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The map label for this gene is zwf [H]

Identifier: 158336018

GI number: 158336018

Start: 2916640

End: 2918169

Strand: Direct

Name: zwf [H]

Synonym: AM1_2877

Alternate gene names: 158336018

Gene position: 2916640-2918169 (Clockwise)

Preceding gene: 158336017

Following gene: 158336019

Centisome position: 44.85

GC content: 51.76

Gene sequence:

>1530_bases
ATGGTTACGCTTGCTGAAAATCCGCTCCGCGTCGGTCTACGCCAAGAACGCACACCAGAGCCTCTGATTATGGTGATCTT
TGGTGCCTCTGGTGACCTCACCCAACGGAAACTAGTCCCTGCCCTCTACCATCTGAAACAACAGCGCCGCCTGCCAGCGG
AACTAACCATCGTCGGTGTTGCCCGACGGGAGTGGAGTGATGATTACTTCCGGCAACAGATGCGCGAAGGGATTGAAGAA
TTTTCGGATGGGATTCAGTCGGAAGAGGTCTGGAATAGCTTTGCCGAAGGGTTATTTTATTGCCCTGGCAATATGGACGA
TCCCCAAGCCTATCAAAAGCTGAAAGCTCGTTTAGAAGAACTGGATGGTCGTCGCGGCACCATGGGCAACCGGGTGTTTT
ATCTGGCGGTATCTCCTAAGTTTTTTGCGGAAGCGATTCAGCAACTGGGAGCCGCCCAGATGTTGGCGGATCCCGTTAAA
ACACGGCTAGTGATTGAAAAGCCCTTTGGTCGGGATTTAGGATCAGCCCAATCCCTTAACAAGGTTGTACAAGAGGTCTG
CGCCGAAAACCAGGTCTATCGCATTGATCATTACCTGGGTAAGGAAACCGTTCAGAACTTGCTGATCTTTCGGTTTGCCA
ACGCCATTTTCGAACCCCTATGGAATCGACAGTTTGTTGACCATGTTCAAATTACCGTGGCGGAAACCGTGGGGGTAGAA
GAGCGAGCAGGCTATTACGAAACCTCCGGTGCCCTGCGGGATATGGTCCAGAACCATATTATGCAGCTGCTTTGCCTCAC
GGCAATGGAACCCCCGAACTCCTTGGATGCCGATGCAATTCGCACAGAGAAAGTCAAAGTGGTCCAAGCCATGCGCTTGG
CAGATATCCATAACCTCGAGAATTCTGCTATTCGCGGCCAATATACCCAAGGCTGGATGAAAGGCGAGCAGGTGCCGGGC
TATCACCAAGAACCCGGTGTAAGTCCCAAATCCACAACGCCCACCTATGTAGCCTTGAAGCTGCTGATTGACAACTGGCG
CTGGCAAGGGGTGCCCTTTTATCTGCGCACCGGTAAACGTTTGCCCAAAAAGGTGTCCGAGATTTCTATCCATTTTCGCC
AAGTACCATTCTTAATCTTTCAATCTGCTGCCCAGCAGGCAAATCCCAATGTATTAGCCATGCGTATTCAGCCTAATGAG
GGAATCTCCCTACGATTTGAAGCCAAAATGCCAGGGCCAGACCTACGGACTCGTTCTGTAGATATGAACTTTAGCTATGG
TTCCTTTTTTGGCCAGTCTACAGGGGATGCCTATGATCGCCTCCTCTTAGACGCTATGCTCGGCGATCAAACTCTGTTTA
CCCGCGGAGATGAAGTTGAGGAGTCTTGGCGGGTGTTAACGCCTGCCTTAACGGCTTGGGAAGAGCCTACAGATCCTGCC
CTAGTGCCCACCTATGAAGCTGGGACTTGGGAACCAGAAGCTGCTGAGCTATTGCTTAACCGCGATGGTCGGCGCTGGCG
ACGACTCTAG

Upstream 100 bases:

>100_bases
CTAGGGGATTGGGCGTTACCCAAACGTCGAAGTGCGCTAGTGCAAAGGGCTGACTTTCACCGTTTCCAAGTTCACCTATT
TCCCTTTGTTTGCCCAGCCT

Downstream 100 bases:

>100_bases
ATCTTTGAATATGCGCACTTAGTTCTCCATTTTCTTCGCCCTATGACTACAAAATCTGCTCCCATCGTCTCTTTGCAAGC
CCCAAAAGACGTTTCGCTCA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MVTLAENPLRVGLRQERTPEPLIMVIFGASGDLTQRKLVPALYHLKQQRRLPAELTIVGVARREWSDDYFRQQMREGIEE
FSDGIQSEEVWNSFAEGLFYCPGNMDDPQAYQKLKARLEELDGRRGTMGNRVFYLAVSPKFFAEAIQQLGAAQMLADPVK
TRLVIEKPFGRDLGSAQSLNKVVQEVCAENQVYRIDHYLGKETVQNLLIFRFANAIFEPLWNRQFVDHVQITVAETVGVE
ERAGYYETSGALRDMVQNHIMQLLCLTAMEPPNSLDADAIRTEKVKVVQAMRLADIHNLENSAIRGQYTQGWMKGEQVPG
YHQEPGVSPKSTTPTYVALKLLIDNWRWQGVPFYLRTGKRLPKKVSEISIHFRQVPFLIFQSAAQQANPNVLAMRIQPNE
GISLRFEAKMPGPDLRTRSVDMNFSYGSFFGQSTGDAYDRLLLDAMLGDQTLFTRGDEVEESWRVLTPALTAWEEPTDPA
LVPTYEAGTWEPEAAELLLNRDGRRWRRL

Sequences:

>Translated_509_residues
MVTLAENPLRVGLRQERTPEPLIMVIFGASGDLTQRKLVPALYHLKQQRRLPAELTIVGVARREWSDDYFRQQMREGIEE
FSDGIQSEEVWNSFAEGLFYCPGNMDDPQAYQKLKARLEELDGRRGTMGNRVFYLAVSPKFFAEAIQQLGAAQMLADPVK
TRLVIEKPFGRDLGSAQSLNKVVQEVCAENQVYRIDHYLGKETVQNLLIFRFANAIFEPLWNRQFVDHVQITVAETVGVE
ERAGYYETSGALRDMVQNHIMQLLCLTAMEPPNSLDADAIRTEKVKVVQAMRLADIHNLENSAIRGQYTQGWMKGEQVPG
YHQEPGVSPKSTTPTYVALKLLIDNWRWQGVPFYLRTGKRLPKKVSEISIHFRQVPFLIFQSAAQQANPNVLAMRIQPNE
GISLRFEAKMPGPDLRTRSVDMNFSYGSFFGQSTGDAYDRLLLDAMLGDQTLFTRGDEVEESWRVLTPALTAWEEPTDPA
LVPTYEAGTWEPEAAELLLNRDGRRWRRL
>Mature_509_residues
MVTLAENPLRVGLRQERTPEPLIMVIFGASGDLTQRKLVPALYHLKQQRRLPAELTIVGVARREWSDDYFRQQMREGIEE
FSDGIQSEEVWNSFAEGLFYCPGNMDDPQAYQKLKARLEELDGRRGTMGNRVFYLAVSPKFFAEAIQQLGAAQMLADPVK
TRLVIEKPFGRDLGSAQSLNKVVQEVCAENQVYRIDHYLGKETVQNLLIFRFANAIFEPLWNRQFVDHVQITVAETVGVE
ERAGYYETSGALRDMVQNHIMQLLCLTAMEPPNSLDADAIRTEKVKVVQAMRLADIHNLENSAIRGQYTQGWMKGEQVPG
YHQEPGVSPKSTTPTYVALKLLIDNWRWQGVPFYLRTGKRLPKKVSEISIHFRQVPFLIFQSAAQQANPNVLAMRIQPNE
GISLRFEAKMPGPDLRTRSVDMNFSYGSFFGQSTGDAYDRLLLDAMLGDQTLFTRGDEVEESWRVLTPALTAWEEPTDPA
LVPTYEAGTWEPEAAELLLNRDGRRWRRL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:
GO:0004345: Glucose-6-phosphate 1-dehydrogenase
GO:0005488: Glucose-6-phosphate 1-dehydrogenase
GO:0005975: Glucose-6-phosphate 1-dehydrogenase
GO:0006006: Glucose-6-phosphate 1-dehydrogenase
GO:0016491: Glucose-6-phosphate 1-dehydrogenase
GO:0050661: Glucose-6-phosphate 1-dehydrogenase
GO:0055114: Glucose-6-phosphate 1-dehydrogenase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=487, Percent_Identity=37.9876796714579, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI108773793, Length=487, Percent_Identity=37.9876796714579, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI52145310, Length=390, Percent_Identity=32.8205128205128, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1788158, Length=495, Percent_Identity=43.2323232323232, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17538218, Length=489, Percent_Identity=37.0143149284254, Blast_Score=325, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=461, Percent_Identity=34.9240780911063, Blast_Score=285, Evalue=9e-78,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=37.344398340249, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=37.344398340249, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI221513548, Length=455, Percent_Identity=30.3296703296703, Blast_Score=208, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58004; Mature: 58004

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLAENPLRVGLRQERTPEPLIMVIFGASGDLTQRKLVPALYHLKQQRRLPAELTIVGV
CCEECCCCHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEE
ARREWSDDYFRQQMREGIEEFSDGIQSEEVWNSFAEGLFYCPGNMDDPQAYQKLKARLEE
HHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHH
LDGRRGTMGNRVFYLAVSPKFFAEAIQQLGAAQMLADPVKTRLVIEKPFGRDLGSAQSLN
HCCCCCCCCCEEEEEEECHHHHHHHHHHHCHHHHHHHHHHHEEEEECCCCCCCCCHHHHH
KVVQEVCAENQVYRIDHYLGKETVQNLLIFRFANAIFEPLWNRQFVDHVQITVAETVGVE
HHHHHHHCCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEHHHCCCH
ERAGYYETSGALRDMVQNHIMQLLCLTAMEPPNSLDADAIRTEKVKVVQAMRLADIHNLE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
NSAIRGQYTQGWMKGEQVPGYHQEPGVSPKSTTPTYVALKLLIDNWRWQGVPFYLRTGKR
CCHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCH
LPKKVSEISIHFRQVPFLIFQSAAQQANPNVLAMRIQPNEGISLRFEAKMPGPDLRTRSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEE
DMNFSYGSFFGQSTGDAYDRLLLDAMLGDQTLFTRGDEVEESWRVLTPALTAWEEPTDPA
ECCCCHHCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCC
LVPTYEAGTWEPEAAELLLNRDGRRWRRL
EEECCCCCCCCHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MVTLAENPLRVGLRQERTPEPLIMVIFGASGDLTQRKLVPALYHLKQQRRLPAELTIVGV
CCEECCCCHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEE
ARREWSDDYFRQQMREGIEEFSDGIQSEEVWNSFAEGLFYCPGNMDDPQAYQKLKARLEE
HHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHH
LDGRRGTMGNRVFYLAVSPKFFAEAIQQLGAAQMLADPVKTRLVIEKPFGRDLGSAQSLN
HCCCCCCCCCEEEEEEECHHHHHHHHHHHCHHHHHHHHHHHEEEEECCCCCCCCCHHHHH
KVVQEVCAENQVYRIDHYLGKETVQNLLIFRFANAIFEPLWNRQFVDHVQITVAETVGVE
HHHHHHHCCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEHHHCCCH
ERAGYYETSGALRDMVQNHIMQLLCLTAMEPPNSLDADAIRTEKVKVVQAMRLADIHNLE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
NSAIRGQYTQGWMKGEQVPGYHQEPGVSPKSTTPTYVALKLLIDNWRWQGVPFYLRTGKR
CCHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCH
LPKKVSEISIHFRQVPFLIFQSAAQQANPNVLAMRIQPNEGISLRFEAKMPGPDLRTRSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEE
DMNFSYGSFFGQSTGDAYDRLLLDAMLGDQTLFTRGDEVEESWRVLTPALTAWEEPTDPA
ECCCCHHCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCC
LVPTYEAGTWEPEAAELLLNRDGRRWRRL
EEECCCCCCCCHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]