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The map label for this gene is inlI [H]

Identifier: 158336627

GI number: 158336627

Start: 3527602

End: 3529485

Strand: Direct

Name: inlI [H]

Synonym: AM1_3495

Alternate gene names: 158336627

Gene position: 3527602-3529485 (Clockwise)

Preceding gene: 158336626

Following gene: 158336630

Centisome position: 54.24

GC content: 43.52

Gene sequence:

>1884_bases
ATGTCGGCACCAGATTTAATCCATACCCTGGAACAGACAACTCGGAAACGACTCAAACAAATGTCTGTTGAGGACTTTAA
TCAAAGTCTGGATGATACCTATCACCATTTGCAACTTCAGCCCAATGCTTATGCCCTAAATGATGAACATCAAATCGTTG
GGCTGAGTTTGCAAGGGGTGGATGGCCATGAATTAGTGGACGCATCCATCGAGCAATATCCACATCTCTCCGCCTTGTAT
TTATTCGATATTGTCTCGCCCGAAATCGTCCCATTTGCCAGTCTCCCAGGACTCTCCACCATTGCCCTGTCGGGACAAGA
CGTGACGGCTGCCTCCTATCTTCAGCCAACCACCAATCTCACCACGGTTTATTTAAAAACCACCAATATTTCTGATTATT
CCTTCTTGTCGGACCTCAAGAACCTAACCCACCTCGACTTAAGCAACAATCAGATTGCTGATCTTTCCTTTATCCAAGAC
CTTAAACAACTCACTAGCCTCGGGTTGGCGTCAAACAAAATTGTTGATATCTCAGGACTAAAAGACCTGACGAAACTGAA
CACCCTGAATTTGCGCTCCAATGCAATAGACGATTATTCCGTGTTGCTCAATCTCAAAGAACTTCGCCAACTAACGGTTA
GTGTTCGTGAAGCAACCGATCTTGCCTTTCTACAAGATCTTAAAGACCTGACCCATCTAGATCTCAGTTACAACCACTGG
ATTTCTGATATTTCGGTTTTACGCAATCTCCCAAAGCTCACCCATCTAGATTTAGGGTCTAATCAGATTTCGAATATTGC
AGTTTTGCTAGACCTGCAACAACTTACGCACCTGTCTTTAAGTTCCAATCAAATTTCTGATGTTTCTGTCTTACAAACCC
TCCAGGGACTTGAACGTCTGGATGTCAGTGCTAACGAGATTGCTGATATCGCCATCCTACAAAATCTCCAAGGGTTGACC
CATCTGGATATCAGCTCTAACGAAGTGTCTGACATTTCCGTTTTGCAGGATCTCACGACGCTCACCCAACTGAACGTCAG
TTCAAATGAGATTATTGACTATTCCGTTTTACAAGGTCTAACCCAACTCACGAGCCTAGATGTCAGTGATAATCAGATGT
CTGAGATCTCAGACTTACAGGGACTGCACTCACTCACCAGTCTGAACCTCAGCTATAACCAGCTGTCTGATATTTCAGTC
TTACAGGACCTCAAGCAACTGGCTACTCTGAACTTAAGCTACAACCCAGTCTCTGATATTGCAGTACTGCAAAACTTCAA
GGATCTCACCACCCTGAATTTAAGTTTCACCCAGATTACCGACCTCTCCCACCTGCAAGACCTTAAAGGACTAATCAGTT
TAGATTTACATAGCAATCAGATTACAGATATCTCAGCGTTACAAGACCTGGAGGGACTCTACCGGCTGAATGTCAGTGAT
AATCAGCTGTCCGATATTGCTGCATTAAGAAAACTCAAGGGCCTCTTCAGCCTGAATTTAAGCATTAATCAGATTTTAGA
TATTGCAGCCCTACAAGATCTCACAAGACTAACTAGCTTGAATGTCAGTCATAATCAGCTGTCTGATATTTCAGTTTTGC
AGGGACTCACCAGGCTGAACAGTCTAGATTTAGGAGCCAACCAGATTGCTGATATCTCAGTTCTGCAAAATATCCCAGGG
CTTTTTAGTCTGGATTTGCGATTTTCTGATGTTTCTGTGTTTCAAGACTTCAAGGGATTGACCAGTCTGAATCTCAGTTC
TAATCAAATTTCTAGCGTTCCTGAATGGTTACGTGAACAGGGGCTTCCCATTCAAACGGAGGATGAAGAGGCCTTATTCT
GCATTAACTTATGTGGTAATCCCCTCCCAATGTCACCTGGATAG

Upstream 100 bases:

>100_bases
CAAAAGGCAATCAAAATCCAGCTCAAGGCTATACGGATTACTCAAGACCAGGGTCAGAGTAATAAAATCAGTCGTTGGGT
CGTTTCTCTCTTGATTTATT

Downstream 100 bases:

>100_bases
CGTTTGAATATCTGTAGATTGAAGGTATCCAACGAAGCCATCCCCTGACTACATTGCATCTCCTACCAGCACCTGCCAGG
ACAGCTCATTCAAATCAAGA

Product: internalin A protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MSAPDLIHTLEQTTRKRLKQMSVEDFNQSLDDTYHHLQLQPNAYALNDEHQIVGLSLQGVDGHELVDASIEQYPHLSALY
LFDIVSPEIVPFASLPGLSTIALSGQDVTAASYLQPTTNLTTVYLKTTNISDYSFLSDLKNLTHLDLSNNQIADLSFIQD
LKQLTSLGLASNKIVDISGLKDLTKLNTLNLRSNAIDDYSVLLNLKELRQLTVSVREATDLAFLQDLKDLTHLDLSYNHW
ISDISVLRNLPKLTHLDLGSNQISNIAVLLDLQQLTHLSLSSNQISDVSVLQTLQGLERLDVSANEIADIAILQNLQGLT
HLDISSNEVSDISVLQDLTTLTQLNVSSNEIIDYSVLQGLTQLTSLDVSDNQMSEISDLQGLHSLTSLNLSYNQLSDISV
LQDLKQLATLNLSYNPVSDIAVLQNFKDLTTLNLSFTQITDLSHLQDLKGLISLDLHSNQITDISALQDLEGLYRLNVSD
NQLSDIAALRKLKGLFSLNLSINQILDIAALQDLTRLTSLNVSHNQLSDISVLQGLTRLNSLDLGANQIADISVLQNIPG
LFSLDLRFSDVSVFQDFKGLTSLNLSSNQISSVPEWLREQGLPIQTEDEEALFCINLCGNPLPMSPG

Sequences:

>Translated_627_residues
MSAPDLIHTLEQTTRKRLKQMSVEDFNQSLDDTYHHLQLQPNAYALNDEHQIVGLSLQGVDGHELVDASIEQYPHLSALY
LFDIVSPEIVPFASLPGLSTIALSGQDVTAASYLQPTTNLTTVYLKTTNISDYSFLSDLKNLTHLDLSNNQIADLSFIQD
LKQLTSLGLASNKIVDISGLKDLTKLNTLNLRSNAIDDYSVLLNLKELRQLTVSVREATDLAFLQDLKDLTHLDLSYNHW
ISDISVLRNLPKLTHLDLGSNQISNIAVLLDLQQLTHLSLSSNQISDVSVLQTLQGLERLDVSANEIADIAILQNLQGLT
HLDISSNEVSDISVLQDLTTLTQLNVSSNEIIDYSVLQGLTQLTSLDVSDNQMSEISDLQGLHSLTSLNLSYNQLSDISV
LQDLKQLATLNLSYNPVSDIAVLQNFKDLTTLNLSFTQITDLSHLQDLKGLISLDLHSNQITDISALQDLEGLYRLNVSD
NQLSDIAALRKLKGLFSLNLSINQILDIAALQDLTRLTSLNVSHNQLSDISVLQGLTRLNSLDLGANQIADISVLQNIPG
LFSLDLRFSDVSVFQDFKGLTSLNLSSNQISSVPEWLREQGLPIQTEDEEALFCINLCGNPLPMSPG
>Mature_626_residues
SAPDLIHTLEQTTRKRLKQMSVEDFNQSLDDTYHHLQLQPNAYALNDEHQIVGLSLQGVDGHELVDASIEQYPHLSALYL
FDIVSPEIVPFASLPGLSTIALSGQDVTAASYLQPTTNLTTVYLKTTNISDYSFLSDLKNLTHLDLSNNQIADLSFIQDL
KQLTSLGLASNKIVDISGLKDLTKLNTLNLRSNAIDDYSVLLNLKELRQLTVSVREATDLAFLQDLKDLTHLDLSYNHWI
SDISVLRNLPKLTHLDLGSNQISNIAVLLDLQQLTHLSLSSNQISDVSVLQTLQGLERLDVSANEIADIAILQNLQGLTH
LDISSNEVSDISVLQDLTTLTQLNVSSNEIIDYSVLQGLTQLTSLDVSDNQMSEISDLQGLHSLTSLNLSYNQLSDISVL
QDLKQLATLNLSYNPVSDIAVLQNFKDLTTLNLSFTQITDLSHLQDLKGLISLDLHSNQITDISALQDLEGLYRLNVSDN
QLSDIAALRKLKGLFSLNLSINQILDIAALQDLTRLTSLNVSHNQLSDISVLQGLTRLNSLDLGANQIADISVLQNIPGL
FSLDLRFSDVSVFQDFKGLTSLNLSSNQISSVPEWLREQGLPIQTEDEEALFCINLCGNPLPMSPG

Specific function: Unknown. A role in virulence could not be demonstrated [H]

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 MucBP domains [H]

Homologues:

Organism=Homo sapiens, GI21389483, Length=236, Percent_Identity=32.2033898305085, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4506013, Length=251, Percent_Identity=33.8645418326693, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI38348406, Length=347, Percent_Identity=30.835734870317, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI225579152, Length=447, Percent_Identity=29.5302013422819, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI4826772, Length=447, Percent_Identity=29.5302013422819, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI62912470, Length=398, Percent_Identity=27.3869346733668, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI41281398, Length=452, Percent_Identity=28.7610619469027, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI238908508, Length=533, Percent_Identity=27.7673545966229, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI55743114, Length=203, Percent_Identity=33.9901477832512, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI62912472, Length=368, Percent_Identity=26.9021739130435, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI193083139, Length=460, Percent_Identity=28.0434782608696, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI5031707, Length=460, Percent_Identity=28.0434782608696, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI21361633, Length=271, Percent_Identity=29.8892988929889, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI7662320, Length=385, Percent_Identity=28.051948051948, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4504379, Length=381, Percent_Identity=27.2965879265092, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI171846278, Length=340, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI291219891, Length=445, Percent_Identity=24.9438202247191, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI157694513, Length=428, Percent_Identity=26.6355140186916, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71984630, Length=539, Percent_Identity=26.9016697588126, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17536161, Length=253, Percent_Identity=29.6442687747036, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17554124, Length=231, Percent_Identity=30.3030303030303, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17531555, Length=274, Percent_Identity=27.007299270073, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508137, Length=325, Percent_Identity=28, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71981152, Length=355, Percent_Identity=27.0422535211268, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71981160, Length=355, Percent_Identity=27.0422535211268, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980576, Length=518, Percent_Identity=25.4826254826255, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17563924, Length=506, Percent_Identity=25.296442687747, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322455, Length=445, Percent_Identity=29.6629213483146, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221500776, Length=674, Percent_Identity=28.3382789317507, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667524, Length=504, Percent_Identity=28.1746031746032, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17136634, Length=400, Percent_Identity=31, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281363494, Length=418, Percent_Identity=29.9043062200957, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358607, Length=507, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17933612, Length=367, Percent_Identity=30.2452316076294, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664561, Length=494, Percent_Identity=27.7327935222672, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17648023, Length=389, Percent_Identity=28.2776349614396, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221379725, Length=329, Percent_Identity=27.9635258358663, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221379722, Length=329, Percent_Identity=27.9635258358663, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358617, Length=228, Percent_Identity=28.9473684210526, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24662159, Length=377, Percent_Identity=27.8514588859416, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161077058, Length=488, Percent_Identity=27.2540983606557, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574432, Length=503, Percent_Identity=27.037773359841, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24657927, Length=405, Percent_Identity=27.6543209876543, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24657920, Length=405, Percent_Identity=27.6543209876543, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584272, Length=340, Percent_Identity=28.5294117647059, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24661892, Length=426, Percent_Identity=27.4647887323944, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21355407, Length=245, Percent_Identity=31.0204081632653, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17648021, Length=421, Percent_Identity=28.0285035629454, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24660200, Length=417, Percent_Identity=27.5779376498801, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136436, Length=343, Percent_Identity=28.8629737609329, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014755
- InterPro:   IPR014756
- InterPro:   IPR001611
- InterPro:   IPR019931
- InterPro:   IPR012569
- InterPro:   IPR000601
- InterPro:   IPR001899 [H]

Pfam domain/function: PF00560 LRR_1; PF08191 LRR_adjacent [H]

EC number: NA

Molecular weight: Translated: 69122; Mature: 68991

Theoretical pI: Translated: 4.17; Mature: 4.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPDLIHTLEQTTRKRLKQMSVEDFNQSLDDTYHHLQLQPNAYALNDEHQIVGLSLQGV
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCEEEECCCCEEEEEEEECC
DGHELVDASIEQYPHLSALYLFDIVSPEIVPFASLPGLSTIALSGQDVTAASYLQPTTNL
CCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCE
TTVYLKTTNISDYSFLSDLKNLTHLDLSNNQIADLSFIQDLKQLTSLGLASNKIVDISGL
EEEEEEECCCCHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCC
KDLTKLNTLNLRSNAIDDYSVLLNLKELRQLTVSVREATDLAFLQDLKDLTHLDLSYNHW
HHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ISDISVLRNLPKLTHLDLGSNQISNIAVLLDLQQLTHLSLSSNQISDVSVLQTLQGLERL
HHHHHHHHCCCCCEEECCCCCCCCCEEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DVSANEIADIAILQNLQGLTHLDISSNEVSDISVLQDLTTLTQLNVSSNEIIDYSVLQGL
CCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHH
TQLTSLDVSDNQMSEISDLQGLHSLTSLNLSYNQLSDISVLQDLKQLATLNLSYNPVSDI
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AVLQNFKDLTTLNLSFTQITDLSHLQDLKGLISLDLHSNQITDISALQDLEGLYRLNVSD
HHHHCCHHHEEEEEEHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHEEECCCC
NQLSDIAALRKLKGLFSLNLSINQILDIAALQDLTRLTSLNVSHNQLSDISVLQGLTRLN
CHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
SLDLGANQIADISVLQNIPGLFSLDLRFSDVSVFQDFKGLTSLNLSSNQISSVPEWLREQ
CCCCCCHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHCCCEECCCCCHHHHHHHHHHHHC
GLPIQTEDEEALFCINLCGNPLPMSPG
CCCCCCCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SAPDLIHTLEQTTRKRLKQMSVEDFNQSLDDTYHHLQLQPNAYALNDEHQIVGLSLQGV
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCEEEECCCCEEEEEEEECC
DGHELVDASIEQYPHLSALYLFDIVSPEIVPFASLPGLSTIALSGQDVTAASYLQPTTNL
CCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCE
TTVYLKTTNISDYSFLSDLKNLTHLDLSNNQIADLSFIQDLKQLTSLGLASNKIVDISGL
EEEEEEECCCCHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCC
KDLTKLNTLNLRSNAIDDYSVLLNLKELRQLTVSVREATDLAFLQDLKDLTHLDLSYNHW
HHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ISDISVLRNLPKLTHLDLGSNQISNIAVLLDLQQLTHLSLSSNQISDVSVLQTLQGLERL
HHHHHHHHCCCCCEEECCCCCCCCCEEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DVSANEIADIAILQNLQGLTHLDISSNEVSDISVLQDLTTLTQLNVSSNEIIDYSVLQGL
CCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHH
TQLTSLDVSDNQMSEISDLQGLHSLTSLNLSYNQLSDISVLQDLKQLATLNLSYNPVSDI
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AVLQNFKDLTTLNLSFTQITDLSHLQDLKGLISLDLHSNQITDISALQDLEGLYRLNVSD
HHHHCCHHHEEEEEEHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHEEECCCC
NQLSDIAALRKLKGLFSLNLSINQILDIAALQDLTRLTSLNVSHNQLSDISVLQGLTRLN
CHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
SLDLGANQIADISVLQNIPGLFSLDLRFSDVSVFQDFKGLTSLNLSSNQISSVPEWLREQ
CCCCCCHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHCCCEECCCCCHHHHHHHHHHHHC
GLPIQTEDEEALFCINLCGNPLPMSPG
CCCCCCCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]