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The map label for this gene is ndk

Identifier: 158336865

GI number: 158336865

Start: 3787332

End: 3787781

Strand: Reverse

Name: ndk

Synonym: AM1_3733

Alternate gene names: 158336865

Gene position: 3787781-3787332 (Counterclockwise)

Preceding gene: 158336866

Following gene: 158336864

Centisome position: 58.24

GC content: 51.11

Gene sequence:

>450_bases
GTGGAACGAACATTTTTGGCCGTAAAACCAGACGGCGTCCAGCGAGGTCTGGTGGGGGAAATTATCAGCCGTTACGAAGC
CAAAGGGTTTACGTTGGTGGGTCTGAAGCTGATGGTGGTCAGCCGCGAGCTAGCAGAACAACATTACGGCGAGCATAAAG
AAAAGCCTTTCTTTAGTGGCCTGGTAGATTTCATCACCTCTGGTCCCGTAGTAGCCATGGTTTGGGAAGGCAAAGGCGTT
GTAGCTGCAGCTCGGAAAATCATTGGTGCCACCAATCCCCTTGGCTCTGAGCCAGGAACCATTCGCGGCGATTTTGGTAT
CGATATTGGCCGCAATATCATTCATGGATCGGACGCCGTCGAAACAGCCCAGCGCGAAATTAGCCTGTGGTTTAAGTCAG
AAGAACTAGCCGATTGGTCTCCCACTTTAACCTCCTGGATCTACGAATAA

Upstream 100 bases:

>100_bases
CTAGGCGATATCCCCTGATGAGGGTTTCCCTACCTTTACAAATGCCACATCTTTTCTGAGCATAGATAAGGATGTAAACC
CTGAAGGGAGTATTAATTCT

Downstream 100 bases:

>100_bases
CTCCGCCTTGCACTCATCTCTGGTCTAGAGGTGAGTGTTCGGTCTAGCTCAAAACTTATGGTATTTGCATGGCAACCCTT
GCAGATGTTTTAATTCGCCT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MERTFLAVKPDGVQRGLVGEIISRYEAKGFTLVGLKLMVVSRELAEQHYGEHKEKPFFSGLVDFITSGPVVAMVWEGKGV
VAAARKIIGATNPLGSEPGTIRGDFGIDIGRNIIHGSDAVETAQREISLWFKSEELADWSPTLTSWIYE

Sequences:

>Translated_149_residues
MERTFLAVKPDGVQRGLVGEIISRYEAKGFTLVGLKLMVVSRELAEQHYGEHKEKPFFSGLVDFITSGPVVAMVWEGKGV
VAAARKIIGATNPLGSEPGTIRGDFGIDIGRNIIHGSDAVETAQREISLWFKSEELADWSPTLTSWIYE
>Mature_149_residues
MERTFLAVKPDGVQRGLVGEIISRYEAKGFTLVGLKLMVVSRELAEQHYGEHKEKPFFSGLVDFITSGPVVAMVWEGKGV
VAAARKIIGATNPLGSEPGTIRGDFGIDIGRNIIHGSDAVETAQREISLWFKSEELADWSPTLTSWIYE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:
GO:0000166: Nucleoside diphosphate kinase
GO:0004550: Nucleoside diphosphate kinase
GO:0005524: Nucleoside diphosphate kinase
GO:0005737: Nucleoside diphosphate kinase
GO:0006165: Nucleoside diphosphate kinase
GO:0006183: Nucleoside diphosphate kinase
GO:0006228: Nucleoside diphosphate kinase
GO:0006241: Nucleoside diphosphate kinase
GO:0009117: Nucleoside diphosphate kinase
GO:0016301: Nucleoside diphosphate kinase
GO:0016310: Nucleoside diphosphate kinase
GO:0016740: Nucleoside diphosphate kinase
GO:0046872: Nucleoside diphosphate kinase

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4557797, Length=149, Percent_Identity=63.0872483221477, Blast_Score=204, Evalue=2e-53,
Organism=Homo sapiens, GI38045913, Length=149, Percent_Identity=63.0872483221477, Blast_Score=204, Evalue=2e-53,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=61.744966442953, Blast_Score=202, Evalue=1e-52,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=61.744966442953, Blast_Score=201, Evalue=1e-52,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=61.744966442953, Blast_Score=201, Evalue=1e-52,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=61.744966442953, Blast_Score=201, Evalue=1e-52,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=61.744966442953, Blast_Score=201, Evalue=1e-52,
Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=60.8108108108108, Blast_Score=197, Evalue=2e-51,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=56.1151079136691, Blast_Score=172, Evalue=7e-44,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=35.5555555555556, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=35.5555555555556, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI5031951, Length=143, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=32.5925925925926, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=45.2554744525547, Blast_Score=134, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=60.4026845637584, Blast_Score=197, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17507605, Length=97, Percent_Identity=43.298969072165, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=64.8648648648649, Blast_Score=212, Evalue=2e-56,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=62.8378378378378, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=33.5820895522388, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ACAM1 (B0C4I0)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001518040.1
- ProteinModelPortal:   B0C4I0
- SMR:   B0C4I0
- GeneID:   5682539
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_3733
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   AMAR329726:AM1_3733-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16379; Mature: 16379

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFLAVKPDGVQRGLVGEIISRYEAKGFTLVGLKLMVVSRELAEQHYGEHKEKPFFSG
CCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LVDFITSGPVVAMVWEGKGVVAAARKIIGATNPLGSEPGTIRGDFGIDIGRNIIHGSDAV
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCEECCCHHH
ETAQREISLWFKSEELADWSPTLTSWIYE
HHHHHHHHHEECCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MERTFLAVKPDGVQRGLVGEIISRYEAKGFTLVGLKLMVVSRELAEQHYGEHKEKPFFSG
CCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LVDFITSGPVVAMVWEGKGVVAAARKIIGATNPLGSEPGTIRGDFGIDIGRNIIHGSDAV
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCEECCCHHH
ETAQREISLWFKSEELADWSPTLTSWIYE
HHHHHHHHHEECCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA