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The map label for this gene is cysK [H]

Identifier: 158335567

GI number: 158335567

Start: 2422627

End: 2423571

Strand: Reverse

Name: cysK [H]

Synonym: AM1_2417

Alternate gene names: 158335567

Gene position: 2423571-2422627 (Counterclockwise)

Preceding gene: 158335568

Following gene: 158335566

Centisome position: 37.26

GC content: 52.8

Gene sequence:

>945_bases
ATGCGTATTGCCCACGATATTACCGAGCTGATTGGTAAAACGCCGCTCATTCAACTCAATCGCATTCCTGAATCGGAAGG
GTGCCTGGCCAAAATTATTATCAAGCTGGAGAGCCTGAATCCCTCCGCGTCGGTGAAAGATCGGATTGGCAGCAATATGA
TTGCCATTGCCGAAAAGCAAGGACTGATTCATCCCGGTATCACAGTGTTGGTGGAACCCACCTCTGGCAATACGGGAATT
GCCTTGGCGATGGTGGCGGCGGCCAAAGGCTATCGCCTGATCCTAACTATGCCAGAAACCATGAGTGCTGAGCGGCGGGC
AATGCTGCGGGCCTACGGGGCAGAGCTAGAGTTGACTCCAGGTACAGAAGGGATGCGGGGGTGTATTGAACGGGCTCAAG
AGTTGGTGGATACCCTACCCAATGCCTATATGCTCCAGCAGTTTCGCAATCCAGCCAATCCCCAAATTCATCGCCAAACC
ACAGCGGAAGAAATTTGGGCAGATACCGATGGCAAGGTAGATTTCCTCATTGCTGGCGTGGGCACTGGGGGCACCCTAAC
GGGAGTGGCAGAAGCCTTAAAGGCTCGCAAGAAATCATTTCAGGCCATCGCTGTGGAGCCTGAAGGCAGTCCAATTTTAT
CGGGCGGATCACCTGGTCCCCATAAAATTCAAGGGATCGGTGCGGGATTTGTGCCGCCTGTTTTAAAGGTGGATTTGATT
GATGAAGTGATCCTGGTCAAAGATGAAGATGCGATCACCTATGGTCGCCGACTTGCACGAGAAGAAGGGTTGCTATCTGG
GATCTCCTCCGGGGCCGCTTTATGTGCGGCCATCCAAGTGGCCAAACGACCTGAGAATAAGGACAAGCTGATTGTGATGA
TTCAGCCTAGCTTTGGTGAACGCTATCTCAGCACGCCTCTGTTTCACGAGGCGGAGTCGCACTAG

Upstream 100 bases:

>100_bases
ACAAATTGACCTGATGTATTACATCTAAGCTAAGAGCACAGCTCAGCTGCCTGGGCCGCGTTCTCTTCCTTGATTGCACT
GATAAGCAGAGACTGTCACT

Downstream 100 bases:

>100_bases
TCATGGCTAACGCTAGATTCGAGATAAGCTGAAACCTTTATTCTTGCGTGGGAGAATCTCCCAAGTGCTGAACTGGGGTT
AGGTAAGACATCCTGGCTGG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MRIAHDITELIGKTPLIQLNRIPESEGCLAKIIIKLESLNPSASVKDRIGSNMIAIAEKQGLIHPGITVLVEPTSGNTGI
ALAMVAAAKGYRLILTMPETMSAERRAMLRAYGAELELTPGTEGMRGCIERAQELVDTLPNAYMLQQFRNPANPQIHRQT
TAEEIWADTDGKVDFLIAGVGTGGTLTGVAEALKARKKSFQAIAVEPEGSPILSGGSPGPHKIQGIGAGFVPPVLKVDLI
DEVILVKDEDAITYGRRLAREEGLLSGISSGAALCAAIQVAKRPENKDKLIVMIQPSFGERYLSTPLFHEAESH

Sequences:

>Translated_314_residues
MRIAHDITELIGKTPLIQLNRIPESEGCLAKIIIKLESLNPSASVKDRIGSNMIAIAEKQGLIHPGITVLVEPTSGNTGI
ALAMVAAAKGYRLILTMPETMSAERRAMLRAYGAELELTPGTEGMRGCIERAQELVDTLPNAYMLQQFRNPANPQIHRQT
TAEEIWADTDGKVDFLIAGVGTGGTLTGVAEALKARKKSFQAIAVEPEGSPILSGGSPGPHKIQGIGAGFVPPVLKVDLI
DEVILVKDEDAITYGRRLAREEGLLSGISSGAALCAAIQVAKRPENKDKLIVMIQPSFGERYLSTPLFHEAESH
>Mature_314_residues
MRIAHDITELIGKTPLIQLNRIPESEGCLAKIIIKLESLNPSASVKDRIGSNMIAIAEKQGLIHPGITVLVEPTSGNTGI
ALAMVAAAKGYRLILTMPETMSAERRAMLRAYGAELELTPGTEGMRGCIERAQELVDTLPNAYMLQQFRNPANPQIHRQT
TAEEIWADTDGKVDFLIAGVGTGGTLTGVAEALKARKKSFQAIAVEPEGSPILSGGSPGPHKIQGIGAGFVPPVLKVDLI
DEVILVKDEDAITYGRRLAREEGLLSGISSGAALCAAIQVAKRPENKDKLIVMIQPSFGERYLSTPLFHEAESH

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=39.8089171974522, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=39.8089171974522, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=39.8089171974522, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=55.9748427672956, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=43.6065573770492, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17535051, Length=302, Percent_Identity=55.6291390728477, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=53.2467532467532, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=54.1528239202658, Blast_Score=306, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI115535073, Length=308, Percent_Identity=52.5974025974026, Blast_Score=303, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=52.9411764705882, Blast_Score=283, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=53.2710280373832, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17534315, Length=312, Percent_Identity=37.8205128205128, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=286, Percent_Identity=37.7622377622378, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=51.7241379310345, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=39.0476190476191, Blast_Score=208, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6321449, Length=338, Percent_Identity=34.6153846153846, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24643623, Length=301, Percent_Identity=41.5282392026578, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI20129101, Length=301, Percent_Identity=41.5282392026578, Blast_Score=206, Evalue=1e-53,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33630; Mature: 33630

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAHDITELIGKTPLIQLNRIPESEGCLAKIIIKLESLNPSASVKDRIGSNMIAIAEKQ
CCCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEHCCCCCCCHHHHHHCCCEEEEECCC
GLIHPGITVLVEPTSGNTGIALAMVAAAKGYRLILTMPETMSAERRAMLRAYGAELELTP
CCCCCCEEEEEECCCCCCCHHHHEEHHCCCCEEEEECCCHHCHHHHHHHHHHCCEEEECC
GTEGMRGCIERAQELVDTLPNAYMLQQFRNPANPQIHRQTTAEEIWADTDGKVDFLIAGV
CCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCEEEEEEEC
GTGGTLTGVAEALKARKKSFQAIAVEPEGSPILSGGSPGPHKIQGIGAGFVPPVLKVDLI
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCEEEECCCCCCCHHHHHHHH
DEVILVKDEDAITYGRRLAREEGLLSGISSGAALCAAIQVAKRPENKDKLIVMIQPSFGE
CEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
RYLSTPLFHEAESH
HHHCCCCCCCCCCC
>Mature Secondary Structure
MRIAHDITELIGKTPLIQLNRIPESEGCLAKIIIKLESLNPSASVKDRIGSNMIAIAEKQ
CCCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEHCCCCCCCHHHHHHCCCEEEEECCC
GLIHPGITVLVEPTSGNTGIALAMVAAAKGYRLILTMPETMSAERRAMLRAYGAELELTP
CCCCCCEEEEEECCCCCCCHHHHEEHHCCCCEEEEECCCHHCHHHHHHHHHHCCEEEECC
GTEGMRGCIERAQELVDTLPNAYMLQQFRNPANPQIHRQTTAEEIWADTDGKVDFLIAGV
CCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCEEEEEEEC
GTGGTLTGVAEALKARKKSFQAIAVEPEGSPILSGGSPGPHKIQGIGAGFVPPVLKVDLI
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCEEEECCCCCCCHHHHHHHH
DEVILVKDEDAITYGRRLAREEGLLSGISSGAALCAAIQVAKRPENKDKLIVMIQPSFGE
CEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
RYLSTPLFHEAESH
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]