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The map label for this gene is aqpZ [H]

Identifier: 158336641

GI number: 158336641

Start: 3552852

End: 3553652

Strand: Direct

Name: aqpZ [H]

Synonym: AM1_3509

Alternate gene names: 158336641

Gene position: 3552852-3553652 (Clockwise)

Preceding gene: 158336640

Following gene: 158336642

Centisome position: 54.63

GC content: 50.56

Gene sequence:

>801_bases
ATGTCGATTACAAAAAAAGTTTTTGCTGAGTTTTTTGGCACGTTCTGGCTGACCTTTGGGGGCTGTGGTAGTGCTGTATT
TGCTGCTGTATACGCCACAAGCTTAGAAGTCGGTGAAGCCAAAGAAGCCTTTCCTTTTTCTTTGGGCATTGGCTTTACAG
GGGTGTCCCTGGCCTTTGGTTTAACGGTTCTGACCATGGCCTATGCGGTAGGCCATATTTCTGGCGGACATTTCAACCCA
GCGGTCTCCTTTGGACTATGGGCAGGCAAGCGATTTTCTGGATCTGAACTCTTGCCTTACATCGTTGCTCAAGTGGTGGG
TGCGATTGCTGCAGCGGGTCTTTTGTATCTCATCGCCAGTGGTGCGGGTCCCATTGATGTTTCCGGTGCGAACCCACTTG
CGACCAATGGATTTGGTGCTCACTCACCCGGTGGCTACAATCTGGTTGCTTGTTTGATCGCAGAAGTCTTGCTCACCATG
ATGTTCCTCTTGATCATCTTGGGTGCCACAGACAGCCGTGCCCCTCAAGGGTTTGCTCCTGTTGCCATTGGTCTAGGCTT
AACCCTGATTCACTTGATCAGCATTCCCATTACCAATACTTCCGTCAACCCTGCTCGTAGTACTGGCCCTGCCTTGATTG
TTGGTTTGGCTGGCAACATGGAGTTATTTGCTCAAGTTTGGCTATTTTGGGTGGCACCGATTGCAGGTGCGATCGCAGCC
GGTTTCATCTATAACGCTCTATTCGAAGCAGATACCACTGCCCCCACTGCAGGTGATCGGAGTTTCGCTGAGCGATCATA
A

Upstream 100 bases:

>100_bases
ACCTTTGCTCATAAAACAAATACGTGAACCTGAAAAGAGTTGCCGAGCCGAGGGGGGTATGAAGTTTATGTTCCTCATGT
TTTGAAGATGGAGTTCATCT

Downstream 100 bases:

>100_bases
GAGAGTCTCTCTCAGTTATTAACGCTCTCTAACATTTGCGAATCGATCAATGTCCTTTTTGCGAGGCTATCTCGCGGCTT
TAATAGATCCCACCTATCGG

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSITKKVFAEFFGTFWLTFGGCGSAVFAAVYATSLEVGEAKEAFPFSLGIGFTGVSLAFGLTVLTMAYAVGHISGGHFNP
AVSFGLWAGKRFSGSELLPYIVAQVVGAIAAAGLLYLIASGAGPIDVSGANPLATNGFGAHSPGGYNLVACLIAEVLLTM
MFLLIILGATDSRAPQGFAPVAIGLGLTLIHLISIPITNTSVNPARSTGPALIVGLAGNMELFAQVWLFWVAPIAGAIAA
GFIYNALFEADTTAPTAGDRSFAERS

Sequences:

>Translated_266_residues
MSITKKVFAEFFGTFWLTFGGCGSAVFAAVYATSLEVGEAKEAFPFSLGIGFTGVSLAFGLTVLTMAYAVGHISGGHFNP
AVSFGLWAGKRFSGSELLPYIVAQVVGAIAAAGLLYLIASGAGPIDVSGANPLATNGFGAHSPGGYNLVACLIAEVLLTM
MFLLIILGATDSRAPQGFAPVAIGLGLTLIHLISIPITNTSVNPARSTGPALIVGLAGNMELFAQVWLFWVAPIAGAIAA
GFIYNALFEADTTAPTAGDRSFAERS
>Mature_265_residues
SITKKVFAEFFGTFWLTFGGCGSAVFAAVYATSLEVGEAKEAFPFSLGIGFTGVSLAFGLTVLTMAYAVGHISGGHFNPA
VSFGLWAGKRFSGSELLPYIVAQVVGAIAAAGLLYLIASGAGPIDVSGANPLATNGFGAHSPGGYNLVACLIAEVLLTMM
FLLIILGATDSRAPQGFAPVAIGLGLTLIHLISIPITNTSVNPARSTGPALIVGLAGNMELFAQVWLFWVAPIAGAIAAG
FIYNALFEADTTAPTAGDRSFAERS

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:
GO:0005215: Aquaporin Z
GO:0005886: Aquaporin Z
GO:0006810: Aquaporin Z
GO:0006833: Aquaporin Z
GO:0015250: Aquaporin Z
GO:0016020: Aquaporin Z
GO:0016021: Aquaporin Z
GO:0055085: Aquaporin Z

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=243, Percent_Identity=37.4485596707819, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI37694062, Length=257, Percent_Identity=36.9649805447471, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4502179, Length=247, Percent_Identity=34.412955465587, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4755125, Length=214, Percent_Identity=35.5140186915888, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4502181, Length=214, Percent_Identity=35.5140186915888, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI6912506, Length=250, Percent_Identity=32.8, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI86792455, Length=264, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI157266307, Length=271, Percent_Identity=31.3653136531365, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI4826645, Length=275, Percent_Identity=27.6363636363636, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI45446752, Length=175, Percent_Identity=32, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI22538420, Length=265, Percent_Identity=30.9433962264151, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI297307120, Length=107, Percent_Identity=37.3831775700935, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787101, Length=245, Percent_Identity=60.8163265306122, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1790362, Length=300, Percent_Identity=28.3333333333333, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71993722, Length=252, Percent_Identity=31.3492063492063, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17558372, Length=209, Percent_Identity=30.1435406698565, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71992966, Length=294, Percent_Identity=26.8707482993197, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17531429, Length=254, Percent_Identity=27.5590551181102, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17531431, Length=254, Percent_Identity=27.5590551181102, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24652747, Length=252, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45551084, Length=252, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24652751, Length=268, Percent_Identity=31.3432835820896, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI19922038, Length=268, Percent_Identity=31.3432835820896, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI45550503, Length=281, Percent_Identity=28.4697508896797, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24762342, Length=201, Percent_Identity=28.8557213930348, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136672, Length=202, Percent_Identity=29.2079207920792, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 27246; Mature: 27115

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITKKVFAEFFGTFWLTFGGCGSAVFAAVYATSLEVGEAKEAFPFSLGIGFTGVSLAFG
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHH
LTVLTMAYAVGHISGGHFNPAVSFGLWAGKRFSGSELLPYIVAQVVGAIAAAGLLYLIAS
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GAGPIDVSGANPLATNGFGAHSPGGYNLVACLIAEVLLTMMFLLIILGATDSRAPQGFAP
CCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
VAIGLGLTLIHLISIPITNTSVNPARSTGPALIVGLAGNMELFAQVWLFWVAPIAGAIAA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
GFIYNALFEADTTAPTAGDRSFAERS
HHHHHHHHHCCCCCCCCCCCHHCCCC
>Mature Secondary Structure 
SITKKVFAEFFGTFWLTFGGCGSAVFAAVYATSLEVGEAKEAFPFSLGIGFTGVSLAFG
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHH
LTVLTMAYAVGHISGGHFNPAVSFGLWAGKRFSGSELLPYIVAQVVGAIAAAGLLYLIAS
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GAGPIDVSGANPLATNGFGAHSPGGYNLVACLIAEVLLTMMFLLIILGATDSRAPQGFAP
CCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
VAIGLGLTLIHLISIPITNTSVNPARSTGPALIVGLAGNMELFAQVWLFWVAPIAGAIAA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
GFIYNALFEADTTAPTAGDRSFAERS
HHHHHHHHHCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]