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The map label for this gene is speA [H]

Identifier: 158334821

GI number: 158334821

Start: 1635648

End: 1637672

Strand: Reverse

Name: speA [H]

Synonym: AM1_1658

Alternate gene names: 158334821

Gene position: 1637672-1635648 (Counterclockwise)

Preceding gene: 158334822

Following gene: 158334818

Centisome position: 25.18

GC content: 49.93

Gene sequence:

>2025_bases
ATGGAAAACGGTCGAAACCGTGAAGATAGGGCTACCAAAATTTCCCAAACTCTAGCGGCAGAGTTGGAGAATGGTCATTC
AGCGCCGATGCGAGAACGACCGCTGACATCAGACCCAAACCCTGAACAGACAGATGCGGCATGGTCGATTGAGGAAAGCG
AAAAGCTCTACCGCATTCGGGGCTGGGGAGAACCCTATTTTTCCGTTAATGCAGCGGGCCATGTAACCGTATCGCCCAAG
GCTGATCGAGGGGGCTCTTTAGACCTCTATGAGCTGGTCCAGTCCCTGCAGCAGCGAGATATCCATGCCCCTTTGCTGAT
CCGATTTTCAGACATTTTGGCGGATCGAATTGAGCGATTAAACGCTTGTTTCGCCAAAGCGATCGCACGCTACAGCTATC
CCGGCCGCTACCGAGGCGTTTTTCCCGTTAAATGTAATCAACAGCGTCATCTTGTAGAAGACTTGGTCCGTTTTGGGCAG
CCCCACCAGTTTGGATTAGAGGCGGGTTCCAAACCAGAATTACTGATTGCCATTGCCTCCCTCAAAACCTCTGGTGCGTT
GCTGATCTGCAATGGCTATAAAGATTTGGAATATGTCGAAACCGCTATGCTGGCCCAGCGTTTGGGCCATCAGGCGATTA
TTGTGATTGAACAACTCGAAGAAGTGGAGCTGGTGATCGAAGCTAGCCGTCGGCTCCAGATTCAGCCGATTTTGGGTGTT
CGTGCCAAGCTCAGCGCCAAAGGGATTGGCCGATGGGGGACGAGTGCGGGGGACCGCGCTAAATTTGGCCTCAACATTCC
AGAAGTTGTAGCCGCTGTCGAGCATCTGCGGGCCGCGAATCTACTGAACTCTTTGCAGCTGCTTCATTTCCATATTGGTT
CTCAAATCTCAGCCATTAGCGTCATCAAAGATGCCCTGCGAGAAGCCAGTCAAATCTATGTAGAGCTGGCCCGATTGGGG
GCCAATATGAAGTTCTTAGATGTGGGTGGTGGCTTGGGGGTTGATTACGACGGGTCTAAAAGTAACTCGGCGGCGTCTAA
AAACTACAATATGCAGAATTACGCCAATGATGTCGTGGCTGAGGTGAAGGAAGCTTGCGCGGAAGCAGATATCCCTGTGC
CTACCCTAGTGAGTGAAAGTGGACGGGCGATTGCTTCTCACCAGTCTGTCCTGATTATGAATGTACTGGGCAGTAGCGAC
ACCCTCAACCTCACCCCAGAACCCGCTCAGGCCGACGAACATCTGATTATTCGGAATCTCTGGGAAACCTATCAAACTAT
TGATACCGAGAACTATCAAGAAGCCTATCATGATGCTCTCCAGTTCAAGGAAGAAGCGGTTAGCCTGTTTGGGTTTGGCT
ATCTGAGCCTGGAAGGGCGGGCTAGGGTCGAGCGACTCTGTGGGGCCTGTTGTCAGAGAATACTTGCGATCGCACGAAAA
GACGATGATGTGGCTGTCGACTTAGAAGATCTTGAACGCCGAATGGCGTCGCTTTATTACACGAATCTGTCGGTGTTTCA
ATCTGCCCCTGATACCTGGGCCATTGATCAGCTGTTCCCGATTATGCCGATTCACCGCTTAGAAGAAGAACCCACCCAAA
GGGGAACCCTCGTCGATCTCACCTGCGATAGTGATGGCAAAATCGATCAATTTATCTATTCTCGTGATACCAAACCTATT
CTGGAGCTACATACCTTAAAGCCCAACGAACCCTATTATTTGGGGATGTTTCTGAACGGTGCCTATCAAGAAGTCATGGG
TAATCTGCATAATTTATTTGGCGATACCAATGTCGTCCATATTGATTTGACTCCGATGGGGTATCACATTGCCCATGTGG
TTAAGGGGGACACAATTACCGAGGTGCTGGAATATGTCCAATATGACGCCGATGATCTGATAGAAGAAATTCGCAAACAG
TCTGAGGTGGCATTGCAAGAACAGCACATCACATTACCAGAAGCCCAGCTGCTCCTCAAAAATTATGAGCGTAGTCTCAG
AAGCTATACCTACCTCAAATCCTGA

Upstream 100 bases:

>100_bases
GCCCGGTTGAGAACTGTGGAGTCCTGGGATGATGTGCCTGCCTGCGCCCTGAAACTCAGCTAAGATGTCTGAAGTGTCGG
GTCGCGCATAGGCAAAAAGC

Downstream 100 bases:

>100_bases
CAATAATTCCTACACTTGATGATGAGTATTTTGTCTTTGCTTGAGTTGGTAATAGGGACTCAACTACAAAAAAACTCTCC
TCCACAGACATATGGAGGAG

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MENGRNREDRATKISQTLAAELENGHSAPMRERPLTSDPNPEQTDAAWSIEESEKLYRIRGWGEPYFSVNAAGHVTVSPK
ADRGGSLDLYELVQSLQQRDIHAPLLIRFSDILADRIERLNACFAKAIARYSYPGRYRGVFPVKCNQQRHLVEDLVRFGQ
PHQFGLEAGSKPELLIAIASLKTSGALLICNGYKDLEYVETAMLAQRLGHQAIIVIEQLEEVELVIEASRRLQIQPILGV
RAKLSAKGIGRWGTSAGDRAKFGLNIPEVVAAVEHLRAANLLNSLQLLHFHIGSQISAISVIKDALREASQIYVELARLG
ANMKFLDVGGGLGVDYDGSKSNSAASKNYNMQNYANDVVAEVKEACAEADIPVPTLVSESGRAIASHQSVLIMNVLGSSD
TLNLTPEPAQADEHLIIRNLWETYQTIDTENYQEAYHDALQFKEEAVSLFGFGYLSLEGRARVERLCGACCQRILAIARK
DDDVAVDLEDLERRMASLYYTNLSVFQSAPDTWAIDQLFPIMPIHRLEEEPTQRGTLVDLTCDSDGKIDQFIYSRDTKPI
LELHTLKPNEPYYLGMFLNGAYQEVMGNLHNLFGDTNVVHIDLTPMGYHIAHVVKGDTITEVLEYVQYDADDLIEEIRKQ
SEVALQEQHITLPEAQLLLKNYERSLRSYTYLKS

Sequences:

>Translated_674_residues
MENGRNREDRATKISQTLAAELENGHSAPMRERPLTSDPNPEQTDAAWSIEESEKLYRIRGWGEPYFSVNAAGHVTVSPK
ADRGGSLDLYELVQSLQQRDIHAPLLIRFSDILADRIERLNACFAKAIARYSYPGRYRGVFPVKCNQQRHLVEDLVRFGQ
PHQFGLEAGSKPELLIAIASLKTSGALLICNGYKDLEYVETAMLAQRLGHQAIIVIEQLEEVELVIEASRRLQIQPILGV
RAKLSAKGIGRWGTSAGDRAKFGLNIPEVVAAVEHLRAANLLNSLQLLHFHIGSQISAISVIKDALREASQIYVELARLG
ANMKFLDVGGGLGVDYDGSKSNSAASKNYNMQNYANDVVAEVKEACAEADIPVPTLVSESGRAIASHQSVLIMNVLGSSD
TLNLTPEPAQADEHLIIRNLWETYQTIDTENYQEAYHDALQFKEEAVSLFGFGYLSLEGRARVERLCGACCQRILAIARK
DDDVAVDLEDLERRMASLYYTNLSVFQSAPDTWAIDQLFPIMPIHRLEEEPTQRGTLVDLTCDSDGKIDQFIYSRDTKPI
LELHTLKPNEPYYLGMFLNGAYQEVMGNLHNLFGDTNVVHIDLTPMGYHIAHVVKGDTITEVLEYVQYDADDLIEEIRKQ
SEVALQEQHITLPEAQLLLKNYERSLRSYTYLKS
>Mature_674_residues
MENGRNREDRATKISQTLAAELENGHSAPMRERPLTSDPNPEQTDAAWSIEESEKLYRIRGWGEPYFSVNAAGHVTVSPK
ADRGGSLDLYELVQSLQQRDIHAPLLIRFSDILADRIERLNACFAKAIARYSYPGRYRGVFPVKCNQQRHLVEDLVRFGQ
PHQFGLEAGSKPELLIAIASLKTSGALLICNGYKDLEYVETAMLAQRLGHQAIIVIEQLEEVELVIEASRRLQIQPILGV
RAKLSAKGIGRWGTSAGDRAKFGLNIPEVVAAVEHLRAANLLNSLQLLHFHIGSQISAISVIKDALREASQIYVELARLG
ANMKFLDVGGGLGVDYDGSKSNSAASKNYNMQNYANDVVAEVKEACAEADIPVPTLVSESGRAIASHQSVLIMNVLGSSD
TLNLTPEPAQADEHLIIRNLWETYQTIDTENYQEAYHDALQFKEEAVSLFGFGYLSLEGRARVERLCGACCQRILAIARK
DDDVAVDLEDLERRMASLYYTNLSVFQSAPDTWAIDQLFPIMPIHRLEEEPTQRGTLVDLTCDSDGKIDQFIYSRDTKPI
LELHTLKPNEPYYLGMFLNGAYQEVMGNLHNLFGDTNVVHIDLTPMGYHIAHVVKGDTITEVLEYVQYDADDLIEEIRKQ
SEVALQEQHITLPEAQLLLKNYERSLRSYTYLKS

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:
GO:0003824: Biosynthetic arginine decarboxylase
GO:0006527: Biosynthetic arginine decarboxylase
GO:0006596: Biosynthetic arginine decarboxylase
GO:0008295: Biosynthetic arginine decarboxylase
GO:0008792: Biosynthetic arginine decarboxylase
GO:0016829: Biosynthetic arginine decarboxylase
GO:0016831: Biosynthetic arginine decarboxylase
GO:0046872: Biosynthetic arginine decarboxylase

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=641, Percent_Identity=38.5335413416537, Blast_Score=479, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 75387; Mature: 75387

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENGRNREDRATKISQTLAAELENGHSAPMRERPLTSDPNPEQTDAAWSIEESEKLYRIR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCHHCCCEEEEE
GWGEPYFSVNAAGHVTVSPKADRGGSLDLYELVQSLQQRDIHAPLLIRFSDILADRIERL
CCCCCCEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NACFAKAIARYSYPGRYRGVFPVKCNQQRHLVEDLVRFGQPHQFGLEAGSKPELLIAIAS
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEE
LKTSGALLICNGYKDLEYVETAMLAQRLGHQAIIVIEQLEEVELVIEASRRLQIQPILGV
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCEEEEECCCC
RAKLSAKGIGRWGTSAGDRAKFGLNIPEVVAAVEHLRAANLLNSLQLLHFHIGSQISAIS
HHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VIKDALREASQIYVELARLGANMKFLDVGGGLGVDYDGSKSNSAASKNYNMQNYANDVVA
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
EVKEACAEADIPVPTLVSESGRAIASHQSVLIMNVLGSSDTLNLTPEPAQADEHLIIRNL
HHHHHHHCCCCCCCHHHCCCCCEECCCCCEEEEEECCCCCEEECCCCCCCCCHHHHHHHH
WETYQTIDTENYQEAYHDALQFKEEAVSLFGFGYLSLEGRARVERLCGACCQRILAIARK
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
DDDVAVDLEDLERRMASLYYTNLSVFQSAPDTWAIDQLFPIMPIHRLEEEPTQRGTLVDL
CCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCHHHHCCCCCCCCCEEEE
TCDSDGKIDQFIYSRDTKPILELHTLKPNEPYYLGMFLNGAYQEVMGNLHNLFGDTNVVH
EECCCCCHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCEEE
IDLTPMGYHIAHVVKGDTITEVLEYVQYDADDLIEEIRKQSEVALQEQHITLPEAQLLLK
EEECCCCEEEHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NYERSLRSYTYLKS
HHHHHHHHHHHCCC
>Mature Secondary Structure
MENGRNREDRATKISQTLAAELENGHSAPMRERPLTSDPNPEQTDAAWSIEESEKLYRIR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCHHCCCEEEEE
GWGEPYFSVNAAGHVTVSPKADRGGSLDLYELVQSLQQRDIHAPLLIRFSDILADRIERL
CCCCCCEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NACFAKAIARYSYPGRYRGVFPVKCNQQRHLVEDLVRFGQPHQFGLEAGSKPELLIAIAS
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEE
LKTSGALLICNGYKDLEYVETAMLAQRLGHQAIIVIEQLEEVELVIEASRRLQIQPILGV
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCEEEEECCCC
RAKLSAKGIGRWGTSAGDRAKFGLNIPEVVAAVEHLRAANLLNSLQLLHFHIGSQISAIS
HHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VIKDALREASQIYVELARLGANMKFLDVGGGLGVDYDGSKSNSAASKNYNMQNYANDVVA
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
EVKEACAEADIPVPTLVSESGRAIASHQSVLIMNVLGSSDTLNLTPEPAQADEHLIIRNL
HHHHHHHCCCCCCCHHHCCCCCEECCCCCEEEEEECCCCCEEECCCCCCCCCHHHHHHHH
WETYQTIDTENYQEAYHDALQFKEEAVSLFGFGYLSLEGRARVERLCGACCQRILAIARK
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
DDDVAVDLEDLERRMASLYYTNLSVFQSAPDTWAIDQLFPIMPIHRLEEEPTQRGTLVDL
CCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCHHHHCCCCCCCCCEEEE
TCDSDGKIDQFIYSRDTKPILELHTLKPNEPYYLGMFLNGAYQEVMGNLHNLFGDTNVVH
EECCCCCHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCEEE
IDLTPMGYHIAHVVKGDTITEVLEYVQYDADDLIEEIRKQSEVALQEQHITLPEAQLLLK
EEECCCCEEEHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NYERSLRSYTYLKS
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]