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The map label for this gene is hisD [H]

Identifier: 158336043

GI number: 158336043

Start: 2938372

End: 2939679

Strand: Direct

Name: hisD [H]

Synonym: AM1_2902

Alternate gene names: 158336043

Gene position: 2938372-2939679 (Clockwise)

Preceding gene: 158336042

Following gene: 158336044

Centisome position: 45.18

GC content: 52.98

Gene sequence:

>1308_bases
GTGGTCAGGATTCTCCGGTTGTCAGAGATGACATCTGAAGAACTCGCTTCCATCAAACGACGGGCCGAGTTAGATATTGA
ACAAGCGCTAGCTGTCGCCAAAGAAGTGATTGACGAGATTCGCGCCGACGGTGATCAGGGCGTGATCAAATACGTGCGTA
AATTTGATTTTCCCGGTGCCACTGCCGAAAATCTTAAAGTGACTGAAGCTGAGTTTGCTGCTGCCCGCGAGCAAGTCGAG
CCTGAAATCAAAGCGGCGATTGAGCAAGCCTATCGCAACATCAAAGAAGTACACGAGCGGCAAATGCCAGAAGAAGTGCA
GCTTGCCGAAATCGATGGCGGCGTCTTTGCTGGGGAGAAAGTCACCCCCATTGCCAGTGCTGGACTATACGTGCCTCGGG
GTAAAGGCTCCTTTCCTTCTGTGATGCTGATGCTTAGCGTGCCTGCGGTGGTGGCCGGGGTGGAAAAGGTAGTCGTCTGC
ACGCCACCTGATAAGAACGGCACCGTTGAGCCTGCCTCTCTTGTGGCTGCTGAACTTGCAGGGGTCAAAGATATTTATAA
ACTCGGTGGCATCCAAGCGATCGCAGGTATGGCGATTGGCACAGAAACCGTTCCTAAAGTCGATAAAATCACCGGACCTT
GTAACGTTTATGGCTCCGCCGCTAAGCGATTGCTCTACGGCACCGTTGATGTGGGCTTACCCGCTGGCCCCAGTGAATCC
ATTATTCTTACGGACGAAACCACCGATCCTCGCATTGCAGCCCTCGATCTGCTTGTAGAAGCAGAGCATGGTCCTGACTC
GGCAGGCTTACTGGTGACCCACAGCGAAGACCTCGCCAAAGCTGCCTCCAAACATGCTGATGACTATATGGAGAAGCTAC
CGGACTGGCGTAAAAACTTTTGCCAAACCGGGTTGTCTTCCTATGGTGGTATTATTCTGACCTCTAGTCTGGAAGAATCC
ATCGACTTCTTGAACGAGTATGCCCCTGAGCATTTGGAAGTCCTTGTCCAAGACCCCCTCAGCGTTCTCGGCAAAATCAA
GAACGCCGGTGAAATTCTGCTTGGTCCCTATACCCCGATTCCAACGGCCAACTACTGCATCGGTGTTAACGCTATTCTGC
CGACGGGCGGCTTTGCTCGTTCCTACTCGGCGGTGTCGGTATACGACTTCCTCAAACGCACCGGGATTGGTTATTTAACC
CAGGAAGGCTTTGCTCGCTTAGGTCATACGGCTCAGACCTTGGCAGAGCATGAGGACTTCCCAGCCCATGCCATGGCCAT
TCGTGAGCGCAAGAACCTGCTCCCGTAA

Upstream 100 bases:

>100_bases
TCAAGTTTGTTAACCCCGCTTCTGAGCTAAGCTAGTAATGCTTATACACCGCTCGACGACATGTATCGGTCGTCGATTAT
TGATTTAAAGGAGACAGCAC

Downstream 100 bases:

>100_bases
GGGGCGGCATTACCGAGGGTTACCGTGTCCGATCAACTCCTGTATCAGATTCAGACCTTACAGTTTTCTGATCAGGCAGC
GGCGAATGCCCTGCTGAAGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MVRILRLSEMTSEELASIKRRAELDIEQALAVAKEVIDEIRADGDQGVIKYVRKFDFPGATAENLKVTEAEFAAAREQVE
PEIKAAIEQAYRNIKEVHERQMPEEVQLAEIDGGVFAGEKVTPIASAGLYVPRGKGSFPSVMLMLSVPAVVAGVEKVVVC
TPPDKNGTVEPASLVAAELAGVKDIYKLGGIQAIAGMAIGTETVPKVDKITGPCNVYGSAAKRLLYGTVDVGLPAGPSES
IILTDETTDPRIAALDLLVEAEHGPDSAGLLVTHSEDLAKAASKHADDYMEKLPDWRKNFCQTGLSSYGGIILTSSLEES
IDFLNEYAPEHLEVLVQDPLSVLGKIKNAGEILLGPYTPIPTANYCIGVNAILPTGGFARSYSAVSVYDFLKRTGIGYLT
QEGFARLGHTAQTLAEHEDFPAHAMAIRERKNLLP

Sequences:

>Translated_435_residues
MVRILRLSEMTSEELASIKRRAELDIEQALAVAKEVIDEIRADGDQGVIKYVRKFDFPGATAENLKVTEAEFAAAREQVE
PEIKAAIEQAYRNIKEVHERQMPEEVQLAEIDGGVFAGEKVTPIASAGLYVPRGKGSFPSVMLMLSVPAVVAGVEKVVVC
TPPDKNGTVEPASLVAAELAGVKDIYKLGGIQAIAGMAIGTETVPKVDKITGPCNVYGSAAKRLLYGTVDVGLPAGPSES
IILTDETTDPRIAALDLLVEAEHGPDSAGLLVTHSEDLAKAASKHADDYMEKLPDWRKNFCQTGLSSYGGIILTSSLEES
IDFLNEYAPEHLEVLVQDPLSVLGKIKNAGEILLGPYTPIPTANYCIGVNAILPTGGFARSYSAVSVYDFLKRTGIGYLT
QEGFARLGHTAQTLAEHEDFPAHAMAIRERKNLLP
>Mature_435_residues
MVRILRLSEMTSEELASIKRRAELDIEQALAVAKEVIDEIRADGDQGVIKYVRKFDFPGATAENLKVTEAEFAAAREQVE
PEIKAAIEQAYRNIKEVHERQMPEEVQLAEIDGGVFAGEKVTPIASAGLYVPRGKGSFPSVMLMLSVPAVVAGVEKVVVC
TPPDKNGTVEPASLVAAELAGVKDIYKLGGIQAIAGMAIGTETVPKVDKITGPCNVYGSAAKRLLYGTVDVGLPAGPSES
IILTDETTDPRIAALDLLVEAEHGPDSAGLLVTHSEDLAKAASKHADDYMEKLPDWRKNFCQTGLSSYGGIILTSSLEES
IDFLNEYAPEHLEVLVQDPLSVLGKIKNAGEILLGPYTPIPTANYCIGVNAILPTGGFARSYSAVSVYDFLKRTGIGYLT
QEGFARLGHTAQTLAEHEDFPAHAMAIRERKNLLP

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:
GO:0000105: Histidinol dehydrogenase
GO:0004399: Histidinol dehydrogenase
GO:0008152: Histidinol dehydrogenase
GO:0008270: Histidinol dehydrogenase
GO:0008652: Histidinol dehydrogenase
GO:0016491: Histidinol dehydrogenase
GO:0046872: Histidinol dehydrogenase
GO:0051287: Histidinol dehydrogenase
GO:0055114: Histidinol dehydrogenase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=435, Percent_Identity=36.0919540229885, Blast_Score=274, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6319819, Length=423, Percent_Identity=34.0425531914894, Blast_Score=223, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46727; Mature: 46727

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRILRLSEMTSEELASIKRRAELDIEQALAVAKEVIDEIRADGDQGVIKYVRKFDFPGA
CEEEEEHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
TAENLKVTEAEFAAAREQVEPEIKAAIEQAYRNIKEVHERQMPEEVQLAEIDGGVFAGEK
CCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCC
VTPIASAGLYVPRGKGSFPSVMLMLSVPAVVAGVEKVVVCTPPDKNGTVEPASLVAAELA
CCCHHHCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHH
GVKDIYKLGGIQAIAGMAIGTETVPKVDKITGPCNVYGSAAKRLLYGTVDVGLPAGPSES
HHHHHHHHCCHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHEEEECCCCCCCCCC
IILTDETTDPRIAALDLLVEAEHGPDSAGLLVTHSEDLAKAASKHADDYMEKLPDWRKNF
EEEECCCCCCHHEEHHHEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCHHHHHHH
CQTGLSSYGGIILTSSLEESIDFLNEYAPEHLEVLVQDPLSVLGKIKNAGEILLGPYTPI
HHHHHHHCCCEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
PTANYCIGVNAILPTGGFARSYSAVSVYDFLKRTGIGYLTQEGFARLGHTAQTLAEHEDF
CCCCEEEECCEECCCCCCHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHCCCC
PAHAMAIRERKNLLP
CHHHHHHHHHHCCCC
>Mature Secondary Structure
MVRILRLSEMTSEELASIKRRAELDIEQALAVAKEVIDEIRADGDQGVIKYVRKFDFPGA
CEEEEEHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
TAENLKVTEAEFAAAREQVEPEIKAAIEQAYRNIKEVHERQMPEEVQLAEIDGGVFAGEK
CCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCC
VTPIASAGLYVPRGKGSFPSVMLMLSVPAVVAGVEKVVVCTPPDKNGTVEPASLVAAELA
CCCHHHCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHH
GVKDIYKLGGIQAIAGMAIGTETVPKVDKITGPCNVYGSAAKRLLYGTVDVGLPAGPSES
HHHHHHHHCCHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHEEEECCCCCCCCCC
IILTDETTDPRIAALDLLVEAEHGPDSAGLLVTHSEDLAKAASKHADDYMEKLPDWRKNF
EEEECCCCCCHHEEHHHEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCHHHHHHH
CQTGLSSYGGIILTSSLEESIDFLNEYAPEHLEVLVQDPLSVLGKIKNAGEILLGPYTPI
HHHHHHHCCCEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
PTANYCIGVNAILPTGGFARSYSAVSVYDFLKRTGIGYLTQEGFARLGHTAQTLAEHEDF
CCCCEEEECCEECCCCCCHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHCCCC
PAHAMAIRERKNLLP
CHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]