Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 158334567

GI number: 158334567

Start: 1373675

End: 1375069

Strand: Reverse

Name: fumC [H]

Synonym: AM1_1394

Alternate gene names: 158334567

Gene position: 1375069-1373675 (Counterclockwise)

Preceding gene: 158334572

Following gene: 158334566

Centisome position: 21.14

GC content: 48.32

Gene sequence:

>1395_bases
GTGCGGATTGAAACCGATAGTATGGGCAGCGTTGAGGTGCCGAGTGATTGTTATTGGGGCGCACAAACTCAACGGTCTCT
AAAATATTTTGCGATAGGCGATGACAAAATGCCGAGGGCGATGATTCGTGCCTTGGGCCTGGTTAAGCAAGCGGCAGCAA
AAGTGAATTTGACTTTGGATCGCCTGTCCCCAGAGGTGGCTAACTTGATTGTTGAGGCTGCCACCGAAGTGGTGAATGGT
CGATGGGATGATCAGTTCCCTTTACGGGTGTGGCAGACCGGCAGTGGCACTCAATCCAATATGAATGCCAATGAGGTGAT
TGCCAATCGCGCTATTGAGCTAGCGAATGGTCAATTGGGGAGTAAAGATCCTTGTCATCCCAATGATCATGTCAATCTGT
CTCAGTCATCGAATGATGTGTTTCCGACCGCTATGCATATTGCAGCTTTGGAGCAACTTGTCCATCAATTGATTCCTCAG
GTGACTGACCTTCGCGATGCCTTAGGGACCAAGGCTGGAGAATTTGATGGAATTGTCAAAATTGGCCGTACTCATTTGAT
GGATGCTGTGCCACTAACGTTAGGACAAGAGTTTTCGGGATATGTTGCTCAATTGGAACAAAATCTAACGCGACTCCAGC
ATACATTGCCACACCTGTATGAATTGGTTTTGGGGGGAACGGCTGTGGGGACTGGATTGAATACTCACCCTGAGTTCGCA
AAGCGAGTTGCTGACCAAATTGCAGAATTGACGGGTTTGCCCTTTGTGACTGCCCCGAATAAATTTGCAGGACTGGCTGC
CCATGATGCTTTAGTGATGACGAGTGGTGCGCTAAAAACCTTGGCTTGTAGTTTGGTCAAGATTGCCAATGACTTGCGCT
GGATGGCGTCGGGACCTCGCTGTGGATTGGGGGAGTTAAGCTTGCCAGCCAATGAACCAGGGTCGTCCATTATGCCTGGA
AAGGTGAATCCAACTCAGTGTGAAGCGTTAACGATGGTTTGCGCTCAGGTGATTGGTAATGACACAGCGATTAGTTTTGC
GGGGAGTCAGGGTAACCTAGAGCTGAATGTCTTTAAGCCAGTGATTATTCACAATCTTTTGCACTCTATTCGCATTCTTT
CGGATGCCTGTGATGCGTTCAAAACCTATCTGGTTGTTGGTGTTCAACCCAACTTGTCGCAAATAGAAACCTACCTGAAT
CAGTCATTGATGTTGGTGACAGCGCTAACGCCTCAAATTGGTTACGACCGGGCAGCACAAGTTGCGAAACAAGCGTATCA
AACGGGCCAAACCTTACGAGAAACTTGCGTCGCCCTTGGCTTTCTAACGGCTGAAGAATTCGATCAATCTGTGCAACCGG
TGCAAATGACTCACCCGTGGGACTCAAATATTTGA

Upstream 100 bases:

>100_bases
CCACGTTAACGTATGGTTGTACCATACTCTAAAATTTGCTGACATTTCTCGAAAAAAGGCCGAACTACGCATGTCTCAAC
TATCTCAGCGTAACGATAAA

Downstream 100 bases:

>100_bases
TTTTTTTACTAGACGTTCAGAACTGTCCTGATTCCTTAGTTTTTGGTTGATACTATGACTCAATTTCGGATGTTACCGAC
TGCGATCGCGGGTCTGATCG

Product: fumarate hydratase, class II

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MRIETDSMGSVEVPSDCYWGAQTQRSLKYFAIGDDKMPRAMIRALGLVKQAAAKVNLTLDRLSPEVANLIVEAATEVVNG
RWDDQFPLRVWQTGSGTQSNMNANEVIANRAIELANGQLGSKDPCHPNDHVNLSQSSNDVFPTAMHIAALEQLVHQLIPQ
VTDLRDALGTKAGEFDGIVKIGRTHLMDAVPLTLGQEFSGYVAQLEQNLTRLQHTLPHLYELVLGGTAVGTGLNTHPEFA
KRVADQIAELTGLPFVTAPNKFAGLAAHDALVMTSGALKTLACSLVKIANDLRWMASGPRCGLGELSLPANEPGSSIMPG
KVNPTQCEALTMVCAQVIGNDTAISFAGSQGNLELNVFKPVIIHNLLHSIRILSDACDAFKTYLVVGVQPNLSQIETYLN
QSLMLVTALTPQIGYDRAAQVAKQAYQTGQTLRETCVALGFLTAEEFDQSVQPVQMTHPWDSNI

Sequences:

>Translated_464_residues
MRIETDSMGSVEVPSDCYWGAQTQRSLKYFAIGDDKMPRAMIRALGLVKQAAAKVNLTLDRLSPEVANLIVEAATEVVNG
RWDDQFPLRVWQTGSGTQSNMNANEVIANRAIELANGQLGSKDPCHPNDHVNLSQSSNDVFPTAMHIAALEQLVHQLIPQ
VTDLRDALGTKAGEFDGIVKIGRTHLMDAVPLTLGQEFSGYVAQLEQNLTRLQHTLPHLYELVLGGTAVGTGLNTHPEFA
KRVADQIAELTGLPFVTAPNKFAGLAAHDALVMTSGALKTLACSLVKIANDLRWMASGPRCGLGELSLPANEPGSSIMPG
KVNPTQCEALTMVCAQVIGNDTAISFAGSQGNLELNVFKPVIIHNLLHSIRILSDACDAFKTYLVVGVQPNLSQIETYLN
QSLMLVTALTPQIGYDRAAQVAKQAYQTGQTLRETCVALGFLTAEEFDQSVQPVQMTHPWDSNI
>Mature_464_residues
MRIETDSMGSVEVPSDCYWGAQTQRSLKYFAIGDDKMPRAMIRALGLVKQAAAKVNLTLDRLSPEVANLIVEAATEVVNG
RWDDQFPLRVWQTGSGTQSNMNANEVIANRAIELANGQLGSKDPCHPNDHVNLSQSSNDVFPTAMHIAALEQLVHQLIPQ
VTDLRDALGTKAGEFDGIVKIGRTHLMDAVPLTLGQEFSGYVAQLEQNLTRLQHTLPHLYELVLGGTAVGTGLNTHPEFA
KRVADQIAELTGLPFVTAPNKFAGLAAHDALVMTSGALKTLACSLVKIANDLRWMASGPRCGLGELSLPANEPGSSIMPG
KVNPTQCEALTMVCAQVIGNDTAISFAGSQGNLELNVFKPVIIHNLLHSIRILSDACDAFKTYLVVGVQPNLSQIETYLN
QSLMLVTALTPQIGYDRAAQVAKQAYQTGQTLRETCVALGFLTAEEFDQSVQPVQMTHPWDSNI

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:
GO:0003824: Fumarate hydratase, class II
GO:0004333: Fumarate hydratase, class II
GO:0005737: Fumarate hydratase, class II
GO:0006099: Fumarate hydratase, class II
GO:0006106: Fumarate hydratase, class II
GO:0016829: Fumarate hydratase, class II
GO:0045239: Fumarate hydratase, class II

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=61.1713665943601, Blast_Score=569, Evalue=1e-162,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=50, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=62.5, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=42.4242424242424, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=59.6529284164859, Blast_Score=562, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=60.8562691131498, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=60.3036876355748, Blast_Score=566, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=58.8744588744589, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=58.8744588744589, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=56.0606060606061, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=56.8034557235421, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=51.0822510822511, Blast_Score=474, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50133; Mature: 50133

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIETDSMGSVEVPSDCYWGAQTQRSLKYFAIGDDKMPRAMIRALGLVKQAAAKVNLTLD
CCCCCCCCCCCCCCCCCCCCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEHH
RLSPEVANLIVEAATEVVNGRWDDQFPLRVWQTGSGTQSNMNANEVIANRAIELANGQLG
HCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
SKDPCHPNDHVNLSQSSNDVFPTAMHIAALEQLVHQLIPQVTDLRDALGTKAGEFDGIVK
CCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
IGRTHLMDAVPLTLGQEFSGYVAQLEQNLTRLQHTLPHLYELVLGGTAVGTGLNTHPEFA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHH
KRVADQIAELTGLPFVTAPNKFAGLAAHDALVMTSGALKTLACSLVKIANDLRWMASGPR
HHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHCCCCC
CGLGELSLPANEPGSSIMPGKVNPTQCEALTMVCAQVIGNDTAISFAGSQGNLELNVFKP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHH
VIIHNLLHSIRILSDACDAFKTYLVVGVQPNLSQIETYLNQSLMLVTALTPQIGYDRAAQ
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHH
VAKQAYQTGQTLRETCVALGFLTAEEFDQSVQPVQMTHPWDSNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MRIETDSMGSVEVPSDCYWGAQTQRSLKYFAIGDDKMPRAMIRALGLVKQAAAKVNLTLD
CCCCCCCCCCCCCCCCCCCCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEHH
RLSPEVANLIVEAATEVVNGRWDDQFPLRVWQTGSGTQSNMNANEVIANRAIELANGQLG
HCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
SKDPCHPNDHVNLSQSSNDVFPTAMHIAALEQLVHQLIPQVTDLRDALGTKAGEFDGIVK
CCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
IGRTHLMDAVPLTLGQEFSGYVAQLEQNLTRLQHTLPHLYELVLGGTAVGTGLNTHPEFA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHH
KRVADQIAELTGLPFVTAPNKFAGLAAHDALVMTSGALKTLACSLVKIANDLRWMASGPR
HHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHCCCCC
CGLGELSLPANEPGSSIMPGKVNPTQCEALTMVCAQVIGNDTAISFAGSQGNLELNVFKP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHH
VIIHNLLHSIRILSDACDAFKTYLVVGVQPNLSQIETYLNQSLMLVTALTPQIGYDRAAQ
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHH
VAKQAYQTGQTLRETCVALGFLTAEEFDQSVQPVQMTHPWDSNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]