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The map label for this gene is accB [H]

Identifier: 158337060

GI number: 158337060

Start: 3982260

End: 3982727

Strand: Reverse

Name: accB [H]

Synonym: AM1_3932

Alternate gene names: 158337060

Gene position: 3982727-3982260 (Counterclockwise)

Preceding gene: 158337061

Following gene: 158337058

Centisome position: 61.24

GC content: 47.44

Gene sequence:

>468_bases
GTGGAATTTGATCTCAACCAACTCCGTGAACTATTAGCAATTCTCAATCAAACGGATATTGATGAGCTAAGCCTTAAAAG
TAATGATTTTGAGCTGACTATCCATAAGGCAAACCAAACCACAGCGACGGTCTCCTCTGCGACCGCACAGCCAATGGTTA
TGGATGCCGCTGCACTAGAAGCTGCAGTTCCAGACTCTTCTCCCCCTTCTGCACCTGATAAGAAATGGGTCGATGTGATT
TCTCCGATGGTAGGTACGTTTTATCGTTCCCCCGCCCCCGATGAGCCGCCTTTTGTAGAAGTTGGGGATGCCGCCCGACG
TGGGCAAACCATCTGCATTATCGAAGCAATGAAGTTAATGAATGAGCTAGAAGCTGAGGTGAATGGCGAAATCGTTGAGA
TTCTCGTAGAAAACGGAGAACCTATTGAATTTGGTCAAACCCTCATGCGCATTAACCCTTCGAGCTAG

Upstream 100 bases:

>100_bases
GCAGGTGATGGTCCCTTTATTTATTTCTGAAGGAGAAAGAATTAAAGTGGATACCCGCAACGACTCCTATCTAGGCCGAG
AGTAAGGAGTAACATCAACG

Downstream 100 bases:

>100_bases
CCGTTATCTTCGAAACCCGCAGATGAGGATGCAATACTGCCATCCGGCATAATCGTATCTTTCAAGATGGCGTCGGTTAG
ATCGATGTGCTCTAAGTTAG

Product: acetyl-CoA carboxylase, biotin carboxyl carrier protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MEFDLNQLRELLAILNQTDIDELSLKSNDFELTIHKANQTTATVSSATAQPMVMDAAALEAAVPDSSPPSAPDKKWVDVI
SPMVGTFYRSPAPDEPPFVEVGDAARRGQTICIIEAMKLMNELEAEVNGEIVEILVENGEPIEFGQTLMRINPSS

Sequences:

>Translated_155_residues
MEFDLNQLRELLAILNQTDIDELSLKSNDFELTIHKANQTTATVSSATAQPMVMDAAALEAAVPDSSPPSAPDKKWVDVI
SPMVGTFYRSPAPDEPPFVEVGDAARRGQTICIIEAMKLMNELEAEVNGEIVEILVENGEPIEFGQTLMRINPSS
>Mature_155_residues
MEFDLNQLRELLAILNQTDIDELSLKSNDFELTIHKANQTTATVSSATAQPMVMDAAALEAAVPDSSPPSAPDKKWVDVI
SPMVGTFYRSPAPDEPPFVEVGDAARRGQTICIIEAMKLMNELEAEVNGEIVEILVENGEPIEFGQTLMRINPSS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:
GO:0003989: Acetyl-CoA carboxylase, biotin carboxyl carrier protein
GO:0006633: Acetyl-CoA carboxylase, biotin carboxyl carrier protein
GO:0009317: Acetyl-CoA carboxylase, biotin carboxyl carrier protein

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=155, Percent_Identity=37.4193548387097, Blast_Score=110, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 16901; Mature: 16901

Theoretical pI: Translated: 3.91; Mature: 3.91

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFDLNQLRELLAILNQTDIDELSLKSNDFELTIHKANQTTATVSSATAQPMVMDAAALE
CCCCHHHHHHHHHHHCCCCCCHHEECCCCEEEEEEECCCCEEEHHCCCCCCHHHHHHHHH
AAVPDSSPPSAPDKKWVDVISPMVGTFYRSPAPDEPPFVEVGDAARRGQTICIIEAMKLM
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHCCCEEHHHHHHHHH
NELEAEVNGEIVEILVENGEPIEFGQTLMRINPSS
HHHHHHCCCEEEEEEECCCCCCHHCCCEEECCCCC
>Mature Secondary Structure
MEFDLNQLRELLAILNQTDIDELSLKSNDFELTIHKANQTTATVSSATAQPMVMDAAALE
CCCCHHHHHHHHHHHCCCCCCHHEECCCCEEEEEEECCCCEEEHHCCCCCCHHHHHHHHH
AAVPDSSPPSAPDKKWVDVISPMVGTFYRSPAPDEPPFVEVGDAARRGQTICIIEAMKLM
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHCCCEEHHHHHHHHH
NELEAEVNGEIVEILVENGEPIEFGQTLMRINPSS
HHHHHHCCCEEEEEEECCCCCCHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]