Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 158335944

GI number: 158335944

Start: 2832970

End: 2833626

Strand: Reverse

Name: msrA [H]

Synonym: AM1_2802

Alternate gene names: 158335944

Gene position: 2833626-2832970 (Counterclockwise)

Preceding gene: 158335948

Following gene: 158335943

Centisome position: 43.57

GC content: 47.03

Gene sequence:

>657_bases
ATGGCTCTTTTTGGATTATTTGGGAAAAAGCTCACGTTACCTACTGCGGAGGAGGCATTAGCAGGTCGAACAACGCCAAT
GCCTGTTCCTGAAAAGCACTTTGTCAACGGTCATGCTCTCAAACCTCCATTTCCTGAAGGAATGGAACAAGCCATGTTCG
GTTTGGGGTGTTTTTGGGGAGCTGAGCGACGCTTTTGGCAACAAGAAGGGGTGTATGTGACTGCTGTGGGCTATGCCAGT
GGTATAACGCCTAACCCAACGTATCAAGAAGTCTGTTCAGGTATGACCGGGCATAACGAAGTGGTGATGGTCATTTTTGA
CCCCTCAAAAATTAGCTATGAAAGCTTGCTGCAAGTTTTTTGGGAAAGCCATAATCCAACCCAAGGGATGCAGCAAGGGA
ATGATGTGGGCACGCAATATCGCTCTGGGGTTTACACCTACTCTGATCAGCAAAAAGCGCTAGCGTTGTCTTCCAAGAAG
ATTTATCAGGATGCCTTACAAAAAGCTGGCCTCAGCGAAATTACGACTGAAGTGTTGGATGCTCCTGAATTCTACTATGC
GGAAGATTATCACCAGCAATACTTGGCAAAAAACCCGGGTGGCTATTGTGGATTAGGAGGGACTAGCGTGACATGCCCTC
CGTTAGTAGAAGCATAA

Upstream 100 bases:

>100_bases
GATGTTGATCTATGACATGTCAAGGGAAACGTGCCCATCCATGAATTCGTTACCCTGAAGATAGTATCTCTCTGTTCTTC
ATCAATTAATTTTTGGTACT

Downstream 100 bases:

>100_bases
ATCTTCAGTGCAATTTCTCTATCAGACCATCACTTCAAATAGTAGAAGTTAATCACGAGAGATTGCACTGAAGATTTTGC
TATTCAGGGTAGATCGACGT

Product: methionine-S-sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MALFGLFGKKLTLPTAEEALAGRTTPMPVPEKHFVNGHALKPPFPEGMEQAMFGLGCFWGAERRFWQQEGVYVTAVGYAS
GITPNPTYQEVCSGMTGHNEVVMVIFDPSKISYESLLQVFWESHNPTQGMQQGNDVGTQYRSGVYTYSDQQKALALSSKK
IYQDALQKAGLSEITTEVLDAPEFYYAEDYHQQYLAKNPGGYCGLGGTSVTCPPLVEA

Sequences:

>Translated_218_residues
MALFGLFGKKLTLPTAEEALAGRTTPMPVPEKHFVNGHALKPPFPEGMEQAMFGLGCFWGAERRFWQQEGVYVTAVGYAS
GITPNPTYQEVCSGMTGHNEVVMVIFDPSKISYESLLQVFWESHNPTQGMQQGNDVGTQYRSGVYTYSDQQKALALSSKK
IYQDALQKAGLSEITTEVLDAPEFYYAEDYHQQYLAKNPGGYCGLGGTSVTCPPLVEA
>Mature_217_residues
ALFGLFGKKLTLPTAEEALAGRTTPMPVPEKHFVNGHALKPPFPEGMEQAMFGLGCFWGAERRFWQQEGVYVTAVGYASG
ITPNPTYQEVCSGMTGHNEVVMVIFDPSKISYESLLQVFWESHNPTQGMQQGNDVGTQYRSGVYTYSDQQKALALSSKKI
YQDALQKAGLSEITTEVLDAPEFYYAEDYHQQYLAKNPGGYCGLGGTSVTCPPLVEA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=202, Percent_Identity=59.4059405940594, Blast_Score=259, Evalue=1e-69,
Organism=Homo sapiens, GI208609995, Length=182, Percent_Identity=62.0879120879121, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI208609993, Length=197, Percent_Identity=46.7005076142132, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI1790665, Length=212, Percent_Identity=58.4905660377358, Blast_Score=232, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=41.4965986394558, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=39.622641509434, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24664627, Length=167, Percent_Identity=35.9281437125749, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45553131, Length=163, Percent_Identity=34.9693251533742, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24664631, Length=167, Percent_Identity=34.7305389221557, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23971; Mature: 23840

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFGLFGKKLTLPTAEEALAGRTTPMPVPEKHFVNGHALKPPFPEGMEQAMFGLGCFWG
CCCHHCCCCEECCCCHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
AERRFWQQEGVYVTAVGYASGITPNPTYQEVCSGMTGHNEVVMVIFDPSKISYESLLQVF
HHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHH
WESHNPTQGMQQGNDVGTQYRSGVYTYSDQQKALALSSKKIYQDALQKAGLSEITTEVLD
HHCCCCCCHHHCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
APEFYYAEDYHQQYLAKNPGGYCGLGGTSVTCPPLVEA
CCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
ALFGLFGKKLTLPTAEEALAGRTTPMPVPEKHFVNGHALKPPFPEGMEQAMFGLGCFWG
CCHHCCCCEECCCCHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
AERRFWQQEGVYVTAVGYASGITPNPTYQEVCSGMTGHNEVVMVIFDPSKISYESLLQVF
HHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHH
WESHNPTQGMQQGNDVGTQYRSGVYTYSDQQKALALSSKKIYQDALQKAGLSEITTEVLD
HHCCCCCCHHHCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
APEFYYAEDYHQQYLAKNPGGYCGLGGTSVTCPPLVEA
CCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA