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The map label for this gene is mrdB [H]

Identifier: 158334620

GI number: 158334620

Start: 1440971

End: 1442248

Strand: Direct

Name: mrdB [H]

Synonym: AM1_1450

Alternate gene names: 158334620

Gene position: 1440971-1442248 (Clockwise)

Preceding gene: 158334619

Following gene: 158334621

Centisome position: 22.16

GC content: 49.22

Gene sequence:

>1278_bases
ATGCTCATCAATAAAACGCTGCGCAAATGGTTTCCCTGGCGAACCTGGATTCAGCCTTGGGACAATATCGACCGCTGGTT
GCTGCTGTTAGCGATTGGGTTAACCGTGTTTGGCGGCATTTTAATTCGAAGTACCCAAGCCACTCAGGGTTGGACGGATT
GGCTCCAACACTGGACCATTGGAGCGATTGGGGTGGCCATTGCTATGACGATTGCCACCTGGCCCTATCAAATTTTATTG
AGTTTGCATTGGCTGATATATGCGGTGACGAACTTGTCCTTGATCGCCGTTATCGCCATCGGAACTAGCGAACTGGGGGC
TCAGCGATGGATCTCCGTTGCCGGTTTTAATGTGCAGCCATCTGAATTTGCCAAAGTGGGGGTCATTATTTCCCTGGCAG
CCCTACTTCACCATCGACCCGCCACTAAGCTATCGTCAGTACTTCAGATTCTAGCCATTACTTTTGTGCCTTGGGCGTTA
GTGCTAGTACAGCCCGACTTAGGAACATCTCTAGTGTTTGCGGCCATTACCCTAGGCATGATGTATTGGGCCAATGCCAA
TTTGGGATGGATTGTGCTGCTCTTTTCTCCCTTAATTTCCGGCATTTTATTCAATATCCCCCCCACTTCCCATTGGTTAT
GGATTATTTGGGCGATTTGGTTGGTGACGATTGCGTTTATCGGTTGGCTCAGCATCCCTGTTCGGATGATCGGGGGACTT
GGCGCTCTGTTGATTAATTTAGGCTCTGGTGTTTTGGGTAGAGTCGCTTGGGGATTTCTCCAGGATTATCAAAAAGCGCG
GATTATCTTGTTTCTCGACCCTGAGCAAGATCCTTTGGGTGGCGGCTATCACCTCATTCAATCTCGGATTGCCATTGGCT
CCGGGCAGTTGTGGGGTCGAGGGCTGGACCAAGGCACCCAAACTGGGTTGAGTTTTATCCCGGAACAGCATACGGATTTT
ATTTTTTCAGCTGCGGGTGAGCAATTTGGCTTTGTCGGCAGTTTGCTTTTGATTGTCGCCATTTGGCTATTATGCATGCG
CCTAATCTTTGTGGCGTTGAATGCGGAAGACGATTTTGGCTCTTTAATCGCCATCGGTGTGCTGTCGATGGTTATTTTTC
AGGTCTTTGTGAACATTAGTATGACCATCGGCCTGGCCCCTGTGACGGGAATTCCTTTGCCTTGGCTAAGCTATGGTCGT
TCAGCCCTGTTGACGAACTTTATTGCCATAGGGCTGGTGGAATCCGTGGCCAACCATCGTAAAAAACGCAGATTTTAG

Upstream 100 bases:

>100_bases
TGCGACGGAGGTGGCAGCGAAGGTTTCGGTCGCGGCTTTGACTTAAGTTGTTAGTTTAAGACCACTGCTTTTCATACAGC
CTTTAAGTTCCGATTCTTCC

Downstream 100 bases:

>100_bases
CAGCTCCCCCGCGAAGGGGAATTAGTCCACTATGATAAAAAAGCTATTGTGATGCAGTTAAGGTCTAAAACGAATGAGCG
CCATGATTTTGCCCGGTTCA

Product: cell cycle protein FtsW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLINKTLRKWFPWRTWIQPWDNIDRWLLLLAIGLTVFGGILIRSTQATQGWTDWLQHWTIGAIGVAIAMTIATWPYQILL
SLHWLIYAVTNLSLIAVIAIGTSELGAQRWISVAGFNVQPSEFAKVGVIISLAALLHHRPATKLSSVLQILAITFVPWAL
VLVQPDLGTSLVFAAITLGMMYWANANLGWIVLLFSPLISGILFNIPPTSHWLWIIWAIWLVTIAFIGWLSIPVRMIGGL
GALLINLGSGVLGRVAWGFLQDYQKARIILFLDPEQDPLGGGYHLIQSRIAIGSGQLWGRGLDQGTQTGLSFIPEQHTDF
IFSAAGEQFGFVGSLLLIVAIWLLCMRLIFVALNAEDDFGSLIAIGVLSMVIFQVFVNISMTIGLAPVTGIPLPWLSYGR
SALLTNFIAIGLVESVANHRKKRRF

Sequences:

>Translated_425_residues
MLINKTLRKWFPWRTWIQPWDNIDRWLLLLAIGLTVFGGILIRSTQATQGWTDWLQHWTIGAIGVAIAMTIATWPYQILL
SLHWLIYAVTNLSLIAVIAIGTSELGAQRWISVAGFNVQPSEFAKVGVIISLAALLHHRPATKLSSVLQILAITFVPWAL
VLVQPDLGTSLVFAAITLGMMYWANANLGWIVLLFSPLISGILFNIPPTSHWLWIIWAIWLVTIAFIGWLSIPVRMIGGL
GALLINLGSGVLGRVAWGFLQDYQKARIILFLDPEQDPLGGGYHLIQSRIAIGSGQLWGRGLDQGTQTGLSFIPEQHTDF
IFSAAGEQFGFVGSLLLIVAIWLLCMRLIFVALNAEDDFGSLIAIGVLSMVIFQVFVNISMTIGLAPVTGIPLPWLSYGR
SALLTNFIAIGLVESVANHRKKRRF
>Mature_425_residues
MLINKTLRKWFPWRTWIQPWDNIDRWLLLLAIGLTVFGGILIRSTQATQGWTDWLQHWTIGAIGVAIAMTIATWPYQILL
SLHWLIYAVTNLSLIAVIAIGTSELGAQRWISVAGFNVQPSEFAKVGVIISLAALLHHRPATKLSSVLQILAITFVPWAL
VLVQPDLGTSLVFAAITLGMMYWANANLGWIVLLFSPLISGILFNIPPTSHWLWIIWAIWLVTIAFIGWLSIPVRMIGGL
GALLINLGSGVLGRVAWGFLQDYQKARIILFLDPEQDPLGGGYHLIQSRIAIGSGQLWGRGLDQGTQTGLSFIPEQHTDF
IFSAAGEQFGFVGSLLLIVAIWLLCMRLIFVALNAEDDFGSLIAIGVLSMVIFQVFVNISMTIGLAPVTGIPLPWLSYGR
SALLTNFIAIGLVESVANHRKKRRF

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=364, Percent_Identity=37.6373626373626, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786277, Length=401, Percent_Identity=28.6783042394015, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 46966; Mature: 46966

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLINKTLRKWFPWRTWIQPWDNIDRWLLLLAIGLTVFGGILIRSTQATQGWTDWLQHWTI
CCCCHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
GAIGVAIAMTIATWPYQILLSLHWLIYAVTNLSLIAVIAIGTSELGAQRWISVAGFNVQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHEEECCHHHHHHHHHHHCCCCCCH
SEFAKVGVIISLAALLHHRPATKLSSVLQILAITFVPWALVLVQPDLGTSLVFAAITLGM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHH
MYWANANLGWIVLLFSPLISGILFNIPPTSHWLWIIWAIWLVTIAFIGWLSIPVRMIGGL
HHHCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALLINLGSGVLGRVAWGFLQDYQKARIILFLDPEQDPLGGGYHLIQSRIAIGSGQLWGR
HHHHHHHCCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCC
GLDQGTQTGLSFIPEQHTDFIFSAAGEQFGFVGSLLLIVAIWLLCMRLIFVALNAEDDFG
CCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
SLIAIGVLSMVIFQVFVNISMTIGLAPVTGIPLPWLSYGRSALLTNFIAIGLVESVANHR
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHH
KKRRF
HHCCC
>Mature Secondary Structure
MLINKTLRKWFPWRTWIQPWDNIDRWLLLLAIGLTVFGGILIRSTQATQGWTDWLQHWTI
CCCCHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
GAIGVAIAMTIATWPYQILLSLHWLIYAVTNLSLIAVIAIGTSELGAQRWISVAGFNVQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHEEECCHHHHHHHHHHHCCCCCCH
SEFAKVGVIISLAALLHHRPATKLSSVLQILAITFVPWALVLVQPDLGTSLVFAAITLGM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHH
MYWANANLGWIVLLFSPLISGILFNIPPTSHWLWIIWAIWLVTIAFIGWLSIPVRMIGGL
HHHCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALLINLGSGVLGRVAWGFLQDYQKARIILFLDPEQDPLGGGYHLIQSRIAIGSGQLWGR
HHHHHHHCCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCC
GLDQGTQTGLSFIPEQHTDFIFSAAGEQFGFVGSLLLIVAIWLLCMRLIFVALNAEDDFG
CCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
SLIAIGVLSMVIFQVFVNISMTIGLAPVTGIPLPWLSYGRSALLTNFIAIGLVESVANHR
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHH
KKRRF
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]