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The map label for this gene is aacC [H]

Identifier: 158336267

GI number: 158336267

Start: 3159406

End: 3160155

Strand: Direct

Name: aacC [H]

Synonym: AM1_3129

Alternate gene names: 158336267

Gene position: 3159406-3160155 (Clockwise)

Preceding gene: 158336266

Following gene: 158336271

Centisome position: 48.58

GC content: 49.07

Gene sequence:

>750_bases
TTGTACATATCATCTGAGCAACTAAAACAAGATCTGATAAATGTCGGTGTCTGTGCTGGCGATACGCTTATGGTCCATGC
TTCACTTCGCGCCCTTGGACCCATCGACGGCAGAGCTGAAGCATTGGTAAGGACTGTGCTTTCAGTCTTGGGAAATCAAG
GGACACTCGTCGCTTATGTCGATTTTGAACCGACGCCCGATATTCCTTACTTCGATCCGCAAAGGTCGCCAGCTAGTCAA
GAATTTGGTGTCTTAGTTGAAGTGGTTCGGACTTGGCCGGGAGCGGTTCGTTCTCTTAATCCTGGTGCCTCCATGGTGGC
GATTGGCGCTCAGGCTGAGTGGCTATGTCACGGTCATCCTCTGAACTATGGCTATGGTCCTGGTTCTCCCTTATCTAAGC
TGGTGGAAATTGGTGGAAAAATTCTATTGCTGGGCTCGGATTTGAACAATGTGACGATTCTCCATTACGCCGAACATTGT
GCTCGGTTGCCCAATAAGCGCGTGATTCAGCGGACCGATCGAATGCTTGTCGATGAGACTGTTGTGGATGTTGGCATCGA
AGAATTCGATACGAGTGCATTGGTGATTGATGCAATGCCGACGGATTACTTTGCGCAGATTACCCAGGAATTTGTAGACG
CTAGATATGCTCACACGGGCAGGGTAGGCAATGCACCCTCAATTCTTCTTCCAGCGCCAGAATTTGTATCCTTTGCGATC
GCAAAAATGGAACGAGAATTTGGTGGGTGA

Upstream 100 bases:

>100_bases
CGACCTGCATTAAGGTTGAACGGATAGACCACAAGTTTAATACTCAAGACTGTAAGGCTTGTGATGGCAGAAGTGTGATC
CAAGACGGACAAGGTAATAG

Downstream 100 bases:

>100_bases
GTGGTTCAATCAGTACTGGTCATTCTTCAACCCTTTGTAGGGATAAATTTTTAGAACAATACGATTTCGTTAAAAAGTAG
TCGCTGGATAGGCCAACCCC

Product: aminoglycoside 3-N-acetyltransferase

Products: NA

Alternate protein names: ACC(3)-III; Aminocyclitol 3-N-acetyltransferase type III; Gentamicin-(3)-N-acetyl-transferase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MYISSEQLKQDLINVGVCAGDTLMVHASLRALGPIDGRAEALVRTVLSVLGNQGTLVAYVDFEPTPDIPYFDPQRSPASQ
EFGVLVEVVRTWPGAVRSLNPGASMVAIGAQAEWLCHGHPLNYGYGPGSPLSKLVEIGGKILLLGSDLNNVTILHYAEHC
ARLPNKRVIQRTDRMLVDETVVDVGIEEFDTSALVIDAMPTDYFAQITQEFVDARYAHTGRVGNAPSILLPAPEFVSFAI
AKMEREFGG

Sequences:

>Translated_249_residues
MYISSEQLKQDLINVGVCAGDTLMVHASLRALGPIDGRAEALVRTVLSVLGNQGTLVAYVDFEPTPDIPYFDPQRSPASQ
EFGVLVEVVRTWPGAVRSLNPGASMVAIGAQAEWLCHGHPLNYGYGPGSPLSKLVEIGGKILLLGSDLNNVTILHYAEHC
ARLPNKRVIQRTDRMLVDETVVDVGIEEFDTSALVIDAMPTDYFAQITQEFVDARYAHTGRVGNAPSILLPAPEFVSFAI
AKMEREFGG
>Mature_249_residues
MYISSEQLKQDLINVGVCAGDTLMVHASLRALGPIDGRAEALVRTVLSVLGNQGTLVAYVDFEPTPDIPYFDPQRSPASQ
EFGVLVEVVRTWPGAVRSLNPGASMVAIGAQAEWLCHGHPLNYGYGPGSPLSKLVEIGGKILLLGSDLNNVTILHYAEHC
ARLPNKRVIQRTDRMLVDETVVDVGIEEFDTSALVIDAMPTDYFAQITQEFVDARYAHTGRVGNAPSILLPAPEFVSFAI
AKMEREFGG

Specific function: Resistance to antibiotics containing the 2-deoxy- streptamine ring including dibekacin, gentamicin, kanamycin, sisomicin, tobramycin, neomycin and to a lesser extent netilmicin [H]

COG id: COG2746

COG function: function code V; Aminoglycoside N3'-acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the antibiotic N-acetyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003679 [H]

Pfam domain/function: PF02522 Antibiotic_NAT [H]

EC number: =2.3.1.81 [H]

Molecular weight: Translated: 26993; Mature: 26993

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYISSEQLKQDLINVGVCAGDTLMVHASLRALGPIDGRAEALVRTVLSVLGNQGTLVAYV
CCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEE
DFEPTPDIPYFDPQRSPASQEFGVLVEVVRTWPGAVRSLNPGASMVAIGAQAEWLCHGHP
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEEECCCCEEEECCCC
LNYGYGPGSPLSKLVEIGGKILLLGSDLNNVTILHYAEHCARLPNKRVIQRTDRMLVDET
CCCCCCCCCHHHHHHHCCCEEEEEECCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHH
VVDVGIEEFDTSALVIDAMPTDYFAQITQEFVDARYAHTGRVGNAPSILLPAPEFVSFAI
HHHCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHH
AKMEREFGG
HHHHHHHCC
>Mature Secondary Structure
MYISSEQLKQDLINVGVCAGDTLMVHASLRALGPIDGRAEALVRTVLSVLGNQGTLVAYV
CCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEE
DFEPTPDIPYFDPQRSPASQEFGVLVEVVRTWPGAVRSLNPGASMVAIGAQAEWLCHGHP
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEEECCCCEEEECCCC
LNYGYGPGSPLSKLVEIGGKILLLGSDLNNVTILHYAEHCARLPNKRVIQRTDRMLVDET
CCCCCCCCCHHHHHHHCCCEEEEEECCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHH
VVDVGIEEFDTSALVIDAMPTDYFAQITQEFVDARYAHTGRVGNAPSILLPAPEFVSFAI
HHHCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHH
AKMEREFGG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1649572 [H]