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The map label for this gene is virA [H]

Identifier: 158335125

GI number: 158335125

Start: 1962845

End: 1964458

Strand: Direct

Name: virA [H]

Synonym: AM1_1966

Alternate gene names: 158335125

Gene position: 1962845-1964458 (Clockwise)

Preceding gene: 158335124

Following gene: 158335128

Centisome position: 30.18

GC content: 47.4

Gene sequence:

>1614_bases
ATGTTCCGCCAGTATGGTCGCCTGAAGCATTGGCTTGAACTATCACCGACAGAAGTTTTACGAGGACGGTTATCCAGAAA
AATTGCGTTTTGGATCTTTGCAGGACTAGTGTTGATCGAAATCATTATTCTGCTGCCGTCCTATGCCAAAAGAGAACAAG
ACCTGCTGACCGATCTAGAACAGACTGGGATGGCAACCCTCAAACCTTGGGTGAACATTCCCTGGGACCGCTTATCCGCA
GACAACTCAACATTGCTACAGCAATCGCTGGTTTTTGATTCACGGTTACGGGGGGCTGTTGTGCTCTCTCCTCGGGGTCA
AATCGTTGCCCAATTTGGGACAGCGCCTACTCTCCAATCATCAGACTTAAGTCGTTCGCCTATCACTCGATCGCTACATA
CGAATGACCTCATCTATGACATCGCTTGGTCTCCCTCTGAATTCGGCACCACAAAATATACTGTCATTGCCAGTCTTGAT
GCCTCACAGGTCAAGAGAGAGAAAATTGCTTACCTATGGCGGATTATCGGACTGATTGTCTTAATCTGTGTGACGGTAAC
ATTGGTGACGATGTTAGCCCTCAGACCGCTGGTGCTCAAACCCATCGACCAGTTAAGACTAGACCTGCAAAAAGTGGGAC
TAGCCATTAATCACGATCAGTCGCAACCTGCTCTAGCGACCCAGAGTATTCGGAGAAGTGATGAACTTGGCGAAGTCGTC
GCCACTTTTCACCTGATGGTGTCCCAGATCTATGACAATGTCCACGAGCGCAAGCAAGTGGAGCATCAGTTACAAGAACT
CAATGAAGATTTAGTTAAGACGCTAACCGAACTCAAAGCCGCCCAAGCTAGCTTGGTAGAGGCCGAAAAGATGGCAGCTC
TGGGCACACTTGTCGCCGGAGTAGCCCATGAAATCAATACCCCCATCGGCACCAGCATTACCGTTGCCTCTACACTAGCT
GACGAAACCCATGTTTTTTTGGAAGCTGCCCAATCAGGACAGCTCAAACGTTCAGTTCTCAACCATTACATCGACGTCGC
TCGCCAATCAACCCAACTCATTAACAGCAATTTGGATCGAGCCGGTCAACTGATTCAAAGCTTCAAACAAGTTGCAGTCG
ACCAATCTCATCAATCGGTCAGAACGTTTAATCTTAAGACTTACCTCGACGAAATTGGCACCAGCCTGCAACCTCAAATC
AAACGGTCAGGGCACCAGCTGAACATCCTTGGGGACGATGATATTGTCCTGACACAGGATCCCGGTATTTTCGCCCAAAT
CATAACGAATCTGGTCACTAATTCGATTAAGCATGCTTATCCATCCGATATAAATGGCACTCTCCAACTCCAGATCACAG
CAGCCAACAACCAAGTCATCCTGGATTATTGTGATGATGGTTGTGGGATTTCACAGGATCTGCTCAACAAAATTTTCGAT
CCCTTTTTTACGACCGCCCGCCATATCGGGGGAACTGGGCTAGGTCTGCATATTGTTTACAACATTGTTGTGCAATCGTT
GAACGGAACCATTGATGTCCAGAGTCAGGAACACAAAGGCAGTCAATTTAAAATTACGTTTCCCTTAACTCCCTCCCCTC
CAGTAGAAACATAA

Upstream 100 bases:

>100_bases
AGACTTATGCAGCGGCAGTAAGTTTCAACTTGAACTGGTCAATAATTTGAATAGAGGGCCGCATTTCTCCCCAACTGCCA
ACACTGCAACAATTCGCACT

Downstream 100 bases:

>100_bases
GCGGGCAAAACCTTTAGGAATCAAGGCTCACCATTCCTGATGCTCAACGCCTAACCCTTGTCGAACATTCAGTGCCTGAT
AGTGAAGTGGCTTACGGCAG

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: LHR virA [H]

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MFRQYGRLKHWLELSPTEVLRGRLSRKIAFWIFAGLVLIEIIILLPSYAKREQDLLTDLEQTGMATLKPWVNIPWDRLSA
DNSTLLQQSLVFDSRLRGAVVLSPRGQIVAQFGTAPTLQSSDLSRSPITRSLHTNDLIYDIAWSPSEFGTTKYTVIASLD
ASQVKREKIAYLWRIIGLIVLICVTVTLVTMLALRPLVLKPIDQLRLDLQKVGLAINHDQSQPALATQSIRRSDELGEVV
ATFHLMVSQIYDNVHERKQVEHQLQELNEDLVKTLTELKAAQASLVEAEKMAALGTLVAGVAHEINTPIGTSITVASTLA
DETHVFLEAAQSGQLKRSVLNHYIDVARQSTQLINSNLDRAGQLIQSFKQVAVDQSHQSVRTFNLKTYLDEIGTSLQPQI
KRSGHQLNILGDDDIVLTQDPGIFAQIITNLVTNSIKHAYPSDINGTLQLQITAANNQVILDYCDDGCGISQDLLNKIFD
PFFTTARHIGGTGLGLHIVYNIVVQSLNGTIDVQSQEHKGSQFKITFPLTPSPPVET

Sequences:

>Translated_537_residues
MFRQYGRLKHWLELSPTEVLRGRLSRKIAFWIFAGLVLIEIIILLPSYAKREQDLLTDLEQTGMATLKPWVNIPWDRLSA
DNSTLLQQSLVFDSRLRGAVVLSPRGQIVAQFGTAPTLQSSDLSRSPITRSLHTNDLIYDIAWSPSEFGTTKYTVIASLD
ASQVKREKIAYLWRIIGLIVLICVTVTLVTMLALRPLVLKPIDQLRLDLQKVGLAINHDQSQPALATQSIRRSDELGEVV
ATFHLMVSQIYDNVHERKQVEHQLQELNEDLVKTLTELKAAQASLVEAEKMAALGTLVAGVAHEINTPIGTSITVASTLA
DETHVFLEAAQSGQLKRSVLNHYIDVARQSTQLINSNLDRAGQLIQSFKQVAVDQSHQSVRTFNLKTYLDEIGTSLQPQI
KRSGHQLNILGDDDIVLTQDPGIFAQIITNLVTNSIKHAYPSDINGTLQLQITAANNQVILDYCDDGCGISQDLLNKIFD
PFFTTARHIGGTGLGLHIVYNIVVQSLNGTIDVQSQEHKGSQFKITFPLTPSPPVET
>Mature_537_residues
MFRQYGRLKHWLELSPTEVLRGRLSRKIAFWIFAGLVLIEIIILLPSYAKREQDLLTDLEQTGMATLKPWVNIPWDRLSA
DNSTLLQQSLVFDSRLRGAVVLSPRGQIVAQFGTAPTLQSSDLSRSPITRSLHTNDLIYDIAWSPSEFGTTKYTVIASLD
ASQVKREKIAYLWRIIGLIVLICVTVTLVTMLALRPLVLKPIDQLRLDLQKVGLAINHDQSQPALATQSIRRSDELGEVV
ATFHLMVSQIYDNVHERKQVEHQLQELNEDLVKTLTELKAAQASLVEAEKMAALGTLVAGVAHEINTPIGTSITVASTLA
DETHVFLEAAQSGQLKRSVLNHYIDVARQSTQLINSNLDRAGQLIQSFKQVAVDQSHQSVRTFNLKTYLDEIGTSLQPQI
KRSGHQLNILGDDDIVLTQDPGIFAQIITNLVTNSIKHAYPSDINGTLQLQITAANNQVILDYCDDGCGISQDLLNKIFD
PFFTTARHIGGTGLGLHIVYNIVVQSLNGTIDVQSQEHKGSQFKITFPLTPSPPVET

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=250, Percent_Identity=30.8, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=362, Percent_Identity=25.6906077348066, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788549, Length=262, Percent_Identity=27.8625954198473, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=283, Percent_Identity=26.8551236749117, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1789149, Length=300, Percent_Identity=27, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788393, Length=238, Percent_Identity=25.6302521008403, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=238, Percent_Identity=25.2100840336134, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI48994928, Length=308, Percent_Identity=25.974025974026, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786912, Length=279, Percent_Identity=27.5985663082437, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59583; Mature: 59583

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRQYGRLKHWLELSPTEVLRGRLSRKIAFWIFAGLVLIEIIILLPSYAKREQDLLTDLE
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QTGMATLKPWVNIPWDRLSADNSTLLQQSLVFDSRLRGAVVLSPRGQIVAQFGTAPTLQS
HCCCEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCC
SDLSRSPITRSLHTNDLIYDIAWSPSEFGTTKYTVIASLDASQVKREKIAYLWRIIGLIV
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
LICVTVTLVTMLALRPLVLKPIDQLRLDLQKVGLAINHDQSQPALATQSIRRSDELGEVV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHH
ATFHLMVSQIYDNVHERKQVEHQLQELNEDLVKTLTELKAAQASLVEAEKMAALGTLVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHEINTPIGTSITVASTLADETHVFLEAAQSGQLKRSVLNHYIDVARQSTQLINSNLDR
HHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
AGQLIQSFKQVAVDQSHQSVRTFNLKTYLDEIGTSLQPQIKRSGHQLNILGDDDIVLTQD
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCEEEECC
PGIFAQIITNLVTNSIKHAYPSDINGTLQLQITAANNQVILDYCDDGCGISQDLLNKIFD
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHH
PFFTTARHIGGTGLGLHIVYNIVVQSLNGTIDVQSQEHKGSQFKITFPLTPSPPVET
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MFRQYGRLKHWLELSPTEVLRGRLSRKIAFWIFAGLVLIEIIILLPSYAKREQDLLTDLE
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QTGMATLKPWVNIPWDRLSADNSTLLQQSLVFDSRLRGAVVLSPRGQIVAQFGTAPTLQS
HCCCEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCC
SDLSRSPITRSLHTNDLIYDIAWSPSEFGTTKYTVIASLDASQVKREKIAYLWRIIGLIV
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
LICVTVTLVTMLALRPLVLKPIDQLRLDLQKVGLAINHDQSQPALATQSIRRSDELGEVV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHH
ATFHLMVSQIYDNVHERKQVEHQLQELNEDLVKTLTELKAAQASLVEAEKMAALGTLVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHEINTPIGTSITVASTLADETHVFLEAAQSGQLKRSVLNHYIDVARQSTQLINSNLDR
HHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
AGQLIQSFKQVAVDQSHQSVRTFNLKTYLDEIGTSLQPQIKRSGHQLNILGDDDIVLTQD
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCEEEECC
PGIFAQIITNLVTNSIKHAYPSDINGTLQLQITAANNQVILDYCDDGCGISQDLLNKIFD
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHH
PFFTTARHIGGTGLGLHIVYNIVVQSLNGTIDVQSQEHKGSQFKITFPLTPSPPVET
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3595559 [H]