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The map label for this gene is mltA [H]

Identifier: 158336463

GI number: 158336463

Start: 3359651

End: 3360829

Strand: Reverse

Name: mltA [H]

Synonym: AM1_3327

Alternate gene names: 158336463

Gene position: 3360829-3359651 (Counterclockwise)

Preceding gene: 158336464

Following gene: 158336456

Centisome position: 51.68

GC content: 50.64

Gene sequence:

>1179_bases
ATGTTTTTTCTGACTCTGCCTTTGCTTTTGGGGTGTACCGCTGCCACCACGCCGCTCACGGCGGCAACACCCCCGGTGGA
CCCTCTACCCTTAAAGGTCGTCTCTACAGATCAACTGCCCAAGGGTCTAGCAAAGGACCAACAGTTATGGAACAAAGTAA
ATGGTCAGAAAGGTGACTATAAAGCGTTACTGACGGCCATTGATCATAGCTTGGAGTATTTAGGAACTGACAAAGCTCAG
AAGGATTATCAAGACTACAAAGTTCCAGGGATTACCCGCGATCGCGTTTCCCGTAGCCTTCGTCGGTTTCGTCAGCTAGT
GGTGCAGGCGAAGTCTCCACAGGCGCTGGAAACAGCAGTCAAAAAGGAGTTTCAGTTTTACCAATCCATCGGTAATGACC
AAAAGGGTAATGTCGATTTTACGGGATATTATGAGGCGACCTATCCCGCGAGCCGCCAACCCACCACCGAGTTTCGCTAT
CCCCTATATCAGGCTCCAGCAGATTTAAAGGCATGGCCCAAGCCCCATCCCACCCGCGCCGAGTTAGAGGGGGCCGATGG
TTTGCAAGCCTCTCAAGGTCCGTTAAAGGGATTGGAGTTGGTATGGCTACGCGATCGCATCCAGGCATTCCTCGTGCAAG
TCCAAGGATCCGCCCGCCTCGGATTAACAGATGGAACAGAAATGACTGTCGGTTATGCTGGAAAAACCGCTCATCCCTAC
ACCAGTATCGGTAAAGCTTTAATTGCCGATGGCAAATTCACTCTAGAGGAATTGAGTCTTCCCGTCGTCCTCCAGTACTT
CGAAGAGAATCCTCAAGATTTAGATCTCTATATCCCCAAAAACAAAAGCTTTGTTTTCTTCCAGGAAACCTTTGGCTCAC
CTCCCATGGGCAATCTCAATGTCCCCGTCACCGATGAGCGGTCCATTGCTACGGATAAATCGCTGATGCCCCCTGGCGCG
CTAGCGCTGATTCAAACCAACTTGCCCTACTACAATGCCAGCCAGACGTTGGAATTCAAAGATGTCAGCCGATTTGTGCT
GGATCACGATACAGGCAGCGCCATCAAGGGTCCAGGCCGGGTAGATATTTTTATGGGCACTGGGGCAAAAGCAAAAGAAC
GGGCAGGAGTCATGACGGGATCCGGGCAGCTCTATTATTTACTACTCAAAGACAACTGA

Upstream 100 bases:

>100_bases
GAGTATATGGTGATCCGGCCATCTAGTATTACGGCCATTCGTGTGGAACCTGTTTTCTTATCTAGCGTCGACCGTTATTA
AGTTCTGATGGTTTGACTGC

Downstream 100 bases:

>100_bases
TACCATTAGCCCCAGGACATAGGGGTTGGCATTGTCAACCAAGTGAAGGCCACTGCCAATCCCAACCACAGCAAAAAACA
ATTGCGGGTCAGGCGAATCG

Product: membrane-bound lytic transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MFFLTLPLLLGCTAATTPLTAATPPVDPLPLKVVSTDQLPKGLAKDQQLWNKVNGQKGDYKALLTAIDHSLEYLGTDKAQ
KDYQDYKVPGITRDRVSRSLRRFRQLVVQAKSPQALETAVKKEFQFYQSIGNDQKGNVDFTGYYEATYPASRQPTTEFRY
PLYQAPADLKAWPKPHPTRAELEGADGLQASQGPLKGLELVWLRDRIQAFLVQVQGSARLGLTDGTEMTVGYAGKTAHPY
TSIGKALIADGKFTLEELSLPVVLQYFEENPQDLDLYIPKNKSFVFFQETFGSPPMGNLNVPVTDERSIATDKSLMPPGA
LALIQTNLPYYNASQTLEFKDVSRFVLDHDTGSAIKGPGRVDIFMGTGAKAKERAGVMTGSGQLYYLLLKDN

Sequences:

>Translated_392_residues
MFFLTLPLLLGCTAATTPLTAATPPVDPLPLKVVSTDQLPKGLAKDQQLWNKVNGQKGDYKALLTAIDHSLEYLGTDKAQ
KDYQDYKVPGITRDRVSRSLRRFRQLVVQAKSPQALETAVKKEFQFYQSIGNDQKGNVDFTGYYEATYPASRQPTTEFRY
PLYQAPADLKAWPKPHPTRAELEGADGLQASQGPLKGLELVWLRDRIQAFLVQVQGSARLGLTDGTEMTVGYAGKTAHPY
TSIGKALIADGKFTLEELSLPVVLQYFEENPQDLDLYIPKNKSFVFFQETFGSPPMGNLNVPVTDERSIATDKSLMPPGA
LALIQTNLPYYNASQTLEFKDVSRFVLDHDTGSAIKGPGRVDIFMGTGAKAKERAGVMTGSGQLYYLLLKDN
>Mature_392_residues
MFFLTLPLLLGCTAATTPLTAATPPVDPLPLKVVSTDQLPKGLAKDQQLWNKVNGQKGDYKALLTAIDHSLEYLGTDKAQ
KDYQDYKVPGITRDRVSRSLRRFRQLVVQAKSPQALETAVKKEFQFYQSIGNDQKGNVDFTGYYEATYPASRQPTTEFRY
PLYQAPADLKAWPKPHPTRAELEGADGLQASQGPLKGLELVWLRDRIQAFLVQVQGSARLGLTDGTEMTVGYAGKTAHPY
TSIGKALIADGKFTLEELSLPVVLQYFEENPQDLDLYIPKNKSFVFFQETFGSPPMGNLNVPVTDERSIATDKSLMPPGA
LALIQTNLPYYNASQTLEFKDVSRFVLDHDTGSAIKGPGRVDIFMGTGAKAKERAGVMTGSGQLYYLLLKDN

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Note=In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=265, Percent_Identity=32.8301886792453, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 43310; Mature: 43310

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFLTLPLLLGCTAATTPLTAATPPVDPLPLKVVSTDQLPKGLAKDQQLWNKVNGQKGDY
CEEEEEHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHH
KALLTAIDHSLEYLGTDKAQKDYQDYKVPGITRDRVSRSLRRFRQLVVQAKSPQALETAV
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KKEFQFYQSIGNDQKGNVDFTGYYEATYPASRQPTTEFRYPLYQAPADLKAWPKPHPTRA
HHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCHHHCCCHHCCCCCCCCCCCCCCCCC
ELEGADGLQASQGPLKGLELVWLRDRIQAFLVQVQGSARLGLTDGTEMTVGYAGKTAHPY
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHEEEEECCCCEECCCCCCEEEEEECCCCCCCH
TSIGKALIADGKFTLEELSLPVVLQYFEENPQDLDLYIPKNKSFVFFQETFGSPPMGNLN
HHHCHHHCCCCCEEHHHCCHHHHHHHHHCCCCCEEEEEECCCCEEEEEHHCCCCCCCCCC
VPVTDERSIATDKSLMPPGALALIQTNLPYYNASQTLEFKDVSRFVLDHDTGSAIKGPGR
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEHHHHHHHEEECCCCCCCCCCCE
VDIFMGTGAKAKERAGVMTGSGQLYYLLLKDN
EEEEECCCCCHHHHCCEEECCCCEEEEEEECC
>Mature Secondary Structure
MFFLTLPLLLGCTAATTPLTAATPPVDPLPLKVVSTDQLPKGLAKDQQLWNKVNGQKGDY
CEEEEEHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHH
KALLTAIDHSLEYLGTDKAQKDYQDYKVPGITRDRVSRSLRRFRQLVVQAKSPQALETAV
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KKEFQFYQSIGNDQKGNVDFTGYYEATYPASRQPTTEFRYPLYQAPADLKAWPKPHPTRA
HHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCHHHCCCHHCCCCCCCCCCCCCCCCC
ELEGADGLQASQGPLKGLELVWLRDRIQAFLVQVQGSARLGLTDGTEMTVGYAGKTAHPY
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHEEEEECCCCEECCCCCCEEEEEECCCCCCCH
TSIGKALIADGKFTLEELSLPVVLQYFEENPQDLDLYIPKNKSFVFFQETFGSPPMGNLN
HHHCHHHCCCCCEEHHHCCHHHHHHHHHCCCCCEEEEEECCCCEEEEEHHCCCCCCCCCC
VPVTDERSIATDKSLMPPGALALIQTNLPYYNASQTLEFKDVSRFVLDHDTGSAIKGPGR
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEHHHHHHHEEECCCCCCCCCCCE
VDIFMGTGAKAKERAGVMTGSGQLYYLLLKDN
EEEEECCCCCHHHHCCEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]