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The map label for this gene is purQ

Identifier: 158334604

GI number: 158334604

Start: 1426147

End: 1426854

Strand: Reverse

Name: purQ

Synonym: AM1_1434

Alternate gene names: 158334604

Gene position: 1426854-1426147 (Counterclockwise)

Preceding gene: 158334605

Following gene: 158334603

Centisome position: 21.94

GC content: 51.98

Gene sequence:

>708_bases
ATGAAGTTCGGTGTGCTGGTATTTCCAGGATCAAATTGCGATCGCGATGTCGTATTGGTCACTCGCGATCTGCTTAAACA
GCCCACTCGTATGGTCTGGCACCAAGAAACAGATATTAGTGATTTAGATGTCGTGGTTATTCCCGGTGGGTTTAGCTACG
GGGACTACCTGCGCTGTGGGGCTATTTCCCGATTTTCGCCCGCTATGCAGGCCACCATGGCCCACGCTGAGCAAGGCAAG
CTGGTCTTGGGAATTTGCAATGGGTTTCAGGTTCTGACGGAATCAGGATTATTGCCAGGGGCCTTAGTCCGAAATCGAGA
TCTGCATTTTATTTGCGATCGCGTTCCCGTGCGAGTAGAAAGAACGAACCTACCCTGGACCCAAGCCTATCAAGCGGGGC
AGGTGATTACCCTGCCCATTGCCCATGGTGAAGGCTGTTACTATGCCGATCCAGAGACCCTCAAACAGCTCCAAGCCAAT
CAGCAAATTCTGTTCCGCTATTGTCAGCCCAATGGTGAAATTACGCCAGATTCCAACCCCAACGGCTCGGTGGAGAACAT
TGCCGGTATTTGTAATCGACAAGGTAATGTGGTTGGCATGATGCCTCACCCCGAGCGAGCCTCTGATCCGACCTTGGGCT
ATACCGATGGCCTTTTACTCTTTCAAGGCGTATTGAACAGCCTCATGGCGCAAGGTGTGACGGCCTGA

Upstream 100 bases:

>100_bases
GTCAACAGGTTGATCGGATGTGTGATCAGCTCTTGGCGAATCCAGTGATTGAAAATTATCGGTTCGATCTGCAATTGGCC
CCAACGGCGGGAGCAGCAAA

Downstream 100 bases:

>100_bases
GTCAGCGAAAGGAGACAGCATCGATGCCCTCTCTCCTGCCTTTGCGTCGAATGCGTTGTTTCTTAAATCTATTAGATCAA
GGCCTGCTTGCTTCAATAGG

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKFGVLVFPGSNCDRDVVLVTRDLLKQPTRMVWHQETDISDLDVVVIPGGFSYGDYLRCGAISRFSPAMQATMAHAEQGK
LVLGICNGFQVLTESGLLPGALVRNRDLHFICDRVPVRVERTNLPWTQAYQAGQVITLPIAHGEGCYYADPETLKQLQAN
QQILFRYCQPNGEITPDSNPNGSVENIAGICNRQGNVVGMMPHPERASDPTLGYTDGLLLFQGVLNSLMAQGVTA

Sequences:

>Translated_235_residues
MKFGVLVFPGSNCDRDVVLVTRDLLKQPTRMVWHQETDISDLDVVVIPGGFSYGDYLRCGAISRFSPAMQATMAHAEQGK
LVLGICNGFQVLTESGLLPGALVRNRDLHFICDRVPVRVERTNLPWTQAYQAGQVITLPIAHGEGCYYADPETLKQLQAN
QQILFRYCQPNGEITPDSNPNGSVENIAGICNRQGNVVGMMPHPERASDPTLGYTDGLLLFQGVLNSLMAQGVTA
>Mature_235_residues
MKFGVLVFPGSNCDRDVVLVTRDLLKQPTRMVWHQETDISDLDVVVIPGGFSYGDYLRCGAISRFSPAMQATMAHAEQGK
LVLGICNGFQVLTESGLLPGALVRNRDLHFICDRVPVRVERTNLPWTQAYQAGQVITLPIAHGEGCYYADPETLKQLQAN
QQILFRYCQPNGEITPDSNPNGSVENIAGICNRQGNVVGMMPHPERASDPTLGYTDGLLLFQGVLNSLMAQGVTA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:
GO:0000166: Phosphoribosylformylglycinamidine synthase 1
GO:0003824: Phosphoribosylformylglycinamidine synthase 1
GO:0004642: Phosphoribosylformylglycinamidine synthase 1
GO:0005524: Phosphoribosylformylglycinamidine synthase 1
GO:0005737: Phosphoribosylformylglycinamidine synthase 1
GO:0006164: Phosphoribosylformylglycinamidine synthase 1
GO:0006189: Phosphoribosylformylglycinamidine synthase 1
GO:0006541: Phosphoribosylformylglycinamidine synthase 1
GO:0009236: Phosphoribosylformylglycinamidine synthase 1
GO:0016874: Phosphoribosylformylglycinamidine synthase 1

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=185, Percent_Identity=33.5135135135135, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17553022, Length=189, Percent_Identity=28.042328042328, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321498, Length=186, Percent_Identity=31.7204301075269, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24582111, Length=194, Percent_Identity=31.4432989690722, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24582109, Length=194, Percent_Identity=31.4432989690722, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17137292, Length=194, Percent_Identity=31.4432989690722, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_ACAM1 (B0C7S1)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001515776.1
- ProteinModelPortal:   B0C7S1
- GeneID:   5680254
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_1434
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   CLSK2316661
- BioCyc:   AMAR329726:AM1_1434-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 25720; Mature: 25720

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 203-203 ACT_SITE 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGVLVFPGSNCDRDVVLVTRDLLKQPTRMVWHQETDISDLDVVVIPGGFSYGDYLRCG
CCEEEEEECCCCCCCCEEEEEHHHHHCHHHHHEECCCCCCCCEEEEECCCCCCCCCEECC
AISRFSPAMQATMAHAEQGKLVLGICNGFQVLTESGLLPGALVRNRDLHFICDRVPVRVE
CCHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCHHHCCCCEEEEECCCCEEEE
RTNLPWTQAYQAGQVITLPIAHGEGCYYADPETLKQLQANQQILFRYCQPNGEITPDSNP
ECCCCHHHHHCCCCEEEEEEECCCCCEECCHHHHHHHHCCHHEEEEEECCCCCCCCCCCC
NGSVENIAGICNRQGNVVGMMPHPERASDPTLGYTDGLLLFQGVLNSLMAQGVTA
CCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKFGVLVFPGSNCDRDVVLVTRDLLKQPTRMVWHQETDISDLDVVVIPGGFSYGDYLRCG
CCEEEEEECCCCCCCCEEEEEHHHHHCHHHHHEECCCCCCCCEEEEECCCCCCCCCEECC
AISRFSPAMQATMAHAEQGKLVLGICNGFQVLTESGLLPGALVRNRDLHFICDRVPVRVE
CCHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCHHHCCCCEEEEECCCCEEEE
RTNLPWTQAYQAGQVITLPIAHGEGCYYADPETLKQLQANQQILFRYCQPNGEITPDSNP
ECCCCHHHHHCCCCEEEEEEECCCCCEECCHHHHHHHHCCHHEEEEEECCCCCCCCCCCC
NGSVENIAGICNRQGNVVGMMPHPERASDPTLGYTDGLLLFQGVLNSLMAQGVTA
CCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA