Click here to switch to the map view.

The map label for this gene is icfA [H]

Identifier: 158336604

GI number: 158336604

Start: 3505165

End: 3506133

Strand: Reverse

Name: icfA [H]

Synonym: AM1_3470

Alternate gene names: 158336604

Gene position: 3506133-3505165 (Counterclockwise)

Preceding gene: 158336609

Following gene: 158336603

Centisome position: 53.91

GC content: 50.88

Gene sequence:

>969_bases
GTGAAAAAGCTAGTTCGTGGTCTACAAGAGTTTAAGCAAAGCTATGTTGCCCAAAATCAAGAACTCTTAGAAGAACTCTC
TCACGGTCAAAAGCCCCGTGTCCTATTTATCTCCTGCTCTGATTCGCGGGTTGACCCCAATCTGATTACCCAGACGGATG
TAGGAGAATTATTTGTCATCCGTAATGCCGGTAATATTGTGCCCCCCTATGGAGCGGCCAATGGCGGCGAAGGTGGCACC
ATTGAATATGCCATTGCTGCTCTAGAGATCGATCAAGTGGTGATCTGCGGCCATTCCCACTGTGGGGCGATGAAAGGGCT
GATGAAGCTGAATAAGCTGCAAGCAGATATGCCCTTGGTCTATGACTGGTTACAACATGCCGAAACCACCCGACGATTGG
TGGCAGAGAACTATCCCGAATCCCAAGGGGAAGAGCGGGTTGAAATTTTAGTGGCCGAAAATGTCTTGGTACAGATTGAT
AATCTGAAGACATATCCCATTGTGCGATCGCGGCTGCTGCAGGGCAAACTGCAAATTTATGGCTGGATTTATCACATCGA
GACTGGGGAAGTCTTGGCCTATGATGACCAGACCCATACCTACATCCCTCCTCAAAGCCAGCTGTTAGACCCTCCTCCCA
GCTTGCCGTCTCGCTTAGAGCAATATTTAATTAGCACCCATGCGCCGCCGGTCGCTTGTGAAGTGCCAACCCCTCGACTT
CAGTCAGCGTCTTCAAGTCCAGCGGCTTCTCCCGTCAATGGTACGCCTGCAGCAGATCGTATCCGCTCTCAGCTCAATGC
TCTCTTGAAAGCGTCGCCGGATTCCTGGGTGGACGTAGAAGACCGTATGCGATCCATGAGCAAGCTGCTTGAAGATGCCC
GCCATGAAGGCATGAGCGCTAGCGAAGCCCAGAATTATCATCATCAATTCTCAGAACAGATTCCCAGGTGGCTGCGGCAA
ATGGGATAG

Upstream 100 bases:

>100_bases
TAGTTTAAACTGAAGTCTTGAGAAGATTACAATCCCAGAACTTGCGTGGACTAAGCCGGATGACATGGTTCGCGCCAAGT
CGTGTCAAGGAAGTTGAGTC

Downstream 100 bases:

>100_bases
CCTTTGGGGGGGCACCTATACATGGCGACAATACACCCTGCTGGTCATCTCAATATTTTGCCTGTAAAGCTTTTTCGCTG
ATAAGCCTAGTCCTGCTAAA

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKKLVRGLQEFKQSYVAQNQELLEELSHGQKPRVLFISCSDSRVDPNLITQTDVGELFVIRNAGNIVPPYGAANGGEGGT
IEYAIAALEIDQVVICGHSHCGAMKGLMKLNKLQADMPLVYDWLQHAETTRRLVAENYPESQGEERVEILVAENVLVQID
NLKTYPIVRSRLLQGKLQIYGWIYHIETGEVLAYDDQTHTYIPPQSQLLDPPPSLPSRLEQYLISTHAPPVACEVPTPRL
QSASSSPAASPVNGTPAADRIRSQLNALLKASPDSWVDVEDRMRSMSKLLEDARHEGMSASEAQNYHHQFSEQIPRWLRQ
MG

Sequences:

>Translated_322_residues
MKKLVRGLQEFKQSYVAQNQELLEELSHGQKPRVLFISCSDSRVDPNLITQTDVGELFVIRNAGNIVPPYGAANGGEGGT
IEYAIAALEIDQVVICGHSHCGAMKGLMKLNKLQADMPLVYDWLQHAETTRRLVAENYPESQGEERVEILVAENVLVQID
NLKTYPIVRSRLLQGKLQIYGWIYHIETGEVLAYDDQTHTYIPPQSQLLDPPPSLPSRLEQYLISTHAPPVACEVPTPRL
QSASSSPAASPVNGTPAADRIRSQLNALLKASPDSWVDVEDRMRSMSKLLEDARHEGMSASEAQNYHHQFSEQIPRWLRQ
MG
>Mature_322_residues
MKKLVRGLQEFKQSYVAQNQELLEELSHGQKPRVLFISCSDSRVDPNLITQTDVGELFVIRNAGNIVPPYGAANGGEGGT
IEYAIAALEIDQVVICGHSHCGAMKGLMKLNKLQADMPLVYDWLQHAETTRRLVAENYPESQGEERVEILVAENVLVQID
NLKTYPIVRSRLLQGKLQIYGWIYHIETGEVLAYDDQTHTYIPPQSQLLDPPPSLPSRLEQYLISTHAPPVACEVPTPRL
QSASSSPAASPVNGTPAADRIRSQLNALLKASPDSWVDVEDRMRSMSKLLEDARHEGMSASEAQNYHHQFSEQIPRWLRQ
MG

Specific function: Reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation [H]

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786534, Length=203, Percent_Identity=43.8423645320197, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1786318, Length=180, Percent_Identity=32.2222222222222, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25147564, Length=236, Percent_Identity=25, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI115532990, Length=245, Percent_Identity=22.8571428571429, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324292, Length=182, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24645213, Length=246, Percent_Identity=25.2032520325203, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 35959; Mature: 35959

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVRGLQEFKQSYVAQNQELLEELSHGQKPRVLFISCSDSRVDPNLITQTDVGELFVI
CHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCEECCCCCCEEEE
RNAGNIVPPYGAANGGEGGTIEYAIAALEIDQVVICGHSHCGAMKGLMKLNKLQADMPLV
ECCCCCCCCCCCCCCCCCCEEEEEEEEEEECEEEEECCCHHHHHHHHHHHHHHHCCCHHH
YDWLQHAETTRRLVAENYPESQGEERVEILVAENVLVQIDNLKTYPIVRSRLLQGKLQIY
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEECCCCCCHHHHHHHHHCCEEEE
GWIYHIETGEVLAYDDQTHTYIPPQSQLLDPPPSLPSRLEQYLISTHAPPVACEVPTPRL
EEEEEEECCCEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHH
QSASSSPAASPVNGTPAADRIRSQLNALLKASPDSWVDVEDRMRSMSKLLEDARHEGMSA
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
SEAQNYHHQFSEQIPRWLRQMG
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKLVRGLQEFKQSYVAQNQELLEELSHGQKPRVLFISCSDSRVDPNLITQTDVGELFVI
CHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCEECCCCCCEEEE
RNAGNIVPPYGAANGGEGGTIEYAIAALEIDQVVICGHSHCGAMKGLMKLNKLQADMPLV
ECCCCCCCCCCCCCCCCCCEEEEEEEEEEECEEEEECCCHHHHHHHHHHHHHHHCCCHHH
YDWLQHAETTRRLVAENYPESQGEERVEILVAENVLVQIDNLKTYPIVRSRLLQGKLQIY
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEECCCCCCHHHHHHHHHCCEEEE
GWIYHIETGEVLAYDDQTHTYIPPQSQLLDPPPSLPSRLEQYLISTHAPPVACEVPTPRL
EEEEEEECCCEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHH
QSASSSPAASPVNGTPAADRIRSQLNALLKASPDSWVDVEDRMRSMSKLLEDARHEGMSA
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
SEAQNYHHQFSEQIPRWLRQMG
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584776 [H]