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The map label for this gene is arlS [H]

Identifier: 158334651

GI number: 158334651

Start: 1470621

End: 1472135

Strand: Reverse

Name: arlS [H]

Synonym: AM1_1481

Alternate gene names: 158334651

Gene position: 1472135-1470621 (Counterclockwise)

Preceding gene: 158334652

Following gene: 158334650

Centisome position: 22.64

GC content: 47.72

Gene sequence:

>1515_bases
GTGGGTGAACTTCCGATCAAATCTTCCCTGGGTAAGGGATGGCGAAACGTCTCTCCTCAGTTGCGCCAAGCTGTGAATCC
TAAGTCACTCCAGTTTCGGCTGACGGCTAGTATTGCAGGACTGATTGCTGTGGGGTTAACCAGTGTCGCTGTATGGACGA
GCTGGAAGATGCAGCGGATTTTGATTTCTAGTCATAAGCAAAAAATTGTTGATATTAGCGATCGCATTGCGGATGATGTG
GTGCTTTATCAACAAGATGAGATGTTCCCGCTGCAAAAGAGTATTGAAAAAGCGATTAACAATCGGTCTGGACGTAATTT
ACTGCTGTGGGTCAACGATTCCCAAGAAAATTTGGTGGCGATGTCTGCCAATATGTCGGGGCCAACGTGGCAACGATTTG
AAGGCCCTGGTTCGTTGGCAACGGCTTTCCGAGACAGCATTGTCCCCAAGGTCTATCACATTCAAGGGCGAGATTTTGTC
GCCTGCCATAGCCCTTTAATGGTGAGGAACCAGTCTTTGGGAACGTTATTTGTGGCTCAAGATATTACTGAGGATCAACG
CCAGTTTATCGCTAGTGTGCAATCTCTGGCTTTGGCTAGTTCAGTTGCTGTTGTCTTGATCACTTTGGCTTTAACTTGGT
ATGTGCATCGTTCCTTACGCTCCTTAAGCCAAATGGACTTAATGACAAAAGCCATTTCGCCGGATGATTTAGGGAAGACA
AAGGTAGAAATTGATAATGCGCCCAGTGAAATCCAAGAATTGACAGAGACTTTCAATCGGATGTTGGAGCGCCTATCTGA
GGCTTGGCATGAGCAGCAGCATGCTACGGAGCGACAGCGAGAGTTTGTGGGCAATGTCTCCCATGAACTGCGAACGCCTC
TCACGATTGTCCGAGGCTATTTGCAAAGTATTCAACGGCGGGGCGATAACCTGACTGAAATGCAGCGGGAAGCCTTGGAA
ATCTCTACGGCTGAGGCGAACCTGACGATTCAGTTATTGCAAGATTTACTGTGTTTAGCCCGAGCGGATGATGGGTATAT
GCCTTATCATCTGGAGACGTTGATTCTGAACGATGTGGCGGTAGAAGTCGTTAATATGGCAGACAAGTTTAATCAGCGTC
AGATTGATTTGGAGTTTGAGTCTCCTCTAATTCCCGTTTTTGCTGATGCGAAGCGTCTCCAACAGGTATTGGTAAACTTG
GTGGAAAATGCGATTAAATATTCTGCAACGACGGAACCTGTCACAGTGAAGCTAGAACAACGAGAGGACTCAGCTTTGAT
TCATGTGTGCGATCGCGGCGATGGTATCCCTCTCAAACAACAGTCCCGCATTTTTGAACGTTTTTATCGATTAGATGAAG
CCCGAGCCCGCTGTACCGGTGGCGTTGGTCTGGGCCTCTCCCTAGTCAAGACCTTTACCGAAGGCATGGGAGGACAAGTC
AGTGTCCTGTCTGCCGAGGGTGAAGGCAGTACATTCACCGTGACGTTACCCATATCTCCTGAAGCAAAAATATGA

Upstream 100 bases:

>100_bases
GACGGTGACGTTTAATCTTTACGGACTGACGGATTATCAGAACCGATACAGCTTTGATTCAGTTTCCCATACCGCTAAGT
TATTTTGAGGGACGGCTAGC

Downstream 100 bases:

>100_bases
CAGCACATATTCTCCTGGTTGAAGACGAAACCAAACTGGCTCAATTTGTTGAAATGGAACTGACCCATGAGGGGTATCAG
GTGACCGTGGCCAATGATGG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MGELPIKSSLGKGWRNVSPQLRQAVNPKSLQFRLTASIAGLIAVGLTSVAVWTSWKMQRILISSHKQKIVDISDRIADDV
VLYQQDEMFPLQKSIEKAINNRSGRNLLLWVNDSQENLVAMSANMSGPTWQRFEGPGSLATAFRDSIVPKVYHIQGRDFV
ACHSPLMVRNQSLGTLFVAQDITEDQRQFIASVQSLALASSVAVVLITLALTWYVHRSLRSLSQMDLMTKAISPDDLGKT
KVEIDNAPSEIQELTETFNRMLERLSEAWHEQQHATERQREFVGNVSHELRTPLTIVRGYLQSIQRRGDNLTEMQREALE
ISTAEANLTIQLLQDLLCLARADDGYMPYHLETLILNDVAVEVVNMADKFNQRQIDLEFESPLIPVFADAKRLQQVLVNL
VENAIKYSATTEPVTVKLEQREDSALIHVCDRGDGIPLKQQSRIFERFYRLDEARARCTGGVGLGLSLVKTFTEGMGGQV
SVLSAEGEGSTFTVTLPISPEAKI

Sequences:

>Translated_504_residues
MGELPIKSSLGKGWRNVSPQLRQAVNPKSLQFRLTASIAGLIAVGLTSVAVWTSWKMQRILISSHKQKIVDISDRIADDV
VLYQQDEMFPLQKSIEKAINNRSGRNLLLWVNDSQENLVAMSANMSGPTWQRFEGPGSLATAFRDSIVPKVYHIQGRDFV
ACHSPLMVRNQSLGTLFVAQDITEDQRQFIASVQSLALASSVAVVLITLALTWYVHRSLRSLSQMDLMTKAISPDDLGKT
KVEIDNAPSEIQELTETFNRMLERLSEAWHEQQHATERQREFVGNVSHELRTPLTIVRGYLQSIQRRGDNLTEMQREALE
ISTAEANLTIQLLQDLLCLARADDGYMPYHLETLILNDVAVEVVNMADKFNQRQIDLEFESPLIPVFADAKRLQQVLVNL
VENAIKYSATTEPVTVKLEQREDSALIHVCDRGDGIPLKQQSRIFERFYRLDEARARCTGGVGLGLSLVKTFTEGMGGQV
SVLSAEGEGSTFTVTLPISPEAKI
>Mature_503_residues
GELPIKSSLGKGWRNVSPQLRQAVNPKSLQFRLTASIAGLIAVGLTSVAVWTSWKMQRILISSHKQKIVDISDRIADDVV
LYQQDEMFPLQKSIEKAINNRSGRNLLLWVNDSQENLVAMSANMSGPTWQRFEGPGSLATAFRDSIVPKVYHIQGRDFVA
CHSPLMVRNQSLGTLFVAQDITEDQRQFIASVQSLALASSVAVVLITLALTWYVHRSLRSLSQMDLMTKAISPDDLGKTK
VEIDNAPSEIQELTETFNRMLERLSEAWHEQQHATERQREFVGNVSHELRTPLTIVRGYLQSIQRRGDNLTEMQREALEI
STAEANLTIQLLQDLLCLARADDGYMPYHLETLILNDVAVEVVNMADKFNQRQIDLEFESPLIPVFADAKRLQQVLVNLV
ENAIKYSATTEPVTVKLEQREDSALIHVCDRGDGIPLKQQSRIFERFYRLDEARARCTGGVGLGLSLVKTFTEGMGGQVS
VLSAEGEGSTFTVTLPISPEAKI

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=252, Percent_Identity=30.952380952381, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1786783, Length=334, Percent_Identity=26.6467065868263, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1789149, Length=273, Percent_Identity=31.1355311355311, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786912, Length=264, Percent_Identity=31.0606060606061, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=32.3404255319149, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788279, Length=300, Percent_Identity=28, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=30.8943089430894, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790346, Length=263, Percent_Identity=28.8973384030418, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=30.1310043668122, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1787894, Length=269, Percent_Identity=29.368029739777, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=261, Percent_Identity=28.3524904214559, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790551, Length=306, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=28.1385281385281, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=30.3571428571429, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790861, Length=341, Percent_Identity=26.6862170087977, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=262, Percent_Identity=27.0992366412214, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=245, Percent_Identity=27.7551020408163, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789808, Length=310, Percent_Identity=27.741935483871, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=292, Percent_Identity=26.7123287671233, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56359; Mature: 56228

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELPIKSSLGKGWRNVSPQLRQAVNPKSLQFRLTASIAGLIAVGLTSVAVWTSWKMQRI
CCCCCCCHHHCCCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LISSHKQKIVDISDRIADDVVLYQQDEMFPLQKSIEKAINNRSGRNLLLWVNDSQENLVA
HHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEE
MSANMSGPTWQRFEGPGSLATAFRDSIVPKVYHIQGRDFVACHSPLMVRNQSLGTLFVAQ
EECCCCCCCCHHCCCCCHHHHHHHHHCCCEEEEECCCCEEEECCCCEEECCCCCEEEEEH
DITEDQRQFIASVQSLALASSVAVVLITLALTWYVHRSLRSLSQMDLMTKAISPDDLGKT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KVEIDNAPSEIQELTETFNRMLERLSEAWHEQQHATERQREFVGNVSHELRTPLTIVRGY
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
LQSIQRRGDNLTEMQREALEISTAEANLTIQLLQDLLCLARADDGYMPYHLETLILNDVA
HHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VEVVNMADKFNQRQIDLEFESPLIPVFADAKRLQQVLVNLVENAIKYSATTEPVTVKLEQ
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
REDSALIHVCDRGDGIPLKQQSRIFERFYRLDEARARCTGGVGLGLSLVKTFTEGMGGQV
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEE
SVLSAEGEGSTFTVTLPISPEAKI
EEEEECCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
GELPIKSSLGKGWRNVSPQLRQAVNPKSLQFRLTASIAGLIAVGLTSVAVWTSWKMQRI
CCCCCCHHHCCCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LISSHKQKIVDISDRIADDVVLYQQDEMFPLQKSIEKAINNRSGRNLLLWVNDSQENLVA
HHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEE
MSANMSGPTWQRFEGPGSLATAFRDSIVPKVYHIQGRDFVACHSPLMVRNQSLGTLFVAQ
EECCCCCCCCHHCCCCCHHHHHHHHHCCCEEEEECCCCEEEECCCCEEECCCCCEEEEEH
DITEDQRQFIASVQSLALASSVAVVLITLALTWYVHRSLRSLSQMDLMTKAISPDDLGKT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KVEIDNAPSEIQELTETFNRMLERLSEAWHEQQHATERQREFVGNVSHELRTPLTIVRGY
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
LQSIQRRGDNLTEMQREALEISTAEANLTIQLLQDLLCLARADDGYMPYHLETLILNDVA
HHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VEVVNMADKFNQRQIDLEFESPLIPVFADAKRLQQVLVNLVENAIKYSATTEPVTVKLEQ
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
REDSALIHVCDRGDGIPLKQQSRIFERFYRLDEARARCTGGVGLGLSLVKTFTEGMGGQV
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEE
SVLSAEGEGSTFTVTLPISPEAKI
EEEEECCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA