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The map label for this gene is ndhA

Identifier: 158335314

GI number: 158335314

Start: 2154553

End: 2155671

Strand: Direct

Name: ndhA

Synonym: AM1_2158

Alternate gene names: 158335314

Gene position: 2154553-2155671 (Clockwise)

Preceding gene: 158335313

Following gene: 158335315

Centisome position: 33.13

GC content: 48.88

Gene sequence:

>1119_bases
ATGAACCCAGGTATTGATCTTGAACAACGCTTTGTTGAAACTTTAATGGAATTGGGGTTAACCCCCGGTGTCGCCAAAAC
CATTTGGCTTCCGATCCCCATGTTGTTGATGATTATCGGCGCAACAGTGGGAGTCCTGGTTTCGGTTTGGCTAGAACGAA
AAATTTCAGCGGCGGCTCAGCAACGGATTGGCCCCGAATATATTGGACCGCTGGGCATCCTAGCGCCAGTGGCAGACGGC
ATCAAACTCGTCTTTAAAGAAGACATTGTGCCAGCCAATACCGACCCCTGGCTTTTTACGTTAGGTCCCATCCTGGTCGT
CATCCCTGTCTTTTTCTCCTATCTGATTGTCCCGTTTGGTCAGAATATTCTGATTACAGACCTAGGGATTGGCATCTTTT
TCTGGATTGCCTTATCTAGCATTGCGCCAATCGGTCTGCTAATGGCGGGATATTCCTCCAATAACAAGTACTCTTTGCTG
GGTGGACTCCGAGCTGCAGCCCAATCCATCAGCTATGAAATCCCACTGGCCTTAGCAGTCTTGGCTGTGGTGATGATGTC
CAACAGCCTCAGCACCATTGACATTGTTAACCAGCAATCAGGCTATGGCATCCTCGGATGGAACGTTATTCGCCAGCCCA
TTGGGTTCATGTTGTTTTGGATTGCAGCCTTGGCGGAATGTGAACGTCTCCCTTTTGACTTACCCGAAGCGGAAGAAGAA
TTGGTGGCCGGTTACCAAACCGAATATGCAGGCATGAAGTTTGCTCTGTTCTATTTGGGGTCCTACGTCAACCTCGTACT
GTCCTCAATTCTGGTAGCGGTCCTCTACTTTGGCGGTTGGGACCTCCCCATTCCAGCAACCATGATTGCAGACTGGATTA
ATGTCGATCCCAACAATGCCATTTTTGAGTTAGTGACGGCTGGCCTAGGCTTGGTAATGACCCTGCTGAAAGCCTATTTC
TTCCTGTTCCTAGCTATTTTGTTGCGCTGGACCGTTCCTCGAGTCCGTATTGACCAGCTTTTAGATTTTGGTTGGAAATT
TTTACTGCCTGTGGGATTGGTGAACCTCCTTCTCACCGCCGGTCTGAAATTAGCGTTTCCTTTTGCCTTTGGTGGATAG

Upstream 100 bases:

>100_bases
GGAGCATGAAGTTATTCTCCTAGAAACTCGCCTAGGCGTATATACTGGTTTAGGCATCAAGAAACTTTACAAATCATAAA
TTCAGTAAGAATGGGCGGCA

Downstream 100 bases:

>100_bases
GCACAAGGTAAATTTTCTAAACTTAAAACTAACGCCAGCCTTCATCTGCCGACATCTGAGAGTGAACATCCATGCTCAAG
TTTCTGAATCAAGTCACCAG

Product: NADH dehydrogenase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit 1; NDH-1 subunit 1; NDH-A

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNPGIDLEQRFVETLMELGLTPGVAKTIWLPIPMLLMIIGATVGVLVSVWLERKISAAAQQRIGPEYIGPLGILAPVADG
IKLVFKEDIVPANTDPWLFTLGPILVVIPVFFSYLIVPFGQNILITDLGIGIFFWIALSSIAPIGLLMAGYSSNNKYSLL
GGLRAAAQSISYEIPLALAVLAVVMMSNSLSTIDIVNQQSGYGILGWNVIRQPIGFMLFWIAALAECERLPFDLPEAEEE
LVAGYQTEYAGMKFALFYLGSYVNLVLSSILVAVLYFGGWDLPIPATMIADWINVDPNNAIFELVTAGLGLVMTLLKAYF
FLFLAILLRWTVPRVRIDQLLDFGWKFLLPVGLVNLLLTAGLKLAFPFAFGG

Sequences:

>Translated_372_residues
MNPGIDLEQRFVETLMELGLTPGVAKTIWLPIPMLLMIIGATVGVLVSVWLERKISAAAQQRIGPEYIGPLGILAPVADG
IKLVFKEDIVPANTDPWLFTLGPILVVIPVFFSYLIVPFGQNILITDLGIGIFFWIALSSIAPIGLLMAGYSSNNKYSLL
GGLRAAAQSISYEIPLALAVLAVVMMSNSLSTIDIVNQQSGYGILGWNVIRQPIGFMLFWIAALAECERLPFDLPEAEEE
LVAGYQTEYAGMKFALFYLGSYVNLVLSSILVAVLYFGGWDLPIPATMIADWINVDPNNAIFELVTAGLGLVMTLLKAYF
FLFLAILLRWTVPRVRIDQLLDFGWKFLLPVGLVNLLLTAGLKLAFPFAFGG
>Mature_372_residues
MNPGIDLEQRFVETLMELGLTPGVAKTIWLPIPMLLMIIGATVGVLVSVWLERKISAAAQQRIGPEYIGPLGILAPVADG
IKLVFKEDIVPANTDPWLFTLGPILVVIPVFFSYLIVPFGQNILITDLGIGIFFWIALSSIAPIGLLMAGYSSNNKYSLL
GGLRAAAQSISYEIPLALAVLAVVMMSNSLSTIDIVNQQSGYGILGWNVIRQPIGFMLFWIAALAECERLPFDLPEAEEE
LVAGYQTEYAGMKFALFYLGSYVNLVLSSILVAVLYFGGWDLPIPATMIADWINVDPNNAIFELVTAGLGLVMTLLKAYF
FLFLAILLRWTVPRVRIDQLLDFGWKFLLPVGLVNLLLTAGLKLAFPFAFGG

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=34.3137254901961, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1788618, Length=340, Percent_Identity=42.0588235294118, Blast_Score=244, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU1C_ACAM1 (B0BZW2)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001516486.1
- GeneID:   5680972
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_2158
- HOGENOM:   HBG727670
- OMA:   IFWICAL
- ProtClustDB:   PRK06076
- BioCyc:   AMAR329726:AM1_2158-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: 1.6.5.3

Molecular weight: Translated: 40678; Mature: 40678

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf317628)-; HASH(0xed1a578)-; HASH(0xdeb2328)-; HASH(0xed1a2d8)-; HASH(0xed1b274)-; HASH(0xed19cfc)-; HASH(0xed1ab90)-; HASH(0xed19f78)-; HASH(0xed1acf8)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPGIDLEQRFVETLMELGLTPGVAKTIWLPIPMLLMIIGATVGVLVSVWLERKISAAAQ
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYIGPLGILAPVADGIKLVFKEDIVPANTDPWLFTLGPILVVIPVFFSYLIVPFG
HCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
QNILITDLGIGIFFWIALSSIAPIGLLMAGYSSNNKYSLLGGLRAAAQSISYEIPLALAV
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAVVMMSNSLSTIDIVNQQSGYGILGWNVIRQPIGFMLFWIAALAECERLPFDLPEAEEE
HHHHHHCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LVAGYQTEYAGMKFALFYLGSYVNLVLSSILVAVLYFGGWDLPIPATMIADWINVDPNNA
HHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHH
IFELVTAGLGLVMTLLKAYFFLFLAILLRWTVPRVRIDQLLDFGWKFLLPVGLVNLLLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLKLAFPFAFGG
CHHHCCCCCCCH
>Mature Secondary Structure
MNPGIDLEQRFVETLMELGLTPGVAKTIWLPIPMLLMIIGATVGVLVSVWLERKISAAAQ
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYIGPLGILAPVADGIKLVFKEDIVPANTDPWLFTLGPILVVIPVFFSYLIVPFG
HCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
QNILITDLGIGIFFWIALSSIAPIGLLMAGYSSNNKYSLLGGLRAAAQSISYEIPLALAV
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAVVMMSNSLSTIDIVNQQSGYGILGWNVIRQPIGFMLFWIAALAECERLPFDLPEAEEE
HHHHHHCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LVAGYQTEYAGMKFALFYLGSYVNLVLSSILVAVLYFGGWDLPIPATMIADWINVDPNNA
HHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHH
IFELVTAGLGLVMTLLKAYFFLFLAILLRWTVPRVRIDQLLDFGWKFLLPVGLVNLLLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLKLAFPFAFGG
CHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA