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The map label for this gene is serS

Identifier: 158335226

GI number: 158335226

Start: 2061690

End: 2062964

Strand: Direct

Name: serS

Synonym: AM1_2069

Alternate gene names: 158335226

Gene position: 2061690-2062964 (Clockwise)

Preceding gene: 158335225

Following gene: 158335227

Centisome position: 31.7

GC content: 50.43

Gene sequence:

>1275_bases
GTGATTGATTTAAAGCAGCTAAGGGAGAATCCTGAAGCCTTTGCAGAGTGCCTCAGTCGACGAGGTGACTATGATTTGCA
GGCTATTTTGGACCTGGATCAAAAACAGCGTGAACTAGAAACCGAGCGATCGCAACTGCAAGCCCGAAGTAACCAAATTG
GTAAAACCATTGGTGAACGGATGAAAGGGGGCGCTAATCCCAAGGATCCTGAGATTCAAAACCTGCGGCAGGAAGGCAGT
ACCGTCAAAGCCACCCTCAGCGATTTAGAGCCGAAAGAGCGTGATCTTAAAGCTGAAATTGGTGAGCTGCTGTTAACGAT
ACCGAATTTACCCAGTGATGATACGCCGGTCGGTAAAGACGAAACCGCTAACGTCGAAGTGAGTCGCTGGGGGGACGAAT
ATATTCCTAAAAACGCCAAGCTCGCTCACTGGGAGATTGGCGAAAACCTGGGGATTTTGAATTTTGAGCGCTCCGTTAAA
GTCGCTCAAAGCCGCTTTGCCACCTTGGTGGGGGCGGGGGCTGCCCTTGAACGCGCCCTGATTCAATTTATGCTCGACCA
GCAGGTGGAAGCGGGCTATGTCGAAGTTTTACCACCCGTTCTCGTTAACAGTGACTCCTTAACGGCCACTGGACAACTGC
CCAAATTTGCCGAAGAAAGTTTCAAATGTGCTGAGGATGATTTGTGGCTCAGCCCAACGGCTGAAGTTCCCGTCACCAAC
CTCTATCGGGATGAGATTATCAATGCCGATGATCTGCCCATTTTTCACTGCGCCTATACCCCTTGTTTTCGCCGAGAAGC
AGGCAGCTACGGCCGCGATACCCGAGGGCTAATTCGATTGCATCAGTTTAATAAGGTGGAACTGGTAAAGCTGGTCCATC
CCAGTACGTCTGCTGCTGAACATGAGGCCCTGGTTAAAAACGCGGCTGCCATCCTCGAAGCCTTGAAGCTGCCCTACCGA
GTGTTGCAGCTCTGTACGGGGGATTTAGGATTCTCTGCTGCTAAATGCTATGACCTGGAAGTCTGGCTCCCTTCAGCCGA
TTGTTATCGGGAGATTTCGAGCTGCTCCAACTTTCTAGATTTCCAAGCCAGGCGAGGGAATATTCGCTTTAAGGAATCTG
GGCAAAAAGGGACTCAGTTTGTCCATACCCTCAATGGTTCAGGCTTAGCAGTCGGTCGGACCATGGCTGCTGTACTAGAG
AATTATCAACAGCCGGATGGCAGCGTTCAAGTCCCCGATGTCTTGCAACCCTATTTAAAACGCAAAGTCTTGTAA

Upstream 100 bases:

>100_bases
CTGGGGTAGAGACGACCTGCCATCTCCAAAGCTGATCGTTACACCTGTATCCGGTATATCCTGTTAAATTGTCGGTATCG
CGCAGCGGAAAAGTTAAGAC

Downstream 100 bases:

>100_bases
ACTCCCGTAGGGACGGACCTTCTACAATGGGTGGGACACTGATGGGGGAATTTCTGTCTGTAAGCGTTACTAAGATGAGT
TATTTGGCATTGCCCAGGCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIDLKQLRENPEAFAECLSRRGDYDLQAILDLDQKQRELETERSQLQARSNQIGKTIGERMKGGANPKDPEIQNLRQEGS
TVKATLSDLEPKERDLKAEIGELLLTIPNLPSDDTPVGKDETANVEVSRWGDEYIPKNAKLAHWEIGENLGILNFERSVK
VAQSRFATLVGAGAALERALIQFMLDQQVEAGYVEVLPPVLVNSDSLTATGQLPKFAEESFKCAEDDLWLSPTAEVPVTN
LYRDEIINADDLPIFHCAYTPCFRREAGSYGRDTRGLIRLHQFNKVELVKLVHPSTSAAEHEALVKNAAAILEALKLPYR
VLQLCTGDLGFSAAKCYDLEVWLPSADCYREISSCSNFLDFQARRGNIRFKESGQKGTQFVHTLNGSGLAVGRTMAAVLE
NYQQPDGSVQVPDVLQPYLKRKVL

Sequences:

>Translated_424_residues
MIDLKQLRENPEAFAECLSRRGDYDLQAILDLDQKQRELETERSQLQARSNQIGKTIGERMKGGANPKDPEIQNLRQEGS
TVKATLSDLEPKERDLKAEIGELLLTIPNLPSDDTPVGKDETANVEVSRWGDEYIPKNAKLAHWEIGENLGILNFERSVK
VAQSRFATLVGAGAALERALIQFMLDQQVEAGYVEVLPPVLVNSDSLTATGQLPKFAEESFKCAEDDLWLSPTAEVPVTN
LYRDEIINADDLPIFHCAYTPCFRREAGSYGRDTRGLIRLHQFNKVELVKLVHPSTSAAEHEALVKNAAAILEALKLPYR
VLQLCTGDLGFSAAKCYDLEVWLPSADCYREISSCSNFLDFQARRGNIRFKESGQKGTQFVHTLNGSGLAVGRTMAAVLE
NYQQPDGSVQVPDVLQPYLKRKVL
>Mature_424_residues
MIDLKQLRENPEAFAECLSRRGDYDLQAILDLDQKQRELETERSQLQARSNQIGKTIGERMKGGANPKDPEIQNLRQEGS
TVKATLSDLEPKERDLKAEIGELLLTIPNLPSDDTPVGKDETANVEVSRWGDEYIPKNAKLAHWEIGENLGILNFERSVK
VAQSRFATLVGAGAALERALIQFMLDQQVEAGYVEVLPPVLVNSDSLTATGQLPKFAEESFKCAEDDLWLSPTAEVPVTN
LYRDEIINADDLPIFHCAYTPCFRREAGSYGRDTRGLIRLHQFNKVELVKLVHPSTSAAEHEALVKNAAAILEALKLPYR
VLQLCTGDLGFSAAKCYDLEVWLPSADCYREISSCSNFLDFQARRGNIRFKESGQKGTQFVHTLNGSGLAVGRTMAAVLE
NYQQPDGSVQVPDVLQPYLKRKVL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=428, Percent_Identity=31.3084112149533, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI8923421, Length=432, Percent_Identity=31.9444444444444, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI225579074, Length=437, Percent_Identity=31.1212814645309, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=49.8839907192575, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17539260, Length=433, Percent_Identity=30.9468822170901, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=341, Percent_Identity=29.9120234604106, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=394, Percent_Identity=33.248730964467, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=346, Percent_Identity=30.0578034682081, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24581334, Length=435, Percent_Identity=31.0344827586207, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI17737985, Length=341, Percent_Identity=28.7390029325513, Blast_Score=141, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ACAM1 (B0BYR8)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001516398.1
- ProteinModelPortal:   B0BYR8
- SMR:   B0BYR8
- GeneID:   5680883
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_2069
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   AMAR329726:AM1_2069-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47218; Mature: 47218

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLKQLRENPEAFAECLSRRGDYDLQAILDLDQKQRELETERSQLQARSNQIGKTIGER
CCCHHHHHCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGGANPKDPEIQNLRQEGSTVKATLSDLEPKERDLKAEIGELLLTIPNLPSDDTPVGKD
HCCCCCCCCCHHHHHHHCCCEEEHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCC
ETANVEVSRWGDEYIPKNAKLAHWEIGENLGILNFERSVKVAQSRFATLVGAGAALERAL
CCCCEEHCCCCHHHCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHH
IQFMLDQQVEAGYVEVLPPVLVNSDSLTATGQLPKFAEESFKCAEDDLWLSPTAEVPVTN
HHHHHHHHHCCCHHHHCCCHHCCCCCCEECCCCCHHHHHHCCCCCCCCEECCCCCCCCHH
LYRDEIINADDLPIFHCAYTPCFRREAGSYGRDTRGLIRLHQFNKVELVKLVHPSTSAAE
HHHHHCCCCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCHHH
HEALVKNAAAILEALKLPYRVLQLCTGDLGFSAAKCYDLEVWLPSADCYREISSCSNFLD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHH
FQARRGNIRFKESGQKGTQFVHTLNGSGLAVGRTMAAVLENYQQPDGSVQVPDVLQPYLK
HHHHCCCEEEECCCCCCHHEEEEECCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHHH
RKVL
HCCC
>Mature Secondary Structure
MIDLKQLRENPEAFAECLSRRGDYDLQAILDLDQKQRELETERSQLQARSNQIGKTIGER
CCCHHHHHCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGGANPKDPEIQNLRQEGSTVKATLSDLEPKERDLKAEIGELLLTIPNLPSDDTPVGKD
HCCCCCCCCCHHHHHHHCCCEEEHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCC
ETANVEVSRWGDEYIPKNAKLAHWEIGENLGILNFERSVKVAQSRFATLVGAGAALERAL
CCCCEEHCCCCHHHCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHH
IQFMLDQQVEAGYVEVLPPVLVNSDSLTATGQLPKFAEESFKCAEDDLWLSPTAEVPVTN
HHHHHHHHHCCCHHHHCCCHHCCCCCCEECCCCCHHHHHHCCCCCCCCEECCCCCCCCHH
LYRDEIINADDLPIFHCAYTPCFRREAGSYGRDTRGLIRLHQFNKVELVKLVHPSTSAAE
HHHHHCCCCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCHHH
HEALVKNAAAILEALKLPYRVLQLCTGDLGFSAAKCYDLEVWLPSADCYREISSCSNFLD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHH
FQARRGNIRFKESGQKGTQFVHTLNGSGLAVGRTMAAVLENYQQPDGSVQVPDVLQPYLK
HHHHCCCEEEECCCCCCHHEEEEECCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHHH
RKVL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA