTTAGGGTGAATGGAGACAGCATGATCGATGCGCATATTACAGATGGAGACA
TCGTCATTATGCGGCCCGTTCAAGAACCGAAAACTATTAAAAATGGAACAATTGTTGCCGCGAGAGTCGAAGGAGAAGGA
ACGACCCTAAAGCGGTTTCACTTAGAAAGGAATGAAGTCACCCTTGAGGCCGCTAATCTGAAATATCAGCCGATCAAAGT
GTTAGCAACACAGGTAGAAATCCAAGGCTCTTTAATTGGAGTATGGCGAAAATATTTTTAA

Upstream 100 bases:

>100_bases
CAGGTGTTTTATTGTTTGCTCTTTACCCTATTAGGTCGAAGGCAATAAAAACCTGTGAGATAACAATAGTGACTCAATGT
GCGCAGGGGCTGGATCAATC

Downstream 100 bases:

>100_bases
AGGAATGTTACGTATAGGTGCCCTTTAAGCTCAAGTGTTATGACACCGTTCTCAGCTTGGCAATCCACATATCAGATGGA
TCGCTGTAATAGTCAATTTC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MEPLSKAQQELFDWLVQFIEQHQHAPSIRQMMQAMKLKSPAPVQSRLDHLRKKGYVDWEIGQARTLRIVHPEHLQSDMDQ
IPILGAIAAGGLIEPFVEVVDSLEFSPKQLPPKSYALRVNGDSMIDAHITDGDIVIMRPVQEPKTIKNGTIVAARVEGEG
TTLKRFHLERNEVTLEAANLKYQPIKVLATQVEIQGSLIGVWRKYF

Sequences:

>Translated_206_residues
MEPLSKAQQELFDWLVQFIEQHQHAPSIRQMMQAMKLKSPAPVQSRLDHLRKKGYVDWEIGQARTLRIVHPEHLQSDMDQ
IPILGAIAAGGLIEPFVEVVDSLEFSPKQLPPKSYALRVNGDSMIDAHITDGDIVIMRPVQEPKTIKNGTIVAARVEGEG
TTLKRFHLERNEVTLEAANLKYQPIKVLATQVEIQGSLIGVWRKYF
>Mature_206_residues
MEPLSKAQQELFDWLVQFIEQHQHAPSIRQMMQAMKLKSPAPVQSRLDHLRKKGYVDWEIGQARTLRIVHPEHLQSDMDQ
IPILGAIAAGGLIEPFVEVVDSLEFSPKQLPPKSYALRVNGDSMIDAHITDGDIVIMRPVQEPKTIKNGTIVAARVEGEG
TTLKRFHLERNEVTLEAANLKYQPIKVLATQVEIQGSLIGVWRKYF

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:
GO:0003677: LexA repressor
GO:0004252: LexA repressor
GO:0006260: LexA repressor
GO:0006281: LexA repressor
GO:0006351: LexA repressor
GO:0006355: LexA repressor
GO:0006508: LexA repressor
GO:0006974: LexA repressor
GO:0009432: LexA repressor
GO:0016787: LexA repressor

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=210, Percent_Identity=30.952380952381, Blast_Score=91, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23322; Mature: 23322

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLSKAQQELFDWLVQFIEQHQHAPSIRQMMQAMKLKSPAPVQSRLDHLRKKGYVDWEI
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEC
GQARTLRIVHPEHLQSDMDQIPILGAIAAGGLIEPFVEVVDSLEFSPKQLPPKSYALRVN
CCCEEEEEECHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
GDSMIDAHITDGDIVIMRPVQEPKTIKNGTIVAARVEGEGTTLKRFHLERNEVTLEAANL
CCCEEEEEECCCCEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEEEEEECCC
KYQPIKVLATQVEIQGSLIGVWRKYF
CCCHHHHHEEHHHHCHHHHHHHHHCC
>Mature Secondary Structure
MEPLSKAQQELFDWLVQFIEQHQHAPSIRQMMQAMKLKSPAPVQSRLDHLRKKGYVDWEI
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEC
GQARTLRIVHPEHLQSDMDQIPILGAIAAGGLIEPFVEVVDSLEFSPKQLPPKSYALRVN
CCCEEEEEECHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
GDSMIDAHITDGDIVIMRPVQEPKTIKNGTIVAARVEGEGTTLKRFHLERNEVTLEAANL
CCCEEEEEECCCCEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEEEEEECCC
KYQPIKVLATQVEIQGSLIGVWRKYF
CCCHHHHHEEHHHHCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA