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The map label for this gene is glmS [H]

Identifier: 158335527

GI number: 158335527

Start: 2378855

End: 2379892

Strand: Direct

Name: glmS [H]

Synonym: AM1_2375

Alternate gene names: 158335527

Gene position: 2378855-2379892 (Clockwise)

Preceding gene: 158335526

Following gene: 158335529

Centisome position: 36.58

GC content: 49.81

Gene sequence:

>1038_bases
ATGAGTTACCAATCGGATGTGCTGGAACAACCTCAAGTTCTACACCAGCTAATTCACACCTATCAGCACCATACCGTTTG
GTCTCTCTTATCTGAATATCCTCAGAGGTCCATTCTTTTAACAGGCATGGGGGCTTCCTACAATGCCCTCTATCCAGCTT
GGTTTTACCTGAACCAGCAGGGTAAAACAGCCCTTCATCTCGAAACCTCTACCTTAATTCACTACCTTCCGACTCTGCTA
GAGAGACCAAGCCTGATCGTGGCCGCCTCTCAATCGGGAGAAAGTATTGAACTCCAGAAATTAGTGGCGCAAATTGAAGC
TCAACGCCATCAAAGTTCACAGCCCCCTGTGCTGATTAGCGTTACGAACTCCCCACAAAATACCTTGGCAGATCATAGTG
ATGTGGCATTACCCACGGCAGCCGGTCCCGAAGTTGGGATTGCCACCAAAACCTATACCAGCTCGATGTTAGTGCTTCAC
TTTATCGCCAGGGCATTAGCTGGCCAGCTCTACCCTCAAGACTTTGAGTATGGGGATGAGATCGCATCCCAAGCTCAAAC
CTTTCTCCAAAAGCGTCAAACCGACATCTCCAAAGCGTTTAATGTCCTAAAGGCAAGTACCTACATCAGCATTATTGGCC
GTGGTCCAGCCTTAGCAACAGCCAACAATGCCGCCTTAATGCTCAAAGAAGGGGTTCGCATACCCGCTGAGGGCTATTCG
GGCGGGCAGTTCCGCCATGGACCGCGAGAAATGATTGCCCCTCAGATCGGTTCGATTGTCTTAACCAGCCCTGATACCAC
CCTGGGCATCAACCAACGCCTTGCAGCCGATATTGTCGAGTATGGCGGGCCAGTGGTTTGCATCGGCCAACCCACCATCG
GGACAACCCATATTCCGCTGCCTGAGATTGAAGATATTTTTCTCCATCCCCTGTTAGAGATTTTGCCGATTCAGCGACTA
GTTGCCCAGTTAGCAGATCAACAAAATATGACGCCTGGAGAATTTCGCTGGTCAGGCAAAGTCGTTGATCAAGAATAG

Upstream 100 bases:

>100_bases
CCGCCCAACTCAGTCCTGAACAACAAAAAGCTTGTACGCCTGCTCCTCTAGAAGGCAAAGATATTCCGGCAGGCGCTCCT
ATTGGCTCAGACCCTACCCC

Downstream 100 bases:

>100_bases
CCGTTACTCTTAAAGCATAAGCGCTCTCAGATTTCTGAGAGCGCTTAAATCATTGTTATCGAGCAATTTTTGGAGATAGC
GACGTTGAAACCTAGCTCAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSYQSDVLEQPQVLHQLIHTYQHHTVWSLLSEYPQRSILLTGMGASYNALYPAWFYLNQQGKTALHLETSTLIHYLPTLL
ERPSLIVAASQSGESIELQKLVAQIEAQRHQSSQPPVLISVTNSPQNTLADHSDVALPTAAGPEVGIATKTYTSSMLVLH
FIARALAGQLYPQDFEYGDEIASQAQTFLQKRQTDISKAFNVLKASTYISIIGRGPALATANNAALMLKEGVRIPAEGYS
GGQFRHGPREMIAPQIGSIVLTSPDTTLGINQRLAADIVEYGGPVVCIGQPTIGTTHIPLPEIEDIFLHPLLEILPIQRL
VAQLADQQNMTPGEFRWSGKVVDQE

Sequences:

>Translated_345_residues
MSYQSDVLEQPQVLHQLIHTYQHHTVWSLLSEYPQRSILLTGMGASYNALYPAWFYLNQQGKTALHLETSTLIHYLPTLL
ERPSLIVAASQSGESIELQKLVAQIEAQRHQSSQPPVLISVTNSPQNTLADHSDVALPTAAGPEVGIATKTYTSSMLVLH
FIARALAGQLYPQDFEYGDEIASQAQTFLQKRQTDISKAFNVLKASTYISIIGRGPALATANNAALMLKEGVRIPAEGYS
GGQFRHGPREMIAPQIGSIVLTSPDTTLGINQRLAADIVEYGGPVVCIGQPTIGTTHIPLPEIEDIFLHPLLEILPIQRL
VAQLADQQNMTPGEFRWSGKVVDQE
>Mature_344_residues
SYQSDVLEQPQVLHQLIHTYQHHTVWSLLSEYPQRSILLTGMGASYNALYPAWFYLNQQGKTALHLETSTLIHYLPTLLE
RPSLIVAASQSGESIELQKLVAQIEAQRHQSSQPPVLISVTNSPQNTLADHSDVALPTAAGPEVGIATKTYTSSMLVLHF
IARALAGQLYPQDFEYGDEIASQAQTFLQKRQTDISKAFNVLKASTYISIIGRGPALATANNAALMLKEGVRIPAEGYSG
GQFRHGPREMIAPQIGSIVLTSPDTTLGINQRLAADIVEYGGPVVCIGQPTIGTTHIPLPEIEDIFLHPLLEILPIQRLV
AQLADQQNMTPGEFRWSGKVVDQE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:
GO:0004360: Glucosamine--fructose-6-phosphate aminotransferase, isomerizing
GO:0005529: Glucosamine--fructose-6-phosphate aminotransferase, isomerizing
GO:0005737: Glucosamine--fructose-6-phosphate aminotransferase, isomerizing
GO:0005975: Glucosamine--fructose-6-phosphate aminotransferase, isomerizing
GO:0008152: Glucosamine--fructose-6-phosphate aminotransferase, isomerizing
GO:0008483: Glucosamine--fructose-6-phosphate aminotransferase, isomerizing
GO:0016051: Glucosamine--fructose-6-phosphate aminotransferase, isomerizing
GO:0016740: Glucosamine--fructose-6-phosphate aminotransferase, isomerizing

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=302, Percent_Identity=24.8344370860927, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790167, Length=348, Percent_Identity=25, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532899, Length=305, Percent_Identity=23.9344262295082, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532897, Length=305, Percent_Identity=23.9344262295082, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357745, Length=304, Percent_Identity=24.3421052631579, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 37807; Mature: 37675

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQSDVLEQPQVLHQLIHTYQHHTVWSLLSEYPQRSILLTGMGASYNALYPAWFYLNQQ
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCC
GKTALHLETSTLIHYLPTLLERPSLIVAASQSGESIELQKLVAQIEAQRHQSSQPPVLIS
CCEEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
VTNSPQNTLADHSDVALPTAAGPEVGIATKTYTSSMLVLHFIARALAGQLYPQDFEYGDE
ECCCCCHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
IASQAQTFLQKRQTDISKAFNVLKASTYISIIGRGPALATANNAALMLKEGVRIPAEGYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCCEEEEECCCCCCCCCCC
GGQFRHGPREMIAPQIGSIVLTSPDTTLGINQRLAADIVEYGGPVVCIGQPTIGTTHIPL
CCCCCCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
PEIEDIFLHPLLEILPIQRLVAQLADQQNMTPGEFRWSGKVVDQE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCEECCCC
>Mature Secondary Structure 
SYQSDVLEQPQVLHQLIHTYQHHTVWSLLSEYPQRSILLTGMGASYNALYPAWFYLNQQ
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCC
GKTALHLETSTLIHYLPTLLERPSLIVAASQSGESIELQKLVAQIEAQRHQSSQPPVLIS
CCEEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
VTNSPQNTLADHSDVALPTAAGPEVGIATKTYTSSMLVLHFIARALAGQLYPQDFEYGDE
ECCCCCHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
IASQAQTFLQKRQTDISKAFNVLKASTYISIIGRGPALATANNAALMLKEGVRIPAEGYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCCEEEEECCCCCCCCCCC
GGQFRHGPREMIAPQIGSIVLTSPDTTLGINQRLAADIVEYGGPVVCIGQPTIGTTHIPL
CCCCCCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
PEIEDIFLHPLLEILPIQRLVAQLADQQNMTPGEFRWSGKVVDQE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA