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The map label for this gene is trm1 [H]

Identifier: 158337019

GI number: 158337019

Start: 3940952

End: 3942052

Strand: Reverse

Name: trm1 [H]

Synonym: AM1_3892

Alternate gene names: 158337019

Gene position: 3942052-3940952 (Counterclockwise)

Preceding gene: 158337020

Following gene: 158337008

Centisome position: 60.61

GC content: 51.32

Gene sequence:

>1101_bases
ATGTCATGGTCTGGGAACGCCACTGATCAATTCCAAGAAGGCAAAGCTCTATTTAAAGTTGGGCCAGCATTTTTTCGCCC
CAGCAGTCGACCCGCCCGCGATTTAGGCATATTGGCGGCGGCTGTCTATCGCCAAAAAATAGGTCACCTAACAGTTTTAG
ATGTGATGACCGGATGTGGGGTGCGATCGCAACGCTATGCCCTAGAAAGTGGTGCCGATTGGATTTGGGCTAACGATGCG
AACCCTGACATGGCAACTGTCTTAACCGATAATTTAAGCCAACTGCCCCCGCAGCGGTATCAGCTTTCGTATCATTCAGC
CGCACAGCTCTTTCCTAAATGCCCAGAACAGTTTGATTTCATTGACTTGGACAGTTTTGGCTTGCCTACCCCTTTTCTGC
AAGGCTGTCTACAAACCGTTAAAGCAGGTGGACTCCTTTATATCACGGGCACGGATAGCCGCACCTTAGCGGGACACAAC
CCCAAGCATAGCCAGCGCTTACTGGGAGCATGGGCACGAACGCATCCTGCTGCCCATGAACAAGGCTTACGGCTATTGTT
AGGGAGTTGCTGGCAACAAGCTCAAATCCTAGGACAAGATATTCAGCCCATTTTCTCTTATTTTCAAGGCCAAATTTATC
GGGTACTCATCCAGGTCACCGCATCCCAATCCCAACATGGCCTGGGATTTATCGGCTATTGTCACCACTGCGGTCACTAT
CAAACCGTCGCTTGGGACCAGCTCAGCCGAGCCACCTGCCCCCACCAAGGTCCACCGTTAACCCTCAGCGGTCCTATGTG
GCTAGGGCCATTGCATCATCCCACCTGGCTCACTTCTATGCAGACGCTTGCCCAGGAATGGGGCTGGTCCGATCGAGTGC
AACTCTTACAGGTGATGCAAGATGAAGCCCTGATGCCGCCTTATTTTTACTCCGTTGCAGACATTGGACGGTGGGGAAAA
ATGGATATACCAAAACGCGATCGCATCATTGCACAACTCCACAAGCAAGGCTATCAGGCCAGCCTCACCCACATTAATCC
CCAAGCCTTCAAAACGGATGCGCCGTTTCATGACTGTCTAACTATTGCTGCAGATATGTGA

Upstream 100 bases:

>100_bases
CCTGATCTCAAAGCGGCCGGTAGCATGTCATGCTCATCCTGGAGATATTGTGTGAGGAGGCTAAAGCGAGATGCTAAGTT
GTTTGGGGCAAACCCCTTAA

Downstream 100 bases:

>100_bases
ACAGCATTAACGTTCTACTATCGGCTCAGTCGAGCGGGACCAACCCACTCATTCCAAGAACTGCTGTAGCCATCGTAAGT
AATAAAGTAACGGTTCCCGC

Product: N2,N2-dimethylguanosine tRNA methyltransferase

Products: NA

Alternate protein names: tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSWSGNATDQFQEGKALFKVGPAFFRPSSRPARDLGILAAAVYRQKIGHLTVLDVMTGCGVRSQRYALESGADWIWANDA
NPDMATVLTDNLSQLPPQRYQLSYHSAAQLFPKCPEQFDFIDLDSFGLPTPFLQGCLQTVKAGGLLYITGTDSRTLAGHN
PKHSQRLLGAWARTHPAAHEQGLRLLLGSCWQQAQILGQDIQPIFSYFQGQIYRVLIQVTASQSQHGLGFIGYCHHCGHY
QTVAWDQLSRATCPHQGPPLTLSGPMWLGPLHHPTWLTSMQTLAQEWGWSDRVQLLQVMQDEALMPPYFYSVADIGRWGK
MDIPKRDRIIAQLHKQGYQASLTHINPQAFKTDAPFHDCLTIAADM

Sequences:

>Translated_366_residues
MSWSGNATDQFQEGKALFKVGPAFFRPSSRPARDLGILAAAVYRQKIGHLTVLDVMTGCGVRSQRYALESGADWIWANDA
NPDMATVLTDNLSQLPPQRYQLSYHSAAQLFPKCPEQFDFIDLDSFGLPTPFLQGCLQTVKAGGLLYITGTDSRTLAGHN
PKHSQRLLGAWARTHPAAHEQGLRLLLGSCWQQAQILGQDIQPIFSYFQGQIYRVLIQVTASQSQHGLGFIGYCHHCGHY
QTVAWDQLSRATCPHQGPPLTLSGPMWLGPLHHPTWLTSMQTLAQEWGWSDRVQLLQVMQDEALMPPYFYSVADIGRWGK
MDIPKRDRIIAQLHKQGYQASLTHINPQAFKTDAPFHDCLTIAADM
>Mature_365_residues
SWSGNATDQFQEGKALFKVGPAFFRPSSRPARDLGILAAAVYRQKIGHLTVLDVMTGCGVRSQRYALESGADWIWANDAN
PDMATVLTDNLSQLPPQRYQLSYHSAAQLFPKCPEQFDFIDLDSFGLPTPFLQGCLQTVKAGGLLYITGTDSRTLAGHNP
KHSQRLLGAWARTHPAAHEQGLRLLLGSCWQQAQILGQDIQPIFSYFQGQIYRVLIQVTASQSQHGLGFIGYCHHCGHYQ
TVAWDQLSRATCPHQGPPLTLSGPMWLGPLHHPTWLTSMQTLAQEWGWSDRVQLLQVMQDEALMPPYFYSVADIGRWGKM
DIPKRDRIIAQLHKQGYQASLTHINPQAFKTDAPFHDCLTIAADM

Specific function: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups [H]

COG id: COG1867

COG function: function code J; N2,N2-dimethylguanosine tRNA methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TRM1 family [H]

Homologues:

Organism=Homo sapiens, GI8923219, Length=344, Percent_Identity=29.6511627906977, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI209862871, Length=344, Percent_Identity=29.6511627906977, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI216548445, Length=318, Percent_Identity=29.559748427673, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17564890, Length=415, Percent_Identity=24.3373493975904, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320325, Length=349, Percent_Identity=26.0744985673352, Blast_Score=126, Evalue=7e-30,
Organism=Drosophila melanogaster, GI19921190, Length=413, Percent_Identity=25.181598062954, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022923
- InterPro:   IPR002905 [H]

Pfam domain/function: PF02005 TRM [H]

EC number: =2.1.1.32 [H]

Molecular weight: Translated: 40896; Mature: 40765

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWSGNATDQFQEGKALFKVGPAFFRPSSRPARDLGILAAAVYRQKIGHLTVLDVMTGCG
CCCCCCCCHHHHCCCHHEEECHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEHHHHHHCCC
VRSQRYALESGADWIWANDANPDMATVLTDNLSQLPPQRYQLSYHSAAQLFPKCPEQFDF
CCHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHEECHHHHHHHHHCCCCCCCE
IDLDSFGLPTPFLQGCLQTVKAGGLLYITGTDSRTLAGHNPKHSQRLLGAWARTHPAAHE
EECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHH
QGLRLLLGSCWQQAQILGQDIQPIFSYFQGQIYRVLIQVTASQSQHGLGFIGYCHHCGHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
QTVAWDQLSRATCPHQGPPLTLSGPMWLGPLHHPTWLTSMQTLAQEWGWSDRVQLLQVMQ
CHHHHHHHHHCCCCCCCCCEEECCCCEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
DEALMPPYFYSVADIGRWGKMDIPKRDRIIAQLHKQGYQASLTHINPQAFKTDAPFHDCL
HCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHCCCCCCHHHHH
TIAADM
HHHCCC
>Mature Secondary Structure 
SWSGNATDQFQEGKALFKVGPAFFRPSSRPARDLGILAAAVYRQKIGHLTVLDVMTGCG
CCCCCCCHHHHCCCHHEEECHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEHHHHHHCCC
VRSQRYALESGADWIWANDANPDMATVLTDNLSQLPPQRYQLSYHSAAQLFPKCPEQFDF
CCHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHEECHHHHHHHHHCCCCCCCE
IDLDSFGLPTPFLQGCLQTVKAGGLLYITGTDSRTLAGHNPKHSQRLLGAWARTHPAAHE
EECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHH
QGLRLLLGSCWQQAQILGQDIQPIFSYFQGQIYRVLIQVTASQSQHGLGFIGYCHHCGHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
QTVAWDQLSRATCPHQGPPLTLSGPMWLGPLHHPTWLTSMQTLAQEWGWSDRVQLLQVMQ
CHHHHHHHHHCCCCCCCCCEEECCCCEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
DEALMPPYFYSVADIGRWGKMDIPKRDRIIAQLHKQGYQASLTHINPQAFKTDAPFHDCL
HCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHCCCCCCHHHHH
TIAADM
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA