Click here to switch to the map view.

The map label for this gene is obgE

Identifier: 158334969

GI number: 158334969

Start: 1794488

End: 1795540

Strand: Direct

Name: obgE

Synonym: AM1_1806

Alternate gene names: 158334969

Gene position: 1794488-1795540 (Clockwise)

Preceding gene: 158334968

Following gene: 158334970

Centisome position: 27.59

GC content: 51.19

Gene sequence:

>1053_bases
ATGCGCTTCATCGACCAAACCGAAATATTCGTCAAAGCCGGAGACGGAGGAGACGGGATGGTAGCCTTCCGACGGGAGAA
ATACGTGCCTGCGGGGGGGCCTGCAGGGGGAAATGGGGGTCGAGGTGGCTCGGTTATTCTCCAGGCTTCAACCCAACTCC
AAACCCTGCTGGATTTCAAATACAAACATCAATTCGTGGCTGAAGATGGCAAACGGGGTGGCCCAAAAAATTTAACCGGG
GCATCGGGACAAGATCGCTTGATTGAAGTTCCCTGCGGCACGGTTATTTATGATGCAGACTCCATGACGTTGTTAGGGGA
TTTAACCACAAATGGGCAAACCCTAACCGTTGCTCAGGGCGGTAAAGGGGGACTAGGAAACAAACATTTTCTGAGCAACC
GCAATCGAGCCCCAGAACATGCGCTACCCGGACTACCTGGAGAGGAGTTTCGACTGCATTTGGAATTGAAGCTATTAGCG
GAGGTTGGCATTATTGGGTTGCCTAATGCGGGTAAATCAACCCTGATCTCCGTCTTATCCGCAGCTCGCCCCAAAATTGC
CGACTATCCTTTCACAACGCTCATTCCCAACCTGGGTGTCGTCCCGAGAGCCACAGGAGATGGCACCGTCTTCGCTGATA
TTCCTGGGCTGATCGAAGGAGCCCATGAGGGAGTCGGTTTAGGCCATGACTTCCTAAGGCATGTTGAGCGCACCCGTCTA
CTGGTTCATCTAGTGGATGCCACCGCAGAGGATCCAGAGCAAGACTACCAGACCATTCAAAAAGAGCTATCCGCCTACGG
CCAAGGCCTACAAAATCGACCCCAATTATTGGTGTTGAACAAAATAGATGCCATGGATTCAGAGCAACTGCTGGAAAAAC
AAGCCTGCTTAGAGCAAATGAGCGGAAGCCCAGTATATTTAATCTCTGCCGTAGCTCAACAGGGTCTAGACACACTACTT
CAGCAAGTCTGGGAGGAACTAGATCGTCTACCTAACGATCTTCAAGAGGCTCCCATACCTGTTCTGGACTCACCCATCTT
AAGAGAAACGTAA

Upstream 100 bases:

>100_bases
CTCCCCTCTAGAATTGCTCAAGCAGCGCTCCGCTTTGGCGATGAACCAGAGGAGTGACAGAATAGCTGTTCCTTCGATAT
TTTTCCCAGACATTACTATT

Downstream 100 bases:

>100_bases
ATTTCAGCAGAAGGAAGTTGAATTATCATTCAATTTGGGAAAGATTAAGTAATAATACGGTATACATTAGCGGTACTCGG
CAACTTTAACTACGGTGACA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRFIDQTEIFVKAGDGGDGMVAFRREKYVPAGGPAGGNGGRGGSVILQASTQLQTLLDFKYKHQFVAEDGKRGGPKNLTG
ASGQDRLIEVPCGTVIYDADSMTLLGDLTTNGQTLTVAQGGKGGLGNKHFLSNRNRAPEHALPGLPGEEFRLHLELKLLA
EVGIIGLPNAGKSTLISVLSAARPKIADYPFTTLIPNLGVVPRATGDGTVFADIPGLIEGAHEGVGLGHDFLRHVERTRL
LVHLVDATAEDPEQDYQTIQKELSAYGQGLQNRPQLLVLNKIDAMDSEQLLEKQACLEQMSGSPVYLISAVAQQGLDTLL
QQVWEELDRLPNDLQEAPIPVLDSPILRET

Sequences:

>Translated_350_residues
MRFIDQTEIFVKAGDGGDGMVAFRREKYVPAGGPAGGNGGRGGSVILQASTQLQTLLDFKYKHQFVAEDGKRGGPKNLTG
ASGQDRLIEVPCGTVIYDADSMTLLGDLTTNGQTLTVAQGGKGGLGNKHFLSNRNRAPEHALPGLPGEEFRLHLELKLLA
EVGIIGLPNAGKSTLISVLSAARPKIADYPFTTLIPNLGVVPRATGDGTVFADIPGLIEGAHEGVGLGHDFLRHVERTRL
LVHLVDATAEDPEQDYQTIQKELSAYGQGLQNRPQLLVLNKIDAMDSEQLLEKQACLEQMSGSPVYLISAVAQQGLDTLL
QQVWEELDRLPNDLQEAPIPVLDSPILRET
>Mature_350_residues
MRFIDQTEIFVKAGDGGDGMVAFRREKYVPAGGPAGGNGGRGGSVILQASTQLQTLLDFKYKHQFVAEDGKRGGPKNLTG
ASGQDRLIEVPCGTVIYDADSMTLLGDLTTNGQTLTVAQGGKGGLGNKHFLSNRNRAPEHALPGLPGEEFRLHLELKLLA
EVGIIGLPNAGKSTLISVLSAARPKIADYPFTTLIPNLGVVPRATGDGTVFADIPGLIEGAHEGVGLGHDFLRHVERTRL
LVHLVDATAEDPEQDYQTIQKELSAYGQGLQNRPQLLVLNKIDAMDSEQLLEKQACLEQMSGSPVYLISAVAQQGLDTLL
QQVWEELDRLPNDLQEAPIPVLDSPILRET

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:
GO:0000166: GTPase obg
GO:0000287: GTPase obg
GO:0003924: GTPase obg
GO:0005525: GTPase obg
GO:0005622: GTPase obg
GO:0005737: GTPase obg
GO:0006184: GTPase obg

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=322, Percent_Identity=42.8571428571429, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI111955139, Length=362, Percent_Identity=34.5303867403315, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI111955063, Length=198, Percent_Identity=37.3737373737374, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4758796, Length=115, Percent_Identity=34.7826086956522, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789574, Length=328, Percent_Identity=48.780487804878, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1787454, Length=130, Percent_Identity=35.3846153846154, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790615, Length=171, Percent_Identity=32.7485380116959, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=328, Percent_Identity=39.0243902439024, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17552324, Length=309, Percent_Identity=29.126213592233, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17509631, Length=172, Percent_Identity=30.8139534883721, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71981008, Length=115, Percent_Identity=34.7826086956522, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555344, Length=115, Percent_Identity=33.9130434782609, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=165, Percent_Identity=42.4242424242424, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319281, Length=123, Percent_Identity=35.7723577235772, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129375, Length=336, Percent_Identity=38.6904761904762, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24585318, Length=300, Percent_Identity=36.3333333333333, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21356473, Length=114, Percent_Identity=35.0877192982456, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_ACAM1 (B0CDA2)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001516141.1
- ProteinModelPortal:   B0CDA2
- SMR:   B0CDA2
- GeneID:   5680622
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_1806
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- ProtClustDB:   PRK12299
- BioCyc:   AMAR329726:AM1_1806-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 37596; Mature: 37596

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFIDQTEIFVKAGDGGDGMVAFRREKYVPAGGPAGGNGGRGGSVILQASTQLQTLLDFK
CCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHH
YKHQFVAEDGKRGGPKNLTGASGQDRLIEVPCGTVIYDADSMTLLGDLTTNGQTLTVAQG
HHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCCEEEEEEECCCCCEEEEECC
GKGGLGNKHFLSNRNRAPEHALPGLPGEEFRLHLELKLLAEVGIIGLPNAGKSTLISVLS
CCCCCCCCHHHCCCCCCCHHCCCCCCCCCEEEEEEEEEEECCCEEECCCCCHHHHHHHHH
AARPKIADYPFTTLIPNLGVVPRATGDGTVFADIPGLIEGAHEGVGLGHDFLRHVERTRL
HCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHH
LVHLVDATAEDPEQDYQTIQKELSAYGQGLQNRPQLLVLNKIDAMDSEQLLEKQACLEQM
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
SGSPVYLISAVAQQGLDTLLQQVWEELDRLPNDLQEAPIPVLDSPILRET
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFIDQTEIFVKAGDGGDGMVAFRREKYVPAGGPAGGNGGRGGSVILQASTQLQTLLDFK
CCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHH
YKHQFVAEDGKRGGPKNLTGASGQDRLIEVPCGTVIYDADSMTLLGDLTTNGQTLTVAQG
HHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCCEEEEEEECCCCCEEEEECC
GKGGLGNKHFLSNRNRAPEHALPGLPGEEFRLHLELKLLAEVGIIGLPNAGKSTLISVLS
CCCCCCCCHHHCCCCCCCHHCCCCCCCCCEEEEEEEEEEECCCEEECCCCCHHHHHHHHH
AARPKIADYPFTTLIPNLGVVPRATGDGTVFADIPGLIEGAHEGVGLGHDFLRHVERTRL
HCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHH
LVHLVDATAEDPEQDYQTIQKELSAYGQGLQNRPQLLVLNKIDAMDSEQLLEKQACLEQM
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
SGSPVYLISAVAQQGLDTLLQQVWEELDRLPNDLQEAPIPVLDSPILRET
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA