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The map label for this gene is mprA [H]

Identifier: 158336874

GI number: 158336874

Start: 3799592

End: 3799957

Strand: Reverse

Name: mprA [H]

Synonym: AM1_3742

Alternate gene names: 158336874

Gene position: 3799957-3799592 (Counterclockwise)

Preceding gene: 158336875

Following gene: 158336873

Centisome position: 58.43

GC content: 53.01

Gene sequence:

>366_bases
ATGAGCAGCAAAATCTTAGTCGTCGATGACCTCCAATCCGAACTGGACTTACTCTGTCAATACCTGACCGAAGAAGGCTA
CACCATCGTCACGGCCACCAATGGCACAGAGGCACTAGAAAAAGTTAGTCAGAACAAGCCCGACGCCATTGTCACCGATT
GGATGATGCCGGAAATGGGCGGGTTAGACCTAGCCCGGAAGCTACGCAAGAACCCCGACACCGCCGATATTCCCGTGGTG
GCCTGTACCGCTAAGAATCGAGATGTCGATCGCATGTGGGCTGCCAAGCAAGGGGTAGAAGCCTATGTCACAAAACCCTG
CACCAAGCAAGAACTCGTGAGTGCCCTGAGAGCGGCAATGAAATAA

Upstream 100 bases:

>100_bases
CAATAGACTCACATTGGGTAGCCCGTCTACCCCACACCACTCTCATTCCAGTTCCTCAACTCTACTTACGTTTCATAACT
TAGCCACCCAAGGACACACC

Downstream 100 bases:

>100_bases
ATGACCCAACAACCGACTGCCTCTACAACTTCACTATCACGACTGCAAGAGCTGCTACCCCAGTTATTTCAGTCCACCCA
GCTCACCGGACAACCCTATC

Product: response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 121; Mature: 120

Protein sequence:

>121_residues
MSSKILVVDDLQSELDLLCQYLTEEGYTIVTATNGTEALEKVSQNKPDAIVTDWMMPEMGGLDLARKLRKNPDTADIPVV
ACTAKNRDVDRMWAAKQGVEAYVTKPCTKQELVSALRAAMK

Sequences:

>Translated_121_residues
MSSKILVVDDLQSELDLLCQYLTEEGYTIVTATNGTEALEKVSQNKPDAIVTDWMMPEMGGLDLARKLRKNPDTADIPVV
ACTAKNRDVDRMWAAKQGVEAYVTKPCTKQELVSALRAAMK
>Mature_120_residues
SSKILVVDDLQSELDLLCQYLTEEGYTIVTATNGTEALEKVSQNKPDAIVTDWMMPEMGGLDLARKLRKNPDTADIPVVA
CTAKNRDVDRMWAAKQGVEAYVTKPCTKQELVSALRAAMK

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=121, Percent_Identity=33.8842975206612, Blast_Score=87, Evalue=4e-19,
Organism=Escherichia coli, GI1788394, Length=120, Percent_Identity=32.5, Blast_Score=76, Evalue=8e-16,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=34.1666666666667, Blast_Score=74, Evalue=2e-15,
Organism=Escherichia coli, GI1788191, Length=110, Percent_Identity=33.6363636363636, Blast_Score=67, Evalue=3e-13,
Organism=Escherichia coli, GI1788905, Length=119, Percent_Identity=36.1344537815126, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI1790860, Length=118, Percent_Identity=28.8135593220339, Blast_Score=64, Evalue=2e-12,
Organism=Escherichia coli, GI2367329, Length=119, Percent_Identity=33.6134453781513, Blast_Score=64, Evalue=3e-12,
Organism=Escherichia coli, GI1787229, Length=114, Percent_Identity=32.4561403508772, Blast_Score=61, Evalue=2e-11,
Organism=Escherichia coli, GI87082012, Length=118, Percent_Identity=30.5084745762712, Blast_Score=61, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=106, Percent_Identity=33.0188679245283, Blast_Score=59, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 13363; Mature: 13231

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKILVVDDLQSELDLLCQYLTEEGYTIVTATNGTEALEKVSQNKPDAIVTDWMMPEMG
CCCCEEEHHCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCEEECCCCCCCC
GLDLARKLRKNPDTADIPVVACTAKNRDVDRMWAAKQGVEAYVTKPCTKQELVSALRAAM
CHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHC
K
C
>Mature Secondary Structure 
SSKILVVDDLQSELDLLCQYLTEEGYTIVTATNGTEALEKVSQNKPDAIVTDWMMPEMG
CCCEEEHHCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCEEECCCCCCCC
GLDLARKLRKNPDTADIPVVACTAKNRDVDRMWAAKQGVEAYVTKPCTKQELVSALRAAM
CHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA