Click here to switch to the map view.

The map label for this gene is napA [H]

Identifier: 158336335

GI number: 158336335

Start: 3237133

End: 3238536

Strand: Direct

Name: napA [H]

Synonym: AM1_3197

Alternate gene names: 158336335

Gene position: 3237133-3238536 (Clockwise)

Preceding gene: 158336334

Following gene: 158336336

Centisome position: 49.77

GC content: 49.36

Gene sequence:

>1404_bases
ATGTGGGATATGAATACATTCATCGATACTTTATCAATGTCACCGCTTCTCCAAGGCGGCATTTCTCAGCCTTGGTTAAT
CGCTGCAGCTAATGCAGATGAAGCGCCCCTCATCCTCTCAGGGGTACTCCTCAGCCTAGTGGTCATTTATCTCGCTAGTA
AGCTTGGCGGTGAGTTATCACAGCTCTTAAACTTACCGCCTGTATTAGGAGAACTAGTCGGAGGGGTGGCGATTGGAGCC
TCAGCCCTGCACCTGCTGGTCTTTGCAGAAGGTGGAACGGTTGCCGCTGATTCCGCCTTAATGCCAATTCTGCAGTTTAT
TGGCGGCAATCTCAGCGCCGAATCCATCACCTCGATTTTTGAAAGCCAGAGCGAAATCATTGAGATTTTGTCCGAGCTGG
GGGTGATTATTCTACTATTTGAAATTGGCTTAGAGTCGGATCTCAGAGAACTAACGGAGGTGGGCTATCAGGCAGTGTTA
GTGGCGGTAGTCGGTGTAGTAGCGCCCTTTGCGGCGGGGACTGCCGGATTGGTGCTGTTGTTCCATATGCCCACGATTCC
ATCGATTTTTGCCGGAGCTGCATTGACGGCAACCAGTATTGGTATTACCTCCAAGGTTCTGTCTGAATTGGGCTTCCTTA
AATCCAAAGAAGGGCAAATTATTGTTGGTGCAGCCATTATTGATGACGTGTTAGGCATTATCGTTTTGGCAGTGGTGGCC
AGCTTGGCTAAAACTGGCGAAGTGGATATCGTTAATGTTCTGTATTTGATTGGTAGCGCCTCAGCATTTTTGGTGGGCTC
TATTCTGCTAGGTCGATTTTTCAATCAAGCCTTTGTGACCATTGCCGACCAACTGAAAACTCGCGGCAAACTAGTGATTC
CTGCTTTGAGTTTTGCTTTTATCATGGCTTTTCTGGCCAATGCGATTCACTTAGAAGCGATTCTGGGGGCCTTTGCTGCT
GGTTTGGTGCTCGATGAAACGGATAAGCGCAAAGAACTGGATAAACAGGTGGTTCCCATTGCCGATATTCTCGTGCCGAT
TTTCTTTGTGACCGTAGGGGCAAAAGCAGACTTGAGCGTCCTCAATCCAGCAGTGCCTGAAAACCGAGAAGGATTAGTGA
TTGCCGCTTTTCTGATTGTGGTCGCCATGATTGGCAAGCTGATGACGGGTTGGACGGTTGTCGGTCAGCCTGGCATTAAT
CGCTTTGCGATTGGCGTTGGCATGATTCCTCGAGGGGAGGTCGGCCTAGTCTTTGCCGGGATTGGTTCAGCCAGTGGTGT
GTTGGATAAACCTTTGGAAGCAGCGATTATTACGATGGTGATTTTGACCACCTTTGTGGCGCCGCCATTGTTACGGGTGG
CGTTTAAAGGCGGTGCGATCGCAATTGAGTCTCCAGCGAACTAG

Upstream 100 bases:

>100_bases
CTGGATCACTATGCGACCTCTGGTTGAAGATAGCTCACCCTCGATCTCTAGATGCTTGATCAAGGATGTTTTTCTGATTT
GACAGATTATTGTTCACTCA

Downstream 100 bases:

>100_bases
CACCTTTCGAGAACTGCGATGCTGGGGTGATATCGCAGTTCCCTCACCCACTTCTCTCACCCCCTTTTTTTAATTAACCC
TTTTTAAAATCACCATGTTA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MWDMNTFIDTLSMSPLLQGGISQPWLIAAANADEAPLILSGVLLSLVVIYLASKLGGELSQLLNLPPVLGELVGGVAIGA
SALHLLVFAEGGTVAADSALMPILQFIGGNLSAESITSIFESQSEIIEILSELGVIILLFEIGLESDLRELTEVGYQAVL
VAVVGVVAPFAAGTAGLVLLFHMPTIPSIFAGAALTATSIGITSKVLSELGFLKSKEGQIIVGAAIIDDVLGIIVLAVVA
SLAKTGEVDIVNVLYLIGSASAFLVGSILLGRFFNQAFVTIADQLKTRGKLVIPALSFAFIMAFLANAIHLEAILGAFAA
GLVLDETDKRKELDKQVVPIADILVPIFFVTVGAKADLSVLNPAVPENREGLVIAAFLIVVAMIGKLMTGWTVVGQPGIN
RFAIGVGMIPRGEVGLVFAGIGSASGVLDKPLEAAIITMVILTTFVAPPLLRVAFKGGAIAIESPAN

Sequences:

>Translated_467_residues
MWDMNTFIDTLSMSPLLQGGISQPWLIAAANADEAPLILSGVLLSLVVIYLASKLGGELSQLLNLPPVLGELVGGVAIGA
SALHLLVFAEGGTVAADSALMPILQFIGGNLSAESITSIFESQSEIIEILSELGVIILLFEIGLESDLRELTEVGYQAVL
VAVVGVVAPFAAGTAGLVLLFHMPTIPSIFAGAALTATSIGITSKVLSELGFLKSKEGQIIVGAAIIDDVLGIIVLAVVA
SLAKTGEVDIVNVLYLIGSASAFLVGSILLGRFFNQAFVTIADQLKTRGKLVIPALSFAFIMAFLANAIHLEAILGAFAA
GLVLDETDKRKELDKQVVPIADILVPIFFVTVGAKADLSVLNPAVPENREGLVIAAFLIVVAMIGKLMTGWTVVGQPGIN
RFAIGVGMIPRGEVGLVFAGIGSASGVLDKPLEAAIITMVILTTFVAPPLLRVAFKGGAIAIESPAN
>Mature_467_residues
MWDMNTFIDTLSMSPLLQGGISQPWLIAAANADEAPLILSGVLLSLVVIYLASKLGGELSQLLNLPPVLGELVGGVAIGA
SALHLLVFAEGGTVAADSALMPILQFIGGNLSAESITSIFESQSEIIEILSELGVIILLFEIGLESDLRELTEVGYQAVL
VAVVGVVAPFAAGTAGLVLLFHMPTIPSIFAGAALTATSIGITSKVLSELGFLKSKEGQIIVGAAIIDDVLGIIVLAVVA
SLAKTGEVDIVNVLYLIGSASAFLVGSILLGRFFNQAFVTIADQLKTRGKLVIPALSFAFIMAFLANAIHLEAILGAFAA
GLVLDETDKRKELDKQVVPIADILVPIFFVTVGAKADLSVLNPAVPENREGLVIAAFLIVVAMIGKLMTGWTVVGQPGIN
RFAIGVGMIPRGEVGLVFAGIGSASGVLDKPLEAAIITMVILTTFVAPPLLRVAFKGGAIAIESPAN

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=375, Percent_Identity=25.0666666666667, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322367, Length=350, Percent_Identity=26.2857142857143, Blast_Score=98, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 48292; Mature: 48292

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWDMNTFIDTLSMSPLLQGGISQPWLIAAANADEAPLILSGVLLSLVVIYLASKLGGELS
CCCHHHHHHHHHCCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCHHHH
QLLNLPPVLGELVGGVAIGASALHLLVFAEGGTVAADSALMPILQFIGGNLSAESITSIF
HHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
ESQSEIIEILSELGVIILLFEIGLESDLRELTEVGYQAVLVAVVGVVAPFAAGTAGLVLL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FHMPTIPSIFAGAALTATSIGITSKVLSELGFLKSKEGQIIVGAAIIDDVLGIIVLAVVA
HHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
SLAKTGEVDIVNVLYLIGSASAFLVGSILLGRFFNQAFVTIADQLKTRGKLVIPALSFAF
HHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
IMAFLANAIHLEAILGAFAAGLVLDETDKRKELDKQVVPIADILVPIFFVTVGAKADLSV
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
LNPAVPENREGLVIAAFLIVVAMIGKLMTGWTVVGQPGINRFAIGVGMIPRGEVGLVFAG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCCCCCCEEEEE
IGSASGVLDKPLEAAIITMVILTTFVAPPLLRVAFKGGAIAIESPAN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
>Mature Secondary Structure
MWDMNTFIDTLSMSPLLQGGISQPWLIAAANADEAPLILSGVLLSLVVIYLASKLGGELS
CCCHHHHHHHHHCCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCHHHH
QLLNLPPVLGELVGGVAIGASALHLLVFAEGGTVAADSALMPILQFIGGNLSAESITSIF
HHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
ESQSEIIEILSELGVIILLFEIGLESDLRELTEVGYQAVLVAVVGVVAPFAAGTAGLVLL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FHMPTIPSIFAGAALTATSIGITSKVLSELGFLKSKEGQIIVGAAIIDDVLGIIVLAVVA
HHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
SLAKTGEVDIVNVLYLIGSASAFLVGSILLGRFFNQAFVTIADQLKTRGKLVIPALSFAF
HHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
IMAFLANAIHLEAILGAFAAGLVLDETDKRKELDKQVVPIADILVPIFFVTVGAKADLSV
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
LNPAVPENREGLVIAAFLIVVAMIGKLMTGWTVVGQPGINRFAIGVGMIPRGEVGLVFAG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCCCCCCEEEEE
IGSASGVLDKPLEAAIITMVILTTFVAPPLLRVAFKGGAIAIESPAN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]