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The map label for this gene is pyrG

Identifier: 158336054

GI number: 158336054

Start: 2947741

End: 2949408

Strand: Direct

Name: pyrG

Synonym: AM1_2914

Alternate gene names: 158336054

Gene position: 2947741-2949408 (Clockwise)

Preceding gene: 158336053

Following gene: 158336057

Centisome position: 45.32

GC content: 49.34

Gene sequence:

>1668_bases
ATGACTAAATTTGTATTTGTAACGGGCGGTGTGGTTTCCAGTATTGGTAAGGGAATTGTCGCTGCGAGCTTGGGCCGCCT
ACTGAAATCCCGTAATTACTCCGTCTCCATTTTGAAGCTTGACCCTTACATCAATGTAGATCCAGGGACCATGAGCCCGT
TCCAGCATGGAGAAGTTTTCGTTACTGATGATGGTGCTGAAACAGATTTGGACTTAGGTCACTATGAGCGCTTTACCGAT
ACAGCCATGTCTCGCCTCAATAGTGTGACGACTGGTTCGATTTACCAATCTGTCTTAAACAAAGAGCGGCGGGGTGACTA
TGAAGGGGGCACGGTGCAAGTGATCCCGCATATCACCAACGAGATTAAAGACCGCATTAAGCGAGTCGCTAAACAAGCAA
CCCCTGACGTCTTAATTATCGAGATTGGCGGCACCGTTGGTGATATTGAGTCATTGCCCTTCTTAGAAGCCATTCGTCAA
TTCCGCAAAGATGTGGGTCGAGACAATATTCTCTATACCCACGTCACCCTAATGCCCTGGATTCCGGCTGCAGGGGAAAT
GAAAACCAAACCCACCCAGCACTCCGTTAAAGAACTCCGCTCGATCGGTATTCAGCCCGATATTTTGGTTTGTCGCTGCG
ATCGCCCCCTCTCTGAAGGCATTAAAGAGAAAGTCTCAGAATTTTGTGATGTTCCCGTCGAGGCGGTGATCACCTCTCAA
GATGCTAGCAGTATTTACGCGGTTCCCCTGATTCTGGAACAGGAAGGGTTAGCCCAGCAGGTTCTCAAGTTTATGCATCT
GGAACAGCGGCGACCTGATCTAACGCAATGGCAAGCTCTAGTTCATCAGCTTGATCATCCCTCACAGACCATTGAAATTG
CTTTGGTTGGTAAGTATGTACAGCTCAGTGACGCCTATTTATCCGTCGTAGAGTCTCTGCAACATGCTGCCGTTGCGCAA
GGGATTGCCGTTCAGATTCGCTGGGTCAACTCAGAAGAAATCGAAGCCCATGGCCCAGATCGATATTTAGCAGACGCGGC
GGGCATTATTGTTCCCGGTGGTTTTGGTATTCGAGGCGTCGATGGCAAAATCGCAGCCATTCAATATGCGCGCGATAATC
AAGTTCCCTTTTTAGGGCTTTGTTTAGGCATGCAATGTGCCGTTATTGAATGGGCTCGCCATATTGCTGGGTTAGAAGAT
GCCAATAGTGCTGAGTTTAATCCCGAAACCCGGAATCCCGTCATTAACTTGTTACCTGAACAGCAGGATGTCGTAGACCT
CGGAGGCACGATGCGGCTGGGACTATATCCCTGCCGTCTATTACCCGATACCCTGGCATCTCGCCTGTATCCCCAGGAGA
CCATTGTGTATGAGCGTCATCGCCATCGCTATGAATTTAACAACGCCTTTCGACCCCTATTTTTAGAGTCTGGCTATGTG
GTGAGTGGCACCTCGCCCGATGGTCGCCTGGTTGAGATGATTGAGCTTCCTTCTCATCCTTTCTTTATTGCCACTCAATT
CCATCCTGAGTTTAGGTCTCGCCCCAATGACCCCCATCCTCTTTTTGCCGGATTAGTGGGTGCCTGTCTAGCAGACAACG
GCAACAATGCGAATCATCATGACAGTACACCTGCAGAACCCTTAGTATCCGAACCGCTGTCGAGCTAA

Upstream 100 bases:

>100_bases
GAGATGAAGTCATCCTTCAAGGTCTTGTAGAAGCTTAACAATCCTCTCTAGAAAGCTATGGCAAAATGGGTCGAATGGAC
GAAAAAGAGTAAAGCTGCTC

Downstream 100 bases:

>100_bases
TTGAGCCGCTCCAATCATCCCTGCCTGGTTGCCCAAAGCAGCAGGCAGAATCACTAAATTTTCCCGAGACGTTGGCATCA
CCCGACGCTCGATTTCTGCT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYSVSILKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFTD
TAMSRLNSVTTGSIYQSVLNKERRGDYEGGTVQVIPHITNEIKDRIKRVAKQATPDVLIIEIGGTVGDIESLPFLEAIRQ
FRKDVGRDNILYTHVTLMPWIPAAGEMKTKPTQHSVKELRSIGIQPDILVCRCDRPLSEGIKEKVSEFCDVPVEAVITSQ
DASSIYAVPLILEQEGLAQQVLKFMHLEQRRPDLTQWQALVHQLDHPSQTIEIALVGKYVQLSDAYLSVVESLQHAAVAQ
GIAVQIRWVNSEEIEAHGPDRYLADAAGIIVPGGFGIRGVDGKIAAIQYARDNQVPFLGLCLGMQCAVIEWARHIAGLED
ANSAEFNPETRNPVINLLPEQQDVVDLGGTMRLGLYPCRLLPDTLASRLYPQETIVYERHRHRYEFNNAFRPLFLESGYV
VSGTSPDGRLVEMIELPSHPFFIATQFHPEFRSRPNDPHPLFAGLVGACLADNGNNANHHDSTPAEPLVSEPLSS

Sequences:

>Translated_555_residues
MTKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYSVSILKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFTD
TAMSRLNSVTTGSIYQSVLNKERRGDYEGGTVQVIPHITNEIKDRIKRVAKQATPDVLIIEIGGTVGDIESLPFLEAIRQ
FRKDVGRDNILYTHVTLMPWIPAAGEMKTKPTQHSVKELRSIGIQPDILVCRCDRPLSEGIKEKVSEFCDVPVEAVITSQ
DASSIYAVPLILEQEGLAQQVLKFMHLEQRRPDLTQWQALVHQLDHPSQTIEIALVGKYVQLSDAYLSVVESLQHAAVAQ
GIAVQIRWVNSEEIEAHGPDRYLADAAGIIVPGGFGIRGVDGKIAAIQYARDNQVPFLGLCLGMQCAVIEWARHIAGLED
ANSAEFNPETRNPVINLLPEQQDVVDLGGTMRLGLYPCRLLPDTLASRLYPQETIVYERHRHRYEFNNAFRPLFLESGYV
VSGTSPDGRLVEMIELPSHPFFIATQFHPEFRSRPNDPHPLFAGLVGACLADNGNNANHHDSTPAEPLVSEPLSS
>Mature_554_residues
TKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYSVSILKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFTDT
AMSRLNSVTTGSIYQSVLNKERRGDYEGGTVQVIPHITNEIKDRIKRVAKQATPDVLIIEIGGTVGDIESLPFLEAIRQF
RKDVGRDNILYTHVTLMPWIPAAGEMKTKPTQHSVKELRSIGIQPDILVCRCDRPLSEGIKEKVSEFCDVPVEAVITSQD
ASSIYAVPLILEQEGLAQQVLKFMHLEQRRPDLTQWQALVHQLDHPSQTIEIALVGKYVQLSDAYLSVVESLQHAAVAQG
IAVQIRWVNSEEIEAHGPDRYLADAAGIIVPGGFGIRGVDGKIAAIQYARDNQVPFLGLCLGMQCAVIEWARHIAGLEDA
NSAEFNPETRNPVINLLPEQQDVVDLGGTMRLGLYPCRLLPDTLASRLYPQETIVYERHRHRYEFNNAFRPLFLESGYVV
SGTSPDGRLVEMIELPSHPFFIATQFHPEFRSRPNDPHPLFAGLVGACLADNGNNANHHDSTPAEPLVSEPLSS

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=552, Percent_Identity=47.6449275362319, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI28559085, Length=582, Percent_Identity=43.298969072165, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI28559083, Length=582, Percent_Identity=43.298969072165, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI221316689, Length=582, Percent_Identity=43.298969072165, Blast_Score=493, Evalue=1e-139,
Organism=Escherichia coli, GI1789142, Length=537, Percent_Identity=54.3761638733706, Blast_Score=587, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI25148299, Length=602, Percent_Identity=41.3621262458472, Blast_Score=446, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319432, Length=561, Percent_Identity=44.0285204991087, Blast_Score=488, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=45.0530035335689, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24664469, Length=547, Percent_Identity=47.8976234003656, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI21357815, Length=492, Percent_Identity=46.9512195121951, Blast_Score=438, Evalue=1e-123,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_ACAM1 (B0CBC7)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001517228.1
- ProteinModelPortal:   B0CBC7
- SMR:   B0CBC7
- GeneID:   5681721
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_2914
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   AMAR329726:AM1_2914-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 61327; Mature: 61195

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 381-381 ACT_SITE 508-508 ACT_SITE 510-510

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYSVSILKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTDTAMSRLNSVTTGSIYQSVLNKERRGDYEGGTVQVIPHITN
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHH
EIKDRIKRVAKQATPDVLIIEIGGTVGDIESLPFLEAIRQFRKDVGRDNILYTHVTLMPW
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECC
IPAAGEMKTKPTQHSVKELRSIGIQPDILVCRCDRPLSEGIKEKVSEFCDVPVEAVITSQ
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECC
DASSIYAVPLILEQEGLAQQVLKFMHLEQRRPDLTQWQALVHQLDHPSQTIEIALVGKYV
CCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEECHH
QLSDAYLSVVESLQHAAVAQGIAVQIRWVNSEEIEAHGPDRYLADAAGIIVPGGFGIRGV
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHCCCCEEECCCCCEECC
DGKIAAIQYARDNQVPFLGLCLGMQCAVIEWARHIAGLEDANSAEFNPETRNPVINLLPE
CCCEEEEEEECCCCCCEEHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCC
QQDVVDLGGTMRLGLYPCRLLPDTLASRLYPQETIVYERHRHRYEFNNAFRPLFLESGYV
CCHHHHCCCEEEECCEEHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCEE
VSGTSPDGRLVEMIELPSHPFFIATQFHPEFRSRPNDPHPLFAGLVGACLADNGNNANHH
EECCCCCCCEEEEEECCCCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCC
DSTPAEPLVSEPLSS
CCCCCCHHHHCCCCC
>Mature Secondary Structure 
TKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYSVSILKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTDTAMSRLNSVTTGSIYQSVLNKERRGDYEGGTVQVIPHITN
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHH
EIKDRIKRVAKQATPDVLIIEIGGTVGDIESLPFLEAIRQFRKDVGRDNILYTHVTLMPW
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECC
IPAAGEMKTKPTQHSVKELRSIGIQPDILVCRCDRPLSEGIKEKVSEFCDVPVEAVITSQ
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECC
DASSIYAVPLILEQEGLAQQVLKFMHLEQRRPDLTQWQALVHQLDHPSQTIEIALVGKYV
CCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEECHH
QLSDAYLSVVESLQHAAVAQGIAVQIRWVNSEEIEAHGPDRYLADAAGIIVPGGFGIRGV
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHCCCCEEECCCCCEECC
DGKIAAIQYARDNQVPFLGLCLGMQCAVIEWARHIAGLEDANSAEFNPETRNPVINLLPE
CCCEEEEEEECCCCCCEEHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCC
QQDVVDLGGTMRLGLYPCRLLPDTLASRLYPQETIVYERHRHRYEFNNAFRPLFLESGYV
CCHHHHCCCEEEECCEEHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCEE
VSGTSPDGRLVEMIELPSHPFFIATQFHPEFRSRPNDPHPLFAGLVGACLADNGNNANHH
EECCCCCCCEEEEEECCCCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCC
DSTPAEPLVSEPLSS
CCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA