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The map label for this gene is trpF

Identifier: 158334801

GI number: 158334801

Start: 1604939

End: 1605592

Strand: Direct

Name: trpF

Synonym: AM1_1638

Alternate gene names: 158334801

Gene position: 1604939-1605592 (Clockwise)

Preceding gene: 158334798

Following gene: 158334802

Centisome position: 24.68

GC content: 48.78

Gene sequence:

>654_bases
ATGCGGGTCAAAATTTGTGGCATTACTCAGCCTGATCAAGGGGTTGCGATCGCAACTCTAGGTGCCGATGCCCTCGGATT
TATCTGTGTCTCTCAGTCTCCCCGCTACGTTACGCCCCAGCAGATTCAGGTGGTTACCCAAGCGTTACCCACACAAACCC
TAAAGGGAGAACCCCTAACCCGGATTGGTGTGTTTGCTAATGCAGCTCTAGACCTGATTCAACAAACTGTAGAAGTCGGC
CAGTTAACCGGAGTCCAACTCCACGGGGATGAGTCCCCAGAATTTTGCCAGCAAGTTAAAGCGAAACTACCCAAGGTTGA
GTTAATCAAAGCGTTTCGGGTTCGTAGTGCTGAAACCCTTGCTCAGATCACGCCCTATGAAGCGATTGCAAATACCCTGC
TCCTCGATGCCTATACACCCCAAGCCTTAGGCGGAACGGGGCATACTTGGGATTGGACGTTGCTCAAGACTTTTACACCA
AAGCTTCCTTGGTTCCTAGCAGGTGGTCTCACTCCTGATAATGTGACACCAGCAATAACGACTTTAACTCCATCAGGAAT
CGATCTTTCAAGTGGAGTGGAACAGTCTCCAGGTAATAAAGATCTGCAAAAAGTAAAGCAGCTCTTTCAGCAGGTTCATA
CGTTAGTGATATAG

Upstream 100 bases:

>100_bases
GAACTGGCGCAAAATTTTGTTTTGTTTTAAGAGTTAACATTTCGCCATAAAAGTGATCCCACCTTATGCTGAAAGAAATA
CATGGGATACGGGGGATTTT

Downstream 100 bases:

>100_bases
GTGATTGTGTCGATTGCTCTGTACCAGAAAACTCATGAAATAACTGAGTAACCCTTTATTCTGCTTCTAACATCTGGAAT
CACTACATTGCTTTGCACTA

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MRVKICGITQPDQGVAIATLGADALGFICVSQSPRYVTPQQIQVVTQALPTQTLKGEPLTRIGVFANAALDLIQQTVEVG
QLTGVQLHGDESPEFCQQVKAKLPKVELIKAFRVRSAETLAQITPYEAIANTLLLDAYTPQALGGTGHTWDWTLLKTFTP
KLPWFLAGGLTPDNVTPAITTLTPSGIDLSSGVEQSPGNKDLQKVKQLFQQVHTLVI

Sequences:

>Translated_217_residues
MRVKICGITQPDQGVAIATLGADALGFICVSQSPRYVTPQQIQVVTQALPTQTLKGEPLTRIGVFANAALDLIQQTVEVG
QLTGVQLHGDESPEFCQQVKAKLPKVELIKAFRVRSAETLAQITPYEAIANTLLLDAYTPQALGGTGHTWDWTLLKTFTP
KLPWFLAGGLTPDNVTPAITTLTPSGIDLSSGVEQSPGNKDLQKVKQLFQQVHTLVI
>Mature_217_residues
MRVKICGITQPDQGVAIATLGADALGFICVSQSPRYVTPQQIQVVTQALPTQTLKGEPLTRIGVFANAALDLIQQTVEVG
QLTGVQLHGDESPEFCQQVKAKLPKVELIKAFRVRSAETLAQITPYEAIANTLLLDAYTPQALGGTGHTWDWTLLKTFTP
KLPWFLAGGLTPDNVTPAITTLTPSGIDLSSGVEQSPGNKDLQKVKQLFQQVHTLVI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=209, Percent_Identity=33.9712918660287, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320210, Length=219, Percent_Identity=30.1369863013699, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_ACAM1 (B0CA72)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001515973.1
- ProteinModelPortal:   B0CA72
- SMR:   B0CA72
- GeneID:   5680454
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_1638
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- BioCyc:   AMAR329726:AM1_1638-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23382; Mature: 23382

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVKICGITQPDQGVAIATLGADALGFICVSQSPRYVTPQQIQVVTQALPTQTLKGEPLT
CEEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
RIGVFANAALDLIQQTVEVGQLTGVQLHGDESPEFCQQVKAKLPKVELIKAFRVRSAETL
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AQITPYEAIANTLLLDAYTPQALGGTGHTWDWTLLKTFTPKLPWFLAGGLTPDNVTPAIT
HHCCCHHHHHHHHHHCCCCCHHCCCCCCCCCEEHHHHCCCCCCCEEECCCCCCCCCCEEE
TLTPSGIDLSSGVEQSPGNKDLQKVKQLFQQVHTLVI
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVKICGITQPDQGVAIATLGADALGFICVSQSPRYVTPQQIQVVTQALPTQTLKGEPLT
CEEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
RIGVFANAALDLIQQTVEVGQLTGVQLHGDESPEFCQQVKAKLPKVELIKAFRVRSAETL
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AQITPYEAIANTLLLDAYTPQALGGTGHTWDWTLLKTFTPKLPWFLAGGLTPDNVTPAIT
HHCCCHHHHHHHHHHCCCCCHHCCCCCCCCCEEHHHHCCCCCCCEEECCCCCCCCCCEEE
TLTPSGIDLSSGVEQSPGNKDLQKVKQLFQQVHTLVI
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA