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The map label for this gene is gor [H]

Identifier: 158336813

GI number: 158336813

Start: 3733605

End: 3734963

Strand: Direct

Name: gor [H]

Synonym: AM1_3681

Alternate gene names: 158336813

Gene position: 3733605-3734963 (Clockwise)

Preceding gene: 158336812

Following gene: 158336814

Centisome position: 57.41

GC content: 50.04

Gene sequence:

>1359_bases
ATGAGTTACGACTATGATGTATTTGTAATTGGTGCAGGCTCCGGTGGAATTGCCACAGCCCGTCGCGCTGCCGAGTATGG
TGCCAAAGTTGGCATTGCAGAATATGGCCGTTTGGGCGGCACCTGTGTGAATCGCGGCTGTGTACCTAAGAAGCTGATGG
TCTATGCGTCTCACTTCCCGTCCCATTTTGATGCTGCCACAGGCTATGGCTGGAGCCCAGTGGAGAGTCAACTAGACTGG
CTCAAAATGATCACGGCGGTGAATGATGAAGTCACACGTCTTAACGGTATCTATCAACGGATGCTAGATAACTCCAAAGT
GGAAGTCTACCGGGGACGTGCGGCCCTTGTCGATGCCCATACCGTTGCAATCGGTGATCAAAAGGTCACTGCAGATAAGA
TTTTGGTGGCGGTGGGGGGCAAACCCGTTAAGCCTGCCAATATTCCCGGTATCGAACATGCCATTACTTCAGACGATATT
TTTAATCTGAAAGAGCAGCCTAAGCATCTGGTTGTTCTCGGTGGGGGCTATATCGGCATTGAATTTGCCTGCATTCTGAA
AGGATTAGGGTCAGAAGTGACGCTGATTATCCGGGCTGACAAGATTTTGCGCGGTTTTGATGACGATATCCGCACAGAAA
TTCAAGACGCGATGCAGAAGCATGGTATTCGGGTACTGAATAATATGACGGATCTTGCGATCGCAAAATCCGATACGGGA
CTCCAAATCACCGTTAAGCAGGCTGATAATGCTGAGGAAACGATTCTAGCCGACGCTGTAAGCCTGGCGGCGACGGGGCG
TATCCCCAATCTCGAAGGCTTGGGACTGGAAAATACTGCCGTTGAAGTAGACGGCGGTGCGATCTCAGTTAATGAATATA
GCCAGACCGCAGAGCCCAATATCTATTCCGTGGGCGACTGTACAGATCGGATTAACCTCACGCCGGTAGCAATTAACGAA
GGCCGAGCCTTTGCTGATACCCATTTTGGCGGCAAGTCACGAACCATGAGCTATGACAATGTACCGACAGCCATTTTCAC
CACCCCTGAAGCCGCTACGGTGGGTTTAACGGAAGCAGAAGCTCAGGAACAGTATGGCGAAGACAAAATCAAAGTCTTTC
GCAGTCGCTTCCGCCCTATGTATTACACCCTTCCTAATCATGATGTGAAAACCTTGATGAAGTTAGTGGTCAATACCGAC
ACCGATCAGGTTTTAGGAGCGCATATGGTGGGGGACCATGCGGGAGAAATTATTCAAGGGGTTGCGATCGCCGTCAAGAT
AGGAGCTACAAAAGCCCAGTTTGACGCTACTGTCGGGATTCACCCCAGTTCTGCCGAAGAATTTGTAACAATGCGCTAA

Upstream 100 bases:

>100_bases
GATGTCACAGTCTGGAGTTGGTCACCGAGCCAGCTCCAGTGTGCCATGCATTGATTAGGCTAAAGTGAAACGTGATTGAA
TCTGCAAAGGAGGGAAGGCG

Downstream 100 bases:

>100_bases
GCAAGGTGTCACTTTTTGGAATTAAGAGGGCACTTTAAGCTCAGGAATCTGGTATCGAGAGATTCCTCCTCAGAGGATTT
AACCCCTGACTACATGTCAG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSYDYDVFVIGAGSGGIATARRAAEYGAKVGIAEYGRLGGTCVNRGCVPKKLMVYASHFPSHFDAATGYGWSPVESQLDW
LKMITAVNDEVTRLNGIYQRMLDNSKVEVYRGRAALVDAHTVAIGDQKVTADKILVAVGGKPVKPANIPGIEHAITSDDI
FNLKEQPKHLVVLGGGYIGIEFACILKGLGSEVTLIIRADKILRGFDDDIRTEIQDAMQKHGIRVLNNMTDLAIAKSDTG
LQITVKQADNAEETILADAVSLAATGRIPNLEGLGLENTAVEVDGGAISVNEYSQTAEPNIYSVGDCTDRINLTPVAINE
GRAFADTHFGGKSRTMSYDNVPTAIFTTPEAATVGLTEAEAQEQYGEDKIKVFRSRFRPMYYTLPNHDVKTLMKLVVNTD
TDQVLGAHMVGDHAGEIIQGVAIAVKIGATKAQFDATVGIHPSSAEEFVTMR

Sequences:

>Translated_452_residues
MSYDYDVFVIGAGSGGIATARRAAEYGAKVGIAEYGRLGGTCVNRGCVPKKLMVYASHFPSHFDAATGYGWSPVESQLDW
LKMITAVNDEVTRLNGIYQRMLDNSKVEVYRGRAALVDAHTVAIGDQKVTADKILVAVGGKPVKPANIPGIEHAITSDDI
FNLKEQPKHLVVLGGGYIGIEFACILKGLGSEVTLIIRADKILRGFDDDIRTEIQDAMQKHGIRVLNNMTDLAIAKSDTG
LQITVKQADNAEETILADAVSLAATGRIPNLEGLGLENTAVEVDGGAISVNEYSQTAEPNIYSVGDCTDRINLTPVAINE
GRAFADTHFGGKSRTMSYDNVPTAIFTTPEAATVGLTEAEAQEQYGEDKIKVFRSRFRPMYYTLPNHDVKTLMKLVVNTD
TDQVLGAHMVGDHAGEIIQGVAIAVKIGATKAQFDATVGIHPSSAEEFVTMR
>Mature_451_residues
SYDYDVFVIGAGSGGIATARRAAEYGAKVGIAEYGRLGGTCVNRGCVPKKLMVYASHFPSHFDAATGYGWSPVESQLDWL
KMITAVNDEVTRLNGIYQRMLDNSKVEVYRGRAALVDAHTVAIGDQKVTADKILVAVGGKPVKPANIPGIEHAITSDDIF
NLKEQPKHLVVLGGGYIGIEFACILKGLGSEVTLIIRADKILRGFDDDIRTEIQDAMQKHGIRVLNNMTDLAIAKSDTGL
QITVKQADNAEETILADAVSLAATGRIPNLEGLGLENTAVEVDGGAISVNEYSQTAEPNIYSVGDCTDRINLTPVAINEG
RAFADTHFGGKSRTMSYDNVPTAIFTTPEAATVGLTEAEAQEQYGEDKIKVFRSRFRPMYYTLPNHDVKTLMKLVVNTDT
DQVLGAHMVGDHAGEIIQGVAIAVKIGATKAQFDATVGIHPSSAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:
GO:0004362: Glutathione-disulfide reductase
GO:0005737: Glutathione-disulfide reductase
GO:0006749: Glutathione-disulfide reductase
GO:0016491: Glutathione-disulfide reductase
GO:0016668: Glutathione-disulfide reductase
GO:0045454: Glutathione-disulfide reductase
GO:0050660: Glutathione-disulfide reductase
GO:0050661: Glutathione-disulfide reductase
GO:0055114: Glutathione-disulfide reductase

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=41.6846652267819, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI22035672, Length=473, Percent_Identity=39.1120507399577, Blast_Score=295, Evalue=8e-80,
Organism=Homo sapiens, GI33519430, Length=476, Percent_Identity=38.0252100840336, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI33519428, Length=476, Percent_Identity=38.0252100840336, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI33519426, Length=476, Percent_Identity=38.0252100840336, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI148277065, Length=476, Percent_Identity=38.0252100840336, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI148277071, Length=476, Percent_Identity=38.0252100840336, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=33.6134453781513, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI291045268, Length=476, Percent_Identity=30.8823529411765, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=32.1739130434783, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1789915, Length=455, Percent_Identity=39.5604395604396, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI87082354, Length=465, Percent_Identity=30.752688172043, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=29.082774049217, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=28.9473684210526, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1789065, Length=199, Percent_Identity=27.6381909547739, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983429, Length=454, Percent_Identity=44.273127753304, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI71983419, Length=454, Percent_Identity=44.273127753304, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=36.2105263157895, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=33.0561330561331, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=30.3879310344828, Blast_Score=194, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=43.1623931623932, Blast_Score=339, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6321091, Length=469, Percent_Identity=28.997867803838, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=27.7777777777778, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=39.1489361702128, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=39.1489361702128, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=39.1489361702128, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=37.6842105263158, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=32.3275862068966, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48609; Mature: 48478

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDYDVFVIGAGSGGIATARRAAEYGAKVGIAEYGRLGGTCVNRGCVPKKLMVYASHFP
CCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHCC
SHFDAATGYGWSPVESQLDWLKMITAVNDEVTRLNGIYQRMLDNSKVEVYRGRAALVDAH
CCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEE
TVAIGDQKVTADKILVAVGGKPVKPANIPGIEHAITSDDIFNLKEQPKHLVVLGGGYIGI
EEEECCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEECCCEEHH
EFACILKGLGSEVTLIIRADKILRGFDDDIRTEIQDAMQKHGIRVLNNMTDLAIAKSDTG
HHHHHHHCCCCCEEEEEEECHHHHCCCHHHHHHHHHHHHHCCHHHHCCCHHEEEEECCCC
LQITVKQADNAEETILADAVSLAATGRIPNLEGLGLENTAVEVDGGAISVNEYSQTAEPN
EEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCC
IYSVGDCTDRINLTPVAINEGRAFADTHFGGKSRTMSYDNVPTAIFTTPEAATVGLTEAE
EEECCCCCCCCEEEEEEEECCCEEEECCCCCCCCEEECCCCCEEEEECCCCCEECCCHHH
AQEQYGEDKIKVFRSRFRPMYYTLPNHDVKTLMKLVVNTDTDQVLGAHMVGDHAGEIIQG
HHHHHCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
VAIAVKIGATKAQFDATVGIHPSSAEEFVTMR
EEEEEEECCCEECCCEEEECCCCCHHHHEECC
>Mature Secondary Structure 
SYDYDVFVIGAGSGGIATARRAAEYGAKVGIAEYGRLGGTCVNRGCVPKKLMVYASHFP
CCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHCC
SHFDAATGYGWSPVESQLDWLKMITAVNDEVTRLNGIYQRMLDNSKVEVYRGRAALVDAH
CCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEE
TVAIGDQKVTADKILVAVGGKPVKPANIPGIEHAITSDDIFNLKEQPKHLVVLGGGYIGI
EEEECCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEECCCEEHH
EFACILKGLGSEVTLIIRADKILRGFDDDIRTEIQDAMQKHGIRVLNNMTDLAIAKSDTG
HHHHHHHCCCCCEEEEEEECHHHHCCCHHHHHHHHHHHHHCCHHHHCCCHHEEEEECCCC
LQITVKQADNAEETILADAVSLAATGRIPNLEGLGLENTAVEVDGGAISVNEYSQTAEPN
EEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCC
IYSVGDCTDRINLTPVAINEGRAFADTHFGGKSRTMSYDNVPTAIFTTPEAATVGLTEAE
EEECCCCCCCCEEEEEEEECCCEEEECCCCCCCCEEECCCCCEEEEECCCCCEECCCHHH
AQEQYGEDKIKVFRSRFRPMYYTLPNHDVKTLMKLVVNTDTDQVLGAHMVGDHAGEIIQG
HHHHHCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
VAIAVKIGATKAQFDATVGIHPSSAEEFVTMR
EEEEEEECCCEECCCEEEECCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]