Click here to switch to the map view.

The map label for this gene is ndhH

Identifier: 158336469

GI number: 158336469

Start: 3367123

End: 3368307

Strand: Direct

Name: ndhH

Synonym: AM1_3333

Alternate gene names: 158336469

Gene position: 3367123-3368307 (Clockwise)

Preceding gene: 158336468

Following gene: 158336470

Centisome position: 51.77

GC content: 49.87

Gene sequence:

>1185_bases
ATGCCAACCATTGAAACCCGCACCGAACCCATGGTCATTAACATGGGCCCTCAGCACCCTTCCATGCACGGGGTTCTGAG
ACTTATGGTGACCCTAGATGGTGAGAATGTCGTCGATTGCGAACCGGTGATTGGCTATTTGCACCGCGGCATGGAAAAAA
TTGCCGAGAGTCGCTCCAACATCATGTTCGTTCCCTATGTCAGCCGCTGGGATTATGCGGCAGGCATGTTTAACGAAGCC
ATCACGGTCAATGCGCCCGAACGCTTAGCCGATATCAAGGTGCCCAAACGTGCCAGCTACATCCGCGTGATTATGCTGGA
ATTGAATCGGATTGCCAATCACCTGCTTTGGCTGGGTCCCTTCCTCGCAGACGTGGGAGCCCAAACCCCCTTCTTTTACA
TTTTCCGGGAACGGGAAATGATTTACGACTTGTTTGAAGCCGTAAGTGGCATGCGCTTCATCAATAACAACTACTTCCGT
ATGGGCGGCGTTGCGGCTGACCTCACCTATGGTTGGGTCTCCAAATGCCTAGACTTTTGTGATTACTTTCTGCCCAAAGT
TGATGAGTATGAGCGTCTGATTACGAACAACCCCATTTTTATCCGACGTCTCGATGGTGTGGGTACCATTAGCCGCGAAG
ATGCGATTAATTGGGGTTTGTCTGGCCCGATGCTGCGAGGATCAGGTGTTAAGTGGGATCTTCGTCGGGTTGATCATTAC
GAATGCTATGACGACTTTGATTGGGAAGTCCAGTGGGAAACCAAAGGAGATTGTCTAGCCCGCTATTATCTGCGGATTCG
CGAAATGCGAGAATCCGTCAAAATTATTAAGCAAGCCCTAGAGCATCTACCCGGCGGCCCCTACGAAAACTTGGAAGCCA
AGCGGATGATGGAAGGCCGCAAATCAGAGTGGAACTCTTTTGAATATCAGTTCTTGGGTAAGAAGCTTGCCCCCACCTTC
AAAATTCCAGAGGGTGAACTCTATGCCAGAGTCGAAACGGGTAAAGGTGAACTTGGCATTTATCTGATTGGTGATGAGAA
TGTCTTCCCTTGGCGATGGAAGATTCGCGCCCCTGATTTCAACAATTTGCAGGTCTTGCCCCAGTTGCTCAAAGGCATGA
AGGTTGCTGATATTGTGGCGATTCTGGGTAGTATTGACGTGATTATGGGATCCGTCGATCGCTAA

Upstream 100 bases:

>100_bases
TTCTCCTAGACTGCCTCTAGTGAGTGATGTCGGTTACAAATCAGCAGGCTCCACCATTTTTGGGTTGTAGTCGTTTTCTC
AGAAGGAACCGTTACGCAAT

Downstream 100 bases:

>100_bases
GGACGGCTGCTTAACTTTCCATCGCAAGAGGCTTCTGGCTGAGTGGAGGGTGATCCGATGTCTAATGCATCTAAACTGAT
TCAAGAGATGCAGACGTATT

Product: NAD(P)H-quinone oxidoreductase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase subunit H; NADH-plastoquinone oxidoreductase subunit H; NDH-1 subunit H; NDH-H

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MPTIETRTEPMVINMGPQHPSMHGVLRLMVTLDGENVVDCEPVIGYLHRGMEKIAESRSNIMFVPYVSRWDYAAGMFNEA
ITVNAPERLADIKVPKRASYIRVIMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLFEAVSGMRFINNNYFR
MGGVAADLTYGWVSKCLDFCDYFLPKVDEYERLITNNPIFIRRLDGVGTISREDAINWGLSGPMLRGSGVKWDLRRVDHY
ECYDDFDWEVQWETKGDCLARYYLRIREMRESVKIIKQALEHLPGGPYENLEAKRMMEGRKSEWNSFEYQFLGKKLAPTF
KIPEGELYARVETGKGELGIYLIGDENVFPWRWKIRAPDFNNLQVLPQLLKGMKVADIVAILGSIDVIMGSVDR

Sequences:

>Translated_394_residues
MPTIETRTEPMVINMGPQHPSMHGVLRLMVTLDGENVVDCEPVIGYLHRGMEKIAESRSNIMFVPYVSRWDYAAGMFNEA
ITVNAPERLADIKVPKRASYIRVIMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLFEAVSGMRFINNNYFR
MGGVAADLTYGWVSKCLDFCDYFLPKVDEYERLITNNPIFIRRLDGVGTISREDAINWGLSGPMLRGSGVKWDLRRVDHY
ECYDDFDWEVQWETKGDCLARYYLRIREMRESVKIIKQALEHLPGGPYENLEAKRMMEGRKSEWNSFEYQFLGKKLAPTF
KIPEGELYARVETGKGELGIYLIGDENVFPWRWKIRAPDFNNLQVLPQLLKGMKVADIVAILGSIDVIMGSVDR
>Mature_393_residues
PTIETRTEPMVINMGPQHPSMHGVLRLMVTLDGENVVDCEPVIGYLHRGMEKIAESRSNIMFVPYVSRWDYAAGMFNEAI
TVNAPERLADIKVPKRASYIRVIMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLFEAVSGMRFINNNYFRM
GGVAADLTYGWVSKCLDFCDYFLPKVDEYERLITNNPIFIRRLDGVGTISREDAINWGLSGPMLRGSGVKWDLRRVDHYE
CYDDFDWEVQWETKGDCLARYYLRIREMRESVKIIKQALEHLPGGPYENLEAKRMMEGRKSEWNSFEYQFLGKKLAPTFK
IPEGELYARVETGKGELGIYLIGDENVFPWRWKIRAPDFNNLQVLPQLLKGMKVADIVAILGSIDVIMGSVDR

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=396, Percent_Identity=41.1616161616162, Blast_Score=305, Evalue=4e-83,
Organism=Homo sapiens, GI260898743, Length=390, Percent_Identity=40.5128205128205, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI145693162, Length=388, Percent_Identity=38.659793814433, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI1789076, Length=386, Percent_Identity=29.2746113989637, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788832, Length=405, Percent_Identity=28.3950617283951, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17555284, Length=393, Percent_Identity=41.4758269720102, Blast_Score=311, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17568379, Length=393, Percent_Identity=41.7302798982188, Blast_Score=311, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=42.0918367346939, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI221459469, Length=401, Percent_Identity=39.9002493765586, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDHH_ACAM1 (B0BZ27)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001517643.1
- ProteinModelPortal:   B0BZ27
- SMR:   B0BZ27
- GeneID:   5682141
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_3333
- HOGENOM:   HBG459705
- OMA:   FGPFLAD
- ProtClustDB:   PRK07415
- BioCyc:   AMAR329726:AM1_3333-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885

Pfam domain/function: PF00346 Complex1_49kDa

EC number: 1.6.5.3

Molecular weight: Translated: 45572; Mature: 45441

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIETRTEPMVINMGPQHPSMHGVLRLMVTLDGENVVDCEPVIGYLHRGMEKIAESRSN
CCCCCCCCCCEEEEECCCCCCHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
IMFVPYVSRWDYAAGMFNEAITVNAPERLADIKVPKRASYIRVIMLELNRIANHLLWLGP
EEEEEECCCCCHHHHHHCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYIFREREMIYDLFEAVSGMRFINNNYFRMGGVAADLTYGWVSKCLDFC
HHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCHHCCCEEEECCEEEHHHHHHHHHHHHHH
DYFLPKVDEYERLITNNPIFIRRLDGVGTISREDAINWGLSGPMLRGSGVKWDLRRVDHY
HHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHCCCCCCCCCEECCCCCEEEHHCCCCC
ECYDDFDWEVQWETKGDCLARYYLRIREMRESVKIIKQALEHLPGGPYENLEAKRMMEGR
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCC
KSEWNSFEYQFLGKKLAPTFKIPEGELYARVETGKGELGIYLIGDENVFPWRWKIRAPDF
CCCCCCCHHHHHHHHCCCCEECCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCC
NNLQVLPQLLKGMKVADIVAILGSIDVIMGSVDR
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PTIETRTEPMVINMGPQHPSMHGVLRLMVTLDGENVVDCEPVIGYLHRGMEKIAESRSN
CCCCCCCCCEEEEECCCCCCHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
IMFVPYVSRWDYAAGMFNEAITVNAPERLADIKVPKRASYIRVIMLELNRIANHLLWLGP
EEEEEECCCCCHHHHHHCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYIFREREMIYDLFEAVSGMRFINNNYFRMGGVAADLTYGWVSKCLDFC
HHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCHHCCCEEEECCEEEHHHHHHHHHHHHHH
DYFLPKVDEYERLITNNPIFIRRLDGVGTISREDAINWGLSGPMLRGSGVKWDLRRVDHY
HHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHCCCCCCCCCEECCCCCEEEHHCCCCC
ECYDDFDWEVQWETKGDCLARYYLRIREMRESVKIIKQALEHLPGGPYENLEAKRMMEGR
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCC
KSEWNSFEYQFLGKKLAPTFKIPEGELYARVETGKGELGIYLIGDENVFPWRWKIRAPDF
CCCCCCCHHHHHHHHCCCCEECCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCC
NNLQVLPQLLKGMKVADIVAILGSIDVIMGSVDR
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA