Click here to switch to the map view.

The map label for this gene is pepP [H]

Identifier: 158336920

GI number: 158336920

Start: 3845750

End: 3847060

Strand: Reverse

Name: pepP [H]

Synonym: AM1_3790

Alternate gene names: 158336920

Gene position: 3847060-3845750 (Counterclockwise)

Preceding gene: 158336921

Following gene: 158336914

Centisome position: 59.15

GC content: 49.89

Gene sequence:

>1311_bases
ATGCAAGCAGAATATCGCCAACGCCGCCAAAACCTGATGGAAGCCATGGGGTCGGGGGCCGGAATTTTTCGTAGTGCCCC
GATGGCGGTGATGCATAGTGATGTGGAATATAACTTCCGACAAGAAAGTGACTTTTTCTACTTGACGGGGTTTAACGAGC
CCAATGCAGTGGCCGTGCTAGCTCCCCACCATGAAGAGCACCAGTTTGTGCTGTTTGTGCAACCTAAAGATCCGTTGATG
GAGACGTGGACAGGGTATCGAGTAGGGGTCGATCTCGCAAAAGAAGAATATGGGGCCGATGCCGTGTATCCCATTGAGGA
GCTGGATGAACATCTACCCCAATATCTAGCAGGTGCCGATCGGATTTACTTTCATCTGGGATTAGATCAGCCCTTTAATC
AAACGATTTTGAAGCACTGGCAGCGATCGCTGATCAAAGTCCGCAAGGATGGGTTTGGTCCTGTTGCCCTAGAAGATCCC
ATGACAGTGCTCCATCCTCAGCGGCTGATTAAAAGTGAGACTGAACTAGATTTGATGCGTAAGGCTATTGATATTTCTGT
CGAAGCGCATAATTTAGCCCGAGAAGTCGCCCAACCTGGCCGCTATGAATATGAAATCCAAGCAGAGATGGAACGGTTGT
TTCGTTTACGAGGTGGCTTAGGCCCCGCCTATCCTTCCATTGTGGCAGCGGGGGTCAATGGCTGCATTTTGCACTACACG
GAAAATACCTGCCAGCTCCAGGAGCAAGATTTACTGTTGATTGATGCAGGCTGCAGTTATCAGTATTACAACGCCGATAT
TACCCGCACCTTTCCCGTCAGTGGGACATTTACGGCAGAGCAAAAGACCCTGTATGAGTTAGTTTTAGCTGCGCAAGAAG
CTGCGATCGCACAAGTGCAACCGGGCAATCCTTACAACGCCTTCCACGACGCAGCGGTCAAAGTCCTGACCCAAGGCTTA
GTCGATCTGGGCTTACTCAAAGGCGAGGTCGATAAGCTGATTGAAGAAGAAAAATATAAACCCTTTTACATGCACCGCAC
AGGCCATTGGTTGGGGCTAGATGTCCATGATGTGGGCGTCTACAAAAAGGATAAGGACACATGGCAGCCATTACAAGCCG
GACATGTTGTGACGGTAGAACCTGGCATTTACATCGGTCCCGATATTCAACTAGACGAAGATCAGCCAGAAGTACCCGAG
CGATGGCGAGGAATTGGGATTCGCATTGAGGATGATGTGCTGCTCACAGAAACAGGTCATGAGGTTCTCACGGCCGCTGT
TCCTAAATCCATTGCCTCCCTTACCCACTAA

Upstream 100 bases:

>100_bases
ATCACACCAACTAGGCCACCCAAAATCAGGAACGCAACGCTCTCTAAGGCAATTTGCTGCACAATAAGTAGAGAAGCTCG
TCAGCCTGATTGAACGTCTT

Downstream 100 bases:

>100_bases
TGGACTCGTTATTGGCGGCTGTCACGGTTCCGTTACTCCGGCGCTGTATCAACCGTTTAACCACAAATTGCACCAAGACT
AGGCCAAGAATGTAAGGCAA

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MQAEYRQRRQNLMEAMGSGAGIFRSAPMAVMHSDVEYNFRQESDFFYLTGFNEPNAVAVLAPHHEEHQFVLFVQPKDPLM
ETWTGYRVGVDLAKEEYGADAVYPIEELDEHLPQYLAGADRIYFHLGLDQPFNQTILKHWQRSLIKVRKDGFGPVALEDP
MTVLHPQRLIKSETELDLMRKAIDISVEAHNLAREVAQPGRYEYEIQAEMERLFRLRGGLGPAYPSIVAAGVNGCILHYT
ENTCQLQEQDLLLIDAGCSYQYYNADITRTFPVSGTFTAEQKTLYELVLAAQEAAIAQVQPGNPYNAFHDAAVKVLTQGL
VDLGLLKGEVDKLIEEEKYKPFYMHRTGHWLGLDVHDVGVYKKDKDTWQPLQAGHVVTVEPGIYIGPDIQLDEDQPEVPE
RWRGIGIRIEDDVLLTETGHEVLTAAVPKSIASLTH

Sequences:

>Translated_436_residues
MQAEYRQRRQNLMEAMGSGAGIFRSAPMAVMHSDVEYNFRQESDFFYLTGFNEPNAVAVLAPHHEEHQFVLFVQPKDPLM
ETWTGYRVGVDLAKEEYGADAVYPIEELDEHLPQYLAGADRIYFHLGLDQPFNQTILKHWQRSLIKVRKDGFGPVALEDP
MTVLHPQRLIKSETELDLMRKAIDISVEAHNLAREVAQPGRYEYEIQAEMERLFRLRGGLGPAYPSIVAAGVNGCILHYT
ENTCQLQEQDLLLIDAGCSYQYYNADITRTFPVSGTFTAEQKTLYELVLAAQEAAIAQVQPGNPYNAFHDAAVKVLTQGL
VDLGLLKGEVDKLIEEEKYKPFYMHRTGHWLGLDVHDVGVYKKDKDTWQPLQAGHVVTVEPGIYIGPDIQLDEDQPEVPE
RWRGIGIRIEDDVLLTETGHEVLTAAVPKSIASLTH
>Mature_436_residues
MQAEYRQRRQNLMEAMGSGAGIFRSAPMAVMHSDVEYNFRQESDFFYLTGFNEPNAVAVLAPHHEEHQFVLFVQPKDPLM
ETWTGYRVGVDLAKEEYGADAVYPIEELDEHLPQYLAGADRIYFHLGLDQPFNQTILKHWQRSLIKVRKDGFGPVALEDP
MTVLHPQRLIKSETELDLMRKAIDISVEAHNLAREVAQPGRYEYEIQAEMERLFRLRGGLGPAYPSIVAAGVNGCILHYT
ENTCQLQEQDLLLIDAGCSYQYYNADITRTFPVSGTFTAEQKTLYELVLAAQEAAIAQVQPGNPYNAFHDAAVKVLTQGL
VDLGLLKGEVDKLIEEEKYKPFYMHRTGHWLGLDVHDVGVYKKDKDTWQPLQAGHVVTVEPGIYIGPDIQLDEDQPEVPE
RWRGIGIRIEDDVLLTETGHEVLTAAVPKSIASLTH

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=451, Percent_Identity=34.3680709534368, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI149589008, Length=433, Percent_Identity=33.4872979214781, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI260593665, Length=301, Percent_Identity=36.2126245847176, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI260593663, Length=429, Percent_Identity=30.5361305361305, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI264681563, Length=270, Percent_Identity=30, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789275, Length=430, Percent_Identity=45.1162790697674, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI1788728, Length=269, Percent_Identity=33.0855018587361, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1790282, Length=289, Percent_Identity=31.4878892733564, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508215, Length=470, Percent_Identity=29.5744680851064, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71989583, Length=268, Percent_Identity=32.8358208955224, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=447, Percent_Identity=32.8859060402685, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321118, Length=417, Percent_Identity=32.1342925659472, Blast_Score=170, Evalue=5e-43,
Organism=Drosophila melanogaster, GI19920384, Length=454, Percent_Identity=36.3436123348018, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI21357079, Length=435, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49290; Mature: 49290

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEYRQRRQNLMEAMGSGAGIFRSAPMAVMHSDVEYNFRQESDFFYLTGFNEPNAVAVL
CCCHHHHHHHHHHHHHCCCCCHHHCCCHHEEECCCCCCEECCCCEEEEEECCCCCEEEEE
APHHEEHQFVLFVQPKDPLMETWTGYRVGVDLAKEEYGADAVYPIEELDEHLPQYLAGAD
ECCCCCCEEEEEECCCCCHHHHCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
RIYFHLGLDQPFNQTILKHWQRSLIKVRKDGFGPVALEDPMTVLHPQRLIKSETELDLMR
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHCHHHHHCCHHHHHHHH
KAIDISVEAHNLAREVAQPGRYEYEIQAEMERLFRLRGGLGPAYPSIVAAGVNGCILHYT
HHHHEEEHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEE
ENTCQLQEQDLLLIDAGCSYQYYNADITRTFPVSGTFTAEQKTLYELVLAAQEAAIAQVQ
CCCEEECCCCEEEEECCCCEEEECCCEEEEECCCCEECHHHHHHHHHHHHHHHHHHEEEC
PGNPYNAFHDAAVKVLTQGLVDLGLLKGEVDKLIEEEKYKPFYMHRTGHWLGLDVHDVGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEECCCC
YKKDKDTWQPLQAGHVVTVEPGIYIGPDIQLDEDQPEVPERWRGIGIRIEDDVLLTETGH
EECCCCCCCHHHCCCEEEECCCEEECCCCEECCCCCCCCHHHCCCCEEEECCEEEECCCH
EVLTAAVPKSIASLTH
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQAEYRQRRQNLMEAMGSGAGIFRSAPMAVMHSDVEYNFRQESDFFYLTGFNEPNAVAVL
CCCHHHHHHHHHHHHHCCCCCHHHCCCHHEEECCCCCCEECCCCEEEEEECCCCCEEEEE
APHHEEHQFVLFVQPKDPLMETWTGYRVGVDLAKEEYGADAVYPIEELDEHLPQYLAGAD
ECCCCCCEEEEEECCCCCHHHHCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
RIYFHLGLDQPFNQTILKHWQRSLIKVRKDGFGPVALEDPMTVLHPQRLIKSETELDLMR
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHCHHHHHCCHHHHHHHH
KAIDISVEAHNLAREVAQPGRYEYEIQAEMERLFRLRGGLGPAYPSIVAAGVNGCILHYT
HHHHEEEHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEE
ENTCQLQEQDLLLIDAGCSYQYYNADITRTFPVSGTFTAEQKTLYELVLAAQEAAIAQVQ
CCCEEECCCCEEEEECCCCEEEECCCEEEEECCCCEECHHHHHHHHHHHHHHHHHHEEEC
PGNPYNAFHDAAVKVLTQGLVDLGLLKGEVDKLIEEEKYKPFYMHRTGHWLGLDVHDVGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEECCCC
YKKDKDTWQPLQAGHVVTVEPGIYIGPDIQLDEDQPEVPERWRGIGIRIEDDVLLTETGH
EECCCCCCCHHHCCCEEEECCCEEECCCCEECCCCCCCCHHHCCCCEEEECCEEEECCCH
EVLTAAVPKSIASLTH
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]