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The map label for this gene is wecC [H]

Identifier: 158336757

GI number: 158336757

Start: 3681410

End: 3682750

Strand: Reverse

Name: wecC [H]

Synonym: AM1_3625

Alternate gene names: 158336757

Gene position: 3682750-3681410 (Counterclockwise)

Preceding gene: 158336758

Following gene: 158336756

Centisome position: 56.63

GC content: 43.62

Gene sequence:

>1341_bases
GTGTCTGATTCATCTAATTTGTTTAATCACTTAAAAGCAAAAATTCTTGATCGTACAGCAGTTGTTGGAGTAATCGGCCT
CGGGTATGTAGGATTACCATTTGCTGTCGAAAAGGCCAAAGTGGGATTTCATGTGATTGGAGTGGAGCAGAATCCCGATC
GTGCCGATGCTGTAAATGCAGCTCAAAATTACATTCATGATGTTGATTCTGATGAGTTAGCAGCAGTAGTTGCCAACGGT
AAGCTCAAGGCTATCTGTGGGTTTGATCAGGTCTCGCACATGGATGTATTGGTGATTTGCGTACCAACACCATTATCCAA
AAATATGACTCCAAACCTCTCTTATATCGAGAGCGTGACCCAGGGGATAGCACCAGAATTGCGTTCCGGTCAATTGATTA
CCCTTGAATCAACGACTTACCCTGGTACAACGGATGAAGTGATTAAACCTGTGTTGGAGTCTAGCGGCTTAACGCAAGGT
AAAGATTTTTTCTTAGGCCACTCTCCTGAACGGGTTGATCCTGGTAATCAGCGTTACACCACTAAGAATACCAATAAGGT
TGTTGGTGCATCTGACCCTGTCTCCCTAGAAATCGCTACCCTTTTTTATCAGCAAACCATTGATCACGTCGTTCCCGTCA
GCAGCGCTAAAGCTGCTGAGCTAGTTAAGGTTTTTGAGAATACCTTTAGGGCAGTCAATATTGCTCTAGTCAACGAGTTA
GCCATGCTATGTGATCGCATGGATCTGAATGTCTGGGAAGTACTGGATGCCGCTAACACCAAGCCTTTTGGGATTATGCC
TTTCTATCCTGGGCCAGGGGTTGGCGGGCACTGCATTCCCATTGATCCACATTATCTAGAGTGGAAAGCTAAGGAGTTCA
ATTTTGAAACTCATTTTATTGCTTTAGCAGGAGAGATCAATCGGCGGATGCCCGAATTCGTCAGAGAAAAAACGCTACGA
ACCCTGAACCAGATAGGTATAGCCCCATCAAAAGCGAAAGTGCTGGTCATGGGAGTTGCTTATAAAAAAGACTTAGGAGA
TTGGCGTGAATCTCCTTCTATTGACATCGTTAAGCTACTATTACGCGATCACGTGAGCTTGGATTATTATGATCCTTTTG
TGCCAATAATTACGATTGAAGGGCATCAGATGCAATCCGTTGATTTCGGGAACACAACCTTAAGTCAATATGATCTAGTC
ATTATTGCCACAGACCATTCCGCCGTTGACTATGCTCACTTAGTAGAACAGTCAACGGCAATACTAGATACTCGTGGGAT
TACCCGAAAATTATCAGACGCACAATCTACCTCATATCAATCTAAAATTACACTGCTCTAG

Upstream 100 bases:

>100_bases
AGAGCATATATCAATCTCGTTATTGTGATATAAACACTTGAATGAGCATCTGCCTAGACTTATTAAGTCAATGAGTTCCT
TCTAGAGTCCTTTCCCCATT

Downstream 100 bases:

>100_bases
ATCCATTTAGAATTCGTCAGTCTCTCTATGAAACAAGTTGTTGTCGTCGGCGCAGGAAACTGGGGTAAGAACCTCGTCAA
GAATTTTCATGAACTCAATG

Product: UDP-N-acetyl-D-mannosamine 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSDSSNLFNHLKAKILDRTAVVGVIGLGYVGLPFAVEKAKVGFHVIGVEQNPDRADAVNAAQNYIHDVDSDELAAVVANG
KLKAICGFDQVSHMDVLVICVPTPLSKNMTPNLSYIESVTQGIAPELRSGQLITLESTTYPGTTDEVIKPVLESSGLTQG
KDFFLGHSPERVDPGNQRYTTKNTNKVVGASDPVSLEIATLFYQQTIDHVVPVSSAKAAELVKVFENTFRAVNIALVNEL
AMLCDRMDLNVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEFNFETHFIALAGEINRRMPEFVREKTLR
TLNQIGIAPSKAKVLVMGVAYKKDLGDWRESPSIDIVKLLLRDHVSLDYYDPFVPIITIEGHQMQSVDFGNTTLSQYDLV
IIATDHSAVDYAHLVEQSTAILDTRGITRKLSDAQSTSYQSKITLL

Sequences:

>Translated_446_residues
MSDSSNLFNHLKAKILDRTAVVGVIGLGYVGLPFAVEKAKVGFHVIGVEQNPDRADAVNAAQNYIHDVDSDELAAVVANG
KLKAICGFDQVSHMDVLVICVPTPLSKNMTPNLSYIESVTQGIAPELRSGQLITLESTTYPGTTDEVIKPVLESSGLTQG
KDFFLGHSPERVDPGNQRYTTKNTNKVVGASDPVSLEIATLFYQQTIDHVVPVSSAKAAELVKVFENTFRAVNIALVNEL
AMLCDRMDLNVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEFNFETHFIALAGEINRRMPEFVREKTLR
TLNQIGIAPSKAKVLVMGVAYKKDLGDWRESPSIDIVKLLLRDHVSLDYYDPFVPIITIEGHQMQSVDFGNTTLSQYDLV
IIATDHSAVDYAHLVEQSTAILDTRGITRKLSDAQSTSYQSKITLL
>Mature_445_residues
SDSSNLFNHLKAKILDRTAVVGVIGLGYVGLPFAVEKAKVGFHVIGVEQNPDRADAVNAAQNYIHDVDSDELAAVVANGK
LKAICGFDQVSHMDVLVICVPTPLSKNMTPNLSYIESVTQGIAPELRSGQLITLESTTYPGTTDEVIKPVLESSGLTQGK
DFFLGHSPERVDPGNQRYTTKNTNKVVGASDPVSLEIATLFYQQTIDHVVPVSSAKAAELVKVFENTFRAVNIALVNELA
MLCDRMDLNVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEFNFETHFIALAGEINRRMPEFVREKTLRT
LNQIGIAPSKAKVLVMGVAYKKDLGDWRESPSIDIVKLLLRDHVSLDYYDPFVPIITIEGHQMQSVDFGNTTLSQYDLVI
IATDHSAVDYAHLVEQSTAILDTRGITRKLSDAQSTSYQSKITLL

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=415, Percent_Identity=26.0240963855422, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI296040438, Length=324, Percent_Identity=26.2345679012346, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI296040443, Length=261, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI48994968, Length=437, Percent_Identity=31.350114416476, Blast_Score=194, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17560350, Length=427, Percent_Identity=24.824355971897, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17136908, Length=374, Percent_Identity=25.9358288770053, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49015; Mature: 48883

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSSNLFNHLKAKILDRTAVVGVIGLGYVGLPFAVEKAKVGFHVIGVEQNPDRADAVNA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHH
AQNYIHDVDSDELAAVVANGKLKAICGFDQVSHMDVLVICVPTPLSKNMTPNLSYIESVT
HHHHHHCCCCCCEEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
QGIAPELRSGQLITLESTTYPGTTDEVIKPVLESSGLTQGKDFFLGHSPERVDPGNQRYT
HCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCEEE
TKNTNKVVGASDPVSLEIATLFYQQTIDHVVPVSSAKAAELVKVFENTFRAVNIALVNEL
ECCCCEEECCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AMLCDRMDLNVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEFNFETHFI
HHHHHHCCCCHHHHHHCCCCCCCEEECCCCCCCCCCEEEECCCCEEEEEHHHCCCEEEEE
ALAGEINRRMPEFVREKTLRTLNQIGIAPSKAKVLVMGVAYKKDLGDWRESPSIDIVKLL
EEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHCCCCHHHHHHH
LRDHVSLDYYDPFVPIITIEGHQMQSVDFGNTTLSQYDLVIIATDHSAVDYAHLVEQSTA
HHHCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHH
ILDTRGITRKLSDAQSTSYQSKITLL
EEECCCCHHHHHHHHCCCCCCEEEEC
>Mature Secondary Structure 
SDSSNLFNHLKAKILDRTAVVGVIGLGYVGLPFAVEKAKVGFHVIGVEQNPDRADAVNA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHH
AQNYIHDVDSDELAAVVANGKLKAICGFDQVSHMDVLVICVPTPLSKNMTPNLSYIESVT
HHHHHHCCCCCCEEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
QGIAPELRSGQLITLESTTYPGTTDEVIKPVLESSGLTQGKDFFLGHSPERVDPGNQRYT
HCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCEEE
TKNTNKVVGASDPVSLEIATLFYQQTIDHVVPVSSAKAAELVKVFENTFRAVNIALVNEL
ECCCCEEECCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AMLCDRMDLNVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEFNFETHFI
HHHHHHCCCCHHHHHHCCCCCCCEEECCCCCCCCCCEEEECCCCEEEEEHHHCCCEEEEE
ALAGEINRRMPEFVREKTLRTLNQIGIAPSKAKVLVMGVAYKKDLGDWRESPSIDIVKLL
EEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHCCCCHHHHHHH
LRDHVSLDYYDPFVPIITIEGHQMQSVDFGNTTLSQYDLVIIATDHSAVDYAHLVEQSTA
HHHCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHH
ILDTRGITRKLSDAQSTSYQSKITLL
EEECCCCHHHHHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA