Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 158336588

GI number: 158336588

Start: 3482094

End: 3483815

Strand: Direct

Name: mutL [H]

Synonym: AM1_3452

Alternate gene names: 158336588

Gene position: 3482094-3483815 (Clockwise)

Preceding gene: 158336587

Following gene: 158336589

Centisome position: 53.54

GC content: 53.89

Gene sequence:

>1722_bases
ATGGTAGAGTGCGCCCCCGATCTTCAGATTCAGCCTCTGGGAACTGATTTGGTTCATCGAATTGCGGCAGGAGAGGTGAT
TGATTCCCTCGGGGCTGTCGTGCGGGAACTCCTGGATAATGCCTTAGATGCTGGAGCGGATCGCATCAGTGTCTCCCTCT
GGCCCCAAGATTGGCGAATTCAAGTCGTTGATAATGGCCAAGGTCTCACTGCTGCCAATCTAGCTCAAGCGGCTACGCCC
CATACCACCAGCAAACTACAGCGGGAAGAAGATTTATGGGATATCCAGACCCTGGGGTTTCGAGGCGAGGCCCTCCATAG
TTTGGCTCAAATGGGACGATTAGAGATTTGCAGCCGACCTGTGGGATCGGCTCAGGGGTGCCGAGTTCGATACGATCACC
AAGGCCATGTGGTGGCCCAAGAGACGGTTGCGATCGCACCCGGTACCGTTGCCACCGTGGCAGATTTATTCCAAGACTGG
CCGACCCGCAAACAGGCTCTCCCCGATCCAGCACGGCAAATGCGAGGGGTGCAAACCATCATCCATGACTATGCCCTGTG
CCACCCCCAGGTCACCTGGCAAGTACAGCAAAATAATCGCTTGTGGTTTAGTATTGCCCCAGCCAAAGCGGCTCAAGATA
TTCTTCCCCAGCTCTTGGCGACCCTGCAGCCTGGAGATTTATGCCATCATCGCTGTCAGATTCCCGATCTACCAGGAAAT
AATGTAGTGGAAGTAGTGTTGGGCTTACCCGATCGCTGCCATCGCCATCGTCCTGACTGGGTAAAGGTAGCGGTCAATGG
TCGCTGTGTTCAAGTCAGCGGTGAAGATGCAGGCCAGTCTCACCCCTTGGAGCAAACCATCCTAGGGGCGTTTCGACAAA
CCCTACCCCGCCATCGTCATCCTCTATGCTTTATTCATCTCCATGCTGACCCTCAGCATGTAGACTGGCACCGGCACCCT
GCTAAAACCGAGATTTATCTGCGGCATTTGGACCAGTGGCGACCTGCCGTAACCACGACGATTCAGGAAGCGCTGCAAAT
TCCTGCTGAAATTCAGGACTCAGGTCATACTCAGAAAATTCGCCAATTGATGAAAGTGGCGGAGGCTAAAGGGGTTTATC
ACTTACAGCAGCCATCCCTGTTATCTTCCCAGCCTGAGCAAGCAGCGGGGGAGTCCGGCTTTAATGTCCTGAAGGCCATT
GCCCAGTTGCACCGGACCTATATTGTGGCAGAGCATCCTTCGGGAGTCTGGCTGGTGGAGCAGCATATTGCCCATGAGCG
GGTTCTCTACGAGCAGTTGGGGCAAGACTGGCATTTAGTGCCCTTAACCCCACCGATGATGCTACGAGATTTAACCGAGA
GACAGGTGGAGCAGCTCACGGATATTGGTATTGATATTACGGAATTTGGCCATCAGCTGTGGGCCATTCGCTCGGCCCCA
CAACGGCTAGCGGAACGCCCGGATTGCGAAGCGGCCCTGATTGAACTCAGTCAATGTGAGAGTATTGAAGCAGCCTTAGC
CGCCACTGCTTGCCGGAGTGCCATTCGCAATGGCATGGCCCTCAACCTGTTGGAGATGCAAAACTTGTTGGATCAATGGC
AGCAAACCCGTCATCCGCGCACCTGCCCCCATGGACGACCGATTTATTTATCAATGGAAGAAGCAGACTTATCTCGGTTT
TTCCGTCGGCATTGGGTGATTGGTAAAAGTCATGGAATCTAA

Upstream 100 bases:

>100_bases
TATGTGAGGATGGCCCAAACGGGGCATTTCCCCATGTTGGAAGATACCTCCACCTATCTACAGCATATTCACCACTTTTT
AACGCCGGTGACCTGTTGAG

Downstream 100 bases:

>100_bases
ATATCAATGGTGCAACTCAGTAAACAAGGATTGATTCTAGGATTAGGTCCGTTAGCCTTTGCCATCGCCTTTGGGGTGAC
CTACTTCTCCGACCGTGATG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MVECAPDLQIQPLGTDLVHRIAAGEVIDSLGAVVRELLDNALDAGADRISVSLWPQDWRIQVVDNGQGLTAANLAQAATP
HTTSKLQREEDLWDIQTLGFRGEALHSLAQMGRLEICSRPVGSAQGCRVRYDHQGHVVAQETVAIAPGTVATVADLFQDW
PTRKQALPDPARQMRGVQTIIHDYALCHPQVTWQVQQNNRLWFSIAPAKAAQDILPQLLATLQPGDLCHHRCQIPDLPGN
NVVEVVLGLPDRCHRHRPDWVKVAVNGRCVQVSGEDAGQSHPLEQTILGAFRQTLPRHRHPLCFIHLHADPQHVDWHRHP
AKTEIYLRHLDQWRPAVTTTIQEALQIPAEIQDSGHTQKIRQLMKVAEAKGVYHLQQPSLLSSQPEQAAGESGFNVLKAI
AQLHRTYIVAEHPSGVWLVEQHIAHERVLYEQLGQDWHLVPLTPPMMLRDLTERQVEQLTDIGIDITEFGHQLWAIRSAP
QRLAERPDCEAALIELSQCESIEAALAATACRSAIRNGMALNLLEMQNLLDQWQQTRHPRTCPHGRPIYLSMEEADLSRF
FRRHWVIGKSHGI

Sequences:

>Translated_573_residues
MVECAPDLQIQPLGTDLVHRIAAGEVIDSLGAVVRELLDNALDAGADRISVSLWPQDWRIQVVDNGQGLTAANLAQAATP
HTTSKLQREEDLWDIQTLGFRGEALHSLAQMGRLEICSRPVGSAQGCRVRYDHQGHVVAQETVAIAPGTVATVADLFQDW
PTRKQALPDPARQMRGVQTIIHDYALCHPQVTWQVQQNNRLWFSIAPAKAAQDILPQLLATLQPGDLCHHRCQIPDLPGN
NVVEVVLGLPDRCHRHRPDWVKVAVNGRCVQVSGEDAGQSHPLEQTILGAFRQTLPRHRHPLCFIHLHADPQHVDWHRHP
AKTEIYLRHLDQWRPAVTTTIQEALQIPAEIQDSGHTQKIRQLMKVAEAKGVYHLQQPSLLSSQPEQAAGESGFNVLKAI
AQLHRTYIVAEHPSGVWLVEQHIAHERVLYEQLGQDWHLVPLTPPMMLRDLTERQVEQLTDIGIDITEFGHQLWAIRSAP
QRLAERPDCEAALIELSQCESIEAALAATACRSAIRNGMALNLLEMQNLLDQWQQTRHPRTCPHGRPIYLSMEEADLSRF
FRRHWVIGKSHGI
>Mature_573_residues
MVECAPDLQIQPLGTDLVHRIAAGEVIDSLGAVVRELLDNALDAGADRISVSLWPQDWRIQVVDNGQGLTAANLAQAATP
HTTSKLQREEDLWDIQTLGFRGEALHSLAQMGRLEICSRPVGSAQGCRVRYDHQGHVVAQETVAIAPGTVATVADLFQDW
PTRKQALPDPARQMRGVQTIIHDYALCHPQVTWQVQQNNRLWFSIAPAKAAQDILPQLLATLQPGDLCHHRCQIPDLPGN
NVVEVVLGLPDRCHRHRPDWVKVAVNGRCVQVSGEDAGQSHPLEQTILGAFRQTLPRHRHPLCFIHLHADPQHVDWHRHP
AKTEIYLRHLDQWRPAVTTTIQEALQIPAEIQDSGHTQKIRQLMKVAEAKGVYHLQQPSLLSSQPEQAAGESGFNVLKAI
AQLHRTYIVAEHPSGVWLVEQHIAHERVLYEQLGQDWHLVPLTPPMMLRDLTERQVEQLTDIGIDITEFGHQLWAIRSAP
QRLAERPDCEAALIELSQCESIEAALAATACRSAIRNGMALNLLEMQNLLDQWQQTRHPRTCPHGRPIYLSMEEADLSRF
FRRHWVIGKSHGI

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:
GO:0005524: DNA mismatch repair protein MutL
GO:0006281: DNA mismatch repair protein MutL
GO:0006298: DNA mismatch repair protein MutL
GO:0006974: DNA mismatch repair protein MutL
GO:0030983: DNA mismatch repair protein MutL

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=323, Percent_Identity=26.9349845201238, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI189458896, Length=191, Percent_Identity=30.3664921465969, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4505913, Length=185, Percent_Identity=33.5135135135135, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI310128478, Length=185, Percent_Identity=33.5135135135135, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4505911, Length=178, Percent_Identity=30.8988764044944, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI189458898, Length=178, Percent_Identity=30.8988764044944, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI91992162, Length=232, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI91992160, Length=232, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310128480, Length=128, Percent_Identity=31.25, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1790612, Length=390, Percent_Identity=28.974358974359, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71991825, Length=327, Percent_Identity=28.4403669724771, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17562796, Length=192, Percent_Identity=31.25, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=330, Percent_Identity=27.8787878787879, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324247, Length=191, Percent_Identity=33.5078534031414, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=207, Percent_Identity=27.0531400966184, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17136968, Length=375, Percent_Identity=27.2, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17136970, Length=158, Percent_Identity=36.7088607594937, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 64318; Mature: 64318

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVECAPDLQIQPLGTDLVHRIAAGEVIDSLGAVVRELLDNALDAGADRISVSLWPQDWRI
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
QVVDNGQGLTAANLAQAATPHTTSKLQREEDLWDIQTLGFRGEALHSLAQMGRLEICSRP
EEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHCCC
VGSAQGCRVRYDHQGHVVAQETVAIAPGTVATVADLFQDWPTRKQALPDPARQMRGVQTI
CCCCCCCEEEECCCCCEEEECEEEECCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHH
IHDYALCHPQVTWQVQQNNRLWFSIAPAKAAQDILPQLLATLQPGDLCHHRCQIPDLPGN
HHHHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCC
NVVEVVLGLPDRCHRHRPDWVKVAVNGRCVQVSGEDAGQSHPLEQTILGAFRQTLPRHRH
CCEEEEECCCHHHHCCCCCEEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
PLCFIHLHADPQHVDWHRHPAKTEIYLRHLDQWRPAVTTTIQEALQIPAEIQDSGHTQKI
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHCCCCCHHHH
RQLMKVAEAKGVYHLQQPSLLSSQPEQAAGESGFNVLKAIAQLHRTYIVAEHPSGVWLVE
HHHHHHHHHCCCEEECCCCHHCCCCHHHCCCCHHHHHHHHHHHHHHEEEEECCCCEEHHH
QHIAHERVLYEQLGQDWHLVPLTPPMMLRDLTERQVEQLTDIGIDITEFGHQLWAIRSAP
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QRLAERPDCEAALIELSQCESIEAALAATACRSAIRNGMALNLLEMQNLLDQWQQTRHPR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCC
TCPHGRPIYLSMEEADLSRFFRRHWVIGKSHGI
CCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVECAPDLQIQPLGTDLVHRIAAGEVIDSLGAVVRELLDNALDAGADRISVSLWPQDWRI
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
QVVDNGQGLTAANLAQAATPHTTSKLQREEDLWDIQTLGFRGEALHSLAQMGRLEICSRP
EEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHCCC
VGSAQGCRVRYDHQGHVVAQETVAIAPGTVATVADLFQDWPTRKQALPDPARQMRGVQTI
CCCCCCCEEEECCCCCEEEECEEEECCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHH
IHDYALCHPQVTWQVQQNNRLWFSIAPAKAAQDILPQLLATLQPGDLCHHRCQIPDLPGN
HHHHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCC
NVVEVVLGLPDRCHRHRPDWVKVAVNGRCVQVSGEDAGQSHPLEQTILGAFRQTLPRHRH
CCEEEEECCCHHHHCCCCCEEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
PLCFIHLHADPQHVDWHRHPAKTEIYLRHLDQWRPAVTTTIQEALQIPAEIQDSGHTQKI
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHCCCCCHHHH
RQLMKVAEAKGVYHLQQPSLLSSQPEQAAGESGFNVLKAIAQLHRTYIVAEHPSGVWLVE
HHHHHHHHHCCCEEECCCCHHCCCCHHHCCCCHHHHHHHHHHHHHHEEEEECCCCEEHHH
QHIAHERVLYEQLGQDWHLVPLTPPMMLRDLTERQVEQLTDIGIDITEFGHQLWAIRSAP
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QRLAERPDCEAALIELSQCESIEAALAATACRSAIRNGMALNLLEMQNLLDQWQQTRHPR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCC
TCPHGRPIYLSMEEADLSRFFRRHWVIGKSHGI
CCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA