Click here to switch to the map view.

The map label for this gene is ubiB [C]

Identifier: 158335532

GI number: 158335532

Start: 2383309

End: 2385303

Strand: Reverse

Name: ubiB [C]

Synonym: AM1_2380

Alternate gene names: 158335532

Gene position: 2385303-2383309 (Counterclockwise)

Preceding gene: 158335537

Following gene: 158335531

Centisome position: 36.68

GC content: 49.92

Gene sequence:

>1995_bases
ATGACCTTGGCTGAACCGACCTCCCCACAGTCCCCTTCTCTGCCCGCTGGCCCATCAACGGCCGATTTTTCTGGGGTAGC
CGTGGCCACTGAGAGCCCCTCGAACCTCACCTCAGCCATAGAGTTTGAGGCTTACGATCCAGCCAAGATTCAGCAAAAAT
TTCAAGGCCAAATTTTTCGAGTCCTCCAACGATGGGTCACCATCCTCTGGCCATTTCTTCTGCTCTTTGCCCGGCGTTGG
TGGGATAAGCGAACACCAACCTCCCCTGAACGGCAAAAGCGGCGAGCGGTCCAATTAAGAGAAACCCTCACCGCCCTAGG
GCCTGCTTTTATCAAAATTGGTCAGGCCTTATCCACGCGCCCCGATATCCTTACAGGTCCGTACTTAGAAGAATTATCTA
AACTCCAAGATCAGCTGCCAGCATTCTCGAATGAGATTGCCTACCGCTTTATCGAAGAAGAACTGGGACGCCCACCCCAA
GATTTGTATGCCCAATTAACCCCAGAACCCATTGCCGCTGCTTCCCTAGGCCAAGTTTACAAGGGGCAACTGCACTCTGG
AGAATGGGTGGCCGTCAAAGTTCAGCGCCCTGATCTGGCAGAACAGGTCACCCTTGATATCTATATTCTGCGGGGTCTTG
CCGCCTGGGTGCAGAAAAATAACAAATCCATCCGCAGCGATTTAGTCGGCATTCTGGATGAATTTGCCGGACGACTCTTT
GAAGAAGTCGATTATACCCAGGAAGGTCGCAACGCTGAGCGCTTTGCCCATCTGTATGAATACCTCCCTGAAATCTATAT
TCCTAAAATTTATTGGGAATATACCAATCGCCGGGTCTTGACCATGGAGTGGATCACGGGGACTAAACTCAATCAGCCCG
AGAAAATTCAGGCGCAAGGCATTGATGCGCGCCACCTGATTGACGTCGGTGTCAATTGCTCCCTGCGGCAGCTCCTAGAG
CATGGCTTTTTCCATGCAGATCCTCATCCGGGCAACCTGCTGGCTACACCAGATGGCAAGTTGGCCTACCTTGACTTCGG
CATGATGAGCGAAATCAAGCTTGAACAGCGCTATGGTCTGATTAACGCTATTGTCCACATCATTAATCGTGAATTTGAAG
CTTTAGCTCACGACTATGTCCACTTAGGCTTCCTAACTCCAGACACTAATTTAGAACCCATTATTCCGGCCCTAGGCGTA
GTCTTTAACAATGCTTTGGGGGCCAGCGTTGCGGAACTCAATATTCAGAGCATCTTTGATCAGCTGTCTGAAATTATGTA
TGAGTATCCGTTTCGGGTCCCGTCCTACTACGCCCTGATTGTGCGTTCCCTACTGACCATGGAAGGGATTGCCATTGGGG
TAGATAAAGACTTTAAAGTCTTGAGCGCTGCCTATCCCTATGTTGCCAAACGAATTTTGACGGATCCCGCTCCTGAACTC
CGGGAAAGTTTGAAAGACTTACTGTTTAAAGAAAATAGTTTTCGCTGGAATCGCCTCGAAAACCTGATGAAAAATGCCCG
CAACAACTTTGATTACGATCTAAGCGGCTCCCTAGACCAAGCCCTCGATTATCTATTCTCAGAACGAGGAGAACTGATCC
GAGATCGAATGGCGCAAGAGCTCGTCAATGGCATCGATGCTTTTGGGCAGACCACTTGGCATGGTTTGACGGCTAAATTC
CGAGAGCAGATGGGATGGGAGGTCGATGAAGCCTCAGTGGCTGACTTAGAGGCCAATTTTGGCCATATTCAACGCATTTT
TGGATTGTTGCAAGAAACGCCGGGTTTTGACCCTGTTAAGCTTGCCAGCGTGGTTCCGCCTTTGTTGGTTAAACCTGAAA
CCCAAGCCCTAGGCCAGCAAATTGCTACTGGTCTTTTGCAAAAAGCATTGGTACGGGTGATTCGAGAATTTCTTTTACCT
GAGTCGAGTGACGCTGCTGATGGGGCTAGGTATGCACCACCCGTCACTCTCTCCCCTCTGGCTAAGGCTAGCTAA

Upstream 100 bases:

>100_bases
TTAATTGTTACAATGCTTTACAAGAGACCGTATCTTACTGTGGCCTATGCCGTAACTATTCGATACGTCTAAAGCAACAT
TGTCTTAGATCTTTGTACCC

Downstream 100 bases:

>100_bases
GCCAGAGACTAAATAAGCAGATGAACAAAATTAATTACATAGAATTTCCTGGTTGTAAACTACCTGAGTCCTCTGTTTAC
ATCCATTGATTTGATGTTAT

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MTLAEPTSPQSPSLPAGPSTADFSGVAVATESPSNLTSAIEFEAYDPAKIQQKFQGQIFRVLQRWVTILWPFLLLFARRW
WDKRTPTSPERQKRRAVQLRETLTALGPAFIKIGQALSTRPDILTGPYLEELSKLQDQLPAFSNEIAYRFIEEELGRPPQ
DLYAQLTPEPIAAASLGQVYKGQLHSGEWVAVKVQRPDLAEQVTLDIYILRGLAAWVQKNNKSIRSDLVGILDEFAGRLF
EEVDYTQEGRNAERFAHLYEYLPEIYIPKIYWEYTNRRVLTMEWITGTKLNQPEKIQAQGIDARHLIDVGVNCSLRQLLE
HGFFHADPHPGNLLATPDGKLAYLDFGMMSEIKLEQRYGLINAIVHIINREFEALAHDYVHLGFLTPDTNLEPIIPALGV
VFNNALGASVAELNIQSIFDQLSEIMYEYPFRVPSYYALIVRSLLTMEGIAIGVDKDFKVLSAAYPYVAKRILTDPAPEL
RESLKDLLFKENSFRWNRLENLMKNARNNFDYDLSGSLDQALDYLFSERGELIRDRMAQELVNGIDAFGQTTWHGLTAKF
REQMGWEVDEASVADLEANFGHIQRIFGLLQETPGFDPVKLASVVPPLLVKPETQALGQQIATGLLQKALVRVIREFLLP
ESSDAADGARYAPPVTLSPLAKAS

Sequences:

>Translated_664_residues
MTLAEPTSPQSPSLPAGPSTADFSGVAVATESPSNLTSAIEFEAYDPAKIQQKFQGQIFRVLQRWVTILWPFLLLFARRW
WDKRTPTSPERQKRRAVQLRETLTALGPAFIKIGQALSTRPDILTGPYLEELSKLQDQLPAFSNEIAYRFIEEELGRPPQ
DLYAQLTPEPIAAASLGQVYKGQLHSGEWVAVKVQRPDLAEQVTLDIYILRGLAAWVQKNNKSIRSDLVGILDEFAGRLF
EEVDYTQEGRNAERFAHLYEYLPEIYIPKIYWEYTNRRVLTMEWITGTKLNQPEKIQAQGIDARHLIDVGVNCSLRQLLE
HGFFHADPHPGNLLATPDGKLAYLDFGMMSEIKLEQRYGLINAIVHIINREFEALAHDYVHLGFLTPDTNLEPIIPALGV
VFNNALGASVAELNIQSIFDQLSEIMYEYPFRVPSYYALIVRSLLTMEGIAIGVDKDFKVLSAAYPYVAKRILTDPAPEL
RESLKDLLFKENSFRWNRLENLMKNARNNFDYDLSGSLDQALDYLFSERGELIRDRMAQELVNGIDAFGQTTWHGLTAKF
REQMGWEVDEASVADLEANFGHIQRIFGLLQETPGFDPVKLASVVPPLLVKPETQALGQQIATGLLQKALVRVIREFLLP
ESSDAADGARYAPPVTLSPLAKAS
>Mature_663_residues
TLAEPTSPQSPSLPAGPSTADFSGVAVATESPSNLTSAIEFEAYDPAKIQQKFQGQIFRVLQRWVTILWPFLLLFARRWW
DKRTPTSPERQKRRAVQLRETLTALGPAFIKIGQALSTRPDILTGPYLEELSKLQDQLPAFSNEIAYRFIEEELGRPPQD
LYAQLTPEPIAAASLGQVYKGQLHSGEWVAVKVQRPDLAEQVTLDIYILRGLAAWVQKNNKSIRSDLVGILDEFAGRLFE
EVDYTQEGRNAERFAHLYEYLPEIYIPKIYWEYTNRRVLTMEWITGTKLNQPEKIQAQGIDARHLIDVGVNCSLRQLLEH
GFFHADPHPGNLLATPDGKLAYLDFGMMSEIKLEQRYGLINAIVHIINREFEALAHDYVHLGFLTPDTNLEPIIPALGVV
FNNALGASVAELNIQSIFDQLSEIMYEYPFRVPSYYALIVRSLLTMEGIAIGVDKDFKVLSAAYPYVAKRILTDPAPELR
ESLKDLLFKENSFRWNRLENLMKNARNNFDYDLSGSLDQALDYLFSERGELIRDRMAQELVNGIDAFGQTTWHGLTAKFR
EQMGWEVDEASVADLEANFGHIQRIFGLLQETPGFDPVKLASVVPPLLVKPETQALGQQIATGLLQKALVRVIREFLLPE
SSDAADGARYAPPVTLSPLAKAS

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=34.4444444444444, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI40254938, Length=273, Percent_Identity=32.967032967033, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI217035081, Length=256, Percent_Identity=30.46875, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI27363457, Length=308, Percent_Identity=30.8441558441558, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI34147522, Length=305, Percent_Identity=28.1967213114754, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI217416386, Length=242, Percent_Identity=32.6446280991736, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI2367309, Length=405, Percent_Identity=27.4074074074074, Blast_Score=164, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17559152, Length=267, Percent_Identity=32.5842696629214, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI32565180, Length=330, Percent_Identity=24.8484848484848, Blast_Score=87, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323282, Length=270, Percent_Identity=28.8888888888889, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325148, Length=292, Percent_Identity=26.027397260274, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=251, Percent_Identity=26.2948207171315, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24662575, Length=270, Percent_Identity=34.4444444444444, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI22024280, Length=312, Percent_Identity=28.2051282051282, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI18859849, Length=259, Percent_Identity=29.7297297297297, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 74861; Mature: 74730

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAEPTSPQSPSLPAGPSTADFSGVAVATESPSNLTSAIEFEAYDPAKIQQKFQGQIFR
CCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHEEECCCCHHHHHHHHHHHHHH
VLQRWVTILWPFLLLFARRWWDKRTPTSPERQKRRAVQLRETLTALGPAFIKIGQALSTR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDILTGPYLEELSKLQDQLPAFSNEIAYRFIEEELGRPPQDLYAQLTPEPIAAASLGQVY
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHH
KGQLHSGEWVAVKVQRPDLAEQVTLDIYILRGLAAWVQKNNKSIRSDLVGILDEFAGRLF
HCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EEVDYTQEGRNAERFAHLYEYLPEIYIPKIYWEYTNRRVLTMEWITGTKLNQPEKIQAQG
HHHHHHHCCCCHHHHHHHHHHHHHHHCCHHEEEECCCEEEEEEEECCCCCCCCCHHHHCC
IDARHLIDVGVNCSLRQLLEHGFFHADPHPGNLLATPDGKLAYLDFGMMSEIKLEQRYGL
CCHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHH
INAIVHIINREFEALAHDYVHLGFLTPDTNLEPIIPALGVVFNNALGASVAELNIQSIFD
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
QLSEIMYEYPFRVPSYYALIVRSLLTMEGIAIGVDKDFKVLSAAYPYVAKRILTDPAPEL
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHCCCCHHH
RESLKDLLFKENSFRWNRLENLMKNARNNFDYDLSGSLDQALDYLFSERGELIRDRMAQE
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVNGIDAFGQTTWHGLTAKFREQMGWEVDEASVADLEANFGHIQRIFGLLQETPGFDPVK
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCHH
LASVVPPLLVKPETQALGQQIATGLLQKALVRVIREFLLPESSDAADGARYAPPVTLSPL
HHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
AKAS
CCCC
>Mature Secondary Structure 
TLAEPTSPQSPSLPAGPSTADFSGVAVATESPSNLTSAIEFEAYDPAKIQQKFQGQIFR
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHEEECCCCHHHHHHHHHHHHHH
VLQRWVTILWPFLLLFARRWWDKRTPTSPERQKRRAVQLRETLTALGPAFIKIGQALSTR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDILTGPYLEELSKLQDQLPAFSNEIAYRFIEEELGRPPQDLYAQLTPEPIAAASLGQVY
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHH
KGQLHSGEWVAVKVQRPDLAEQVTLDIYILRGLAAWVQKNNKSIRSDLVGILDEFAGRLF
HCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EEVDYTQEGRNAERFAHLYEYLPEIYIPKIYWEYTNRRVLTMEWITGTKLNQPEKIQAQG
HHHHHHHCCCCHHHHHHHHHHHHHHHCCHHEEEECCCEEEEEEEECCCCCCCCCHHHHCC
IDARHLIDVGVNCSLRQLLEHGFFHADPHPGNLLATPDGKLAYLDFGMMSEIKLEQRYGL
CCHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHH
INAIVHIINREFEALAHDYVHLGFLTPDTNLEPIIPALGVVFNNALGASVAELNIQSIFD
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
QLSEIMYEYPFRVPSYYALIVRSLLTMEGIAIGVDKDFKVLSAAYPYVAKRILTDPAPEL
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHCCCCHHH
RESLKDLLFKENSFRWNRLENLMKNARNNFDYDLSGSLDQALDYLFSERGELIRDRMAQE
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVNGIDAFGQTTWHGLTAKFREQMGWEVDEASVADLEANFGHIQRIFGLLQETPGFDPVK
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCHH
LASVVPPLLVKPETQALGQQIATGLLQKALVRVIREFLLPESSDAADGARYAPPVTLSPL
HHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
AKAS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]