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The map label for this gene is prlC [H]

Identifier: 158334549

GI number: 158334549

Start: 1351400

End: 1353511

Strand: Direct

Name: prlC [H]

Synonym: AM1_1376

Alternate gene names: 158334549

Gene position: 1351400-1353511 (Clockwise)

Preceding gene: 158334548

Following gene: 158334550

Centisome position: 20.78

GC content: 52.56

Gene sequence:

>2112_bases
ATGAGCAACGACACCCCCATCGCCGCCCAGGATAATCCCCTCCTCCTCTGTGAAGGCTTACCCCCTTTTGACCAAATTGA
GGCGGAGCACGTGCTGCCTGCCATTACCCAGTTATTAACTGAGCTAGAACAGGACTTAAAAACCCTGGAAGCAGAGGTCC
AACCTACTTGGACGGGCTTGGTGGAGCCTTTAGAACAGCTTGGAGACCGCTTGAGCTGGAGCTGGGGGATTATCGGGCAT
TTGATGGGAGTCAAGAATTCGCCAGAATTACGGGAAGCCTATGAAGCAGGCCAACCTAAGGTGGTGGAATTTATTAATCG
CTTGAGTCAGAGTCGCCCCATTTACGATGCCTATAAACAGCTTCAACAGAGTCCAGACTGGTCTCAGCTTGATCCCGCTC
AGAAACGCATCGTGGAGAGTGCCATTCGGGATGCAGAGCTGTCAGGAGTGGGTCTCACTGGAGAAGCAAAAAAGCGGTTC
AATCAAATTCAGCTAGAGCTAGCGAATCTCTCGACTCAGTTCTCTAATCATGTCTTGGATGCAACAAAGGCCTTTAATAT
CTTGTTGACCAATCCCAAGGAAGTCGCAGGCCTGCCGCCGAGTTTATTAAGCCTGGCAGCCCAGGCAGCCCGAGCCGTAG
GGGAGAAAGACTCAACACCCGAACATGGTCCCTGGTTGATGACCCTCGATATTCCCTGTTTTGGCCCTTTTATGCAACAT
AGCCAGCGCCGTGACTTACGAGAAAAGCTCTATCGCGCCTATATTAGTCGGGCCTCTGAAGGGGAATTTGATAACACCGA
CATTATTGACCGGATTCTGGAGCTGCGGAAAGAAGAAGCCAAGCTGCTCGGCTTCGAGACCTATGCGGAAGCGAGTCTCG
CCAGCAAAATGGCCCCCACGGTGTCTGCCGTTGAAACCTTACAGGAGCAGCTTCGACAAGCCAGTTTCGATCAAGCCACT
GCAGAACTCGACACCCTGAAAACCTTTGCCCAGGAACAAGGATCTGAGGAAAATAGCGATCTAAAACATTGGGATGTCAG
TTTCTGGGCCGAACGCCAGCGGGAAGCCAAGTTTGATATTACCGATGAACAACTGCGCCCCTATTTCCCCCTGCCCCAAG
TCTTAGACGGCTTGTTTAATCTGATCAATCGCCTCTTTGGAGTGACGGTGACCGCCGCCGATGGTCAAGCGCCGGTTTGG
CAGGACGATGTGCGCTATTTTCAAGTGGCCAATGAACAGGGAGAGCCGATCGCCCACTTCTACTTGGATCCCTACTCTCG
ACCTGCAGAGAAGCGGGGCGGGGCCTGGATGGATGAATGTTTGGGTCGTGCCCAGTTCCGTCGGGGCGATACGGTCAAGA
CTCGTTTACCCGTCGCCTACCTCATTTGCAATCAAACTCCCCCAGTAGATGGTAAACCCAGTTTAATGACCTTCCGAGAG
GTGGAAACCCTCTTCCATGAGTTCGGCCATGGGTTGCAGCATATGCTCACCCAGGTAGATTATGCCGGGGCGGCAGGCAT
CAACAATGTGGAATGGGATGCCGTCGAACTGCCCAGCCAGTTTATGGAAAATTGGTGCTACGACCGCCAAACTCTAATGG
GGATGGCCAAGCATTATGAGACAGGGGAGTCATTGCCAGAAGAGTATTACCAGAAGCTATTAGCGGCTCGCACCTATATG
AGCGGTAGTGCCATGCTGCGGCAGCTCCACTTTGGCATGGTGGATATGGAATTGCATCATAACTATGAGCCTGGTGGTTC
TGAGCAAGTGAAACAGGTGCGCGATCGCATCGCCAAAACCACCACTGTCCTGCCTCCTCTCCCTGAAGATTCTTTCCTCT
GTTCCTTTGGTCACATTTTTGCCGGAGGATATTCTGCAGGATATTACAGCTACAAATGGGCCGAAGTGCTCAGTGCCGAC
GCTTTTTCTGCCTTTGAAGAAGCTGGCCTCGAAAATGACGCCGCCATTCGAGAGACGGGCCGCCGCTTTCGCGACACCGT
TTTAGCATTAGGCGGCAGTCAACATCCCATGGAGGTCTTCAAATCCTTTCGAGGGCGAGAACCCAGCACAGAAGCGTTGC
TACGCCATAGTGGTCTCAAAGCCGAAGTCTAA

Upstream 100 bases:

>100_bases
CCCTACAATGTAGAAATGGACTGCTCCATCGATGTAGCTCCATTTCTCATGAGTAACTATGGGATTGACCTAGACTTTTT
GATCAAACATACAGAACATT

Downstream 100 bases:

>100_bases
ATGTTGTGTGGCCAACTTCAATCGCGATTGCTCAACACAACATGCCTGGAAGTTGGCCATGCTAGCATTATCCGAATATT
CGATATCAAGGATGGGGGAA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MSNDTPIAAQDNPLLLCEGLPPFDQIEAEHVLPAITQLLTELEQDLKTLEAEVQPTWTGLVEPLEQLGDRLSWSWGIIGH
LMGVKNSPELREAYEAGQPKVVEFINRLSQSRPIYDAYKQLQQSPDWSQLDPAQKRIVESAIRDAELSGVGLTGEAKKRF
NQIQLELANLSTQFSNHVLDATKAFNILLTNPKEVAGLPPSLLSLAAQAARAVGEKDSTPEHGPWLMTLDIPCFGPFMQH
SQRRDLREKLYRAYISRASEGEFDNTDIIDRILELRKEEAKLLGFETYAEASLASKMAPTVSAVETLQEQLRQASFDQAT
AELDTLKTFAQEQGSEENSDLKHWDVSFWAERQREAKFDITDEQLRPYFPLPQVLDGLFNLINRLFGVTVTAADGQAPVW
QDDVRYFQVANEQGEPIAHFYLDPYSRPAEKRGGAWMDECLGRAQFRRGDTVKTRLPVAYLICNQTPPVDGKPSLMTFRE
VETLFHEFGHGLQHMLTQVDYAGAAGINNVEWDAVELPSQFMENWCYDRQTLMGMAKHYETGESLPEEYYQKLLAARTYM
SGSAMLRQLHFGMVDMELHHNYEPGGSEQVKQVRDRIAKTTTVLPPLPEDSFLCSFGHIFAGGYSAGYYSYKWAEVLSAD
AFSAFEEAGLENDAAIRETGRRFRDTVLALGGSQHPMEVFKSFRGREPSTEALLRHSGLKAEV

Sequences:

>Translated_703_residues
MSNDTPIAAQDNPLLLCEGLPPFDQIEAEHVLPAITQLLTELEQDLKTLEAEVQPTWTGLVEPLEQLGDRLSWSWGIIGH
LMGVKNSPELREAYEAGQPKVVEFINRLSQSRPIYDAYKQLQQSPDWSQLDPAQKRIVESAIRDAELSGVGLTGEAKKRF
NQIQLELANLSTQFSNHVLDATKAFNILLTNPKEVAGLPPSLLSLAAQAARAVGEKDSTPEHGPWLMTLDIPCFGPFMQH
SQRRDLREKLYRAYISRASEGEFDNTDIIDRILELRKEEAKLLGFETYAEASLASKMAPTVSAVETLQEQLRQASFDQAT
AELDTLKTFAQEQGSEENSDLKHWDVSFWAERQREAKFDITDEQLRPYFPLPQVLDGLFNLINRLFGVTVTAADGQAPVW
QDDVRYFQVANEQGEPIAHFYLDPYSRPAEKRGGAWMDECLGRAQFRRGDTVKTRLPVAYLICNQTPPVDGKPSLMTFRE
VETLFHEFGHGLQHMLTQVDYAGAAGINNVEWDAVELPSQFMENWCYDRQTLMGMAKHYETGESLPEEYYQKLLAARTYM
SGSAMLRQLHFGMVDMELHHNYEPGGSEQVKQVRDRIAKTTTVLPPLPEDSFLCSFGHIFAGGYSAGYYSYKWAEVLSAD
AFSAFEEAGLENDAAIRETGRRFRDTVLALGGSQHPMEVFKSFRGREPSTEALLRHSGLKAEV
>Mature_702_residues
SNDTPIAAQDNPLLLCEGLPPFDQIEAEHVLPAITQLLTELEQDLKTLEAEVQPTWTGLVEPLEQLGDRLSWSWGIIGHL
MGVKNSPELREAYEAGQPKVVEFINRLSQSRPIYDAYKQLQQSPDWSQLDPAQKRIVESAIRDAELSGVGLTGEAKKRFN
QIQLELANLSTQFSNHVLDATKAFNILLTNPKEVAGLPPSLLSLAAQAARAVGEKDSTPEHGPWLMTLDIPCFGPFMQHS
QRRDLREKLYRAYISRASEGEFDNTDIIDRILELRKEEAKLLGFETYAEASLASKMAPTVSAVETLQEQLRQASFDQATA
ELDTLKTFAQEQGSEENSDLKHWDVSFWAERQREAKFDITDEQLRPYFPLPQVLDGLFNLINRLFGVTVTAADGQAPVWQ
DDVRYFQVANEQGEPIAHFYLDPYSRPAEKRGGAWMDECLGRAQFRRGDTVKTRLPVAYLICNQTPPVDGKPSLMTFREV
ETLFHEFGHGLQHMLTQVDYAGAAGINNVEWDAVELPSQFMENWCYDRQTLMGMAKHYETGESLPEEYYQKLLAARTYMS
GSAMLRQLHFGMVDMELHHNYEPGGSEQVKQVRDRIAKTTTVLPPLPEDSFLCSFGHIFAGGYSAGYYSYKWAEVLSADA
FSAFEEAGLENDAAIRETGRRFRDTVLALGGSQHPMEVFKSFRGREPSTEALLRHSGLKAEV

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=625, Percent_Identity=29.12, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI14149738, Length=629, Percent_Identity=30.0476947535771, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI156105687, Length=685, Percent_Identity=23.7956204379562, Blast_Score=172, Evalue=8e-43,
Organism=Escherichia coli, GI1789913, Length=697, Percent_Identity=45.3371592539455, Blast_Score=590, Evalue=1e-170,
Organism=Escherichia coli, GI1787819, Length=698, Percent_Identity=30.945558739255, Blast_Score=295, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI71999758, Length=603, Percent_Identity=25.7048092868988, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI32565901, Length=666, Percent_Identity=23.1231231231231, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319793, Length=667, Percent_Identity=28.7856071964018, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322715, Length=696, Percent_Identity=22.4137931034483, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21356111, Length=714, Percent_Identity=29.8319327731092, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI20129717, Length=638, Percent_Identity=21.3166144200627, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 79183; Mature: 79052

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDTPIAAQDNPLLLCEGLPPFDQIEAEHVLPAITQLLTELEQDLKTLEAEVQPTWTGL
CCCCCCCEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VEPLEQLGDRLSWSWGIIGHLMGVKNSPELREAYEAGQPKVVEFINRLSQSRPIYDAYKQ
HHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
LQQSPDWSQLDPAQKRIVESAIRDAELSGVGLTGEAKKRFNQIQLELANLSTQFSNHVLD
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKAFNILLTNPKEVAGLPPSLLSLAAQAARAVGEKDSTPEHGPWLMTLDIPCFGPFMQH
HHHHCEEEECCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHH
SQRRDLREKLYRAYISRASEGEFDNTDIIDRILELRKEEAKLLGFETYAEASLASKMAPT
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHH
VSAVETLQEQLRQASFDQATAELDTLKTFAQEQGSEENSDLKHWDVSFWAERQREAKFDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCC
TDEQLRPYFPLPQVLDGLFNLINRLFGVTVTAADGQAPVWQDDVRYFQVANEQGEPIAHF
CHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEE
YLDPYSRPAEKRGGAWMDECLGRAQFRRGDTVKTRLPVAYLICNQTPPVDGKPSLMTFRE
EECCCCCCHHHCCCCCHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCCCCCCCCHHHHHH
VETLFHEFGHGLQHMLTQVDYAGAAGINNVEWDAVELPSQFMENWCYDRQTLMGMAKHYE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
TGESLPEEYYQKLLAARTYMSGSAMLRQLHFGMVDMELHHNYEPGGSEQVKQVRDRIAKT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCHHHHHHHHHHHHHH
TTVLPPLPEDSFLCSFGHIFAGGYSAGYYSYKWAEVLSADAFSAFEEAGLENDAAIRETG
HCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RRFRDTVLALGGSQHPMEVFKSFRGREPSTEALLRHSGLKAEV
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SNDTPIAAQDNPLLLCEGLPPFDQIEAEHVLPAITQLLTELEQDLKTLEAEVQPTWTGL
CCCCCCEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VEPLEQLGDRLSWSWGIIGHLMGVKNSPELREAYEAGQPKVVEFINRLSQSRPIYDAYKQ
HHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
LQQSPDWSQLDPAQKRIVESAIRDAELSGVGLTGEAKKRFNQIQLELANLSTQFSNHVLD
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKAFNILLTNPKEVAGLPPSLLSLAAQAARAVGEKDSTPEHGPWLMTLDIPCFGPFMQH
HHHHCEEEECCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHH
SQRRDLREKLYRAYISRASEGEFDNTDIIDRILELRKEEAKLLGFETYAEASLASKMAPT
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHH
VSAVETLQEQLRQASFDQATAELDTLKTFAQEQGSEENSDLKHWDVSFWAERQREAKFDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCC
TDEQLRPYFPLPQVLDGLFNLINRLFGVTVTAADGQAPVWQDDVRYFQVANEQGEPIAHF
CHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEE
YLDPYSRPAEKRGGAWMDECLGRAQFRRGDTVKTRLPVAYLICNQTPPVDGKPSLMTFRE
EECCCCCCHHHCCCCCHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCCCCCCCCHHHHHH
VETLFHEFGHGLQHMLTQVDYAGAAGINNVEWDAVELPSQFMENWCYDRQTLMGMAKHYE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
TGESLPEEYYQKLLAARTYMSGSAMLRQLHFGMVDMELHHNYEPGGSEQVKQVRDRIAKT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCHHHHHHHHHHHHHH
TTVLPPLPEDSFLCSFGHIFAGGYSAGYYSYKWAEVLSADAFSAFEEAGLENDAAIRETG
HCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RRFRDTVLALGGSQHPMEVFKSFRGREPSTEALLRHSGLKAEV
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]