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The map label for this gene is kmo [H]

Identifier: 158335509

GI number: 158335509

Start: 2359414

End: 2360691

Strand: Reverse

Name: kmo [H]

Synonym: AM1_2357

Alternate gene names: 158335509

Gene position: 2360691-2359414 (Counterclockwise)

Preceding gene: 158335510

Following gene: 158335508

Centisome position: 36.3

GC content: 47.42

Gene sequence:

>1278_bases
GTGGCTGATCGGCATGTTGTGATTGTGGGAGCAGGTCCTGCTGGGCTTTTACTAGCGGTATACCTGTTAAAACGACCTGG
ATATCGAGTCAGCGTGTTTGAGCAGCGGGCTGACCCTAGGCTAACCCCACAAGTACAGAATCGAACCTTTCCCATTTCAT
TGCAGGAGCGGGGGCAACAGGCCCTTCGCTCAATATCTGGCCTGGAACAGGCTGTTGCCGATCGCAGCACGGTTTGTAAT
GGCACGATCATGCATCAAGCTTCCGGGAAGAGCCGGGCCATTCCTCGCAAGATGTCTAGCTTGATGATTGATCGCTTACA
GATGGTGATGGTCTTGCTTCAGTTTTTATCAGACCAGTACTCATCTGATCAGTTGGTCATCCAGTTTAATTGTCGATGTA
CTCACCTCAATTCAGCCGCGCAAACTCTTCAATTTGAGCAACCCGACGGTGAAGTCATCACCCATACCTATGATGTCGTT
GTGGGGGCAGATGGGGCTCGTTCAAAGTTAAGAGAGGCATTGGTTGAACAGGTTAACTTCCCCTGCGAACAAACTTTAAT
TCCCGATGCCTATAAATCAGTCTTTCTGACTCAGCCAGAAGATGGTGCACCACTGGCTGTGGATAAAGTCCATACCTTGA
ATTTACCCAACAATGTCCGCATGATGTTGGTCCCTCAGGGAAATACACAGCTCAATGGTGTGCTGGTTTTTAAGCGTGAC
CATAGCCCCATCGCCCAATACAACACCAAAGAAGAGATCCTGGCCTTTGTCCAAGAGAATTTTCCCCGGTTTGGTGCACT
GATGACTCTGGATGAAGCAGACGCATTATTGTCACGGCCTGTGGCAAACGTTACCACAGTTCGATGCCAACGGTTTCATG
AAGGTTCGAATATTCTCTTAATTGGAGATGCCGTTCATGCGGTGTCGGCTTCCATTGGTCAAGGCTGTAATTCTGCGCTG
CAAGATGTGTGGGTGTTTAATCAACTCCTAGATCAACACCAAGATAACTGGTCTCAGACCCTACCAGCGTTCTCAGACCA
AAGAATTCCCGAAGTTCATGCCCTTCGAGAACTGTCAGACTATTCTTTTCCCCGCAATAAGTTGCTTGTGACTGAGTTTA
TCTTGCGACTTCAACTTGGCCGTATCCTCAATCGCTGGTTTCCCAAACGATTTCCTCCATTTCTATTTGACCTTATATTT
GACTCCGATCTTCCCTATTCTGAAGTTCTCAAAATTCATCAAGGTTGGATTAATAAAGTTAAAGCATCAACCCGTTAG

Upstream 100 bases:

>100_bases
TGACGTAAGCGCCTGGGATTTCCTGTGCATTGATAACGCTGTGATTTTCAGTGAAATGGGATAATTGGCACATGTTCTGA
TTCCTTAGAGCAGGTACATT

Downstream 100 bases:

>100_bases
AGATGACATTATGTTGATGCTGGATGAACGAGAATCGTCCGCCATTTTTTTATCTTAAAAATTATTCTCGAAAATAATAT
TGACAGCCATTTACTCAAGA

Product: kynurenine 3-monooxygenase

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MADRHVVIVGAGPAGLLLAVYLLKRPGYRVSVFEQRADPRLTPQVQNRTFPISLQERGQQALRSISGLEQAVADRSTVCN
GTIMHQASGKSRAIPRKMSSLMIDRLQMVMVLLQFLSDQYSSDQLVIQFNCRCTHLNSAAQTLQFEQPDGEVITHTYDVV
VGADGARSKLREALVEQVNFPCEQTLIPDAYKSVFLTQPEDGAPLAVDKVHTLNLPNNVRMMLVPQGNTQLNGVLVFKRD
HSPIAQYNTKEEILAFVQENFPRFGALMTLDEADALLSRPVANVTTVRCQRFHEGSNILLIGDAVHAVSASIGQGCNSAL
QDVWVFNQLLDQHQDNWSQTLPAFSDQRIPEVHALRELSDYSFPRNKLLVTEFILRLQLGRILNRWFPKRFPPFLFDLIF
DSDLPYSEVLKIHQGWINKVKASTR

Sequences:

>Translated_425_residues
MADRHVVIVGAGPAGLLLAVYLLKRPGYRVSVFEQRADPRLTPQVQNRTFPISLQERGQQALRSISGLEQAVADRSTVCN
GTIMHQASGKSRAIPRKMSSLMIDRLQMVMVLLQFLSDQYSSDQLVIQFNCRCTHLNSAAQTLQFEQPDGEVITHTYDVV
VGADGARSKLREALVEQVNFPCEQTLIPDAYKSVFLTQPEDGAPLAVDKVHTLNLPNNVRMMLVPQGNTQLNGVLVFKRD
HSPIAQYNTKEEILAFVQENFPRFGALMTLDEADALLSRPVANVTTVRCQRFHEGSNILLIGDAVHAVSASIGQGCNSAL
QDVWVFNQLLDQHQDNWSQTLPAFSDQRIPEVHALRELSDYSFPRNKLLVTEFILRLQLGRILNRWFPKRFPPFLFDLIF
DSDLPYSEVLKIHQGWINKVKASTR
>Mature_424_residues
ADRHVVIVGAGPAGLLLAVYLLKRPGYRVSVFEQRADPRLTPQVQNRTFPISLQERGQQALRSISGLEQAVADRSTVCNG
TIMHQASGKSRAIPRKMSSLMIDRLQMVMVLLQFLSDQYSSDQLVIQFNCRCTHLNSAAQTLQFEQPDGEVITHTYDVVV
GADGARSKLREALVEQVNFPCEQTLIPDAYKSVFLTQPEDGAPLAVDKVHTLNLPNNVRMMLVPQGNTQLNGVLVFKRDH
SPIAQYNTKEEILAFVQENFPRFGALMTLDEADALLSRPVANVTTVRCQRFHEGSNILLIGDAVHAVSASIGQGCNSALQ
DVWVFNQLLDQHQDNWSQTLPAFSDQRIPEVHALRELSDYSFPRNKLLVTEFILRLQLGRILNRWFPKRFPPFLFDLIFD
SDLPYSEVLKIHQGWINKVKASTR

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily [H]

Homologues:

Organism=Homo sapiens, GI187960045, Length=425, Percent_Identity=29.1764705882353, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17562934, Length=441, Percent_Identity=25.8503401360544, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319372, Length=424, Percent_Identity=25.7075471698113, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28573964, Length=418, Percent_Identity=26.555023923445, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: =1.14.13.9 [H]

Molecular weight: Translated: 47844; Mature: 47712

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRHVVIVGAGPAGLLLAVYLLKRPGYRVSVFEQRADPRLTPQVQNRTFPISLQERGQQ
CCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECEEHHHHHHH
ALRSISGLEQAVADRSTVCNGTIMHQASGKSRAIPRKMSSLMIDRLQMVMVLLQFLSDQY
HHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSDQLVIQFNCRCTHLNSAAQTLQFEQPDGEVITHTYDVVVGADGARSKLREALVEQVNF
CCCCEEEEEECEEEECCHHHHHEEEECCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHCC
PCEQTLIPDAYKSVFLTQPEDGAPLAVDKVHTLNLPNNVRMMLVPQGNTQLNGVLVFKRD
CHHHCCCCHHHHHEEEECCCCCCCEEECCEEEECCCCCCEEEEEECCCCCEEEEEEEEEC
HSPIAQYNTKEEILAFVQENFPRFGALMTLDEADALLSRPVANVTTVRCQRFHEGSNILL
CCCHHHCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHHCCCHHHHHHHHHHHCCCCCEEE
IGDAVHAVSASIGQGCNSALQDVWVFNQLLDQHQDNWSQTLPAFSDQRIPEVHALRELSD
EECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHH
YSFPRNKLLVTEFILRLQLGRILNRWFPKRFPPFLFDLIFDSDLPYSEVLKIHQGWINKV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KASTR
HCCCC
>Mature Secondary Structure 
ADRHVVIVGAGPAGLLLAVYLLKRPGYRVSVFEQRADPRLTPQVQNRTFPISLQERGQQ
CCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECEEHHHHHHH
ALRSISGLEQAVADRSTVCNGTIMHQASGKSRAIPRKMSSLMIDRLQMVMVLLQFLSDQY
HHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSDQLVIQFNCRCTHLNSAAQTLQFEQPDGEVITHTYDVVVGADGARSKLREALVEQVNF
CCCCEEEEEECEEEECCHHHHHEEEECCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHCC
PCEQTLIPDAYKSVFLTQPEDGAPLAVDKVHTLNLPNNVRMMLVPQGNTQLNGVLVFKRD
CHHHCCCCHHHHHEEEECCCCCCCEEECCEEEECCCCCCEEEEEECCCCCEEEEEEEEEC
HSPIAQYNTKEEILAFVQENFPRFGALMTLDEADALLSRPVANVTTVRCQRFHEGSNILL
CCCHHHCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHHCCCHHHHHHHHHHHCCCCCEEE
IGDAVHAVSASIGQGCNSALQDVWVFNQLLDQHQDNWSQTLPAFSDQRIPEVHALRELSD
EECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHH
YSFPRNKLLVTEFILRLQLGRILNRWFPKRFPPFLFDLIFDSDLPYSEVLKIHQGWINKV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KASTR
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA