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The map label for this gene is kmo [H]

Identifier: 158336523

GI number: 158336523

Start: 3415238

End: 3416629

Strand: Direct

Name: kmo [H]

Synonym: AM1_3387

Alternate gene names: 158336523

Gene position: 3415238-3416629 (Clockwise)

Preceding gene: 158336522

Following gene: 158336531

Centisome position: 52.51

GC content: 45.33

Gene sequence:

>1392_bases
ATGGTAAATTCTCCATCTGAAAAGCCTCTATCCTCTGAAAAGAACAGGACAGCAGTAGTGGTGGGAGGTGGGCCGACCGG
AACGCTGATAGCTTTGTATCTAGCCCAGGCAGGATGGCATGTATCTGTCTATGAGCAGAGAAGTGCAGATGCTAAAGCGT
CTAGTAATCGTCGTTCATTCAATATTGTGCTTAACAGGCGTGGACTTAAAGCTTTGGAAGACGCTGGTGTTCAGCTGCCG
CCAGATAAGCAAGTATGTATCACAGGTAATATTCGGCATACCGAGAAAGATTCAATTTTGAGAAAAGGATTTAGAACTTC
GGTTTCAGTTGATAGGCATACCCTGGCTCAGTCATTAATTGCGGAAGGGAAAAATCGCTTTCCTGACAACATTCAATATT
ATTTTGAGCAAACTTTATTGCAGCTCAATCTTCACGATAAGACTGCGTTGTTCCAGGAAGCATCAGGGCAACATGAACAG
ACATTTGATTTATTGATAGGAGCAGATGGGATCTCTAGTACTGTCAGGTATTCCATGAGTTCTCAACTCGAAGGATTTAC
AGTCCGACAGCATGCTGACGATATGATGTACAAAATCTGTAACTTAGGATTAGCTGAGCATTTGCCTGGTGCAACGGCAG
AATGGGCAGATGCTTTTCACGTATGGCCTGGTGCTGAACCTGTGACGATGGCTGCCCCACCGAGTGCTGATGGCGTCATC
AGAGCCGTATTGATTTTGCCACAAGAAGGAGAGATTACTTTCGACACAATCCGAACCGAAGCAGATGTATCTGCTTTGTT
TAAAGCAAAGCTTCCGGTTGTGTTTCCTAATTTAGATCAAACGGGTTTCCCCTCTCACTTCGTCCAGGATTTGCTATCAC
AGAAAGCCGCACATGGAGGGTTTACTACTATGTGTAATCGGTTTGAAGATGGGGATTGCGTTGTGCTGTTGGGAGATGCA
GCCCACTCAATTTGGCCATCTTTGGGGCAAGGGTGTAACGTAGCTCTTGAGAGTTGTCGCATTTTTGCTGAGGTGCTGGC
ACATGCACAAGGAGACTTATCTTTGGCTTTACCCGCTTACACGGCAGCTCGTAAACCAGATACAGATGCAGTGGCGAGGC
TCTCTGAAATTGGTTTTGGCGGCAATAAACGAGCATCGAATCCCCTATTTAAGGCTAAAGTCTCGACACTCATACTGATG
CATAAGCTATTGCCAAAGTGGTTTAAGGGATATGCGCTGTTACAGATTGGGAATGCTGATGTCCCTTATGCCAACATTTG
GCAGCAAGCTCAGTCCCAAGAAAAACAATTACTGGGTTTATTCGCCATTGTTGTGGGTATTGTTCCTATGCTCTGGATAA
CGTTTCAGATTATCCACAAGGTCTGGCTTTGA

Upstream 100 bases:

>100_bases
AGGTTTGGTATTTTAAGAATAAATCTTTTGCCATAAACTATTGATAGTTTGACTAAATAATATGCTGTAAAGCTAAAAGA
GCGAGAATTGAGATAAAAGT

Downstream 100 bases:

>100_bases
CGCCCGACTACTAGGTTGCTAAAGATTCGCAAAGCTCATTGATCTAGTCAGCAGCTATGGATGCAGGCTACTTGTCTGCA
AGCACAAATCAGGATCCTAG

Product: hypothetical protein

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MVNSPSEKPLSSEKNRTAVVVGGGPTGTLIALYLAQAGWHVSVYEQRSADAKASSNRRSFNIVLNRRGLKALEDAGVQLP
PDKQVCITGNIRHTEKDSILRKGFRTSVSVDRHTLAQSLIAEGKNRFPDNIQYYFEQTLLQLNLHDKTALFQEASGQHEQ
TFDLLIGADGISSTVRYSMSSQLEGFTVRQHADDMMYKICNLGLAEHLPGATAEWADAFHVWPGAEPVTMAAPPSADGVI
RAVLILPQEGEITFDTIRTEADVSALFKAKLPVVFPNLDQTGFPSHFVQDLLSQKAAHGGFTTMCNRFEDGDCVVLLGDA
AHSIWPSLGQGCNVALESCRIFAEVLAHAQGDLSLALPAYTAARKPDTDAVARLSEIGFGGNKRASNPLFKAKVSTLILM
HKLLPKWFKGYALLQIGNADVPYANIWQQAQSQEKQLLGLFAIVVGIVPMLWITFQIIHKVWL

Sequences:

>Translated_463_residues
MVNSPSEKPLSSEKNRTAVVVGGGPTGTLIALYLAQAGWHVSVYEQRSADAKASSNRRSFNIVLNRRGLKALEDAGVQLP
PDKQVCITGNIRHTEKDSILRKGFRTSVSVDRHTLAQSLIAEGKNRFPDNIQYYFEQTLLQLNLHDKTALFQEASGQHEQ
TFDLLIGADGISSTVRYSMSSQLEGFTVRQHADDMMYKICNLGLAEHLPGATAEWADAFHVWPGAEPVTMAAPPSADGVI
RAVLILPQEGEITFDTIRTEADVSALFKAKLPVVFPNLDQTGFPSHFVQDLLSQKAAHGGFTTMCNRFEDGDCVVLLGDA
AHSIWPSLGQGCNVALESCRIFAEVLAHAQGDLSLALPAYTAARKPDTDAVARLSEIGFGGNKRASNPLFKAKVSTLILM
HKLLPKWFKGYALLQIGNADVPYANIWQQAQSQEKQLLGLFAIVVGIVPMLWITFQIIHKVWL
>Mature_463_residues
MVNSPSEKPLSSEKNRTAVVVGGGPTGTLIALYLAQAGWHVSVYEQRSADAKASSNRRSFNIVLNRRGLKALEDAGVQLP
PDKQVCITGNIRHTEKDSILRKGFRTSVSVDRHTLAQSLIAEGKNRFPDNIQYYFEQTLLQLNLHDKTALFQEASGQHEQ
TFDLLIGADGISSTVRYSMSSQLEGFTVRQHADDMMYKICNLGLAEHLPGATAEWADAFHVWPGAEPVTMAAPPSADGVI
RAVLILPQEGEITFDTIRTEADVSALFKAKLPVVFPNLDQTGFPSHFVQDLLSQKAAHGGFTTMCNRFEDGDCVVLLGDA
AHSIWPSLGQGCNVALESCRIFAEVLAHAQGDLSLALPAYTAARKPDTDAVARLSEIGFGGNKRASNPLFKAKVSTLILM
HKLLPKWFKGYALLQIGNADVPYANIWQQAQSQEKQLLGLFAIVVGIVPMLWITFQIIHKVWL

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily [H]

Homologues:

Organism=Homo sapiens, GI187960045, Length=408, Percent_Identity=26.9607843137255, Blast_Score=133, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17562934, Length=450, Percent_Identity=25.3333333333333, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319372, Length=461, Percent_Identity=22.9934924078091, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28573964, Length=452, Percent_Identity=26.3274336283186, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: =1.14.13.9 [H]

Molecular weight: Translated: 50688; Mature: 50688

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNSPSEKPLSSEKNRTAVVVGGGPTGTLIALYLAQAGWHVSVYEQRSADAKASSNRRSF
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEE
NIVLNRRGLKALEDAGVQLPPDKQVCITGNIRHTEKDSILRKGFRTSVSVDRHTLAQSLI
EEEEECCCCHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
AEGKNRFPDNIQYYFEQTLLQLNLHDKTALFQEASGQHEQTFDLLIGADGISSTVRYSMS
HCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHH
SQLEGFTVRQHADDMMYKICNLGLAEHLPGATAEWADAFHVWPGAEPVTMAAPPSADGVI
HCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCEEECCCCCCEEEECCCCCCCEE
RAVLILPQEGEITFDTIRTEADVSALFKAKLPVVFPNLDQTGFPSHFVQDLLSQKAAHGG
EEEEEECCCCCEEHHHHCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCC
FTTMCNRFEDGDCVVLLGDAAHSIWPSLGQGCNVALESCRIFAEVLAHAQGDLSLALPAY
HHHHHCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCH
TAARKPDTDAVARLSEIGFGGNKRASNPLFKAKVSTLILMHKLLPKWFKGYALLQIGNAD
HHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
VPYANIWQQAQSQEKQLLGLFAIVVGIVPMLWITFQIIHKVWL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVNSPSEKPLSSEKNRTAVVVGGGPTGTLIALYLAQAGWHVSVYEQRSADAKASSNRRSF
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEE
NIVLNRRGLKALEDAGVQLPPDKQVCITGNIRHTEKDSILRKGFRTSVSVDRHTLAQSLI
EEEEECCCCHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
AEGKNRFPDNIQYYFEQTLLQLNLHDKTALFQEASGQHEQTFDLLIGADGISSTVRYSMS
HCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHH
SQLEGFTVRQHADDMMYKICNLGLAEHLPGATAEWADAFHVWPGAEPVTMAAPPSADGVI
HCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCEEECCCCCCEEEECCCCCCCEE
RAVLILPQEGEITFDTIRTEADVSALFKAKLPVVFPNLDQTGFPSHFVQDLLSQKAAHGG
EEEEEECCCCCEEHHHHCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCC
FTTMCNRFEDGDCVVLLGDAAHSIWPSLGQGCNVALESCRIFAEVLAHAQGDLSLALPAY
HHHHHCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCH
TAARKPDTDAVARLSEIGFGGNKRASNPLFKAKVSTLILMHKLLPKWFKGYALLQIGNAD
HHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
VPYANIWQQAQSQEKQLLGLFAIVVGIVPMLWITFQIIHKVWL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA