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The map label for this gene is gnd [H]

Identifier: 158335248

GI number: 158335248

Start: 2083919

End: 2085349

Strand: Reverse

Name: gnd [H]

Synonym: AM1_2091

Alternate gene names: 158335248

Gene position: 2085349-2083919 (Counterclockwise)

Preceding gene: 158335252

Following gene: 158335247

Centisome position: 32.06

GC content: 51.36

Gene sequence:

>1431_bases
ATGCCCCAGCAACAATTTGGACTAATTGGCCTCGCCGTTATGGGGGAAAATTTAGCCCTCAACGTTGAGCGAAATGGCTT
TCCCATTGCTGTCTACAATCGCACACGAGCAAAAACAGATGCCTTTATGGCAGAGCGGGCCCAGGGACGACAAGTAGTCG
CCGCGTTTACACCGGAAGAACTGGTCGCATCCCTCGAACGTCCTCGGCGAATCTTGATCATGGTCAAAGCTGGTGCTCCA
GTGGATGCTGTGATTCAGCAGCTCAAGCCAATGCTGGAACCCGGCGATGTGTTGATTGACGGCGGCAACTCCCTGTATGG
GGACACCGTGCGACGCACAGAAGAATTAGAAGCCGTCGGCCTCCGATTTATTGGTATGGGCGTCAGTGGCGGTGAAGAAG
GTGCCCTCAACGGTCCCAGCCTAATGCCTGGTGGTACGGAAGCTGCCTATAAAGACCTGTCTCCGATTCTGACCAAGATT
GCAGCTCAAGTGGATGACGGGCCTTGTGTCACCTATATTGGCCCAGGGGGTGCTGGTCACTACGTCAAAATGGTCCATAA
CGGCATTGAGTATGGCGATATGCAGCTGATTGCTGAAGCCTATGACCTGCTCAAAAATGTTCTAGGACTGAGTCATACAG
AACTGCATCAGGTCTTTAGTGAGTGGAACACCACGGATGAGCTAAATTCCTTTTTGATTGAAATTACGGCTGAAATTTTC
ACCTATGTTGATCCAGATACTCAGCAGCCTTTAGTGGAGCTGATTTTGGATAAGGCAGGCCAGAAAGGGACAGGTCGCTG
GACTGTGATGAGTGCCTTGGAATTGGGTGTGCCCATCCCCACGATTACAGCCGCTGTGAATGCCCGTATTACCTCATCTT
TCAAAGATGAGCGGGTTAAAGCGTCTCAAATCCTGACGGGTCCCACGGCGACTTTTAGCGGCGATAAGCAAGCCTTTATC
GGCAAAGTTCGGGATGCCCTCTACTGCTCTAAGATTTGTTCCTATGCCCAGGGCATGGCCTTGATGAGTGCGGCGTCACA
GGAGTTCAAGTTCAACTTGAATTTAAGTGAAATCTCCCGGATTTGGAAAGGCGGCTGCATTATCCGGGCGGGCTTCTTGG
ACAAAATTAAATCGGCTTTTGCTGATGATCCGGCCTTGGCAAATTTGCTGCTTGCTCCTGAGTTTCGGCAGACTATTTTG
GACCGGCAGGACGCCTGGCGAGAAGTGATGGCTACGGCAGCTCAATTGGGGATTCCGGTCCCGGCCTTTAGTGCCTCTTT
GGATTACTTTGATAGCTACCGTCGTGATCGCTTGCCCCAAAACCTAACTCAGGCCCAGCGCGATTTTTTTGGTGCCCATA
CCTATCAACGGATTGATAAGGAAGGAACGTTCCATACGGAATGGACCGCCATCAACGAATCCAACAGCTAG

Upstream 100 bases:

>100_bases
TCTCGGCGTCTTTTAATCTCTTCTTCCAGTAGTTCCCATGGGGATCGAGCTACCCTGTAGTCAACGCATTGTGACTCTCA
CTATTTAGAGCAAATTCCTT

Downstream 100 bases:

>100_bases
TTTCCCAAGCTGGATTTTTGTGGGATAAGCTGGAACTGCCGTGGTAGCACGGCAGTTCTCGGTGCAGGGTGGCTATGGCA
AAGCGTGCTTTAAAGATTTT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MPQQQFGLIGLAVMGENLALNVERNGFPIAVYNRTRAKTDAFMAERAQGRQVVAAFTPEELVASLERPRRILIMVKAGAP
VDAVIQQLKPMLEPGDVLIDGGNSLYGDTVRRTEELEAVGLRFIGMGVSGGEEGALNGPSLMPGGTEAAYKDLSPILTKI
AAQVDDGPCVTYIGPGGAGHYVKMVHNGIEYGDMQLIAEAYDLLKNVLGLSHTELHQVFSEWNTTDELNSFLIEITAEIF
TYVDPDTQQPLVELILDKAGQKGTGRWTVMSALELGVPIPTITAAVNARITSSFKDERVKASQILTGPTATFSGDKQAFI
GKVRDALYCSKICSYAQGMALMSAASQEFKFNLNLSEISRIWKGGCIIRAGFLDKIKSAFADDPALANLLLAPEFRQTIL
DRQDAWREVMATAAQLGIPVPAFSASLDYFDSYRRDRLPQNLTQAQRDFFGAHTYQRIDKEGTFHTEWTAINESNS

Sequences:

>Translated_476_residues
MPQQQFGLIGLAVMGENLALNVERNGFPIAVYNRTRAKTDAFMAERAQGRQVVAAFTPEELVASLERPRRILIMVKAGAP
VDAVIQQLKPMLEPGDVLIDGGNSLYGDTVRRTEELEAVGLRFIGMGVSGGEEGALNGPSLMPGGTEAAYKDLSPILTKI
AAQVDDGPCVTYIGPGGAGHYVKMVHNGIEYGDMQLIAEAYDLLKNVLGLSHTELHQVFSEWNTTDELNSFLIEITAEIF
TYVDPDTQQPLVELILDKAGQKGTGRWTVMSALELGVPIPTITAAVNARITSSFKDERVKASQILTGPTATFSGDKQAFI
GKVRDALYCSKICSYAQGMALMSAASQEFKFNLNLSEISRIWKGGCIIRAGFLDKIKSAFADDPALANLLLAPEFRQTIL
DRQDAWREVMATAAQLGIPVPAFSASLDYFDSYRRDRLPQNLTQAQRDFFGAHTYQRIDKEGTFHTEWTAINESNS
>Mature_475_residues
PQQQFGLIGLAVMGENLALNVERNGFPIAVYNRTRAKTDAFMAERAQGRQVVAAFTPEELVASLERPRRILIMVKAGAPV
DAVIQQLKPMLEPGDVLIDGGNSLYGDTVRRTEELEAVGLRFIGMGVSGGEEGALNGPSLMPGGTEAAYKDLSPILTKIA
AQVDDGPCVTYIGPGGAGHYVKMVHNGIEYGDMQLIAEAYDLLKNVLGLSHTELHQVFSEWNTTDELNSFLIEITAEIFT
YVDPDTQQPLVELILDKAGQKGTGRWTVMSALELGVPIPTITAAVNARITSSFKDERVKASQILTGPTATFSGDKQAFIG
KVRDALYCSKICSYAQGMALMSAASQEFKFNLNLSEISRIWKGGCIIRAGFLDKIKSAFADDPALANLLLAPEFRQTILD
RQDAWREVMATAAQLGIPVPAFSASLDYFDSYRRDRLPQNLTQAQRDFFGAHTYQRIDKEGTFHTEWTAINESNS

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:
GO:0004616: 6-phosphogluconate dehydrogenase, decarboxylating
GO:0005488: 6-phosphogluconate dehydrogenase, decarboxylating
GO:0006098: 6-phosphogluconate dehydrogenase, decarboxylating
GO:0016491: 6-phosphogluconate dehydrogenase, decarboxylating
GO:0016616: 6-phosphogluconate dehydrogenase, decarboxylating
GO:0050661: 6-phosphogluconate dehydrogenase, decarboxylating
GO:0050662: 6-phosphogluconate dehydrogenase, decarboxylating
GO:0055114: 6-phosphogluconate dehydrogenase, decarboxylating

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=473, Percent_Identity=53.4883720930233, Blast_Score=489, Evalue=1e-138,
Organism=Escherichia coli, GI1788341, Length=469, Percent_Identity=60.3411513859275, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17542558, Length=473, Percent_Identity=51.3742071881607, Blast_Score=495, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6321695, Length=476, Percent_Identity=50.2100840336134, Blast_Score=487, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6321977, Length=476, Percent_Identity=49.7899159663866, Blast_Score=468, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24639279, Length=469, Percent_Identity=53.091684434968, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52024; Mature: 51893

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQQQFGLIGLAVMGENLALNVERNGFPIAVYNRTRAKTDAFMAERAQGRQVVAAFTPEE
CCCHHHCEEEEEEECCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECHHH
LVASLERPRRILIMVKAGAPVDAVIQQLKPMLEPGDVLIDGGNSLYGDTVRRTEELEAVG
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHC
LRFIGMGVSGGEEGALNGPSLMPGGTEAAYKDLSPILTKIAAQVDDGPCVTYIGPGGAGH
EEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
YVKMVHNGIEYGDMQLIAEAYDLLKNVLGLSHTELHQVFSEWNTTDELNSFLIEITAEIF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TYVDPDTQQPLVELILDKAGQKGTGRWTVMSALELGVPIPTITAAVNARITSSFKDERVK
HHCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ASQILTGPTATFSGDKQAFIGKVRDALYCSKICSYAQGMALMSAASQEFKFNLNLSEISR
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHHH
IWKGGCIIRAGFLDKIKSAFADDPALANLLLAPEFRQTILDRQDAWREVMATAAQLGIPV
HHCCCCEEEEHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAFSASLDYFDSYRRDRLPQNLTQAQRDFFGAHTYQRIDKEGTFHTEWTAINESNS
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
>Mature Secondary Structure 
PQQQFGLIGLAVMGENLALNVERNGFPIAVYNRTRAKTDAFMAERAQGRQVVAAFTPEE
CCHHHCEEEEEEECCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECHHH
LVASLERPRRILIMVKAGAPVDAVIQQLKPMLEPGDVLIDGGNSLYGDTVRRTEELEAVG
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHC
LRFIGMGVSGGEEGALNGPSLMPGGTEAAYKDLSPILTKIAAQVDDGPCVTYIGPGGAGH
EEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
YVKMVHNGIEYGDMQLIAEAYDLLKNVLGLSHTELHQVFSEWNTTDELNSFLIEITAEIF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TYVDPDTQQPLVELILDKAGQKGTGRWTVMSALELGVPIPTITAAVNARITSSFKDERVK
HHCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ASQILTGPTATFSGDKQAFIGKVRDALYCSKICSYAQGMALMSAASQEFKFNLNLSEISR
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHHH
IWKGGCIIRAGFLDKIKSAFADDPALANLLLAPEFRQTILDRQDAWREVMATAAQLGIPV
HHCCCCEEEEHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAFSASLDYFDSYRRDRLPQNLTQAQRDFFGAHTYQRIDKEGTFHTEWTAINESNS
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]