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The map label for this gene is lytC [H]

Identifier: 158335292

GI number: 158335292

Start: 2129510

End: 2131438

Strand: Direct

Name: lytC [H]

Synonym: AM1_2136

Alternate gene names: 158335292

Gene position: 2129510-2131438 (Clockwise)

Preceding gene: 158335291

Following gene: 158335296

Centisome position: 32.74

GC content: 51.74

Gene sequence:

>1929_bases
ATGCGCCACCATTTACAGACTGTCCATAGACAAAGGGGGACAACTCACTCGCTACGCTGGTTACTCCCCAGTCTCTGTGG
ACTCTTTCTCAGTTGTTTACCGGCGGAAGCAGCCCAACTCCAGTCTTGGCGGTTTGATCAAAATCAAAATCGCTTGGAAT
TCACCACGGATGAAGAAATTCGGCCTCGGGTACAGCTCATTCCCAACCCCACTCGCTTAGTCGTCGATCTACCTGGGATT
GTCTTAGGTCAGCGAACCTTAAAGCAGCGTTTGGGAAGCCAGTTTCGCTCCGTCCGCCTCGGACAAGTCAATGCCCAAAC
CGCACGGATTGTAGTGGAATTAGATCCGGCTTATACCCTCGATCCCCAAGAAGTCAAAGTGGAGGGGAACTCACCCACCA
ACTGGTCGATCAATTTACCCACTCCCCAGCGGTGGCAGTCATCAGGTGAAACGACCAACAATACTCCCACAGCATCGGCT
CCAGCCCCTCTACCCCCATCCCAGGTCGTTCAGCCAGCACCTACTCCCTCACCAAAAATCGTCTCCACCAAACCCTCATC
TCCTCCCCTCCAAATTGCCCAAAGCTCATCGGGAATCAGTGATATTTTAGTGACCGTCGATGGTCTTTTCTTGCCGACGA
AGAAGAGTAAGCCCAAAGTAAAAGTCAAGCGCAGCCGCAATAAAAAAGAGATCACATTCAAGATTTCGGGCACCACTATT
GCCCCCCAACTAGCTAAGACCTTCACACCTGGATATCACGGTATCAAAGCCATGACTTTAAAGTCTGTTTCTGATTCAGA
AGCAGAGCTGCTATTAAAGGTAGACAAAGACAGTCCAGACTGGATGGCAAGCGTTAGTCGATTCAGTGGGATTGTACTCT
TACCCAAAGGTGGTCCCTCTGCCAATCGTTCAGCTCGCCGTCCCGGTACAACGGTCAGTTTAGTTTCACCGAATCGTTCC
ACCGCTCCAACCGCCTCAACGAGCCAAATCAATACGATTCGCCGTATAGACTTGGGTGGACGGCAACTCCTTGTCAAAGC
CGATCAACCGATCTCATATACAACCCGCTGGTCGGGCAGAGCCTATCAAATTACGATTAATTCTGCCAAACTTGCAGATG
ACTTAAGAAAACCACGACTAGGCTCTGGCAGCCCTTTGTCAGACATTTCCGTTACAGAATCAGACCGCAATACGGTTATC
ATCACGGCCAAACCCAGCACGAACGTCAGAGTCACCGGGGTTCAGAGACTATCAAATCAGTCGATTGCCCTCAACCTCCT
CCGACCCGGTCAACGCCCCATTACCCGTATTCCGAGTAATCCATTTCCCTCGTCAACAAAATCTCCTCCTCCTGTAACAG
GACGTCCCGTTCGAGGTCGCAAAGTCATCGTGATTGATCCTGGCCATGGCGGGCCTGACCCCGGTGCGATCGGCATTGGC
GGCTTGCGGGAAACGAATGTGGTTTTGGATATTAGCTTAGAAGTTTCTCGCATTCTTCAGCGTCAGGGCGTCGTCGTTTA
TCTCACCCGCACACGAGAAGTGGATGTTGATTTGCCTCCCCGAGTGAGGTTAGCGGAGAGAGTGCGGGCCACTGCGTTTG
TCAGTATCCATGCCAATGCCATTAGCATGAGCCGACCAGATGTGAATGGTCTAGAGACCTATCATGCGCCAGGGGCCCGT
TTAGGAGCCCGCTTGGCTCGAACAGTGCACAACACCATCTTGCGCAGATTAAGGATGCCGGATCGCCGAGTTCGTCCGGC
CCGCTTCTATGTGATTCGCAAAACCTCCATGCCAGCGATTCTGGTCGAAACGGGGTTTCTCACCGGTGCCCAAGACATTG
TTAGGCTAAGAAATCCAGCCTGGCGTAAACAAATGGCCCAAGCTATTGCCCAGGGAATTCTCAACTATTTAAACGGTCGC
TATAACTAG

Upstream 100 bases:

>100_bases
GACTGCCATACCCCTTTTGCGGACTAGGCGAACGTCAAGTGCTCCTACGTTGAGACAGCTTGAAAGCGTTAGGGGGTCGA
TTTATCCATGGAGACATTGC

Downstream 100 bases:

>100_bases
GCAGTCAGTAAAGTTTTTGTGGTGGCAATATTCTGTCGGACCGCCTGGGCGGAAGTCTGCAATGCCTGATAGTCCTCAGC
AGATAAGTCTAGTTCCAATA

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MRHHLQTVHRQRGTTHSLRWLLPSLCGLFLSCLPAEAAQLQSWRFDQNQNRLEFTTDEEIRPRVQLIPNPTRLVVDLPGI
VLGQRTLKQRLGSQFRSVRLGQVNAQTARIVVELDPAYTLDPQEVKVEGNSPTNWSINLPTPQRWQSSGETTNNTPTASA
PAPLPPSQVVQPAPTPSPKIVSTKPSSPPLQIAQSSSGISDILVTVDGLFLPTKKSKPKVKVKRSRNKKEITFKISGTTI
APQLAKTFTPGYHGIKAMTLKSVSDSEAELLLKVDKDSPDWMASVSRFSGIVLLPKGGPSANRSARRPGTTVSLVSPNRS
TAPTASTSQINTIRRIDLGGRQLLVKADQPISYTTRWSGRAYQITINSAKLADDLRKPRLGSGSPLSDISVTESDRNTVI
ITAKPSTNVRVTGVQRLSNQSIALNLLRPGQRPITRIPSNPFPSSTKSPPPVTGRPVRGRKVIVIDPGHGGPDPGAIGIG
GLRETNVVLDISLEVSRILQRQGVVVYLTRTREVDVDLPPRVRLAERVRATAFVSIHANAISMSRPDVNGLETYHAPGAR
LGARLARTVHNTILRRLRMPDRRVRPARFYVIRKTSMPAILVETGFLTGAQDIVRLRNPAWRKQMAQAIAQGILNYLNGR
YN

Sequences:

>Translated_642_residues
MRHHLQTVHRQRGTTHSLRWLLPSLCGLFLSCLPAEAAQLQSWRFDQNQNRLEFTTDEEIRPRVQLIPNPTRLVVDLPGI
VLGQRTLKQRLGSQFRSVRLGQVNAQTARIVVELDPAYTLDPQEVKVEGNSPTNWSINLPTPQRWQSSGETTNNTPTASA
PAPLPPSQVVQPAPTPSPKIVSTKPSSPPLQIAQSSSGISDILVTVDGLFLPTKKSKPKVKVKRSRNKKEITFKISGTTI
APQLAKTFTPGYHGIKAMTLKSVSDSEAELLLKVDKDSPDWMASVSRFSGIVLLPKGGPSANRSARRPGTTVSLVSPNRS
TAPTASTSQINTIRRIDLGGRQLLVKADQPISYTTRWSGRAYQITINSAKLADDLRKPRLGSGSPLSDISVTESDRNTVI
ITAKPSTNVRVTGVQRLSNQSIALNLLRPGQRPITRIPSNPFPSSTKSPPPVTGRPVRGRKVIVIDPGHGGPDPGAIGIG
GLRETNVVLDISLEVSRILQRQGVVVYLTRTREVDVDLPPRVRLAERVRATAFVSIHANAISMSRPDVNGLETYHAPGAR
LGARLARTVHNTILRRLRMPDRRVRPARFYVIRKTSMPAILVETGFLTGAQDIVRLRNPAWRKQMAQAIAQGILNYLNGR
YN
>Mature_642_residues
MRHHLQTVHRQRGTTHSLRWLLPSLCGLFLSCLPAEAAQLQSWRFDQNQNRLEFTTDEEIRPRVQLIPNPTRLVVDLPGI
VLGQRTLKQRLGSQFRSVRLGQVNAQTARIVVELDPAYTLDPQEVKVEGNSPTNWSINLPTPQRWQSSGETTNNTPTASA
PAPLPPSQVVQPAPTPSPKIVSTKPSSPPLQIAQSSSGISDILVTVDGLFLPTKKSKPKVKVKRSRNKKEITFKISGTTI
APQLAKTFTPGYHGIKAMTLKSVSDSEAELLLKVDKDSPDWMASVSRFSGIVLLPKGGPSANRSARRPGTTVSLVSPNRS
TAPTASTSQINTIRRIDLGGRQLLVKADQPISYTTRWSGRAYQITINSAKLADDLRKPRLGSGSPLSDISVTESDRNTVI
ITAKPSTNVRVTGVQRLSNQSIALNLLRPGQRPITRIPSNPFPSSTKSPPPVTGRPVRGRKVIVIDPGHGGPDPGAIGIG
GLRETNVVLDISLEVSRILQRQGVVVYLTRTREVDVDLPPRVRLAERVRATAFVSIHANAISMSRPDVNGLETYHAPGAR
LGARLARTVHNTILRRLRMPDRRVRPARFYVIRKTSMPAILVETGFLTGAQDIVRLRNPAWRKQMAQAIAQGILNYLNGR
YN

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=225, Percent_Identity=30.2222222222222, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI87082163, Length=240, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 70451; Mature: 70451

Theoretical pI: Translated: 11.81; Mature: 11.81

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHHLQTVHRQRGTTHSLRWLLPSLCGLFLSCLPAEAAQLQSWRFDQNQNRLEFTTDEEI
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCCC
RPRVQLIPNPTRLVVDLPGIVLGQRTLKQRLGSQFRSVRLGQVNAQTARIVVELDPAYTL
CCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEECEECCCEEEEEEEECCCCCC
DPQEVKVEGNSPTNWSINLPTPQRWQSSGETTNNTPTASAPAPLPPSQVVQPAPTPSPKI
CCCEEEEECCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCE
VSTKPSSPPLQIAQSSSGISDILVTVDGLFLPTKKSKPKVKVKRSRNKKEITFKISGTTI
EECCCCCCCCEEECCCCCCEEEEEEECCEEECCCCCCCCEEEECCCCCEEEEEEECCCEE
APQLAKTFTPGYHGIKAMTLKSVSDSEAELLLKVDKDSPDWMASVSRFSGIVLLPKGGPS
CHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCC
ANRSARRPGTTVSLVSPNRSTAPTASTSQINTIRRIDLGGRQLLVKADQPISYTTRWSGR
CCCCCCCCCCEEEEECCCCCCCCCCCCHHCCEEEEEECCCCEEEEECCCCCEEEEECCCE
AYQITINSAKLADDLRKPRLGSGSPLSDISVTESDRNTVIITAKPSTNVRVTGVQRLSNQ
EEEEEECCHHHHHHHHCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCEEEEEHHHCCCC
SIALNLLRPGQRPITRIPSNPFPSSTKSPPPVTGRPVRGRKVIVIDPGHGGPDPGAIGIG
CEEEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECC
GLRETNVVLDISLEVSRILQRQGVVVYLTRTREVDVDLPPRVRLAERVRATAFVSIHANA
CCEECCEEEEEEHHHHHHHHHCCEEEEEEECEEECCCCCCCHHHHHHHCEEEEEEEEECE
ISMSRPDVNGLETYHAPGARLGARLARTVHNTILRRLRMPDRRVRPARFYVIRKTSMPAI
EECCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEE
LVETGFLTGAQDIVRLRNPAWRKQMAQAIAQGILNYLNGRYN
EEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRHHLQTVHRQRGTTHSLRWLLPSLCGLFLSCLPAEAAQLQSWRFDQNQNRLEFTTDEEI
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCCC
RPRVQLIPNPTRLVVDLPGIVLGQRTLKQRLGSQFRSVRLGQVNAQTARIVVELDPAYTL
CCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEECEECCCEEEEEEEECCCCCC
DPQEVKVEGNSPTNWSINLPTPQRWQSSGETTNNTPTASAPAPLPPSQVVQPAPTPSPKI
CCCEEEEECCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCE
VSTKPSSPPLQIAQSSSGISDILVTVDGLFLPTKKSKPKVKVKRSRNKKEITFKISGTTI
EECCCCCCCCEEECCCCCCEEEEEEECCEEECCCCCCCCEEEECCCCCEEEEEEECCCEE
APQLAKTFTPGYHGIKAMTLKSVSDSEAELLLKVDKDSPDWMASVSRFSGIVLLPKGGPS
CHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCC
ANRSARRPGTTVSLVSPNRSTAPTASTSQINTIRRIDLGGRQLLVKADQPISYTTRWSGR
CCCCCCCCCCEEEEECCCCCCCCCCCCHHCCEEEEEECCCCEEEEECCCCCEEEEECCCE
AYQITINSAKLADDLRKPRLGSGSPLSDISVTESDRNTVIITAKPSTNVRVTGVQRLSNQ
EEEEEECCHHHHHHHHCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCEEEEEHHHCCCC
SIALNLLRPGQRPITRIPSNPFPSSTKSPPPVTGRPVRGRKVIVIDPGHGGPDPGAIGIG
CEEEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECC
GLRETNVVLDISLEVSRILQRQGVVVYLTRTREVDVDLPPRVRLAERVRATAFVSIHANA
CCEECCEEEEEEHHHHHHHHHCCEEEEEEECEEECCCCCCCHHHHHHHCEEEEEEEEECE
ISMSRPDVNGLETYHAPGARLGARLARTVHNTILRRLRMPDRRVRPARFYVIRKTSMPAI
EECCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEE
LVETGFLTGAQDIVRLRNPAWRKQMAQAIAQGILNYLNGRYN
EEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]