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The map label for this gene is ytpA [H]

Identifier: 158335301

GI number: 158335301

Start: 2137242

End: 2138114

Strand: Direct

Name: ytpA [H]

Synonym: AM1_2145

Alternate gene names: 158335301

Gene position: 2137242-2138114 (Clockwise)

Preceding gene: 158335300

Following gene: 158335303

Centisome position: 32.86

GC content: 49.03

Gene sequence:

>873_bases
ATGCAGATGCAATCAGGATATTTAGTCGGAGCACAGCAGCACACTCTTTACTATCGGGCTTGGTCCCCTGAACGCTCCCC
TCAAGCTGTAGTAGCAATCGTCCACGGTCTTGGCAGTCACAGCAATACCTTCATCGATGCAGTCAATGCTTTAACTCTCC
AGGGCCATGCTGTATATGGCCTAGATCTACGAGGGCATGGTCACTCTTCTGGGCAGCGAGGCTATATCAACCATTGGTCA
GAGTTTAGAGCTGATTTCCACATCTTCCTGCAATTCGTTAAGCACCGAAACCCTGACCTTCCTATCTTTGCCTGGGGACA
TAGTTTAGGGGGTTTGATTGTTCTGGATTACGTCCTACATTCCCCCCAGCGATTGATGGGCATGATGATATCCGGTCTAC
CCATGAGAGTTGTCGGTATTTCACCTTGGAAGCTAGCGATAGCACGTCTTCTATCAAAGCTATGGCCACGGTTTTCACTG
AATACTGGGATCGATCCAGAAAGCAATTCTCGAAATCCAGCCGTCCTGCTAGATCATTCTCAGGATTCACTGCAGCACAC
GCAAGGAACAGCTCGGTTAGCCACTGAATTTCTCCGCATTCAAGCCGAATTACAAGCCCACGCAGCGAATCTCCGTCTAC
CGCTGTTGATGCTCCATGGCAGCAACGATCAGACCGCTTCTCTCTCCGAGAGCGTAGCCTTTTTTCAAAAGGTCGGAAGC
AAGACCAAACAACATCTGGAATATCCAGGAGCCTTTCACGACTTACACGCTGATCTGGATGCCCAAACAGTACTCGCTGA
TATGAGCCAATGGCTCCGTCAACAGCTAACTTCTTTTGAGAAAAACAAGGACCGACAGCTTATAGGCATATAG

Upstream 100 bases:

>100_bases
ATTCGCTATAATAGTATTGGCTTTTCACTCAACAAGCATAAACTGCTCCTGCAGCCACCAATCGAGGGTGTGATTTGCAC
CTGAAGTCAGGAGGTTTCTT

Downstream 100 bases:

>100_bases
TTAGCCTTTTGTGGTCTCTTCCAAAGAGCGAATGAATTCACGAATGATATCGGTCTTGGTCCGTTGTGTCTTTTTCGCAT
AGCGGTCTAATATTTTTAGT

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MQMQSGYLVGAQQHTLYYRAWSPERSPQAVVAIVHGLGSHSNTFIDAVNALTLQGHAVYGLDLRGHGHSSGQRGYINHWS
EFRADFHIFLQFVKHRNPDLPIFAWGHSLGGLIVLDYVLHSPQRLMGMMISGLPMRVVGISPWKLAIARLLSKLWPRFSL
NTGIDPESNSRNPAVLLDHSQDSLQHTQGTARLATEFLRIQAELQAHAANLRLPLLMLHGSNDQTASLSESVAFFQKVGS
KTKQHLEYPGAFHDLHADLDAQTVLADMSQWLRQQLTSFEKNKDRQLIGI

Sequences:

>Translated_290_residues
MQMQSGYLVGAQQHTLYYRAWSPERSPQAVVAIVHGLGSHSNTFIDAVNALTLQGHAVYGLDLRGHGHSSGQRGYINHWS
EFRADFHIFLQFVKHRNPDLPIFAWGHSLGGLIVLDYVLHSPQRLMGMMISGLPMRVVGISPWKLAIARLLSKLWPRFSL
NTGIDPESNSRNPAVLLDHSQDSLQHTQGTARLATEFLRIQAELQAHAANLRLPLLMLHGSNDQTASLSESVAFFQKVGS
KTKQHLEYPGAFHDLHADLDAQTVLADMSQWLRQQLTSFEKNKDRQLIGI
>Mature_290_residues
MQMQSGYLVGAQQHTLYYRAWSPERSPQAVVAIVHGLGSHSNTFIDAVNALTLQGHAVYGLDLRGHGHSSGQRGYINHWS
EFRADFHIFLQFVKHRNPDLPIFAWGHSLGGLIVLDYVLHSPQRLMGMMISGLPMRVVGISPWKLAIARLLSKLWPRFSL
NTGIDPESNSRNPAVLLDHSQDSLQHTQGTARLATEFLRIQAELQAHAANLRLPLLMLHGSNDQTASLSESVAFFQKVGS
KTKQHLEYPGAFHDLHADLDAQTVLADMSQWLRQQLTSFEKNKDRQLIGI

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=284, Percent_Identity=27.8169014084507, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI6005786, Length=284, Percent_Identity=27.8169014084507, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322756, Length=301, Percent_Identity=26.2458471760797, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 32477; Mature: 32477

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMQSGYLVGAQQHTLYYRAWSPERSPQAVVAIVHGLGSHSNTFIDAVNALTLQGHAVYG
CCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHEEECCCEEEE
LDLRGHGHSSGQRGYINHWSEFRADFHIFLQFVKHRNPDLPIFAWGHSLGGLIVLDYVLH
EEEECCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHC
SPQRLMGMMISGLPMRVVGISPWKLAIARLLSKLWPRFSLNTGIDPESNSRNPAVLLDHS
CHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECC
QDSLQHTQGTARLATEFLRIQAELQAHAANLRLPLLMLHGSNDQTASLSESVAFFQKVGS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
KTKQHLEYPGAFHDLHADLDAQTVLADMSQWLRQQLTSFEKNKDRQLIGI
HHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
>Mature Secondary Structure
MQMQSGYLVGAQQHTLYYRAWSPERSPQAVVAIVHGLGSHSNTFIDAVNALTLQGHAVYG
CCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHEEECCCEEEE
LDLRGHGHSSGQRGYINHWSEFRADFHIFLQFVKHRNPDLPIFAWGHSLGGLIVLDYVLH
EEEECCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHC
SPQRLMGMMISGLPMRVVGISPWKLAIARLLSKLWPRFSLNTGIDPESNSRNPAVLLDHS
CHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECC
QDSLQHTQGTARLATEFLRIQAELQAHAANLRLPLLMLHGSNDQTASLSESVAFFQKVGS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
KTKQHLEYPGAFHDLHADLDAQTVLADMSQWLRQQLTSFEKNKDRQLIGI
HHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]