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The map label for this gene is purL

Identifier: 158335761

GI number: 158335761

Start: 2647490

End: 2649841

Strand: Direct

Name: purL

Synonym: AM1_2612

Alternate gene names: 158335761

Gene position: 2647490-2649841 (Clockwise)

Preceding gene: 158335759

Following gene: 158335762

Centisome position: 40.71

GC content: 53.78

Gene sequence:

>2352_bases
ATGGCAAGCCCTGGATCTTCTCCCTTTTCCCCTGAAGAAATTGCTACTGAAGGGCTAAAGCCCGAAGAATACGACGATAT
CGTTCAACGATTGGGTCGCCATCCCAATCGAGCCGAACTGGGCATGTTTGGCGTTATGTGGTCCGAGCATTGCTGCTACA
AGAATTCAAGGCCTTTACTTTCGCAATTTCCCACCGAAGGTAAGCATGTATTAGTTGGCCCTGGAGAGAATGCCGGAGTC
GTCGATTTAGGCAATGGCCTCCAGCTCGCCTTCAAAGTCGAGTCTCATAACCATCCTTCTGCCGTTGAACCGTTTCAGGG
GGCAGCAACGGGAGTCGGCGGCATCTTAAGAGATATTTTCACCATGGGTGCCCGCCCCATTGCCGTCCTCAATTCCCTGC
GATTTGGTGATCTAGACGATGCTCGCACCCGCCGTTTATTTAGTGGGGTGGTGGCCGGAATTGCCCACTATGGCAACTGT
GTGGGCGTGCCGACCGTGGGTGGTGAAGTTTATTTTGATCCTGCCTACACGGGCAATCCCCTCGTCAACGCCATGGCTAT
GGGCCTGATGGAGACCGCTGAGATTGTCAAAGCTGGGGCATCAGGCGTGGGTAATCCGGTGCTTTATGTGGGATCTACCA
CCGGGCGAGACGGTATGGGAGGGGCGAGCTTTGCCAGTGCTGAACTGGATGCCACCTCTGAAGTAGAAGATCGACCCGCT
GTTCAAGTCGGTGACCCATTTTTAGAAAAATCTTTAATTGAAGCCTGTCTAGAAGCCTTCCAAACCGGAGCGGTGGTTGC
TGCTCAAGATATGGGGGCAGCTGGCCTGACCTGCTCCACTGCCGAAATGGCAGAGAAAGGCGGCGTGGGGATTGATCTGG
ATTTAGATCTAATTCCCAACCGAGAAACGGGGATGGTGCCCTACGAATATTTGCTCTCCGAATCCCAAGAGCGGATGTTG
TTTGTGGCCGAAAAAGGTCGGGAACAGGAGCTGATTGATATCTTCCACCGTTGGGGTCTACAGGCCGTCGTTGCCGGTTC
AGTCATTGCTGAACCCATTGTCAAGATTCGGTTCCAAGGAGAAGTAGCGGCAGAAATTCCCGCGACCGCCTTATCCGACA
ATACGCCAATCTATAAGCGTGAGGTGTTAGCTGAACCCCCTGAGTATGTCCAGAAAGCACGGGAGTGGAGTTGCGATCGC
ATCCCCCCTGGCACCGCTGAAGGCATCGAAATCCAAGGCAAACTGAACTCCTGGTCAGACATCCTCCTCCAGCTTCTACA
AGTCCCCACGATTGCCAGCAAACGCTGGGTGTATCGTCAGTACGATCACCAAGTCCAAAACAACACCGTCGTCTTGCCCG
GTGATGCCGATGCCACTATCGTGCGTCTCCGTCCCGTCGCCCACCAAGAAACTCCTGATCAAGGCGTAGACTCCAAAACT
GCAGTTGCCGCCACCATCGATTGCAACTCTCGCTATGTCTATTTAGATCCCTATGAAGGGGCCAAGATGACCGTAGCCGA
AGCCGCTCGCAACTTGAGCTGTGTGGGTGCTGAGCCGATTGCCGTCACCGACAACCTCAACTTTGGCAGCCCCGAAAAAC
CTATTGGCTATTGGCAGCTAGCAGAAGCCTGCCGAGGACTCTCAGAAGCCTGTCGCCATTTACAAACTCCAGTCACGGGC
GGTAATGTCTCCCTCTACAACGAAACTTTTGACGCTGATGGTCAGCCTCAGCCCATCTATCCCACCCCTGTTATTGGCAT
GGTGGGGTTAGTTCCCGATCTCACCAAGACCTGTGTCCAGGGCTGGCAAGCAGACGGCGATCTGATTTATCTACTCGGAA
TTCCCCTCGACGTCCAAAGTGACCTCGTTACCCTAGGAGCCACGGAATATTTAGCCAGCATTCATCATCAGGTAGCCGGT
GAACCACCCCATGCCGATTTAGATCTAGAAGCCCAAGTCCAAGCCACCTGCCGCCACGGCATTCAGCAGGGCTGGCTCCA
CTCGGCCCATGACTGTGCAGAAGGGGGAGTGGCCGTCGCCCTAGCCGAATCCTGCATCAGTGGCCAACGAGGGGCTGACA
TTCAAGTTCCTACCGGTTCAAACCGCTGGGATCAGGTCTTATTTGGTGAAGGGGGGGCCAGGATTGTCATTTCTGTCAGC
GCAACTCATCAAGCCGCCTGGGAATCCTATTTACAAGAACATCTACCTCAATATTGGCAACAGATAGGAACCGTCACCAC
CCCCAATTCAGAGCTCACCCTCACAACAAATGTTCACCAAACCTTAATCAAGGTTAGGATTGAAGAGGCCACTCAACGAT
GGGCTCAAGCCATTGAGTCCAAGCTGGCGTAA

Upstream 100 bases:

>100_bases
TGAATATAAATTTTGAGCATTCCTGAATATCTGAGTCAGGCTGCATCGATACTCTAGATCAACCTGTACAATAGGGACTT
GTGCGATTGGTATAGAGTAC

Downstream 100 bases:

>100_bases
ATCCAGGCTGCTTGAGGCTGGAAAGGACAAATGTTTGTAATGTGTCAGTTTTTCTGGTTTATTCCGTTTACTTAACGACT
TAAATATGTTTCCTGCTGCT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 783; Mature: 782

Protein sequence:

>783_residues
MASPGSSPFSPEEIATEGLKPEEYDDIVQRLGRHPNRAELGMFGVMWSEHCCYKNSRPLLSQFPTEGKHVLVGPGENAGV
VDLGNGLQLAFKVESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGDLDDARTRRLFSGVVAGIAHYGNC
VGVPTVGGEVYFDPAYTGNPLVNAMAMGLMETAEIVKAGASGVGNPVLYVGSTTGRDGMGGASFASAELDATSEVEDRPA
VQVGDPFLEKSLIEACLEAFQTGAVVAAQDMGAAGLTCSTAEMAEKGGVGIDLDLDLIPNRETGMVPYEYLLSESQERML
FVAEKGREQELIDIFHRWGLQAVVAGSVIAEPIVKIRFQGEVAAEIPATALSDNTPIYKREVLAEPPEYVQKAREWSCDR
IPPGTAEGIEIQGKLNSWSDILLQLLQVPTIASKRWVYRQYDHQVQNNTVVLPGDADATIVRLRPVAHQETPDQGVDSKT
AVAATIDCNSRYVYLDPYEGAKMTVAEAARNLSCVGAEPIAVTDNLNFGSPEKPIGYWQLAEACRGLSEACRHLQTPVTG
GNVSLYNETFDADGQPQPIYPTPVIGMVGLVPDLTKTCVQGWQADGDLIYLLGIPLDVQSDLVTLGATEYLASIHHQVAG
EPPHADLDLEAQVQATCRHGIQQGWLHSAHDCAEGGVAVALAESCISGQRGADIQVPTGSNRWDQVLFGEGGARIVISVS
ATHQAAWESYLQEHLPQYWQQIGTVTTPNSELTLTTNVHQTLIKVRIEEATQRWAQAIESKLA

Sequences:

>Translated_783_residues
MASPGSSPFSPEEIATEGLKPEEYDDIVQRLGRHPNRAELGMFGVMWSEHCCYKNSRPLLSQFPTEGKHVLVGPGENAGV
VDLGNGLQLAFKVESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGDLDDARTRRLFSGVVAGIAHYGNC
VGVPTVGGEVYFDPAYTGNPLVNAMAMGLMETAEIVKAGASGVGNPVLYVGSTTGRDGMGGASFASAELDATSEVEDRPA
VQVGDPFLEKSLIEACLEAFQTGAVVAAQDMGAAGLTCSTAEMAEKGGVGIDLDLDLIPNRETGMVPYEYLLSESQERML
FVAEKGREQELIDIFHRWGLQAVVAGSVIAEPIVKIRFQGEVAAEIPATALSDNTPIYKREVLAEPPEYVQKAREWSCDR
IPPGTAEGIEIQGKLNSWSDILLQLLQVPTIASKRWVYRQYDHQVQNNTVVLPGDADATIVRLRPVAHQETPDQGVDSKT
AVAATIDCNSRYVYLDPYEGAKMTVAEAARNLSCVGAEPIAVTDNLNFGSPEKPIGYWQLAEACRGLSEACRHLQTPVTG
GNVSLYNETFDADGQPQPIYPTPVIGMVGLVPDLTKTCVQGWQADGDLIYLLGIPLDVQSDLVTLGATEYLASIHHQVAG
EPPHADLDLEAQVQATCRHGIQQGWLHSAHDCAEGGVAVALAESCISGQRGADIQVPTGSNRWDQVLFGEGGARIVISVS
ATHQAAWESYLQEHLPQYWQQIGTVTTPNSELTLTTNVHQTLIKVRIEEATQRWAQAIESKLA
>Mature_782_residues
ASPGSSPFSPEEIATEGLKPEEYDDIVQRLGRHPNRAELGMFGVMWSEHCCYKNSRPLLSQFPTEGKHVLVGPGENAGVV
DLGNGLQLAFKVESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGDLDDARTRRLFSGVVAGIAHYGNCV
GVPTVGGEVYFDPAYTGNPLVNAMAMGLMETAEIVKAGASGVGNPVLYVGSTTGRDGMGGASFASAELDATSEVEDRPAV
QVGDPFLEKSLIEACLEAFQTGAVVAAQDMGAAGLTCSTAEMAEKGGVGIDLDLDLIPNRETGMVPYEYLLSESQERMLF
VAEKGREQELIDIFHRWGLQAVVAGSVIAEPIVKIRFQGEVAAEIPATALSDNTPIYKREVLAEPPEYVQKAREWSCDRI
PPGTAEGIEIQGKLNSWSDILLQLLQVPTIASKRWVYRQYDHQVQNNTVVLPGDADATIVRLRPVAHQETPDQGVDSKTA
VAATIDCNSRYVYLDPYEGAKMTVAEAARNLSCVGAEPIAVTDNLNFGSPEKPIGYWQLAEACRGLSEACRHLQTPVTGG
NVSLYNETFDADGQPQPIYPTPVIGMVGLVPDLTKTCVQGWQADGDLIYLLGIPLDVQSDLVTLGATEYLASIHHQVAGE
PPHADLDLEAQVQATCRHGIQQGWLHSAHDCAEGGVAVALAESCISGQRGADIQVPTGSNRWDQVLFGEGGARIVISVSA
THQAAWESYLQEHLPQYWQQIGTVTTPNSELTLTTNVHQTLIKVRIEEATQRWAQAIESKLA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=694, Percent_Identity=26.0806916426513, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI48994899, Length=797, Percent_Identity=25.9723964868256, Blast_Score=143, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17553022, Length=699, Percent_Identity=23.032904148784, Blast_Score=89, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321498, Length=850, Percent_Identity=22.1176470588235, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_ACAM1 (B0C6R3)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001516933.1
- ProteinModelPortal:   B0C6R3
- SMR:   B0C6R3
- GeneID:   5681424
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_2612
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   AMAR329726:AM1_2612-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 84127; Mature: 83995

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPGSSPFSPEEIATEGLKPEEYDDIVQRLGRHPNRAELGMFGVMWSEHCCYKNSRPLL
CCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCCCCHH
SQFPTEGKHVLVGPGENAGVVDLGNGLQLAFKVESHNHPSAVEPFQGAATGVGGILRDIF
HHCCCCCCEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
TMGARPIAVLNSLRFGDLDDARTRRLFSGVVAGIAHYGNCVGVPTVGGEVYFDPAYTGNP
HCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCH
LVNAMAMGLMETAEIVKAGASGVGNPVLYVGSTTGRDGMGGASFASAELDATSEVEDRPA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VQVGDPFLEKSLIEACLEAFQTGAVVAAQDMGAAGLTCSTAEMAEKGGVGIDLDLDLIPN
EECCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEECHHHHHHHCCCEEEEEEEECCC
RETGMVPYEYLLSESQERMLFVAEKGREQELIDIFHRWGLQAVVAGSVIAEPIVKIRFQG
CCCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHCCEEEEEECC
EVAAEIPATALSDNTPIYKREVLAEPPEYVQKAREWSCDRIPPGTAEGIEIQGKLNSWSD
CCCCCCCCHHCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHH
ILLQLLQVPTIASKRWVYRQYDHQVQNNTVVLPGDADATIVRLRPVAHQETPDQGVDSKT
HHHHHHHCCCHHHCCHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
AVAATIDCNSRYVYLDPYEGAKMTVAEAARNLSCVGAEPIAVTDNLNFGSPEKPIGYWQL
EEEEEEECCCEEEEECCCCCCEEEHHHHHCCCEECCCCCEEEECCCCCCCCCCCCHHHHH
AEACRGLSEACRHLQTPVTGGNVSLYNETFDADGQPQPIYPTPVIGMVGLVPDLTKTCVQ
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GWQADGDLIYLLGIPLDVQSDLVTLGATEYLASIHHQVAGEPPHADLDLEAQVQATCRHG
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
IQQGWLHSAHDCAEGGVAVALAESCISGQRGADIQVPTGSNRWDQVLFGEGGARIVISVS
HHHHCCCCHHHHHCCCEEHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCCCCEEEEEEE
ATHQAAWESYLQEHLPQYWQQIGTVTTPNSELTLTTNVHQTLIKVRIEEATQRWAQAIES
CHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
KLA
HCC
>Mature Secondary Structure 
ASPGSSPFSPEEIATEGLKPEEYDDIVQRLGRHPNRAELGMFGVMWSEHCCYKNSRPLL
CCCCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCCCCHH
SQFPTEGKHVLVGPGENAGVVDLGNGLQLAFKVESHNHPSAVEPFQGAATGVGGILRDIF
HHCCCCCCEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
TMGARPIAVLNSLRFGDLDDARTRRLFSGVVAGIAHYGNCVGVPTVGGEVYFDPAYTGNP
HCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCH
LVNAMAMGLMETAEIVKAGASGVGNPVLYVGSTTGRDGMGGASFASAELDATSEVEDRPA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VQVGDPFLEKSLIEACLEAFQTGAVVAAQDMGAAGLTCSTAEMAEKGGVGIDLDLDLIPN
EECCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEECHHHHHHHCCCEEEEEEEECCC
RETGMVPYEYLLSESQERMLFVAEKGREQELIDIFHRWGLQAVVAGSVIAEPIVKIRFQG
CCCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHCCEEEEEECC
EVAAEIPATALSDNTPIYKREVLAEPPEYVQKAREWSCDRIPPGTAEGIEIQGKLNSWSD
CCCCCCCCHHCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHH
ILLQLLQVPTIASKRWVYRQYDHQVQNNTVVLPGDADATIVRLRPVAHQETPDQGVDSKT
HHHHHHHCCCHHHCCHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
AVAATIDCNSRYVYLDPYEGAKMTVAEAARNLSCVGAEPIAVTDNLNFGSPEKPIGYWQL
EEEEEEECCCEEEEECCCCCCEEEHHHHHCCCEECCCCCEEEECCCCCCCCCCCCHHHHH
AEACRGLSEACRHLQTPVTGGNVSLYNETFDADGQPQPIYPTPVIGMVGLVPDLTKTCVQ
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GWQADGDLIYLLGIPLDVQSDLVTLGATEYLASIHHQVAGEPPHADLDLEAQVQATCRHG
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
IQQGWLHSAHDCAEGGVAVALAESCISGQRGADIQVPTGSNRWDQVLFGEGGARIVISVS
HHHHCCCCHHHHHCCCEEHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCCCCEEEEEEE
ATHQAAWESYLQEHLPQYWQQIGTVTTPNSELTLTTNVHQTLIKVRIEEATQRWAQAIES
CHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
KLA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA