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The map label for this gene is iscS [H]

Identifier: 158335809

GI number: 158335809

Start: 2701412

End: 2702632

Strand: Reverse

Name: iscS [H]

Synonym: AM1_2660

Alternate gene names: 158335809

Gene position: 2702632-2701412 (Counterclockwise)

Preceding gene: 158335810

Following gene: 158335806

Centisome position: 41.56

GC content: 50.61

Gene sequence:

>1221_bases
ATGATGCCCCCCCTGCCTGAGCGTCCGATTTATCTAGATTGCCAAGCCACGACGCCCGTTGACCCTAGGGTCGTCGAGGC
GATGCTGCCCTACTTTACGGACTGTCCGGGCAATCCTTCTAGCAGCTCTCACCTCTATGGTTGGGAAGCAAAAGCAGTAG
TTGATCTAGCGCGGGAGACCATTGCTCAGGCCATCAGCGCAGATCCACAAGAGATTATCTTTACCAGTGGCGCAACGGAG
GCCAATAATTTAGCGATTAAAGGGGTAGCGGAAGCCTATCTCAGTAAAGGGCGGCATCTGATTACGATGCAAACAGAACA
TAATGCTGTTTTAGAACCCTGTAAATATCTCGAAAAGCTGGGATTTGAGGTAACGTATCTGCTGCCCCAACCGGATGGAC
TGTTGGATGTGAAGGTTCTGGAACAAGCAATCCGGGTCGATACGATTTTAGTGTCGGTCATGGCAGCGAATAATGAAATA
GGGGTATTACAGCCATTGTCTGAAATCGGTCAGGTGTGCCGTCAGCACAATGTTCTTTTTCATACGGATGCGGCTCAGGC
GATTGGCAAAATCCCTTTAGATGTGGAGGCGATGCAGATCGATTTATTGTCGATGACGGGGCATAAGCTCTATGGTCCCA
AAGGGATTGGGGCGCTGTATATTCGCAATCGCAATCCCCATGTGCAGGTTGCGGCTCAACTGCAGGGGGGTGGGCAAGAA
CGAAATGTGCGATCGGGGACGTTACCAACACCACAAATTGTTGGTTTGGGGAAAGCGATTGAGCTAGGGTTAGCTGAGCA
AACGGCAGAGGCAGAGCGGCTAACGGTGCTTAGAAACCGGCTCTGGCAAGAGCTTCAGGTATTGAACGGAATTCACTTGA
ATGGTCATCCGCAACAGCGATTACCGGGGTGTTTGTCGGTCAGTTTTGAAGGGATAGATGGTGCGGCGTTGTTATTGGGG
CTGCAGCCCTATGTGGCGTTGTCTTCAGGATCTGCATGTGCATCTAGTAAACCCACTCCCTCGCATGTGTTAACGGCTTT
AGGGAGGTCTGCTCAACTCTCTAAAGCGACGCTGAGATTTGGGTTAGGTCGATTTACGACTCAAGCAGAGATCGAGCAGG
CAGCTCGCCATGTGATCCGCACGATTCAACAAGGCCAATCATCACAAAAACTTGATGATACAGCTCAGCCTGAGTTGGTA
AAACCTGAAATCCAACCTTGA

Upstream 100 bases:

>100_bases
CACAGATAACCTTAGATATCACACCTATTAATTCCCACTGTTTATACCTAACTTGATACATCTGCAGAAACAGTTTGTGG
TCTTCACTGGCGAAATTTGA

Downstream 100 bases:

>100_bases
TAAATCGTTTCTCAACTCTTTTAAATCCTGAAAGCGTGCCCTCGAGATCGCCCCCCAAAGTAGCGACGACTAATGGTTCC
TTGTTTTTGGGACACTCCCC

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MMPPLPERPIYLDCQATTPVDPRVVEAMLPYFTDCPGNPSSSSHLYGWEAKAVVDLARETIAQAISADPQEIIFTSGATE
ANNLAIKGVAEAYLSKGRHLITMQTEHNAVLEPCKYLEKLGFEVTYLLPQPDGLLDVKVLEQAIRVDTILVSVMAANNEI
GVLQPLSEIGQVCRQHNVLFHTDAAQAIGKIPLDVEAMQIDLLSMTGHKLYGPKGIGALYIRNRNPHVQVAAQLQGGGQE
RNVRSGTLPTPQIVGLGKAIELGLAEQTAEAERLTVLRNRLWQELQVLNGIHLNGHPQQRLPGCLSVSFEGIDGAALLLG
LQPYVALSSGSACASSKPTPSHVLTALGRSAQLSKATLRFGLGRFTTQAEIEQAARHVIRTIQQGQSSQKLDDTAQPELV
KPEIQP

Sequences:

>Translated_406_residues
MMPPLPERPIYLDCQATTPVDPRVVEAMLPYFTDCPGNPSSSSHLYGWEAKAVVDLARETIAQAISADPQEIIFTSGATE
ANNLAIKGVAEAYLSKGRHLITMQTEHNAVLEPCKYLEKLGFEVTYLLPQPDGLLDVKVLEQAIRVDTILVSVMAANNEI
GVLQPLSEIGQVCRQHNVLFHTDAAQAIGKIPLDVEAMQIDLLSMTGHKLYGPKGIGALYIRNRNPHVQVAAQLQGGGQE
RNVRSGTLPTPQIVGLGKAIELGLAEQTAEAERLTVLRNRLWQELQVLNGIHLNGHPQQRLPGCLSVSFEGIDGAALLLG
LQPYVALSSGSACASSKPTPSHVLTALGRSAQLSKATLRFGLGRFTTQAEIEQAARHVIRTIQQGQSSQKLDDTAQPELV
KPEIQP
>Mature_406_residues
MMPPLPERPIYLDCQATTPVDPRVVEAMLPYFTDCPGNPSSSSHLYGWEAKAVVDLARETIAQAISADPQEIIFTSGATE
ANNLAIKGVAEAYLSKGRHLITMQTEHNAVLEPCKYLEKLGFEVTYLLPQPDGLLDVKVLEQAIRVDTILVSVMAANNEI
GVLQPLSEIGQVCRQHNVLFHTDAAQAIGKIPLDVEAMQIDLLSMTGHKLYGPKGIGALYIRNRNPHVQVAAQLQGGGQE
RNVRSGTLPTPQIVGLGKAIELGLAEQTAEAERLTVLRNRLWQELQVLNGIHLNGHPQQRLPGCLSVSFEGIDGAALLLG
LQPYVALSSGSACASSKPTPSHVLTALGRSAQLSKATLRFGLGRFTTQAEIEQAARHVIRTIQQGQSSQKLDDTAQPELV
KPEIQP

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=378, Percent_Identity=54.2328042328042, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI156713448, Length=416, Percent_Identity=37.9807692307692, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI48994898, Length=376, Percent_Identity=52.3936170212766, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1787970, Length=347, Percent_Identity=27.9538904899135, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=25.9259259259259, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI25143064, Length=390, Percent_Identity=50.5128205128205, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17533177, Length=330, Percent_Identity=37.2727272727273, Blast_Score=170, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6319831, Length=371, Percent_Identity=52.0215633423181, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI20129463, Length=378, Percent_Identity=53.4391534391534, Blast_Score=414, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43890; Mature: 43890

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPPLPERPIYLDCQATTPVDPRVVEAMLPYFTDCPGNPSSSSHLYGWEAKAVVDLARET
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHH
IAQAISADPQEIIFTSGATEANNLAIKGVAEAYLSKGRHLITMQTEHNAVLEPCKYLEKL
HHHHHCCCCHHEEEECCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHC
GFEVTYLLPQPDGLLDVKVLEQAIRVDTILVSVMAANNEIGVLQPLSEIGQVCRQHNVLF
CCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEE
HTDAAQAIGKIPLDVEAMQIDLLSMTGHKLYGPKGIGALYIRNRNPHVQVAAQLQGGGQE
EECHHHHHCCCCCCEEHEEEEEEHHCCCEEECCCCCCEEEEECCCCCEEEEEEECCCCCC
RNVRSGTLPTPQIVGLGKAIELGLAEQTAEAERLTVLRNRLWQELQVLNGIHLNGHPQQR
CCCCCCCCCCCHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LPGCLSVSFEGIDGAALLLGLQPYVALSSGSACASSKPTPSHVLTALGRSAQLSKATLRF
CCCEEEEEECCCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
GLGRFTTQAEIEQAARHVIRTIQQGQSSQKLDDTAQPELVKPEIQP
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMPPLPERPIYLDCQATTPVDPRVVEAMLPYFTDCPGNPSSSSHLYGWEAKAVVDLARET
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHH
IAQAISADPQEIIFTSGATEANNLAIKGVAEAYLSKGRHLITMQTEHNAVLEPCKYLEKL
HHHHHCCCCHHEEEECCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHC
GFEVTYLLPQPDGLLDVKVLEQAIRVDTILVSVMAANNEIGVLQPLSEIGQVCRQHNVLF
CCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEE
HTDAAQAIGKIPLDVEAMQIDLLSMTGHKLYGPKGIGALYIRNRNPHVQVAAQLQGGGQE
EECHHHHHCCCCCCEEHEEEEEEHHCCCEEECCCCCCEEEEECCCCCEEEEEEECCCCCC
RNVRSGTLPTPQIVGLGKAIELGLAEQTAEAERLTVLRNRLWQELQVLNGIHLNGHPQQR
CCCCCCCCCCCHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LPGCLSVSFEGIDGAALLLGLQPYVALSSGSACASSKPTPSHVLTALGRSAQLSKATLRF
CCCEEEEEECCCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
GLGRFTTQAEIEQAARHVIRTIQQGQSSQKLDDTAQPELVKPEIQP
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA